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6 results on '"Lietor, Aurora"'

2. EFECTO DE UN EQUIPO MULTIDISCIPLINAR (CÓDIGO TEP) EN EL PRONÓSTICO DE LOS PACIENTES CON TROMBOEMBOLIA DE PULMÓN AGUDA SINTOMÁTICA

Author

González, Sara, Najarro, Marta, Briceño, Winnifer, Rodríguez, Carmen, Barrios, Deisy, Morillo, Raquel, Olavarría, Andreína, Lietor, Aurora, del Olmo, Vicente Gómez, Osorio, Álvaro, Recalde, Ángel Sánchez, Muriel, Alfonso, and Jiménez, David

Abstract

Antecedentes: No se han aclarado suficientemente los beneficios del manejo multidisciplinar (código TEP) de los pacientes con tromboembolia de pulmón (TEP) aguda sintomática. El objetivo de este estudio fue evaluar el efecto sobre la mortalidad a corto plazo del código TEP comparado con la atención habitual.

Published
2024
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4. A pilot study identifying a set of microRNAs as precise diagnostic biomarkers of acute kidney injury

Author

Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Alfonso Martín Escudero, Red Española de Investigación Renal, Aguado-Fraile, Elia, Ramos, Edurne, Conde, Elisa, Rodríguez, Macarena, Martín-Gómez, Laura, Lietor, Aurora, Candela, Ángel, Ponte, Belen, Liaño, Fernando, García-Bermejo, María Laura, Instituto de Salud Carlos III, Comunidad de Madrid, Fundación Alfonso Martín Escudero, Red Española de Investigación Renal, Aguado-Fraile, Elia, Ramos, Edurne, Conde, Elisa, Rodríguez, Macarena, Martín-Gómez, Laura, Lietor, Aurora, Candela, Ángel, Ponte, Belen, Liaño, Fernando, and García-Bermejo, María Laura

Abstract

In the last decade, Acute Kidney Injury (AKI) diagnosis and therapy have not notably improved probably due to delay in the diagnosis, among other issues. Precocity and accuracy should be critical parameters in novel AKI biomarker discovery. microRNAs are key regulators of cell responses to many stimuli and they can be secreted to the extracellular environment. Therefore, they can be detected in body fluids and are emerging as novel disease biomarkers. We aimed to identify and validate serum miRNAs useful for AKI diagnosis and management. Using qRT-PCR arrays in serum samples, we determined miRNAs differentially expressed between AKI patients and healthy controls. Statistical and target prediction analysis allowed us to identify a panel of 10 serum miRNAs. This set was further validated, by qRT-PCR, in two independent cohorts of patients with relevant morbi-mortality related to AKI: Intensive Care Units (ICU) and Cardiac Surgery (CS). Statistical correlations with patient clinical parameter were performed. Our results demonstrated that the 10 selected miRNAs (miR-101-3p, miR-127-3p, miR-210-3p, miR-126-3p, miR-26b-5p, miR-29a-3p, miR-146a-5p, miR-27a-3p, miR-93-3p and miR-10a-5p) were diagnostic biomarkers of AKI in ICU patients, exhibiting areas under the curve close to 1 in ROC analysis. Outstandingly, serum miRNAs estimated before CS predicted AKI development later on, thus becoming biomarkers to predict AKI predisposition. Moreover, after surgery, the expression of the miRNAs was modulated days before serum creatinine increased, demonstrating early diagnostic value. In summary, we have identified a set of serum miRNAs as AKI biomarkers useful in clinical practice, since they demonstrate early detection and high diagnostic value and they recognize patients at risk.

Published
2015

6. Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza

Author

Bermejo-Martin, Jesus F, primary, Ortiz de Lejarazu, Raul, additional, Pumarola, Tomas, additional, Rello, Jordi, additional, Almansa, Raquel, additional, Ramírez, Paula, additional, Martin-Loeches, Ignacio, additional, Varillas, David, additional, Gallegos, Maria C, additional, Serón, Carlos, additional, Micheloud, Dariela, additional, Gomez, Jose Manuel, additional, Tenorio-Abreu, Alberto, additional, Ramos, María J, additional, Molina, M Lourdes, additional, Huidobro, Samantha, additional, Sanchez, Elia, additional, Gordón, Mónica, additional, Fernández, Victoria, additional, del Castillo, Alberto, additional, Marcos, Ma Ángeles, additional, Villanueva, Beatriz, additional, López, Carlos Javier, additional, Rodríguez-Domínguez, Mario, additional, Galan, Juan-Carlos, additional, Cantón, Rafael, additional, Lietor, Aurora, additional, Rojo, Silvia, additional, Eiros, Jose M, additional, Hinojosa, Carmen, additional, Gonzalez, Isabel, additional, Torner, Nuria, additional, Banner, David, additional, Leon, Alberto, additional, Cuesta, Pablo, additional, Rowe, Thomas, additional, and Kelvin, David J, additional

Published
2009
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