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Background: N6-methyladenosine (m6A) methylation played a key role in tumor growth. However, the relationship between m6A and soft tissue sarcoma (STS) was still unclear.Methods: The characterization and patterns of m6A modification in STS (TCGA-SARC and GSE17674) were analyzed comprehensively through bioinformatics and real-time polymerase chain reaction (RT-PCR). The effects of different m6A modification patterns on prognosis and immune infiltration of STS were further explored. Differentially expressed gene (DEG) analysis was performed. Moreover, an m6Ascore was constructed by principal component analysis (PCA). In addition, two immunotherapy datasets (IMvigor210 and GSE78220) and a sarcoma dataset (GSE17618) were used to evaluate the m6Ascore.Results: Huge differences were found in somatic mutation, CNV, and expression of 25 m6A regulators in STS. Two modification patterns (A and B) in STS were further identified and the m6A cluster A showed a better clinical outcome with a lower immune/stromal score compared with the m6A cluster B (p < 0.050).In addition to , most STS samples from m6A cluster A showed a high m6Ascore, which was related to mismatch repair and a better prognosis of STS (p < 0.001). In contrast, the m6A cluster B, characterized by a low m6Ascore, was related to the MYC signaling pathway, which led to a poor prognosis of STS. A high m6Ascore also contributed to a better outcome of PD-1/PD-L1 blockade immunotherapy.Conclusion: The modification patterns of 25 m6A regulators in the STS microenvironment were explored comprehensively. The novel m6Ascore effectively predicted the characteristics of the tumor microenvironment (TME) and outcome in STS and provided novel insights for future immunotherapy.

In recent years, Chinese Government adopts series of policies and actions to advance the building application of the renewable energy resources. Based on the policies for demonstration projects of application of renewable energy sources to buildings (ARESB) in China, this article discusses the policy systems for the demonstration projects in all aspects, including application and review systems, supervision and administration systems, inspection and assessment systems, and the whole policy systems are based on promoting the advance techniques, practicalities, reasonable economy, demonstration and generalization meaning of ARESB. Based on the actual construction and operation of the demonstration projects, the article also analyzes and evaluates the implementation effects and suitability in different areas concerning each technical type, and then analyzes and evaluates issues existing in the implementation of the policies for the demonstration projects of ARESB, with further policy suggestions provided.

Five new lanthanide supramolecular complexes, namely, [Sm(oqa){sub 2}(H{sub 2}O){sub 4}]{sub 2} (ClO{sub 4}){sub 2}.(bpy){sub 2} (1), [Ln(oqa){sub 3}].2H{sub 2}O [Ln=Sm(2), Gd(3)] and [Ln(oqa){sub 2}(NO{sub 3})(H{sub 2}O); Ln=Pr(4), Eu(5)] (oqa=4-oxo-1(4H)-quinolineacetate, bpy=4,4'-bipyridine), have been synthesized under hydrothermal conditions. These complexes exhibit three typical structure features. Complex 1 possesses a dimeric structure, which is further connected together through hydrogen bonds and pi-pi attractions, forming a 3D supramolecular framework. Compounds 2-3 are isomorphous and contain 1D ring-like chains, which are further interconnected by the oqa ligands into 2D sheet-like structures. 4 and 5 exhibit eight-connected 3D network of 4{sup 24}.6{sup 4}-bcu topology. The various coordination modes of carboxylate ligands and the selection of the counterions have clearly affected the topological structures. Furthermore, the solid-state luminescent properties of complexes 1, 2 and 5 were investigated at room temperature and they show intense, characteristic emissions in the visible region. - Graphical abstract Text7: The hydrothermal reactions of the oqa molecules with varied lanthanide ions resulted in the formation of five new complexes, which exhibit three typical structure features.

Reactions of 4-oxo-1(4H)-quinolineacetic acid (Hoqa) and varied metal salts of Zn(II), Cd(II) and Ag(I) resulted in the formation of three new coordination polymers, namely, [Zn(oqa)2]·H2O (1), [Cd(bpy)(oqa)2(H2O)2]·4H2O (2) and [Ag(bpy)(oqa)]·2H2O (3) (bpy = 4,4′-bipyridine). Complex 1 has a three-dimensional (3D) polymeric network with diamondoid topology; compounds 2–3 exhibit one-dimensional (1D) chain structure characteristics, which are further assembled through π–π stacking attractions and hydrogen bonds, forming the 3D supramolecular frameworks. In addition, the solid-state luminescent properties of the ligand Hoqa and complexes 1–2 have been investigated at room temperature.