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Your search keyword '"Liang, Jingou"' showing total 12 results
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12 results on '"Liang, Jingou"'

10. Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivoand in vitro

Author

Huang, Xiaoyu, Ge, Yang, Yang, Bina, Han, Qi, Zhou, Wen, Liang, Jingou, Li, Mingyun, Peng, Xian, Ren, Biao, Yang, Bangcheng, Weir, Michael D., Guo, Qiang, Wang, Haohao, Zhou, Xinxuan, Lu, Xugang, Oates, Thomas W., Xu, Hockin H.K., Deng, Dongmei, Zhou, Xuedong, and Cheng, Lei

Abstract

Peri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials. The method shows good osteogenic properties but weak antibacterial effect. Therefore, we developed combined strategies to combat severe peri-implantitis, which included the use of a novel compound, PD, comprising dendrimers poly(amidoamine) (PAMAM) loading dimethylaminododecyl methacrylate (DMADDM) as well as MAO treatment. Here, we explored the chemical properties of the novel compound PD, and proved that this compound was successfully synthesized, with the loading efficiency and encapsulation efficiency of 23.91% and 31.42%, respectively. We further report the two-stage double benefits capability of PD + MAO: (1) in the first stage, PD + MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitroand in vivo; (2) in the second stage, PD + MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo. This study first reports the two-staged, double benefits of PD + MAO, and demonstrates its potential in clinical applications for inhibiting peri-implantitis, especially in patients with severe infection risk.

Published
2021
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12. A novel pH-responsive monomer inhibits Candida albicans via a dual antifungal mode of action.

Author

Li H, Shi Y, Chen H, Liang J, Zhang S, Li B, Chen J, Li M, Peng X, Zhou X, Ren B, and Cheng L

Abstract

The scarcity of the antifungal drug arsenal highlights an urgent need to develop alternative treatments for candidiasis caused by Candida albicans ( C. albicans ). As pH is closely associated with C. albicans infection, it could be an essential target in a novel approach for designing antifungal therapy. In this study, a novel intelligent antifungal monomer, dodecylmethylaminoethyl methacrylate (DMAEM), with a pH-responsive tertiary amine group and a methacrylate-derived CC double bond group is developed. It is uncovered that the two functional groups of DMAEM contribute to a dual mode of action. Under acidic pH, the tertiary amine of DMAEM protonates into a cationic fungicide, sharing similar structural and functional characteristics with quaternary ammonium salts, which exerts fungicidal activity by targeting the CHK1 two-component system in C. albicans . At neutral pH, the methacrylate-derived CC double bond group contributes to anti-virulence activity by blocking hyphal formation. In addition, it is also identified that DMAEM suppresses filamentation by altering the extracellular vesicles of C. albicans . These findings support that the novel intelligent pH-responsive monomer could be a therapeutic candidate for treating candidiasis.

Published
2024
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