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178 results on '"Liao, Linchuan"'

12. A simple aptamer-dye fluorescence sensor for detecting Δ9-tetrahydrocannabinol and its metabolite in urban sewage.

Author

Wei, Yingnan, Yang, Lin, Ye, Yi, Liao, Linchuan, Dai, Hao, Wei, Zeliang, Lin, Yao, and Zheng, Chengbin

Subjects
SEWAGE, FLUORESCENCE, DETECTORS, DATA visualization
Abstract

This work developed an aptamer-dye complex as a label-free ratiometric fluorescence sensor for rapid analysis of THC and its metabolite in sewage samples. Integrated with a portable fluorescence capture device, this sensor exhibited excellent sensitivity with visualization of as low as 0.6 μM THC via naked-eye observation, and THC analysis can be accomplished within 4 min, which would be a complementary tool for quantifying THC in sewage samples to estimate cannabis consumption. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Assessment of the forensic application of 50 Y-STR markers in a large pedigree.

Author

Ye, Yi, An, Yuran, Yang, Yiwen, Wu, Hao, Zheng, Yuzi, and Liao, Linchuan

Subjects
MICROSATELLITE repeats, Y chromosome, TANDEM repeats, GENEALOGY
Abstract

Short tandem repeats on the Y chromosome (Y-STRs), characterized by paternal inheritance, are valuable in forensic practice. Notably, the potential application of Y-STRs in pedigrees should be drawn upon, especially in China's surname-concentrated natural villages. The study focused on 50 Y-STRs, including 13 rapidly mutating (RM) Y-STRs that largely constitute the current Y-STR commercial kits, and determined the differences in these Y-STRs between branches in a large pedigree and the discriminatory power of these haplotypes in different units for male relatives. As indicated in the results, 14 inconsistencies were observed at 9 Y-STRs between 10 father-son pairs. In addition, these 50 Y-STR haplotypes discriminated 10 out of 47 father-son pairs, 106 of 148 cousin pairs, 70 of 119 uncle-nephew pairs, 17 of 39 brother pairs, and 14 out of 33 grandfather-grandson pairs in a large pedigree. The RM Y-STR set is able to differentiate close male relatives in a large pedigree. [ABSTRACT FROM AUTHOR]

Published
2022
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50. High expression of COUP-TF II cooperated with negative Smad4 expression predicts poor prognosis in patients with colorectal cancer

Author

Wang, Chaoqun, Zhou, Yun, Ruan, Ruoyun, Zheng, Maojin, Han, Wencan, and Liao, Linchuan

Subjects
Adult, Male, Down-Regulation, Kaplan-Meier Estimate, COUP Transcription Factor II, Predictive Value of Tests, Risk Factors, Biomarkers, Tumor, Humans, neoplasms, Aged, Neoplasm Staging, Proportional Hazards Models, Smad4 Protein, PTEN Phosphohydrolase, Middle Aged, Immunohistochemistry, digestive system diseases, Up-Regulation, Treatment Outcome, Tissue Array Analysis, Lymphatic Metastasis, Multivariate Analysis, Original Article, Female, Colorectal Neoplasms
Abstract

Objective: In order to evaluate whether the role of chicken ovalbumin upstream promoter transcription factor II (COUP-TF II) could sever as a predictor to stratify risk of human colorectal cancer (CRC) patients, and to elucidate the preliminary molecular mechanisms of COUP-TF II involved in the development and advancement of CRC reflected by investigating the relationship of COUP-TF II with PTEN, Smad4. Methods: 112 cases tissue microarray and immunohistochemical SP method were used to detect the expression of COUP-TF II, PTEN and Smad4 in CRC tissues and adjacent non-tumorous tissues. The clinical relevance and prognosis of COUP-TF II, PTEN, Smad4 in CRC patients were analyzed. Furthermore, Cox proportional hazards model was performed to indicate the independent prognostic factors for CRC patients using various clinicopathological parameters and COUP-TF II, PTEN and Smad4. Results: COUP-TF II proteins were positively expressed in 65.2% of CRC tissues and 15.5% paired non-CRC tissues, respectively. The expression of COUP-TF II was significantly correlated with TNM stage and lymph node metastasis and a negative correlation with Smad4 expression. Patients bearing higher levels of COUP-TF II expression showed lower DFS and OS. Most importantly, Cox proportional hazards regression analyses showed COUP-TF II positive/Smad4 negative status (DFS, P=0.001; OS, P=0.005) were independent prognostic factors for CRC patients. Conclusion: Positive COUP-TF II expression levels has significant value in determining CRC stage and metastasis and cooperates with negative Smad4 expression contributing to assess prognosis in patients with colorectal cancer, suggesting Smad4 may be involved in the above regulation progress probably.

Published
2015

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