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1. Right heart failure as a source of B-lines at lung ultrasound: prevalence and functional correlates

Author

D'alto, M, primary, Di Maio, M, additional, Liccardo, B, additional, Argiento, P, additional, Romeo, E, additional, Del Giudice, C, additional, Renon, F, additional, Vergara, A, additional, Di Vilio, A, additional, Caiazza, E, additional, Gargani, L, additional, Bossone, E, additional, Golino, P, additional, Picano, E, additional, and Naeije, R, additional

Published
2023
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2. Lung ultrasound, echocardiography and fluid loading for the differential diagnosis of pulmonary hypertension

Author

D'alto, M, primary, Liccardo, B, additional, Di Maio, M, additional, Del Giudice, C, additional, Romeo, E, additional, Argiento, P, additional, Renon, F, additional, Vergara, A, additional, Di Vilio, A, additional, Bossone, E, additional, Rea, G, additional, D'andrea, A, additional, Gargani, L, additional, Golino, P, additional, and Naeije, R, additional

Published
2023
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5. P404 MYOCARDIAL WORK EVALUATION IN PATIENTS WITH SEVERE AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT

Author

D’Arienzo, D, primary, Sperlongano, S, additional, Iannuzzi, A, additional, Renon, F, additional, Del Giudice, C, additional, Liccardo, B, additional, Pezzullo, E, additional, Bocchetti, M, additional, Totaro, A, additional, Bianchi, R, additional, Loffredo, F, additional, Cappelli Bigazzi, M, additional, and Golino, P, additional

Published
2023
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9. Physiological Adaptations of the Heart in Elite Athletes

Author

D’Andrea, A., primary, Radmilovich, J., additional, Riegler, L., additional, Scarafile, R., additional, Liccardo, B., additional, Formisano, T., additional, Carbone, A., additional, America, R., additional, Martone, F., additional, Scherillo, M., additional, Galderisi, M., additional, and Calabrò, R., additional

Published
2018
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10. Myocardial work evaluation in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation

Author

Sperlongano, S, primary, Renon, F, additional, Del Giudice, C, additional, Iannuzzi, A, additional, Bocchetti, M, additional, Liccardo, B, additional, Malvezzi Caracciolo D"aquino, M, additional, Scognamiglio, G, additional, Salerno, G, additional, Ciccarelli, G, additional, Bianchi, R, additional, Tartaglione, D, additional, Cappelli Bigazzi, M, additional, D"andrea, A, additional, and Golino, P, additional

Published
2022
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13. “A BROKEN TRANSPLANTED HEART”: A CASE OF TAKOTSUBO SYNDROME IN A HEART TRANSPLANT RECIPIENT

Author

Delle Femine, F, Liccardo, B, Loffredo, F, Pezzullo, E, D‘Arienzo, D, Amarelli, C, and Golino, P

Abstract

75–year–old female patient went to the emergency department for oppressive chest pain radiating to the left arm and dyspnea, developed after an argument with family members. The patient underwent heart transplant in 2010 because of chronic ischemic heart disease. In history: systemic arterial hypertension, former smoking, dyslipidemia, and chronic renal failure. At blood tests: TnIHS 78.4 ng/L (<29 ng/L), CK–MB 1.9 microg/L, PROBNP–NT 43,000 pg/ml, creatinine 2 mg/dL. ECG showed inverted T waves in DI, AVL and V4 to V6 (fig 1). Transthoracic echocardiography was remarkable for a moderate reduction in systolic function (EF 38%), akinesia of apical portion, mid–segment of the IVS and mid–segment of posterior wall. Coronarography showed epicardial coronaries free of angiographically significant lesions. We decided to not perform ventriculography to avoid worsening renal function. At clinical stabilization, the patient underwent cardiac MRI with evidence of hypokinesia of the mid–ventricular segments with preserved global systolic function and hypo/akinesia of right ventricular apex with endocavitary thrombosis. Tissue characterization images were compatible with the presence of diffuse phlogistic involvement of the left ventricular myocardium (most evident at the mid–ventricular segments), in the absence of areas of myocardial necrosis. On pre–dimission echocardiogram, global left ventricular systolic function appeared markedly improved (auto EF 52%). DISCUSSION Our case is a rare case of Takotsubo syndrome (TS) in a transplanted heart. While TS accounts for 1–2% of all ACS in the general population, there is no precise data on its prevalence in heart transplant recipients. Although the pathophysiological mechanism underlying TS is still debated, there is evidence of hyperactivation of the sympathetic system with excessive catecholamine release. What is particular in our clinical case is that transplanted heart is denervated (because of resection of the post–ganglionic neural axons), although in some patients there is progressive reinnervation starting around the second year. Myocardial scintigraphy with iodine–123 meta iodobenzylguanidine can be used to study reinnervation. In our case, the presence of typical angor may be a clinical indicator of reinnervation, as many transplant patients present with CAV in the absence of chest pain.

Published
2024
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17. Left atrial myocardial function in either physiological or pathological left ventricular hypertrophy: a two-dimensional speckle strain study

Author

D'Andrea, A., De Corato, G., Scarafile, R., Romano, S., Reigler, L., Mita, C., Allocca, F., Limongelli, G., Gigantino, G., Liccardo, B., Cuomo, S., Tagliamonte, G., Caso, P., and Calbro, R.

Subjects
Heart atrium -- Physiological aspects, Heart atrium -- Research, Heart muscle -- Physiological aspects, Heart muscle -- Research, Heart enlargement -- Development and progression, Heart enlargement -- Research, Health, Sports and fitness
Published
2008

20. Three-dimensional echocardiographic evaluation of the right ventricle in patients with uncomplicated systemic lupus erythematosus

Author

Buonauro, A, primary, Sorrentino, R, additional, Esposito, R, additional, Nappi, L, additional, Lobasso, A, additional, Santoro, C, additional, Rivellese, F, additional, Sellitto, V, additional, Rossi, F W, additional, Liccardo, B, additional, Tufano, A, additional, Galderisi, M, additional, and Paulis, A de, additional

Published
2019
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21. UNLOADING STRATEGIES IN ADVANCED HEART FAILURE: THE ROLE OF POINT–OF–CARE ULTRASOUND

Author

Del Giudice, C, Caputo, A, D‘Arienzo, D, Delle Femmine, F, Liccardo, B, Amarelli, C, Marra, C, Loffredo, F, Varricchio, A, and Golino, P

Abstract

Patients with advanced heart failure (HF) exhibit repeated episodes of fluid retention (pulmonary and/or systemic congestion) and/or of reduced cardiac output at rest (peripheral hypoperfusion) requiring hospitalization along with diuretics/inotropic infusion. Pulmonary artery catheter (PAC) provides haemodynamic information to guide the therapy, however PAC is invasive and time consuming. Point of care ultrasonography (POCUS) represents a promising diagnostic tool at the bedside, performed by the physician to assess non invasively volume status, cardiac output and monitor decongestive therapy. Recently, abnormal Doppler flow patterns due to increased right atrial pressure have been described in the hepatic, portal, and intrarenal veins. Thus, the recent venous excess ultrasound score (VExUS) has been used to describe fluid status along with the diameter and collapsibility of the inferior vena cava. Furthermore HF patients show high filling pressures, therefore they often require mechanical or medical unloading. In this regard, point of care ultrasound represents a valid tool to monitor non invasively the filling pressures and the responsiveness to those treatments. Here, we illustrate with several clinical cases where VExUS/POCUS were pivotal in clinical management.

Published
2024
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22. Association between left atrial myocardial function and exercise capacity in patients with either idiophatic or ischemic dilated cardiomyopathy: a two-dimensional speckle strain study

Author

D'Andrea A, Caso P, Romano S, Scarafile R, Cuomo S, Salerno G, Riegler L, LIMONGELLI, Giuseppe, DI SALVO, Giovanni, Romano M, Liccardo B, Iengo R, Ascione L, DEL VISCOVO, Luca, CALABRO', Paolo, Calabrò R., D'Andrea, A, Caso, P, Romano, S, Scarafile, R, Cuomo, S, Salerno, G, Riegler, L, Limongelli, Giuseppe, DI SALVO, Giovanni, Romano, M, Liccardo, B, Iengo, R, Ascione, L, DEL VISCOVO, Luca, Calabro', Paolo, and Calabrò, R.

Published
2009

23. H. pylori Peptide HP(2-20) Promotes Healing of Injured Gastric Mucosa By Interacting with Formyl-Peptyde Receptors

Author

Romano, M, Rossi, FW, Rivellese, F, Salerno, F, Delfino, G, Liccardo, B, Staibano, S, D'Argenio, G, Marone, G, De Paulis, A., PREVETE, Nella, M., Romano, Prevete, Nella, F. W., Rossi, F., Rivellese, F., Salerno, G., Delfino, B., Liccardo, Staibano, Stefania, G., D'Argenio, Marone, Gianni, A. D., Paulis, W B SAUNDERS CO-ELSEVIER INC, Romano, M, Rossi, Fw, Rivellese, F, Salerno, F, Delfino, G, Liccardo, B, Staibano, S, D'Argenio, G, Marone, G, and De Paulis, A.

Published
2009

29. I recettori per l’istamina H1, H2, H3, H4

Author

MARONE, GIANNI, DETORAKI A., GRANATA F., DI MATTEO R., DI MARO E., LICCARDO B., Marone, Gianni, Detoraki, A., Granata, F., DI MATTEO, R., DI MARO, E., and Liccardo, B.

Published
2003

33. Atrial fibrillation: what are the effects of drug therapy on the effectiveness and complications of electrical cardioversion?

Author

Berardo Sarubbi, Ducceschi, V., D Andrea, A., Liccardo, B., Santangelo, L., Iacono, A., Sarubbi, B, Ducceschi, V, D'Andrea, A, Liccardo, B, Santangelo, Lucio, and Iacono, A.

Subjects
Digoxin, Flecainide, Verapamil, Atrial Fibrillation, Electric Countershock, Amiodarone, Humans, Procainamide, Anti-Arrhythmia Agents, Combined Modality Therapy, Quinidine
Abstract

Atrial fibrillation is the most common cardiac rhythm disorder associated with hospitalization. Two therapeutic options have been available: antiarrhythmic drug therapy, and external or internal electrical cardioversion. Electrical cardioversion of atrial fibrillation remains one of the most widely used and effective treatments for the restoration of normal sinus rhythm. However, many patients continue to receive an antiarrhythmic drug before and after cardioversion in an attempt either to cardiovert the arrhythmia chemically or to maintain sinus rhythm after successful cardioversion. Because some pharmacological agents can affect the cardioversion procedure for atrial fibrillation or flutter, and because many patients with such arrhythmias may require electrical cardioversion when they are taking antiarrhythmic drugs, the question of a possible effect of drug therapy on the efficacy and safety of electrical cardioversion of atrial fibrillation arises. Early reports of direct current cardioversion provoking potentially lethal ventricular arrhythmias raised suspicions of an arrhythmogenic role for digoxin antiarrhythmic therapy, and it is customary to withhold these drugs for 24 to 48 h before cardioversion is attempted. However, this complication is likely to arise only in patients who are close to, or actually manifesting, signs of drug toxicity. On the other hand, treatment with therapeutic concentrations of antiarrhythmic drugs before cardioversion may in some cases be associated with a significant reduction in the number of shocks and decreased energy required to restore sinus rhythm, a lower incidence of postshock arrhythmias and a reduced risk of early recurrence of atrial fibrillation.

Published
1998

36. Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: a Doppler myocardial and strain imaging analysis * COMMENTARY

Author

D'Andrea, A., primary, Caso, P., additional, Salerno, G., additional, Scarafile, R., additional, De Corato, G., additional, Mita, C., additional, Di Salvo, G., additional, Severino, S., additional, Cuomo, S., additional, Liccardo, B., additional, Esposito, N., additional, Calabro, R., additional, and Giada, F., additional

Published
2007
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45. Prognostic value of supine bicycle exercise stress echocardiography in patients with known or suspected coronary artery disease.

Author

D'Andrea A, Severino S, Caso P, Liccardo B, Forni A, Fusco A, Piccolo RL, Scherillo M, Mininni N, and Calabró R

Abstract

AIMS: To assess the prognostic significance of supine bicycle exercise stress echocardiography (ESE) for cardiac events, and the ESE additional role compared to other traditional clinical and echo variables, in patients with proven or suspected coronary artery disease (CAD). METHODS AND RESULTS: Clinical status and long-term outcome were assessed in 607 patients, for a mean period of 49.9 +/- 12.5 months. ESE was performed for the diagnosis of suspected CAD in 267 patients, and for the risk stratification in 340 patients. At baseline, the mean value of WMSI was 1.22 +/- 0.36, and the mean left ventricular ejection fraction was 58.2 +/- 10.9%. The ESE was positive for ischemia in 210 patients (34.9%), while the ECG was suggestive for ischemia in 157 patients. At peak effort, the mean WMSI was 1.38 +/- 0.46. Low work load was achieved by 158 patients (26.1%). During the follow-up period there were 222 events, including 48 cardiac deaths and 34 acute non-fatal myocardial infarction. By multivariable model, cigarette smoking, peak WMSI, positive ESE for ischemia and low work load were the only independent predictors of cardiac death. The cumulative 5-year mean survival rate according to ESE response was 95.9% in patients with negative ESE, and 81.7% in positive ESE (p < 0.00001). CONCLUSIONS: In patients with known or suspected CAD able to perform a physical stress, bicycle ESE is able to stratify patients at higher risk of cardiac events. The final report of an ESE performed for prognostic purpose should include both the assessment of induced dyssinergy and the evaluation of indexes of the extent and the severity of myocardial ischemia. [ABSTRACT FROM AUTHOR]

Published
2005

46. Prognostic value of pharmacological stress echocardiography in diabetic patients.

Author

D'Andrea, A, Severino, S, Caso, P, De Simone, L, Liccardo, B, Forni, A, Pascotto, M, Di Salvo, G, Scherillo, M, Mininni, N, and Calabrò, R

Subjects
STRESS echocardiography, PEOPLE with diabetes, CORONARY disease, MYOCARDIAL infarction, UNIVARIATE analysis, ISCHEMIA, PATIENTS
Abstract

Our study was undertaken to assess the prognostic significance of pharmacological stress echocardiography in 325 diabetic patients. Pharmacological stress echocardiography was performed for diagnosis of coronary artery disease in 128 patients, and for risk stratification in 197 patients. Follow-up was 34 months. Cardiac-related death and non-fatal myocardial infarction were considered hard events. During the follow-up period, there were 38 deaths and 23 acute non-fatal myocardial infarctions. By univariate analysis, a pharmacological stress echocardiography positive response for ischaemia indicated an increased risk of cardiovascular death. However, by multivariate analysis, advanced age and peak ejection fraction <40% were the only independent predictors of cardiac death. The same peak ejection fraction (EF) <40%, rest wall motion score index and previous myocardial infarction were independent predictors of hard events. After dividing the population into two subgroups on the basis of EF at rest, only a peak EF <40% and a pharmacological stress echocardiography positive test were powerful independent predictors of cardiovascular mortality. [ABSTRACT FROM AUTHOR]

Published
2003
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50. Repolarization abnormalities in patients with idiopathic ventricular tachycardias

Author

Ducceschi, V., D Andrea, A., Berardo Sarubbi, Liccardo, B., Mayer, M. S., Salvi, G., Santangelo, L., Iacono, A., Ducceschi, V, D'Andrea, A, Sarubbi, B, Liccardo, B, Mayer, M, Salvi, G, Santangelo, Lucio, and Iacono, A.

Subjects
Adult, Male, Electrocardiography, Tachycardia, Ventricular, Humans, Female, Sex Ratio, Middle Aged
Abstract

Twenty patients without laboratory evidence of cardiac disease who underwent electrophysiological study because of recurrent ventricular tachyarrhythmias.The study population was divided into two groups: group A (20 patients [six males and 14 females] mean age 42.2 +/- 13 years), with idiopathic ventricular tachycardia (VT), and group B (30 controls [10 males and 20 females] mean age 43.6 +/- 16 years). Noninvasive multiparametric analysis of the ventricular repolarization phase was performed on the standard 12-lead electrocardiogram by using a digitizer connected with a computerized system. The intervals JT, heart rate-corrected JT (JTc), JT apex (JTa), heart rate-corrected JTa (JTac), T apex T end (TaTe) and heart rate-corrected TaTe (TaTec) were measured and considered to be representative of the whole depolarization process. QT dispersions (QTeD) and QTc dispersions (QTecD) were calculated to assess the degree of spatial inhomogeneity of action potential duration.Patients in group A had higher JT (272 +/- 36 ms versus 265 +/- 25 ms, P = 0.01), JTc (336 +/- 28 ms versus 318 +/- 18 ms, P = 0.01), JTa (210 +/- 28 ms versus 185 +/- 28 ms, P = 0.001) and JTac (240 +/- 20 ms versus 215 +/- 13 ms, P0.001) values than those of patients in group B, despite shorter TaTe (71 +/- 10 ms versus 90 +/- 18 ms, P0.001) and TaTec (88 +/- 12 ms versus 110 +/- 12 ms, P0.001). Moreover, QTeD and QTecD were significantly longer in group A than in group B (55 +/- 18 ms versus 42 +/- 19 ms [P = 0.01] and 80 +/- 18 ms versus 55 +/- 28 ms [P = 0.001], respectively).Patients with idiopathic VT exhibit inhomogeneous prolongation of ventricular repolarization, due to a considerable increase in the initial part in association with a shorter terminal phase, as well as a greater dispersion of ventricular repolarization.

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