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For a set of connected graphs, a spanning subgraph H of G is called a -factor if each component of H is isomorphic to a member of . In this paper, some sufficient conditions with regard to tight toughness, isolated toughness and binding number bounds to guarantee the existence of the { K 1 , j : 1 ≤ j ≤ 2 k } -factor and { P 2 , P 5 } -factor for any graph are obtained. [ABSTRACT FROM AUTHOR]

By sending out questionnaires to 106 counselors of 98 colleges and universities, panel discussion and interviewing, the authors implement a fairly comprehensive survey on the development of the financial aid system of assisting impoverished students in higher education institutes (HEIs) in China, including national student loans, award fund supported by government, on campus work-study and subsidy, etc. This paper aims at probing into some major problems that exist in this system and offer some suggestions and countermeasures on how to improve and develop the system.

For a vertex set S of G , we use κ S (G) to denote the maximum number of edge-disjoint Steiner trees of G such that any two of such trees intersect in S. The generalized k -connectivity of G is defined as κ k (G) = min S ⊆ V (G) , | S | = k κ S (G). We get that for any generalized Petersen graph G = G P (n , k) with n ≥ k + 3 , κ t (G) = 1 when t ≥ 2 k + 5. We give the values of κ k (G) for Petersen graph G P (5 , 2) , where 3 ≤ k ≤ 1 0 , and the values of κ k (G) for generalized Petersen graph G P (n , 1) , where n ≥ 3 and 3 ≤ k ≤ 2 n. [ABSTRACT FROM AUTHOR]

Impressive clinical benefit is seen in clinic with PD‐1 inhibitors on portion of cancer patients. Yet, there remains an urgent need to develop effective synergizers to expand their clinical application. Tumor‐associated macrophage (TAM), a type of M2‐polarized macrophage, eliminates or suppresses T‐cell‐mediated anti‐tumor responses. Transforming TAMs into M1 macrophages is an attractive strategy of anti‐tumor therapy. Here, we conducted a high‐throughput screening and found that Carfilzomib potently drove M2 macrophages to express M1 cytokines, phagocytose tumor cells, and present antigens to T cells. Mechanistically, Carfilzomib elicited unfolded protein response (UPR), activated IRE1α to recruit TRAF2, and activated NF‐κB to transcribe genes encoding M1 markers in M2 macrophages. In vivo, Carfilzomib effectively rewired tumor microenvironment through reprogramming TAMs into M1‐like macrophages and shrank autochthonous lung cancers in transgenic mouse model. More importantly, Carfilzomib synergized with PD‐1 antibody to almost completely regress autochthonous lung cancers. Given the safety profiles of Carfilzomib in clinic, our work suggested a potentially immediate application of combinational treatment with Carfilzomib and PD‐1 inhibitors for patients with solid tumors. Synopsis: Tumor‐associated macrophages (TAMs) are highly immunosuppressive. A high‐throughput drug screening was performed to identify FDA‐approved drugs that can reprogram TAMs into immunostimulatory M1 macrophages. Carfilzomib, together with two other protease inhibitors, was identified as capable of reprogramming M2 into M1 macrophages.ER stress‐IRE1a‐TRAF2‐NF‐kappa B axis was found responsible for the reprogramming.Carfilzomib treatment effectively shrinks autochthonous lung cancers in a transgenic mouse model.Carfilzomib synergized with PD‐1 antibody to completely regress autochthonous lung cancers in mice. [ABSTRACT FROM AUTHOR]

Two novel 3D Cd-MOFs, namely {[Cd4(HDDCP)2(4,4′-bibp)2(H2O)2]·2.5(DOA)·1.5(H2O)}n (1) and {[Cd2(HDDCP)(1,4-bib)(H2O)]·H2O}n (2), where H5DDCP = 2,4-di(2′,5′-dicarboxylphenyl)benzoic acid, 4,4′-bibp = 4,4′-bis(imidazolyl)biphenyl and 1,4-bib = 1,4-bis(1-imidazoly)benzene, have been solvothermally synthesized and structurally characterized by single crystal X-ray diffraction, elemental analysis (EA), thermogravimetric analysis (TGA) and infrared (IR) analysis. The structural analysis showed that 1 should be regarded as a complex 3D structure based on different 1D Cd–(COO) or Cd–(COO)–(COOH) rods as SBUs, and 2 was viewed as a complex 3D framework based on 1D Cd–(COO) rods as SBUs. MOFs 1 and 2 have good stability in boiling water, and alkaline/acidic aqueous solutions (pH = 4–10). The adsorption measurements indicated that the adsorption capacity of 1 for CO2 and CH4 is greater than that of 2, while the adsorption selectivity of 1 for CO2 is superior to that for CH4, which is attributed to the fact that 1 has a larger porosity and CO2 has characteristics such as a linear structure, larger polarizability and significant quadrupole moment. Furthermore, luminescence studies revealed that both 1 and 2 can be used as a highly selective and sensitive sensor for sensing TNP or Fe3+ ions in aqueous solution or soil samples, and the fluorescence quenching mechanism was explored in this work. [ABSTRACT FROM AUTHOR]