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2,083 results on '"Lieb K"'

1. Perspectives on Dialectical Behavior Therapy and Mentalization-Based Therapy for Borderline Personality Disorder: Same, Different, Complementary?

Author

Stoffers-Winterling JM, Storebø OJ, Simonsen E, Sedoc Jørgensen M, Pereira Ribeiro J, Kongerslev MT, and Lieb K

Subjects
psychotherapy, treatment, dialectic behavior therapy dbt, mentalization-based therapy mbt, borderline personality disorder, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Jutta M Stoffers-Winterling,1 Ole Jakob Storebø,2,3 Erik Simonsen,4,5 Mie Sedoc Jørgensen,2 Johanne Pereira Ribeiro,2,3 Mickey T Kongerslev,2,3,5 Klaus Lieb1 1Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; 2Psychiatric Research Unit, Psychiatry Region Zealand, Slagelse, Denmark; 3Department of Psychology, University of Southern Denmark, Odense, Denmark; 4Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; 5Mental Health Services East, Psychiatry Region Zealand, Roskilde, DenmarkCorrespondence: Ole Jakob Storebø, Psychiatric Research Unit, Psychiatry Region Zealand, Fælledvej 6, Slagelse, 4200, Denmark, Tel +45 24965917, Email ojst@regionsjaelland.dkAbstract: Current evidence suggests that individuals with borderline personality disorder (BPD) are likely to benefit from specialized, or BPD-specific, treatments. Dialectical behavior therapy (DBT) and mentalization-based treatment (MBT) are currently the most intensively researched BPD treatments. Reviewing the current research, this paper highlights similarities and differences between the two treatments, and discusses possible ways they could complement each other. As the effectiveness of specialized treatments for BPD in general has been determined with some certainty, research now tends towards individualized approaches, identifying predictors of optimal treatment response. However, it is still to be settled who might profit from a combination of or sequential treatment with DBT and MBT.Keywords: psychotherapy, treatment, dialectical behavior therapy, DBT, mentalization-based therapy, MBT, borderline personality disorder

Published
2022

2. THMC instabilities and the Multiphysics of Earthquakes

Author

Regenauer-Lieb, K., Hu, M., and Schrank, C.

Subjects
Physics - Geophysics, Nonlinear Sciences - Pattern Formation and Solitons
Abstract

Theoretical approaches to earthquake instabilities propose shear dominated instabilities as a source mechanism. Here we take a fresh look at the role of possible volumetric instabilities preceding a shear instability. We investigate the phenomena that may prepare earthquake instabilities using coupling of Thermo-Hydro-Mechano-Chemical (THMC) reaction-diffusion equations in a THMC diffusion matrix. We show that the off-diagonal cross-diffusivities can give rise to cross-diffusion slow (no inertia) pressure waves and propose that a resonance phenomenon of the long-wavelength limit causes constructive interference and triggers the seismic moment release., Comment: 7 pages, 3 figures, 1 table

Published
2019

13. Resilienz der Gesundheitsforschung als Voraussetzung für Resilienz der Gesundheitsversorgung - das Infrastrukturkonzept 'PREparedness and PAndemic REsponse in Deutschland' (PREPARED) des Netzwerks Universitätsmedizin

Author

Hoffmann, J, Lang, C, Scheithauer, S, Fenz, D, Berens, M, Panchyrz, I, Harst, L, Adorjan, K, Apfelbacher, C, Ciesek, S, Denkinger, C, Drosten, C, Geffers, C, Geraedts, M, Greve, M, Haier, J, Hecker, R, Hoffmann, W, Karch, A, Koch, T, Krefting, D, Lieb, K, Meerpohl, J, Menk, M, Rehfuess, E, Skoetz, N, Sopka, S, Schildmann, J, Taddicken, M, van den Berg, N, von Lengerke, T, Winkler, E, Schmitt, J, PREPARED Study Group, Hoffmann, J, Lang, C, Scheithauer, S, Fenz, D, Berens, M, Panchyrz, I, Harst, L, Adorjan, K, Apfelbacher, C, Ciesek, S, Denkinger, C, Drosten, C, Geffers, C, Geraedts, M, Greve, M, Haier, J, Hecker, R, Hoffmann, W, Karch, A, Koch, T, Krefting, D, Lieb, K, Meerpohl, J, Menk, M, Rehfuess, E, Skoetz, N, Sopka, S, Schildmann, J, Taddicken, M, van den Berg, N, von Lengerke, T, Winkler, E, Schmitt, J, and PREPARED Study Group

Published
2024

18. Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production

Author

Candelario-Jalil, E., Akundi, R. S., Bhatia, H. S., Lieb, K., Appel, K., Munoz, E., Hull, M., and Fiebich, B. L.

Subjects
Quantitative Biology - Subcellular Processes, Quantitative Biology - Molecular Networks
Abstract

In the present study, we show that ascorbic acid dose-dependently inhibited interleukin-1beta (IL-1beta)-mediated PGE2 synthesis in the human neuronal cell line, SK-N-SH. Furthermore, in combination with aspirin, ascorbic acid augmented the inhibitory effect of aspirin on PGE2 synthesis. However, ascorbic acid had no synergistic effect along with other COX inhibitors (SC-58125 and indomethacin). The inhibition of IL-1beta-mediated PGE2 synthesis by ascorbic acid was not due to the inhibition of the expression of COX-2 or microsomal prostaglandin E synthase (mPGES-1). Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress. Our results provide in vitro evidence that the neuroprotective effects of ascorbic acid may depend, at least in part, on its ability to reduce neuronal COX-2 activity and PGE2 synthesis, owing to its antioxidant properties. Further, these experiments suggest that a combination of aspirin with ascorbic acid constitutes a novel approach to render COX-2 more sensitive to inhibition by aspirin, allowing an anti-inflammatory therapy with lower doses of aspirin, thereby avoiding the side effects of the usually high dose aspirin treatment.

Published
2007

20. Very high rotational frequencies and band termination in 73Br

Author

Plettner, C., Schnare, H., Schwengner, R., K&aumlbler, L., D&oumlau, F., Algora, A., deAngelis, G ., Gadea, A., Napoli, D. R., Eberth, J., Steinhardt, T., Thelen, O., Hausmann, M., M&uumller, A., Jungclaus, A., Lieb, K. P., Jenkins, D. G., Wadsworth, R., Wilson, A. N., and Frauendorf, S.

Subjects
Nuclear Experiment
Abstract

Rotational bands in 73Br have been investigated up to spins of 65/2 using the EUROBALL III spectrometer. One of the negative-parity bands displays the highest rotational frequency 1.85 MeV reported to date in nuclei with mass number greater than 25. At high frequencies, the experimental dynamic moment of inertia for all bands decrease to very low values, indicating a loss of collectivity. The bands are described in the configuration-dependent cranked Nilsson-Strutinsky model. The calculations indicate that one of the negative-parity bands is observed up to its terminating single-particle state at spin 63/2. This result establishes the first band termination case in the A = 70 mass region., Comment: 6 pages, 6 figures, submitted to Phys. Rev. C as a Rapid Communication

Published
2000
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27. Psychological Resilience Factors and Their Association With Weekly Stressor Reactivity During the COVID-19 Outbreak in Europe: Prospective Longitudinal Study.

Author

Bögemann, S.A., Puhlmann, L.M.C., Wackerhagen, C., Zerban, M., Riepenhausen, A., Köber, G., Yuen, K.S.L., Pooseh, S., Marciniak, M.A., Reppmann, Z.C., Uściƚko, A., Weermeijer, J.D.M., Lenferink, D.B., Mituniewicz, J., Robak, N., Donner, N.C., Mestdagh, M., Verdonck, S., Dick, R. van, Kleim, B., Lieb, K., Leeuwen, J.M.C. van, Kobylińska, D., Myin-Germeys, I., Walter, H., Tüscher, O., Hermans, E.J., Veer, I.M., Kalisch, R., Bögemann, S.A., Puhlmann, L.M.C., Wackerhagen, C., Zerban, M., Riepenhausen, A., Köber, G., Yuen, K.S.L., Pooseh, S., Marciniak, M.A., Reppmann, Z.C., Uściƚko, A., Weermeijer, J.D.M., Lenferink, D.B., Mituniewicz, J., Robak, N., Donner, N.C., Mestdagh, M., Verdonck, S., Dick, R. van, Kleim, B., Lieb, K., Leeuwen, J.M.C. van, Kobylińska, D., Myin-Germeys, I., Walter, H., Tüscher, O., Hermans, E.J., Veer, I.M., and Kalisch, R.

Abstract

Item does not contain fulltext, BACKGROUND: Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low "stressor reactivity" [SR]), were reported during the first wave of the COVID-19 pandemic in 2020. OBJECTIVE: Extending these findings, we here examined prospective relationships and weekly dynamics between the same RFs and SR in a longitudinal sample during the aftermath of the first wave in several European countries. METHODS: Over 5 weeks of app-based assessments, participants reported weekly stressor exposure, mental health problems, RFs, and demographic data in 1 of 6 different languages. As (partly) preregistered, hypotheses were tested cross-sectionally at baseline (N=558), and longitudinally (n=200), using mixed effects models and mediation analyses. RESULTS: RFs at baseline, including positive appraisal style (PAS), optimism (OPT), general self-efficacy (GSE), perceived good stress recovery (REC), and perceived social support (PSS), were negatively associated with SR scores, not only cross-sectionally (baseline SR scores; all P<.001) but also prospectively (average SR scores across subsequent weeks; positive appraisal (PA), P=.008; OPT, P<.001; GSE, P=.01; REC, P<.001; and PSS, P=.002). In both associations, PAS mediated the effects of PSS on SR (cross-sectionally: 95% CI -0.064 to -0.013; prospectively: 95% CI -0.074 to -0.0008). In the analyses of weekly RF-SR dynamics, the RFs PA of stressors generally and specifically related to the COVID-19 pandemic, and GSE were negatively associated with SR in a contemporaneous fashion (PA, P<.001; PAC,P=.03; and GSE, P<.001), but not in a lagged fashion (PA, P=.36; PAC, P=.52; and GSE, P=.06). CONCLUSIONS: We identified psychological RFs that prospectively predict resilience and cofluctuate with weekly SR within individuals. These prospective results endorse that the previously reported RF-SR associations do not exclusively re

Published
2023

28. Coping with COVID: risk and resilience factors for mental health in a German representative panel study

Author

Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, Walter, Henrik, Riepenhausen, A, Veer, I, Wackerhagen, C, Reppmann, Z, Köber, G, Ayuso-Mateos, J, Bögemann, S, Corrao, G, Felez-Nobrega, M, Abad, J, Hermans, E, van Leeuwen, J, Lieb, K, Lorant, V, Mary-Krause, M, Mediavilla, R, Melchior, M, Mittendorfer-Rutz, E, Monzio Compagnoni, M, Pan, K, Puhlmann, L, Roelofs, K, Sijbrandij, M, Smith, P, Tüscher, O, Witteveen, A, Zerban, M, Kalisch, R, Kröger, H, Walter, H, Riepenhausen, Antje, Veer, Ilya M., Wackerhagen, Carolin, Reppmann, Zala C., Köber, Göran, Ayuso-Mateos, José Luis, Bögemann, Sophie A., Corrao, Giovanni, Felez-Nobrega, Mireia, Abad, Josep Maria Haro, Hermans, Erno, van Leeuwen, Judith, Lieb, Klaus, Lorant, Vincent, Mary-Krause, Murielle, Mediavilla, Roberto, Melchior, Maria, Mittendorfer-Rutz, Ellenor, Monzio Compagnoni, Matteo, Pan, Kuan-Yu, Puhlmann, Lara, Roelofs, Karin, Sijbrandij, Marit, Smith, Pierre, Tüscher, Oliver, Witteveen, Anke, Zerban, Matthias, Kalisch, Raffael, Kröger, Hannes, and Walter, Henrik

Abstract

Background: The COVID-19 pandemic might affect mental health. Data from population-representative panel surveys with multiple waves including pre-COVID data investigating risk and protective factors are still rare. Methods: In a stratified random sample of the German household population (n=6,684), we conducted survey-weighted multiple linear regressions to determine the association of various psychological risk and protective factors assessed between 2015 and 2020 with changes in psychological distress (PD; measured via PHQ-4) from pre-pandemic (average of 2016 and 2019) to peri-pandemic (both 2020 and 2021) time points. Control analyses on PD change between two pre-pandemic time points (2016 and 2019) were conducted. Regularized regressions were computed to inform on which factors were statistically most influential in the multicollinear setting. Results: PHQ-4 scores in 2020 (M=2.45) and 2021 (M=2.21) were elevated compared to 2019 (M=1.79). Several risk factors (catastrophizing, neuroticism, asking for instrumental support) and protective factors (perceived stress recovery, positive reappraisal, optimism) were identified for the peri-pandemic outcomes. Control analyses revealed that in pre-pandemic times, neuroticism and optimism were predominantly related to PD changes. Regularized regression mostly confirmed the results and highlighted perceived stress recovery as most consistent influential protective factor across peri-pandemic outcomes. Conclusions: We identified several psychological risk and protective factors related to PD outcomes during the COVID-19 pandemic. Comparison to pre-pandemic data stress the relevance of longitudinal assessments to potentially reconcile contradictory findings. Implications and suggestions for targeted prevention and intervention programs during highly stressful times such as pandemics are discussed.

Published
2023

38. Loneliness during the Covid-19 Pandemic in Germany: Impact of social factors and polygenic risk scores on interpersonal differences in loneliness and mental health

Author

von Werthern, N.M., Ahrens, K.F., Neumann, R.J., Kollmann, B., Kranz, T.M., Lieb, K., Tüscher, O., Reif, A., Fiebach, C.J., and Plichta, M.M.

Abstract

The outbreak of Covid-19 negatively affected mental health and elevated loneliness. The subjective feeling of loneliness is influenced by genetic and social factors and has a negative impact on mental health. From March 2020 to June 2021 loneliness was investigated in N = 517 individuals using monthly acquired questionnaire data and Latent Growth Curve Analysis. Three classes (“average”, 40%; “not lonely”, 38%; “elevated loneliness”, 22%) were identified, that differ significantly regarding loneliness, mental dysfunction, and response to the lockdown phases. Associations of social factors and polygenic risk scores (PRSs, n = 361) with class membership were investigated. Individuals with a high PRS for neuroticism are more likely to belong to the “elevated loneliness” class, living with another person is a protective factor. As the “ loneliness” class was at highest risk of mental dysfunction, our findings underscore the importance of identifying those individuals to implement counteractive measures.

Published
2023
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39. Integrative Psychotherapie

Author

Herpertz, S. C., Jacob, G., Külz, A. K., Lieb, K., Schramm, E., Stoffers, J., Voderholzer, U., Möller, H.-J., editor, Laux, G., editor, and Kapfhammer, H.-P., editor

Published
2011
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