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2. Common genetic susceptibility loci link PFAPA syndrome, Behçet’s disease, and recurrent aphthous stomatitis

Author

The Genomic Ascertainment Cohort, Manthiram, Kalpana, Preite, Silvia, Dedeoglu, Fatma, Demir, Selcan, Ozen, Seza, Edwards, Kathryn M., Lapidus, Sivia, Katz, Alexander E., Feder, Henry M., Lawton, Maranda, Licameli, Greg R., Wright, Peter F., Le, Julie, Barron, Karyl S., Ombrello, Amanda K., Barham, Beverly, Romeo, Tina, Jones, Anne, Srinivasalu, Hemalatha, Mudd, Pamela A., DeBiasi, Roberta L., Gül, Ahmet, Marshall, Gary S., Jones, Olcay Y., Chandrasekharappa, Settara C., Stepanovskiy, Yuriy, Ferguson, Polly J., Schwartzberg, Pamela L., Remmers, Elaine F., and Kastner, Daniel L.

Published
2020

6. Vestibular Preservation in Pediatric Cochlear Implantation.

Author

Licameli, Greg R., Wang, Alicia, Zhou, Guangwei, Faller, David, Kenna, Margaret, Poe, Dennis, Shearer, Eliot, Oster, Linda, and Brodsky, Jacob R.

Abstract

Objectives: Evaluate the rate of preserved vestibular function in pediatric cochlear implant surgery. Study Design: Retrospective case review. Methods: Pre‐ and post‐operative vestibular tests were compared in children who underwent cochlear implantation at a tertiary level pediatric hospital over a 4‐year period. Results: Data from 59 implanted ears in 44 children was included. Median age was 2.8 years at initial testing (range 7 months – 21 years) with 1:1 male/female ratio. Implant surgeries were 26 unilateral, 13 bilateral simultaneous, and 5 bilateral sequential. The majority were implanted with slim, non‐styletted electrodes (86.4%) via a round window approach (91.5%). Normal pre‐operative results were preserved post‐operatively on rotary chair testing in 75% (21/28) of patients, cervical vestibular evoked myogenic potential testing in (75%) 30/40 of ears tested, ocular vestibular evoked myogenic potential testing in 85.7% (6/7) of ears tested, video head impulse testing in 100% (9/9) of ears tested, and computerized dynamic posturography in 100% (5/5) of patients tested. Overall, 62.5% of patients had no new deficits on any vestibular test performed post‐operatively. Conclusions: Preservation rates of vestibular function following cochlear implant surgery were higher in this cohort than what has been reported in many earlier studies. Contemporary, less traumatic electrodes and insertion techniques may be a significant factor. The risk of causing a new, severe bilateral vestibular loss with long‐term functional impacts appears to be low. Further study is warranted on the impacts of different cochlear implant electrode designs and insertion approaches on post‐operative vestibular preservation. Level of Evidence: 4, Case Series Laryngoscope, 134:1913–1918, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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7. International Pediatric Otolaryngology Group (IPOG) Consensus Recommendations: Congenital Cholesteatoma

Author

Denoyelle, Françoise, Simon, François, Chang, Kay W., Chan, Kenny H., Cheng, Alan G., Cheng, Alan T., Choo, Daniel I., Daniel, Sam J., Farinetti, Anne, Garabedian, Erea-Noël, Greinwald, John H., Hoff, Stephen R., Hone, Stephen, Licameli, Greg R., Papsin, Blake C., Poe, Dennis S., Pransky, Seth, Smith, Richard J. H., Triglia, Jean-Michel, Walton, Joanna, Zalzal, George, and Leboulanger, Nicolas

Published
2020
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15. Contributors

Author

Abuzeid, Waleed M., primary, Adams, Meredith E., additional, Adamson, Peter A., additional, Adenis, Antoine, additional, Akst, Seth, additional, Albers, Sheri L., additional, Albert, David, additional, Alexander, Ronda E., additional, Archbold, Sue, additional, Armstrong, William B., additional, Arriaga, Moisés A., additional, Arts, H. Alexander, additional, Ashram, Yasmine A., additional, Aviv, Jonathan E., additional, Aygun, Nafi, additional, Backous, Douglas D., additional, Baker, Shan R., additional, Balkany, Thomas J., additional, Baloh, Robert W., additional, Barkmeier-Kraemer, Julie, additional, Baroody, Fuad M., additional, Bartlett, Nancy L., additional, Baskin, Jonathan Z., additional, Bastian, Robert W., additional, Bauer, Carol A., additional, Benninger, Michael S., additional, Bhama, Prabhat K., additional, Bhatti, Nasir Islam, additional, Blitzer, Andrew, additional, Boardman, Simone, additional, Boss, Emily F., additional, Brackmann, Derald E., additional, Bradford, Carol R., additional, Branstetter, Barton F., additional, Braun, Edward B., additional, Briggs, Robert J.S., additional, Brodie, Hilary A., additional, Brown, Carolyn J., additional, Brown, David J., additional, Brown, Kevin D., additional, Browne, J. Dale, additional, Buatti, John M., additional, Buchmann, Luke, additional, Byrne, Patrick J., additional, Galzada, Gabriel G., additional, Carey, John P., additional, Casselbrant, Margaretha L., additional, Castelnuovo, Paolo, additional, Chang, Steven, additional, Chegar, Burke E., additional, Chen, Amy, additional, Chen, Eunice Y., additional, Chen, Theodore, additional, Chepeha, Douglas B., additional, Cheuk, Alice, additional, Chheda, Neil N., additional, Chien, Wade, additional, Choi, Sukgi S., additional, Chole, Richard A., additional, Christian, James M., additional, Chu, Eugene A., additional, Citardi, Martin J., additional, Cohen, Marc A., additional, Collins, Savita, additional, Collop, Nancy A., additional, Contencin, Philippe, additional, Cook, Raymond, additional, Corey, Jacquelynne, additional, Cotton, Robin T., additional, Couch, Marion Everett, additional, Courey, Mark S., additional, Crane, Benjamin T., additional, Crumley, Roger L., additional, Cruz, Oswaldo Laércio M., additional, Culicchia, Frank, additional, Cummings, Charles W., additional, Cunningham, Calhoun D., additional, Davis, Greg E., additional, Davis, Larry E., additional, Day, Terry A., additional, De la Cruz, Antonio, additional, Santina, Charles C. Della, additional, Denlinger, Chadrick, additional, Derkay, Craig S., additional, Diaz, Rodney C., additional, Dobie, Robert A., additional, Galli, Suzanne K. Doud, additional, Duncan, Newton O., additional, Eggers, Scott D.Z., additional, Eisbruch, Avraham, additional, Eisele, David W., additional, El-Kashlan, Hussam K., additional, Elluru, Ravindhra G., additional, Ende, Kevin H., additional, Erman, Audrey B., additional, Fakhri, Samer, additional, Fakhry, Carole, additional, Farrior, Edward H., additional, Farrior, Richard T., additional, Faust, Russell A., additional, Ferguson, Berrylin J., additional, Flint, Paul W., additional, Francis, Howard W., additional, Fried, Marvin P., additional, Friedland, David R., additional, Friedman, Oren, additional, Frodel, John L., additional, Funk, Gerry F., additional, Gantz, Bruce J., additional, Garrett, C. Gaelyn, additional, Gartner-Schmidt, Jackie, additional, Gay, William Donald, additional, Ge, Norman N., additional, Gillespie, M. Boyd, additional, Girod, Douglas A., additional, Goding, George S., additional, Goldberg, Andrew N., additional, Goldenberg, David, additional, Graney, Daniel O., additional, Grant, Nazaneen N., additional, Grégoire, Vincent, additional, Gries, Heike, additional, Gubbels, Samuel P., additional, Guss, Joel, additional, Ha, Patrick, additional, Hamilton, Grant S., additional, Hanna, Ehab Y., additional, Harker, Lee A., additional, Harréus, Uli, additional, Harrison, Robert V., additional, Haughey, Bruce H., additional, Hellstein, John W., additional, Herzer, Kurt, additional, Hildebrand, Michael S., additional, Hilgers, Frans J.M., additional, Hill, Justin D., additional, Hinni, Michael L., additional, Hoffman, Henry T., additional, Holbrook, Eric H., additional, Holinger, Lauren D., additional, Holzapfel, Allison MacGregor, additional, Hom, David B., additional, House, John W., additional, House, Joyce Colton, additional, Hullar, Timothy E., additional, Husein, Murad, additional, Ing, Steven, additional, Iseli, Tim A., additional, Ishman, Stacey, additional, Jackler, Robert K., additional, Jameson, Brian, additional, Jenkins, Herman A., additional, Jin, Hong-Ryol, additional, Joe, John K., additional, Joe, Stephanie A., additional, Johnson, Gary, additional, Johnson, Rhonda, additional, Johnson, Tiffany A., additional, Johnson, Timothy M., additional, Jones, Nick S., additional, Kabaker, Sheldon S., additional, Karnell, Lucy H., additional, Kashima, Matthew L., additional, Kellman, Robert M., additional, Kelly, Paul E., additional, Kennedy, David W., additional, Khalid, Ayesha N., additional, Kies, Merrill S., additional, Kileny, Paul R., additional, Kim, David W., additional, Kim, Jason H., additional, Kim, Theresa B., additional, Kimberling, William J., additional, Koh, Jeffrey, additional, Kokot, Niels, additional, Koltai, Peter J., additional, Kozak, Frederick K., additional, Krakovitz, Paul R., additional, Kridel, Russell W.H., additional, Kumar, Parvesh, additional, Kunduk, Melda, additional, Laccourreye, Ollivier, additional, Lacey, JoAnne, additional, Lai, Stephen Y., additional, Lal, Devyani, additional, Lalwani, Anil K., additional, Lambert, Paul R., additional, Lassig, Amy Anne, additional, Latchaw, Richard E., additional, Leahy, Kevin P., additional, Lee, Daniel J., additional, Lee, Ken K., additional, Lee, Nancy, additional, Lefebvre, Jean-Louis, additional, Lefton-Greif, Maureen A., additional, Leopold, Donald A., additional, Lewis, James S., additional, Li, Daqing, additional, Lian, Timothy S., additional, Licameli, Greg R., additional, Limb, Charles J., additional, Logemann, Jeri A., additional, Loh, Thomas, additional, Lonsbury-Martin, Brenda L., additional, Lopez, Manuel A., additional, Lusk, Rodney P., additional, Lustig, Lawrence R., additional, Lysakowski, Anna, additional, MacArthur, Carol J., additional, Maisel, Robert H., additional, Malone, James P., additional, Mandel, Ellen M., additional, Mandel, Susan J., additional, Manning, Scott C., additional, Mark, Lynette, additional, Markt, Jeffery C., additional, Marsh, Michael, additional, Martin, Glen K., additional, Mattox, Douglas E., additional, McCaffrey, Thomas V., additional, McCulloch, Timothy M., additional, McGee, JoAnn, additional, McGuire, John F., additional, McJunkin, Jonathan, additional, McMurray, J. Scott, additional, Merati, Albert L., additional, Merchant, Saumil N., additional, Messner, Anna H., additional, Michelson, James, additional, Milczuk, Henry A., additional, Minor, Lloyd B., additional, Mobley, Steven Ross, additional, Muntz, Harlan, additional, Murakami, Craig S., additional, Myer, Charles M., additional, Naclerio, Robert M., additional, Nadol, Joseph B., additional, Nassif, Paul S., additional, Nedzelski, Julian, additional, Nicolai, Piero, additional, Nielsen, David R., additional, Niparko, John K., additional, Norton, Susan J., additional, Nouraei, S.A. Reza, additional, Nuss, Daniel W., additional, Nussenbaum, Brian, additional, Odland, Rick M., additional, O'Donoghue, Gerard, additional, Oliver, Eric R., additional, O’Malley, Bert W., additional, O’Reilly, Robert C., additional, Ospina, Juan Camilo, additional, Ossoff, Robert H., additional, Otto, Kristen J., additional, Packer, Mark D., additional, Pallanch, John, additional, Palmer, James N., additional, Park, Stephen S., additional, Patel, Sundip, additional, Patterson, G. Alexander, additional, Pearson, Bruce W., additional, Pellitteri, Phillip K., additional, Perkins, Jonathan A., additional, Perkins, Stephen W., additional, Pero, Colin D., additional, Pignatari, Shirley S.N., additional, Pletcher, Steven D., additional, Popovtzer, Aron, additional, Postma, Gregory N., additional, Potsic, William P., additional, Poznanovic, Sheri A., additional, Quatela, Vito C., additional, Rabinov, C. Rose, additional, Ramachandran, Virginia, additional, Randolph, Gregory W., additional, Rassekh, Christopher H., additional, Rauch, Steven D., additional, Reinisch, Lou, additional, Richardson, Mark, A., additional, Richter, Gresham T., additional, Ridgway, James M., additional, Robbins, K. Thomas, additional, Roediger, Frederick C., additional, Rogers, Jeremy, additional, Ronen, Ohad, additional, Rosenfeld, Richard M., additional, Rotter, Bruce E., additional, Rubinstein, Jay T., additional, Ruckenstein, Michael J., additional, Rumboldt, Zoran, additional, Runge-Samuelson, Christina L., additional, Rybak, Leonard P., additional, Sadoughi, Babak, additional, Salassa, John R., additional, Salinas, Thomas J., additional, Samant, Sandeep, additional, Samlan, Robin A., additional, Samy, Ravi N., additional, Sandel, Henry D., additional, Sandhu, Guri S., additional, Sando, Isamu, additional, Sauder, Cara, additional, Scarlett, Jeremy A., additional, Scher, Richard L., additional, Schessel, David A., additional, Schmalbach, Cecelia E., additional, Schwedt, Todd J., additional, Sciubba, James J., additional, Sequeira, Sunitha, additional, Seshamani, Meena, additional, Shelton, Clough, additional, Shepard, Neil T., additional, Ship, Jonathan A., additional, Shirley, W. Peyton, additional, Shnayder, Yelizaveta, additional, Shvidler, Joseph, additional, Sie, Kathleen C.Y., additional, Simmen, Daniel B., additional, Smith, Marshall E., additional, Smith, Richard J.H., additional, Sofferman, Robert A., additional, Soma, Marlene, additional, Stach, Brad A., additional, Staecker, Hinrich, additional, Stamm, Aldo Cassol, additional, Stankiewicz, James A., additional, Stavinoha, Rose, additional, Sterni, Laura M., additional, Steward, David L., additional, Stocks, Rose Mary S., additional, Sudhoff, Holger H., additional, Sunwoo, John B., additional, Swanson, Neil A., additional, Swanson, Veronica C., additional, Swarm, Robert A., additional, Sykes, Jonathan M., additional, Tan, Luke, additional, Tardy, M. Eugene, additional, Tatum, Sherard A., additional, Taylor, S. Mark, additional, Teissier, Natacha, additional, Telian, Steven A., additional, Terris, David J., additional, Teufert, Karen B., additional, Thomas, J. Regan, additional, Thompson, James N., additional, Toriumi, Dean M., additional, Torres, Alejandro I., additional, Travers, Joseph B., additional, Travers, Susan P., additional, Tsue, Terance T., additional, Tufano, Ralph P., additional, Tunkel, David E., additional, Turner, Michael D., additional, Uppaluri, Ravindra, additional, Vaezi, Michael F., additional, Van den Abbeele, Thierry, additional, van den Brekel, Michiel W.M., additional, Vaysberg, Mikhail, additional, Vokes, David E., additional, Wackym, P. Ashley, additional, Wakefield, Tamekia L., additional, Walner, David L., additional, Walsh, Edward J., additional, Walvekar, Rohan R., additional, Wang, Tom D., additional, Warren, Frank M., additional, Weber, Randal S., additional, Wein, Richard O., additional, Weinstein, Gregory S., additional, Weitzel, Erik Kent, additional, Welling, D. Bradley, additional, Wemer, Richard D., additional, Wetmore, Ralph F., additional, Weymuller, Ernest A., additional, Wiatrak, Brian J., additional, Wiet, Gregory J., additional, Wiggins, Richard H., additional, Willey, Andrea, additional, William, William N., additional, Williams, Glenn B., additional, Wippold, Franz J., additional, Woodson, Gayle Ellen, additional, Woolley, Audie L., additional, Wootten, Christopher T., additional, Wormald, Peter-John, additional, Yingling, Charles D., additional, Yueh, Bevan, additional, Yung, Rex C., additional, Zaldívar, Renzo A., additional, Zalzal, George H., additional, Zee, David S., additional, Zimbler, Marc S., additional, Zinreich, S. James, additional, and Zwolan, Teresa A., additional

Published
2010
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16. Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement

Author

Sidell, Douglas R., primary, Balakrishnan, Karthik, additional, Best, Simon R., additional, Zur, Karen, additional, Buckingham, Julia, additional, De Alarcon, Alessandro, additional, Baroody, Fuad M., additional, Bock, Jonathan M., additional, Boss, Emily F., additional, Bower, Charles M., additional, Campisi, Paolo, additional, Chen, Sharon F., additional, Clarke, Jeffrey M., additional, Clarke, Kevin D., additional, Cocciaglia, Alejandro, additional, Cotton, Robin T., additional, Cuestas, Giselle, additional, Davis, Kara L., additional, DeFago, Victor H., additional, Dikkers, Frederik G., additional, Dossans, Ines, additional, Florez, Walter, additional, Fox, Elizabeth, additional, Friedman, Aaron D., additional, Grant, Nazaneen, additional, Hamdi, Osama, additional, Hogikyan, Norman D., additional, Johnson, Kaalan, additional, Johnson, Liane B., additional, Johnson, Romaine F., additional, Kelly, Peggy, additional, Klein, Adam M., additional, Lawlor, Claire M., additional, Leboulanger, Nicolas, additional, Levy, Alejandro G., additional, Lam, Derek, additional, Licameli, Greg R., additional, Long, Steve, additional, Lott, David G., additional, Manrique, Dayse, additional, McMurray, James Scott, additional, Meister, Kara D., additional, Messner, Anna H., additional, Mohr, Michael, additional, Mudd, Pamela, additional, Mortelliti, Anthony J., additional, Novakovic, Daniel, additional, Ongkasuwan, Julian, additional, Peer, Shazia, additional, Piersiala, Krysztof, additional, Prager, Jeremy D., additional, Pransky, Seth M., additional, Preciado, Diego, additional, Raynor, Tiffany, additional, Rinkel, Rico N. P. M., additional, Rodriguez, Hugo, additional, Rodríguez, Verónica P., additional, Russell, John, additional, Scatolini, María Laura, additional, Scheffler, Patrick, additional, Smith, David F., additional, Smith, Lee P., additional, Smith, Marshall E., additional, Smith, Richard J. H., additional, Sorom, Abraham, additional, Steinberg, Amalia, additional, Stith, John A., additional, Thompson, Dana, additional, Thompson, Jerome W., additional, Varela, Patricio, additional, White, David R., additional, Wineland, Andre M., additional, Yang, Christina J., additional, Zdanski, Carlton J., additional, and Derkay, Craig S., additional

Published
2021
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21. Additional file 1 of Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

Author

Amarilyo, Gil, Rothman, Deborah, Manthiram, Kalpana, Edwards, Kathryn M., Li, Suzanne C., Marshall, Gary S., Cagri Yildirim-Toruner, Haines, Kathleen, Ferguson, Polly J., Lionetti, Geraldina, Cherian, Julie, Yongdong Zhao, DeLaMora, Patricia, Syverson, Grant, Nativ, Simona, Twilt, Marinka, Michelow, Ian C., Stepanovskiy, Yuriy, Akaluck Thatayatikom, Harel, Liora, Shoghik Akoghlanian, Tucker, Lori, Marques, Mariana Correia, Hemalatha Srinivasalu, Propst, Evan J., Licameli, Greg R., Dedeoglu, Fatma, and Sivia Lapidus

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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29. Pathologic Quiz Case 2

Author

Licameli, Greg R., Tunkel, David E., and Westra, William H.

Published
1997

31. Common genetic susceptibility loci link PFAPA syndrome, Behçet's disease, and recurrent aphthous stomatitis.

Author

Manthiram, Kalpana, Preite, Silvia, Dedeoglu, Fatma, Demir, Selcan, Ozen, Seza, Edwards, Kathryn M., Lapidus, Sivia, Katz, Alexander E., Feder Jr, Henry M., Lawton, Maranda, Licameli, Greg R., Wright, Peter F., Le, Julie, Barron, Karyl S., Ombrello, Amanda K., Barham, Beverly, Romeo, Tina, Jones, Anne, Srinivasalu, Hemalatha, and Mudd, Pamela A.

Subjects
BEHCET'S disease, STOMATITIS, PATHOLOGY, SYNDROMES, CELL physiology
Abstract

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. The disease appears to cluster in families, but the pathogenesis is unknown. We queried two European-American cohorts and one Turkish cohort (total n = 231) of individuals with PFAPA for common variants previously associated with two other oropharyngeal ulcerative disorders, Behçet's disease and recurrent aphthous stomatitis. In a metaanalysis, we found that a variant upstream of IL12A (rs17753641) is strongly associated with PFAPA (OR 2.13, P = 6 X 10-9). We demonstrated that monocytes from individuals who are heterozygous or homozygous for this risk allele produce significantly higher levels of IL-12p70 upon IFN-γ and LPS stimulation than those from individuals without the risk allele. We also found that variants near STAT4, IL10, and CCR1-CCR3 were significant susceptibility loci for PFAPA, suggesting that the pathogenesis of PFAPA involves abnormal antigen-presenting cell function and T cell activity and polarization, thereby implicating both innate and adaptive immune responses at the oropharyngeal mucosa. Our results illustrate genetic similarities among recurrent aphthous stomatitis, PFAPA, and Behçet's disease, placing these disorders on a common spectrum, with recurrent aphthous stomatitis on the mild end, Behçet's disease on the severe end, and PFAPA intermediate. We propose naming these disorders Behçet's spectrum disorders to highlight their relationship. HLA alleles may be factors that influence phenotypes along this spectrum as we found new class I and II HLA associations for PFAPA distinct from Behçet's disease and recurrent aphthous stomatitis. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Periodic Fever, Aphthosis, Pharyngitis, and Adenitis Syndrome: Analysis of Patients From Two Geographic Areas.

Author

Batu, Ezgi D., Kara Eroğlu, Fehime, Tsoukas, Paul, Hausmann, Jonathan S., Bilginer, Yelda, Kenna, Margaret A., Licameli, Greg R., Fuhlbrigge, Robert C., Özen, Seza, Dedeoğlu, Fatma, Kara Eroğlu, Fehime, Özen, Seza, and Dedeoğlu, Fatma

Abstract

Objective: Periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) syndrome is a periodic fever syndrome of childhood with an unknown etiology. Our aim was to compare the features between PFAPA syndrome patients from Turkey and those from the US, and patients with and without MEFV variants, and to test the performance of the Eurofever criteria in excluding other autoinflammatory disorders.Methods: Seventy-one children with PFAPA syndrome, followed in Hacettepe University, in Ankara, Turkey, and 60 patients at Boston Children's Hospital in the US were enrolled. MEFV gene-variant analysis was performed in 56 patients with Sanger sequencing.Results: In patients from Turkey, symptom onset was at a younger age, fever attacks were of shorter duration, and pharyngitis was more frequent, whereas adenitis, headache, and nausea/vomiting were less frequent during attacks, when compared to patients from the US (P < 0.05). More patients from the Turkish cohort were classified in the familial Mediterranean fever (FMF) group according to the Eurofever criteria than patients from the US (66.2% versus 10%; P < 0.001). Two patients were diagnosed with FMF after MEFV analysis. Twenty-one patients (37.5%) had a single MEFV variant. No significant differences in phenotype were found between patients with and without MEFV variants.Conclusion: The differences between patients from the Turkish and US cohorts may be due to epigenetic or environmental factors. In addition, the Eurofever FMF criteria may perform better in certain areas, if the weight of ethnic origin parameter or cutoff values were modified. [ABSTRACT FROM AUTHOR]

Published
2016
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36. 08:18: Hearing Loss in Patients with Cystic Fibrosis

Author

Choi, Sukgi S, primary, Park, Albert H, additional, Luz, Jennifer, additional, Cheng, Alan G, additional, Johnston, Patrick R, additional, Uluer, Ahmet, additional, Licameli, Greg R, additional, Kenna, Margaret A, additional, and Jones, Dwight T, additional

Published
2007
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45. Prognosis Tool Based on a Modified Children's Implant Profile for Use in Pediatric Cochlear Implant Candidacy Evaluation.

Author

Graham O'Brien, Lynne C., Valim, Clarissa, Neault, Marilyn, Kammerer, Betsy, Clark, Terrell, Johnston, Jennifer, Culver, Stacey, Jing Zhou, Kenna, Margaret A., and Licameli, Greg R.

Subjects
PROGNOSIS, COMMUNICATION methodology, DEAFNESS, EAR surgery, PATIENT selection, ACADEMIC medical centers, COCHLEAR implants, STATISTICAL correlation, DECISION making, EXPERIMENTAL design, HEALTH care teams, LONGITUDINAL method, RESEARCH methodology, HEALTH outcome assessment, REGRESSION analysis, STATISTICAL sampling, SPEECH evaluation, STATISTICS, LOGISTIC regression analysis, RETROSPECTIVE studies, RESEARCH methodology evaluation, DATA analysis software, DESCRIPTIVE statistics
Abstract

Objectives: We developed a prediction tool to assist in evaluation of pediatric candidates for cochlear implantation (CI) and to help plan for preoperative and postoperative support. Methods: Between 1995 and 2005,277 patients underwent CI at Children's Hospital Boston. Of these 277 patients, 250 had at least 2 years of post-CI follow-up and adequate pre-CI information for rating by our prediction tool. Of the 250, 106 were randomly selected for inclusion. The patients were divided into group A (auditory/oral communicator); group B (auditory/oral communicator with visual assistance), group C (visual/manual communicator with auditory/oral skills assistance), and group D (will not derive communicative benefit from implant). Predictions were performed with clinical assessment and two statistical techniques: regression modeling and classification and regression tree (CART) analysis. Results: Among patients who became auditory/oral communicators (group A), clinical assessment predicted that outcome accurately 65% of the time, CART analysis had intermediate sensitivity (79%), and regression modeling was the most sensitive (95%). Groups B through D were predicted 45% of the time by regression modeling, 90% of the time by clinical assessment, and 100% of the time by CART analysis. Conclusions: A combination of speech-language, medical, and educational constructs can provide a reliable prediction of the communication outcome. Our goal for the prognosis tool is to make it part of the overall candidacy process in supporting decision-making about CI and planning for post-CI therapy. [ABSTRACT FROM AUTHOR]

Published
2012
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