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Acute Chronic Liver Failure (ACLF) is the most common type of Liver Failure. The clinical symptoms are complex and changeable, the treatment is difficult and the fatality rate is high.It has become an urgent problem to actively seek effective treatment means and improve the clinical efficacy of ACLF patients. Studies have shown that decreased intestinal barrier function and bacterial endotoxin translocation in ACLF patients are considered to be the key causes of enterogenic endotoxemia, and traditional Chinese medicine enema has certain advantages in adjuvant treatment of this disease. However, due to the lack of evidence, there is no specific method or suggestion, so it is necessary to carry out systematic evaluation on Traditional Chinese medicine enema for acute chronic liver failure and provide effective evidence for further research.

Additional file 3: Supplementary Fig. 3. A Stratified Analysis of Niacin Intakes Below and Above the Recommended Levels. A for all-cause mortality, B for cancer mortality. Adjusted for age, sex, race, bmi, education, smoking status, drinking, diabetes, aspirin use, physical activity, energy intake, protein intake, sugar, carbohydrate, total fat intake, Vit B1, VitB2, Cholesterol, fiber.

Additional file 1: Supplementary Fig. 1. Dose-Response Relationship Between Niacin Intake and Mortality. A for cancer-specific mortality, B for all-cause mortality. Adjusted for age, sex, race, bmi, education, smoking status, drinking, diabetes, aspirin use, physical activity, energy intake, protein intake, sugar, carbohydrate, total fat intake, Vit B1, VitB2, Cholesterol, fiber.

Additional file 2: Supplementary Fig. 2. Histogram for Niacin Intake in Supplement Group And no Supplement Group.