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156 results on '"Liao, Naishun"'

6. METTL16 Mediated LncRNA TIALD m6A Modification contributes to hepatocellular carcinoma metastasis via inducing AURKA lysosomal degradation

Author

Zhao, Bixing, primary, Wang, Yingchao, additional, Zhong, Yue, additional, Zheng, Xiaoyuan, additional, Cheng, Niangmei, additional, Yang, Yong, additional, Yang, Ye, additional, Wang, Fei, additional, Zhuang, Qiuyu, additional, Huang, Yao, additional, Guo, Wuhua, additional, Liao, Naishun, additional, Yang, Xiao-Yu, additional, and Liu, Xiao-Long, additional

Published
2023
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14. Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel.

Author

Zhuang, Qiuyu, Zhao, Binyu, Lin, Zhiwen, Liang, Yuzhi, Zhao, Qingfu, Wang, Yunhao, Liao, Naishun, Tu, Haibin, Zheng, Youshi, Chen, Hengkai, Zeng, Yongyi, Zhang, Da, and Liu, Xiaolong

Subjects
MICE, HUMAN herpesvirus 1, TUMOR microenvironment, ONCOLYTIC virotherapy, IMMUNOTHERAPY
Abstract

Oncolytic virotherapy can lead to tumor lysis and systemic anti-tumor immunity, but the therapeutic potential in humans is limited due to the impaired virus replication and the insufficient ability to overcome the immunosuppressive tumor microenvironment (TME). To solve the above problems, we identified that Indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor Navoximod promoted herpes simplex virus type 1 (HSV-1) replication and HSV-1-mediated oncolysis in tumor cells, making it a promising combination modality with HSV-1-based virotherapy. Thus, we loaded HSV-1 and Navoximod together in an injectable and biocompatible hydrogel (V-Navo@gel) for hepatocellular carcinoma (HCC) virotherapy. The hydrogel formed a local delivery reservoir to maximize the viral replication and distribution at the tumor site with a single-dose injection. Notably, V-Navo@gel improved the disease-free survival time of HCC- bearing mice and protects the mice against tumor recurrence. What's more, V-Navo@gel also showed an effective therapeutic efficacy in the rabbit orthotopic liver cancer model. Mechanistically, we further discovered that our combination strategy entirely reprogramed the TME through single-cell RNA sequencing. All these results collectively indicated that the combination of Navoximod with HSV-1 could boost the viral replication and reshape TME for tumor eradication through the hydrogel reservoir. An injectable and biocompatible hydrogel loaded with both Indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor and herpes simplex virus type 1 (HSV-1) displays synergistic anti-cancer effects in vivo by remodeling the tumor microenvironment and generating immune memory effects. [ABSTRACT FROM AUTHOR]

Published
2023
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23. pH/hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02408a

Author

Zhang, Da, Cai, Zhixiong, Liao, Naishun, Lan, Shanyou, Wu, Ming, Sun, Haiyan, Wei, Zuwu, Li, Juan, and Liu, Xiaolong

Subjects
Chemistry, education
Abstract

We have integrated the pH/hypoxia-triggered Fe(iii)-banoxantrone (AQ4N) prodrug and semiconducting polymer dots (SPs) for programmable triggered cancer photothermal-chemotherapy., Although photothermal therapy (PTT) has become a compelling strategy for cancer therapy, few studies concern the physiological consequences of PTT ablation. Herein, we discover that PTT-induced hyperthermia can aggravate tumor hypoxia, which may increase the risk of tumor recurrence and reduce PTT efficacy. We thus integrated the pH/hypoxia-triggered Fe(iii)-banoxantrone (AQ4N) prodrug and semiconducting polymer dots (SPs) for programmable triggered cancer photothermal-chemotherapy. A SP-hybridized mesoporous silica framework, decorated by dopamine and polyethylene glycol, named PPMSF, was synthesized by a simple method, and then served as an efficient photo-absorbing agent (PTA) and drug carrier. Fe(iii)-AQ4N and Mn(ii) were then coordinated with PPMSF (abbreviated Mn-APPMSF) via coordination effects. The nanohybrids exhibited tumor micro-environment pH triggered drug release. Under the irradiation of NIR light, magnetic resonance imaging (MRI) tracked the accumulation of the nanohybrids in tumors which then destroyed tumor cells by local hyperthermia, this can consequently aggravate the tumor hypoxia levels. Intriguingly, the aggravated hypoxia can further enhance the reduction of AQ4N to significantly improve therapeutic efficacy and effectively inhibit tumor growth when compared with traditional PTT. These results indicate the potential of our nanohybrids as a programmable synergistic agent for cancer therapy.

Published
2018

26. HIF-1α and HDAC1 Mediated Down-Regulation of FAM99A Contributes to Hypoxia Induced HCC Metastasis

Author

Zhao, Bixing, primary, Ke, Kun, additional, Wang, Yingchao, additional, Wang, Fei, additional, Shi, Yingjun, additional, Li, Zhenli, additional, Zheng, Xiaoyuan, additional, Huang, Jingyun, additional, Liao, Naishun, additional, Cai, Zhixiong, additional, Lai, Yongping, additional, Zheng, Youshi, additional, Yang, Xiaoyu, additional, Liu, Xiaolong, additional, and Liu, Jingfeng, additional

Published
2020
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27. Inflammatory Micro-environment Contributes to Stemness Properties and Metastatic Potential of HCC via the NF-κB/miR-497/SALL4 Axis

Author

Zhao, Bixing, primary, Wang, Yingchao, additional, Tan, Xionghong, additional, Ke, Kun, additional, Zheng, Xiaoyuan, additional, Wang, Fei, additional, Lan, Shubing, additional, Liao, Naishun, additional, Cai, Zhixiong, additional, Shi, Yingjun, additional, Zheng, Youshi, additional, Lai, Yongping, additional, Wang, Lili, additional, Li, Qin, additional, Liu, Jingfeng, additional, Huang, Aimin, additional, and Liu, Xiaolong, additional

Published
2019
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33. An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy

Author

Zhao, Bixing, primary, Wang, Yingchao, additional, Tan, Xionghong, additional, Zheng, Xiaoyuan, additional, Wang, Fei, additional, Ke, Kun, additional, Zhang, Cuilin, additional, Liao, Naishun, additional, Dang, Yuan, additional, Shi, Yingjun, additional, Zheng, Youshi, additional, Gao, Yunzhen, additional, Li, Qin, additional, Liu, Xiaolong, additional, and Liu, Jingfeng, additional

Published
2019
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39. Ultrastructural change of the subchondral bone increases the severity of cartilage damage in osteoporotic osteoarthritis of the knee in rabbits

Author

Zhang, Jiahui, primary, Chen, Sainan, additional, Chen, Wenlie, additional, Huang, Yunmei, additional, Lin, Ruhui, additional, Huang, Meiya, additional, Wu, Yinsheng, additional, Zheng, Liangpu, additional, Li, Zuanfang, additional, Liao, Naishun, additional, Ye, Jinxia, additional, and Liu, Xianxiang, additional

Published
2018
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44. Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma

Author

Zhang, Da, primary, Zheng, Aixian, additional, Li, Juan, additional, Wu, Ming, additional, Wu, Lingjie, additional, Wei, Zuwu, additional, Liao, Naishun, additional, Zhang, Xiaolong, additional, Cai, Zhixiong, additional, Yang, Huanghao, additional, Liu, Gang, additional, Liu, Xiaolong, additional, and Liu, Jingfeng, additional

Published
2017
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