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Your search keyword '"Lichtscheidl, Irene"' showing total 203 results
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203 results on '"Lichtscheidl, Irene"'

5. An acoustically-driven biochip - Impact of flow on the cell-association of targeted drug carriers

Author

Fillafer, Christian, Ratzinger, Gerda, Neumann, Jürgen, Guttenberg, Zeno, Dissauer, Silke, Lichtscheidl, Irene, Wirth, Michael, Gabor, Franz, and Schneider, Matthias

Subjects
Physics - Biological Physics, Physics - Medical Physics, Quantitative Biology - Cell Behavior
Abstract

The interaction of targeted drug carriers with epithelial and endothelial barriers in vivo is largely determined by the dynamics of the body fluids. To simulate these conditions in binding assays, a fully biocompatible in vitro model was developed which can accurately mimic a wide range of physiological flow conditions on a thumbnail-format cell-chip. This acoustically-driven microfluidic system was used to study the interaction characteristics of protein-coated particles with cells. Poly(D,L-lactide-co-glycolide) (PLGA) microparticles (2.86 {\pm} 0.95 {\mu}m) were conjugated with wheat germ agglutinin (WGA-MP, cytoadhesive protein) or bovine serum albumin (BSA-MP, nonspecific protein) and their binding to epithelial cell monolayers was investigated under stationary and flow conditions. While mean numbers of 1500 {\pm} 307 mm-2 WGA-MP and 94 {\pm} 64 mm-2 BSA-MP respectively were detected to be cell-bound in the stationary setup, incubation at increasing flow velocities increasingly antagonized the attachment of both types of surface-modified particles. However, while binding of BSA-MP was totally inhibited by flow, grafting with WGA resulted in a pronounced anchoring effect. This was indicated by a mean number of 747 {\pm} 241 mm-2 and 104 {\pm} 44 mm-2 attached particles at shear rates of 0.2 s-1 and 1 s-1 respectively. Due to the compactness of the fluidic chip which favours parallelization, this setup represents a highly promising approach towards a screening platform for the performance of drug delivery vehicles under physiological flow conditions. In this regard, the flow-chip is expected to provide substantial information for the successful design and development of targeted micro- and nanoparticulate drug carrier systems., Comment: 19 pages

Published
2011
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9. MAPK Signaling

Author

Ovečka, Miroslav, Lichtscheidl, Irene K., Mancuso, Stefano, editor, and Balu¿ka, Franti¿ek, editor

Published
2009
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10. Salt-induced subcellular kinase relocation and seedling susceptibility caused by overexpression of Medicago SIMKK in Arabidopsis

Author

Ovečka, Miroslav, Takáč, Tomáš, Komis, George, Vadovič, Pavol, Bekešová, Slávka, Doskočilová, Anna, Smékalová, Veronika, Luptovčiak, Ivan, Šamajová, Olga, Schweighofer, Alois, Meskiene, Irute, Jonak, Claudia, Křenek, Pavel, Lichtscheidl, Irene, Škultéty, L'udovít, Hirt, Heribert, and Šamaj, Jozef

Published
2014
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13. The roots of carnivorous plants

Author

Adlassnig, Wolfram, Peroutka, Marianne, Lambers, Hans, Lichtscheidl, Irene K., De Kok, Luit J., editor, Stulen, Ineke, editor, Lambers, Hans, editor, and Colmer, Timothy D., editor

Published
2005
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39. Silicon Uptake and Localisation in Date Palm (Phoenix dactylifera) – A Unique Association With Sclerenchyma

Author

Bokor, Boris, primary, Soukup, Milan, additional, Vaculík, Marek, additional, Vd’ačný, Peter, additional, Weidinger, Marieluise, additional, Lichtscheidl, Irene, additional, Vávrová, Silvia, additional, Šoltys, Katarína, additional, Sonah, Humira, additional, Deshmukh, Rupesh, additional, Bélanger, Richard R., additional, White, Philip J., additional, El-Serehy, Hamed A., additional, and Lux, Alexander, additional

Published
2019
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47. BioRem—Database for Remediation of Heavy Metal Rich Habitats and Protection of Their Biodiversity

Author

Othmar Horak, Lichtscheidl Irene, Mario Leyva, Wolfram Adlassnig, Lukas Nebel, Gerhard Kreitner, Gregor Eder, and Edwin Palomino

Subjects
education.field_of_study, Resource (biology), Database, business.industry, Environmental remediation, Ecology (disciplines), Environmental resource management, Population, Biodiversity, General Medicine, computer.software_genre, Habitat, Environmental science, Identification (biology), Ecosystem, business, education, computer
Abstract

BioRem is an open access on-line resource, which aims to document the biodiversity of terrestrial heavy metal rich sites around the globe that are the habitats of specialized metal tolerant organisms (MTOs). A comprehensive inventory of MTOs together with an analysis of environmental conditions and research about the adaptations of MTOs shall support the development of holistic models about the functioning of heavy metal ecosystems and lead to an improved understanding of interactions and adaptation strategies of MTOs. Furthermore, the database enables the identification of plants and microorganisms suited for remediation actions where protection of the population and the environment is needed. Information about scientific data shall lay the ground for the definition of heavy metal habitats with unique biocoenoses as reservoirs of biodiversity: accordingly, BioRem shall be a resource for education and for dissemination of our knowledge about the ecology of heavy metal rich sites and their habitats, and it shall provide tools for the evaluation of socio-economic strategies for either remediation or preservation of heavy metal habitats. Where needed, alternative strategies for the survival of MTOs shall be developed, hence contributing to the aim of the G?teborg 2010 target to halt loss of biodiversity.

Published
2013

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