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147 results on '"Liao, Ruoxi"'

16. Pharmacokinetics and pharmacodynamics of sacubitril/valsartan in peritoneal dialysis patients

Author

He, Yi, primary, Jin, Ying, additional, Xue, Hen, additional, Liu, Runhan, additional, Zhang, Mengyu, additional, Liao, Ruoxi, additional, Chen, Maoli, additional, Zhou, Xueli, additional, He, Xueqin, additional, Qin, Min, additional, Li, Kuo, additional, Zou, Huiqun, additional, Gan, Ying, additional, Wang, Zhenlei, additional, Zheng, Li, additional, Zhong, Hui, additional, and Fu, Ping, additional

Published
2023
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18. Targeting Regulatory T Cell Plasticity with BCL-2 Inhibition

Author

Liao, Ruoxi

Subjects
Oncology
Abstract

The specific BCL-2 small molecule inhibitor venetoclax has been shown to effectively induce apoptosis in a wide range of malignancies either alone and in combination with other drugs. Based upon these results, there has been considerable growth in its use in clinical studies used alone and in combination with chemotherapy and immune-based therapies. Lympho- cytes, and T cells in particular, rely heavily on BCL-2 for survival and function. This has been determined largely by genetic deletion or overexpression of BCL-2 in murine models. However, the adaptive effects of short or long-term small molecule BCL-2 family blockade on surviving immune cell subsets and their function is not fully understood. In the current work, we aimed to better understand the effect of long-term systemic treatment with venetoclax on regulatory T (Treg) cells, which are relatively apoptotically resistant to specific BCL-2 drugging compared to other T cells. Our results indicate that long-term BCL-2 blockade by venetoclax results in Treg plasticity towards a TH17-like functional state which aids in anti-PD-1 efficacy. Our data further highlights the importance of Treg instability on the efficacy of anti-PD-1 checkpoint blockade which will be beneficial for the clinical efficacy of immunotherapy.

Published
2023
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32. Associations Between 25-Hydroxyvitamin D, Kidney Function, and Insulin Resistance Among Adults in the United States of America

Author

Geng, Jiwen, primary, Qiu, Yuxuan, additional, Li, Yupei, additional, Li, Jiameng, additional, Liao, Ruoxi, additional, Du, Heyue, additional, Jiang, Luojia, additional, Wang, Liya, additional, Qin, Zheng, additional, Yang, Qinbo, additional, Yu, Qiao, additional, Zhang, Zhuyun, additional, and Su, Baihai, additional

Published
2022
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42. A narrative review of exosomes in vascular calcification

Author

Qin, Zheng, primary, Liao, Ruoxi, additional, Xiong, Yuqin, additional, Jiang, Luojia, additional, Li, Jiameng, additional, Wang, Liya, additional, Han, Mei, additional, Sun, Si, additional, Geng, Jiwen, additional, Yang, Qinbo, additional, Zhang, Zhuyun, additional, Li, Yupei, additional, Du, Heyue, additional, and Su, Baihai, additional

Published
2021
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45. The effects of citrate dialysate in hemodialysis on polymorphonuclear elastase interaction with tissue factor and its inhibitor

Author

Li, Jiameng, primary, Sun, Si, additional, Han, Mei, additional, Wang, Liya, additional, Liao, Ruoxi, additional, Xiong, Yuqin, additional, Li, Yupei, additional, Jiang, Heng, additional, Qin, Zheng, additional, Maharjan, Anil, additional, Cozzolino, Mario, additional, Zarbock, Alexander, additional, and Su, Baihai, additional

Published
2019
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50. Vascular calcification is associated with Wnt‐signaling pathway and blood pressure variability in chronic kidney disease rats.

Author

Liao, Ruoxi, Wang, Liya, Li, Jiameng, Sun, Si, Xiong, Yuqin, Li, Yupei, Han, Mei, Jiang, Heng, Anil, Mahajan, and Su, Baihai

Subjects
*CHRONIC kidney failure, *BLOOD pressure, *RAT diseases, *CARDIOVASCULAR diseases risk factors, *CALCIFICATION
Abstract

Aim: Vascular calcification (VC) is a common complication in chronic kidney disease (CKD) and has been shown to be associated with increased cardiovascular events and mortality. This study was to explore the role of Wnt‐signaling pathway in CKD VC, and the association between VC and blood pressure variability (BPV) which is a risk factor of cardiovascular events. Methods: Adult male Sprague‐Dawley rats were divided into adenine‐induced CKD group (n = 5), 5/6 nephrectomy CKD group (n = 5), sham group (n = 5) and control group (n = 5). Low‐calcium‐high‐phosphate diets were introduced to induce vascular calcification. Both daytime (hour‐to‐hour during the day) and mid‐term (day‐to‐day for 9 days) blood pressure (BP) were collected and analyzed for BPV metrics. At sacrifice, kidney, heart and aorta samples were taken for histological analyses. Calcium deposition in aorta was identified with Alizarin Red stain and graded. Immunohistochemistry stain and western blot were performed for Wnt3a, Wnt5a, β‐catenin, sclerostin, osteopontin, and α‐SMA. Results: Compared with control rats, CKD rats suffered from markedly severer VC (Grade 2.6 ± 0.2 and 1.8 ± 0.8 vs 0.0 ± 0.0 and 0.2 ± 0.4, P =.0010). VC was positively correlated with vascular Wnt3a and β‐catenin expression (P =.0032 and.0000), but not significantly associated with Wnta5a or sclerostin. Besides, CKD rats showed increased BPV (P <.001), which was also positively correlated with VC. Conclusion: We confirmed that CKD rats had enhanced Wnt‐signaling in vascular tissue and severer aorta calcification together with increased BPV. Wnt pathway may be a potential target in future VC and BPV management in CKD. SUMMARY AT A GLANCE: Vascular calcification was positively correlated with Wnt‐signaling and blood pressure variability (BPV) based on two experimental CKD models. These findings provide a new potential target for BPV management. [ABSTRACT FROM AUTHOR]

Published
2020
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