Search

Your search keyword '"Liguori, Maria"' showing total 304 results
Start Over Author "Liguori, Maria"
304 results on '"Liguori, Maria"'

6. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis

Author

Roberto Cangemi, Valeria Raparelli, Giovanni Talerico, Stefania Basili, Francesco Violi, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Sacerdoti David, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Perticone Francesco, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Andriulli Angelo, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Raimondo Giovanni, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Picardi Antonio, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davì Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Licata Anna, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Gargovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Pietrangelo Antonello, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Corazza Gino Roberto, Caldwell Stephen Hugh, Angelico Francesco, Del Ben Maria, Napoleone Laura, Polimeni Licia, Proietti Marco, Raparelli Valeria, Romiti Giulio Francesco, Ruscio Eleonora, Severoni Andrea, Talerico Giovanni, Toriello Filippo, and Vestri Annarita

Subjects
Albumin, Cirrhosis, Portal Vein Thrombosis, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background and Aims: Hypoalbuminemia, as defined by serum albumin (SA) levels ≤35 g/L, is associated to venous and arterial thrombosis in general population and in patients at risk of cardiovascular disease. It is unknown if SA ≤35 g/L is also associated to portal vein thrombosis (PVT) in cirrhosis. Methods: Cirrhotic patients enrolled in the Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry (PRO-LIVER) study (n = 753), were followed-up for 2 years to assess the risk of PVT, that was diagnosed by Doppler ultrasonography. Child-Pugh classes, Model for End-Stage Liver Disease score, presence of hepatocellular carcinoma and laboratory variables including SA, D-dimer, and high-sensitivity C-reactive protein (hs-CRP) were measured at baseline. Results: SA ≤35 g/L was detected in 52% of patients. A logistic multivariate regression analysis showed that higher Child-Pugh class, hepatocellular carcinoma and thrombocytopenia were significantly associated to SA ≤35 g/L. In a subgroup of patients where data regarding hs-CRP and D-dimer were available, SA ≤35 g/L was inversely associated with hs-CRP and D-dimer. During the follow-up, a total of 61 patients experienced PVT. A Kaplan Meier survival analysis showed SA ≤35 g/L was associated to increased risk of PVT compared to SA >35 g/L (P = .005). A multivariate Cox proportional hazards regression analysis showed that male sex, lower platelet count, and SA ≤35 g/L remained associated to PVT after adjusting for confounding factors. Conclusion: Cirrhotic patients with SA ≤35 g/L are at higher risk of experiencing PVT compared to those with SA >35 g/L and could be considered as potential candidates to anticoagulant prophylaxis for PVT prevention.

Published
2024
Full Text
View/download PDF

7. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis

Author

Giuseppe, Palasciano, Felicia, D’Alitto, Ostilio, Palmieri Vincenzo, Daniela, Santovito, Dario, Di Michele, Giuseppe, Croce, David, Sacerdoti, Silvia, Brocco, Silvano, Fasolato, Lara, Cecchetto, Giancarlo, Bombonato, Michele, Bertoni, Tea, Restuccia, Paola, Andreozzi, Livia, Liguori Maria, Francesco, Perticone, Benedetto, Caroleo, Maria, Perticone, Orietta, Staltari, Roberto, Manfredini, Alfredo, De Giorgi, Maurizio, Averna, Antonina, Giammanco, Alessandro, Granito, Irene, Pettinari, Sara, Marinelli, Luigi, Bolondi, Lorenzo, Falsetti, Aldo, Salvi, Emanuele, Durante-Mangoni, Flavio, Cesaro, Vincenza, Farinaro, Enrico, Ragone, Ignazio, Morana, Angelo, Andriulli, Antonio, Ippolito, Angelo, Iacobellis, Grazia, Niro, Antonio, Merla, Giovanni, Raimondo, Sergio, Maimone, Irene, Cacciola, Doriana, Varvara, Davide, Drenaggi, Silvia, Staffolani, Antonio, Picardi, Umberto, Vespasiani-Gentilucci, Giovanni, Galati, Paolo, Gallo, Giovanni, Davì, Cosima, Schiavone, Francesca, Santilli, Claudio, Tana, Anna, Licata, Maurizio, Soresi, Battista, Bianchi Giovanni, Isabella, Carderi, Antonio, Pinto, Antonino, Tuttolomondo, Giovanni, Ferrari, Paolo, Gresele, Tiziana, Fierro, Olivia, Morelli, Giacomo, Laffi, Giulio, Romanelli Roberto, Umberto, Arena, Cristina, Stasi, Antonio, Gasbarrini, Matteo, Gargovich, Assunta, Zocco Maria, Laura, Riccardi, Elena, Ainora Maria, William, Capeci, Pio, Martino Giuseppe, Lorenzo, Nobili, Maurizio, Cavallo, Pierluigi, Frugiuele, Antonio, Greco, Antonello, Pietrangelo, Paolo, Ventura, Chiara, Cuoghi, Matteo, Marcacci, Gaetano, Serviddio, Gianluigi, Vendemiale, Rosanna, Villani, Ruggiero, Gargano, Gianpaolo, Vidili, Valentina, Di Cesare, Maristella, Masala, Giuseppe, Delitala, Pietro, Invernizzi, Giovanni, Di Minno, Antonella, Tufano, Francesco, Purrello, Graziella, Privitera, Alessandra, Forgione, Valentina, Curigliano, Marco, Senzolo, Kryssia Isabel, Rodríguez-Castro, Gianluigi, Giannelli, Carla, Serra, Sergio, Neri, Pietro, Pignataro, Mario, Rizzetto, Wilma, Debernardi Venon, Gianluca, Svegliati Baroni, Gaetano, Bergamaschi, Michela, Masotti, Filippo, Costanzo, Roberto, Corazza Gino, Hugh, Caldwell Stephen, Francesco, Angelico, Ben Maria, Del, Laura, Napoleone, Licia, Polimeni, Marco, Proietti, Valeria, Raparelli, Francesco, Romiti Giulio, Eleonora, Ruscio, Andrea, Severoni, Giovanni, Talerico, Filippo, Toriello, Annarita, Vestri, Cangemi, Roberto, Raparelli, Valeria, Talerico, Giovanni, Basili, Stefania, and Violi, Francesco

Published
2024
Full Text
View/download PDF

8. Chapter Il Piccolo Masaccio e le Terre Nuove. Creativity and Computer Graphics for Museum Edutainment

Author

Zucchi, Valentina, Guidazzoli, Antonella, Bellavia, Giovanni, De Luca, Daniele, Liguori, Maria Chiara, Delli Ponti, Francesca, Farroni, Federica, and Chiavarini, Beatrice

Subjects
Educational Video, Masaccio, Computer Graphics
Abstract

Since its opening, the Museum of the New Towns, housed in the Palazzo di Arnolfo in San Giovanni Valdarno, has dedicated a particular attention to the relationship with its audiences. In this context, the video “Il piccolo Masaccio e le Terre Nuove” has the purpose of bringing children and young people, in particular, closer to the museum main themes. The video presents a series of very different techniques, such as live shots, taken also by drone, Computer Graphics, 2D drawings executed with a tablet, drawings sketched with traditional techniques, such as India ink and watercolours, and digital videos taken from Google Earth.

Published
2018
Full Text
View/download PDF

9. A Flexible and Adaptable Workflow to Develop and Visualise Industrial Digital Twins

Author

Guidazzoli, Antonella, Imboden, Silvano, Zuzolo, Paolo, De Luca, Daniele, Peruch, Eleonora, Pascolo, Eric, Farroni, Federica, Liguori, Maria Chiara, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Ardito, Carmelo, editor, Lanzilotti, Rosa, editor, Malizia, Alessio, editor, Petrie, Helen, editor, Piccinno, Antonio, editor, Desolda, Giuseppe, editor, and Inkpen, Kori, editor

Published
2021
Full Text
View/download PDF

10. 'I Went to America to See Ancient Italian Paintings': The Problem of the Re-contextualization of Artworks Uprooted from Their Original Settings

Author

Fachechi, Grazia Maria, Guidazzoli, Antonella, De Luca, Daniele, Liguori, Maria Chiara, Verri, Luigi, Bellavia, Giovanni, Barbosa, Simone Diniz Junqueira, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Sivalingam, Krishna M., Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, Ghosh, Ashish, Series Editor, Duguleană, Mihai, editor, Carrozzino, Marcello, editor, Gams, Matjaž, editor, and Tanea, Iulian, editor

Published
2019
Full Text
View/download PDF

11. A Predictive Model for MicroRNA Expressions in Pediatric Multiple Sclerosis Detection

Author

Casalino, Gabriella, Castellano, Giovanna, Consiglio, Arianna, Liguori, Maria, Nuzziello, Nicoletta, Primiceri, Davide, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Torra, Vicenç, editor, Narukawa, Yasuo, editor, Pasi, Gabriella, editor, and Viviani, Marco, editor

Published
2019
Full Text
View/download PDF

14. Contributors

Author

Abi Khalil, Charbel, primary, Akins, Robert E., additional, Alenghat, T., additional, Allen, Emily G, additional, Altorok, N., additional, Altucci, Lucia, additional, Balcerczyk, Aneta, additional, Barragán, Isabel, additional, Biesiekierska, Marta, additional, Biradar, Vinayak S., additional, Blossom, Sarah J., additional, Chaves, Patricia, additional, Chen, D., additional, Chen, Hong, additional, Chen, Shijia Alexia, additional, Cheng, Baoli, additional, Chun, P., additional, Ciesielski, Oskar, additional, Colon-Diaz, Maricarmen, additional, Cox, O.H., additional, Cozma, Angela, additional, Cui, Xiaolong, additional, Dekker, F.J., additional, Dell’Aversana, Carmela, additional, Demirdizen, Engin, additional, Deng, Jiali, additional, Deobagkar, Deepti D., additional, Dvir-Ginzberg, Mona, additional, Ehnes, Devon, additional, Eissenberg, J.C., additional, Elosegui, Perla M., additional, Fodor, Adriana, additional, Ganesan, A., additional, Giorgio, Cristina, additional, Guo, Mengying, additional, Hall, J.G., additional, Hashimoto-Hill, S., additional, Imam, Mustapha Umar, additional, Ismail, Maznah, additional, Jaramillo, Alexander J., additional, Jennings, M.P., additional, Jin, Peng, additional, Johnson, A.C., additional, Kahaleh, B., additional, Kelly, D.R., additional, Koliada, Alexander, additional, Kolliputi, Narasaiah, additional, Kumar, Ashok, additional, Lee, R.S., additional, Levenson, Anait S., additional, Levy, Shiri, additional, Ligon, C.O., additional, Liguori, Maria, additional, Liu, Ji, additional, Louwies, T., additional, Lu, Qianjin, additional, Luo, Shuaihantian, additional, Lushchak, Oleh, additional, Meerveld, B. Greenwood-Van, additional, Miller, Rachel L., additional, Nagaraja, V., additional, Navada, Shyamala C., additional, Nuzziello, Nicoletta, additional, Oh, Jessica, additional, Oltra, Elisa, additional, Onieva, Juan Luis, additional, Ooi, Der Jiun, additional, Pirola, Luciano, additional, Proschinger, S., additional, Rajpathak, Shriram N., additional, Robinson, Karyn G., additional, Roman, Gabriela, additional, Ruohola-Baker, Hannele, additional, Rusu, Adriana, additional, Sanusi, Kamaldeen Olalekan, additional, Schenk, A., additional, Seib, K.L., additional, Sgueglia, Giulia, additional, Shu, Liqi, additional, Singh, J., additional, Sitar-Tăut, Adela, additional, Soto, Edwin Y., additional, Suharoschi, Ramona, additional, Tajbakhsh, J., additional, Tambaro, Francesco Paolo, additional, Taranda, Julian, additional, Thoutam, Akshaya, additional, Tollefsbol, Trygve O., additional, Trojer, P., additional, Turcan, Sevin, additional, Uthman, Yaaqub Abiodun, additional, Vaiserman, Alexander, additional, Vulturar, Romana, additional, Wang, Huan, additional, Wapenaar, H., additional, Weksberg, R., additional, Xiao, Junjie, additional, Xu, Guanying Bianca, additional, Zeng, Chang, additional, Zhang, Wei, additional, Zhang, Zhou, additional, and Zimmer, P., additional

Published
2021
Full Text
View/download PDF

18. A rare cause of recurrent syncope: chemodectoma of left carotid

Author

Arturo, Claudia, primary, D'Alessandro, Lucia, additional, Poggiano, Maria Rita, additional, Orefice, Giuseppe, additional, Longobardo, Antonietta, additional, Liguori, Maria, additional, Arcamone, Celeste, additional, Di Scala, Antonio, additional, Di Gennaro, Ciro, additional, and Di Micco, Pierpaolo, additional

Published
2023
Full Text
View/download PDF

21. Open Creative Framework for a Smart Cultural City: Bologna Porticoes and the Involvement of Citizens for a UNESCO Candidacy

Author

Guidazzoli, Antonella, Liguori, Maria Chiara, Felicori, Mauro, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Nesi, Paolo, editor, and Santucci, Raffaella, editor

Published
2013
Full Text
View/download PDF

22. A Google Cloud Approach to Implement a Graphical Data Access Interface Binding Heterogeneous Cultural Repositories

Author

Coralini, Antonella, Guidazzoli, Antonella, Lenzi, Fiamma, Spigarolo, Micaela, Baglivo, Antonio, Liguori, Maria Chiara, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Ioannides, Marinos, editor, Fritsch, Dieter, editor, Leissner, Johanna, editor, Davies, Rob, editor, Remondino, Fabio, editor, and Caffo, Rossella, editor

Published
2012
Full Text
View/download PDF

24. IL SUPERCALCOLATORE PRE-EXASCALE LEONARDO: CONTRIBUTI AL MONDO DEL PATRIMONIO CULTURALE.

Author

Guidazzoli, Antonella and Chiara Liguori, Maria

Subjects
ARTIFICIAL intelligence, CULTURAL property, HIGH technology, BIG data, SUPERCOMPUTERS, POSSIBILITY
Abstract

Copyright of Archeomatica is the property of MediaGEO and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

27. Dysregulation of Gene Expressions in Multiple Sclerosis: TNFSF13B and Other Candidate Genes.

Author

Consiglio, Arianna, Nuzziello, Nicoletta, and Liguori, Maria

Subjects
GENE expression, MULTIPLE sclerosis, AMYOTROPHIC lateral sclerosis, GENETIC regulation, DEMYELINATION, NEUROMUSCULAR diseases
Abstract

Background: In previous investigations of combined miRNAs/mRNAs expressions in neurodegenerative diseases like Multiple Sclerosis (MS) and Amyotrophic Lateral Sclerosis (ALS) we have targeted some interesting genes and molecular pathways that needed further confirmation. Methods: By nanofluidic qPCR analysis, we aimed to verify the expression of genes that resulted differentially expressed in the previous analyses. Data from MS patients -- either the pediatric and the adult occurrence of the disease (adMS and pedMS, respectively) -- was compared to age-matched healthy groups. As neurological controls we recruited a cohort of ALS subjects, considering published searches of possible genetic similarities between the two diseases. Results: The main results confirmed the involvement of most of the investigated genes in pedMS and adMS, like BACH2 and MICAL3. On the other hand, suggestive MS candidate genes like TNFSF13B showed an interesting trend possibly influenced by interfering factors, such as concomitant disease-modifying treatments; it is worth noting that TNFSF13B was one of the genes upregulated in ALS compared to age-matched adMS patients, together with the transcription factor TFDP1. Conclusions: Although with caution due to the small sample size, this study confirms the interest in transcriptomic analysis supported by integrated and educated bioinformatics evaluations, to shed further light in complex neurological diseases. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

28. Mutation analysis of the SPG4 gene in Italian patients with pure and complicated forms of spastic paraplegia

Author

Magariello, Angela, Muglia, Maria, Patitucci, Alessandra, Ungaro, Carmine, Mazzei, Rosalucia, Gabriele, Anna Lia, Sprovieri, Teresa, Citrigno, Luigi, Conforti, Francesca Luisa, Liguori, Maria, Gambardella, Antonio, Bono, Francesco, Piccoli, Tommaso, Patti, Francesco, Zappia, Mario, Mancuso, Michelangelo, Iemolo, Franco, and Quattrone, Aldo

Published
2010
Full Text
View/download PDF

29. An Investigation of the Role of Common and Rare Variants in a Large Italian Multiplex Family of Multiple Sclerosis Patients

Author

Barizzone, Nadia, primary, Cagliani, Rachele, additional, Basagni, Chiara, additional, Clarelli, Ferdinando, additional, Mendozzi, Laura, additional, Agliardi, Cristina, additional, Forni, Diego, additional, Tosi, Martina, additional, Mascia, Elisabetta, additional, Favero, Francesco, additional, Corà, Davide, additional, Corrado, Lucia, additional, Sorosina, Melissa, additional, Esposito, Federica, additional, Zuccalà, Miriam, additional, Vecchio, Domizia, additional, Liguori, Maria, additional, Comi, Cristoforo, additional, Comi, Giancarlo, additional, Martinelli, Vittorio, additional, Filippi, Massimo, additional, Leone, Maurizio, additional, Martinelli-Boneschi, Filippo, additional, Caputo, Domenico, additional, Sironi, Manuela, additional, Guerini, Franca Rosa, additional, and D’Alfonso, Sandra, additional

Published
2021
Full Text
View/download PDF

34. Genome-wide association study in musicianʼs dystonia: A risk variant at the arylsulfatase G locus?

Author

Lohmann, Katja, Schmidt, Alexander, Schillert, Arne, Winkler, Susen, Albanese, Alberto, Baas, Frank, Bentivoglio, Anna Rita, Borngräber, Friederike, Brüggemann, Norbert, Defazio, Giovanni, Del Sorbo, Francesca, Deuschl, Günther, Edwards, Mark J., Gasser, Thomas, Gómez-Garre, Pilar, Graf, Julia, Groen, Justus L., Grünewald, Anne, Hagenah, Johann, Hemmelmann, Claudia, Jabusch, Hans-Christian, Kaji, Ryuji, Kasten, Meike, Kawakami, Hideshi, Kostic, Vladimir S., Liguori, Maria, Mir, Pablo, Münchau, Alexander, Ricchiuti, Felicia, Schreiber, Stefan, Siegesmund, Katharina, Svetel, Marina, Tijssen, Marina A.J., Valente, Enza Maria, Westenberger, Ana, Zeuner, Kirsten E., Zittel, Simone, Altenmüller, Eckart, Ziegler, Andreas, and Klein, Christine

Published
2014
Full Text
View/download PDF

37. Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis

Author

Savettieri, Giovanni, Messina, Demetrio, Andreoli, Virginia, Bonavita, Simona, Caltagirone, Carlo, Cittadella, Rita, Farina, Deborah, Fazio, Maria Carolina, Girlanda, Paolo, Le Pira, Francesco, Liguori, Maria, Lugaresi, Alessandra, Nocentini, Ugo, Reggio, Arturo, Salemi, Giuseppe, Tedeschi, Gioacchino, Trojano, Maria, Valentino, Paola, and Quattrone, Aldo

Published
2004
Full Text
View/download PDF

41. Apolipoprotein E genotype does not influence the progression of multiple sclerosis

Author

Savettieri, Giovanni, Andreoli, Virginia, Bonavita, Simona, Cittadella, Rita, Caltagirone, Carlo, Fazio, Maria Carolina, Girlanda, Paolo, Pira, Francesco, Liguori, Maria, Logroscino, Giancarlo, Lugaresi, Alessandra, Nocentini, Ugo, Reggio, Arturo, Salemi, Giuseppe, Serra, Paolo, Tedeschi, Gioacchino, Toma, Lucia, Trojano, Maria, Valentino, Paola, and Quattrone, Aldo

Subjects
Apolipoproteins -- Research, Multiple sclerosis -- Development and progression, Multiple sclerosis -- Research, Genetic polymorphisms -- Research, Health
Abstract

Byline: Giovanni Savettieri (1), Virginia Andreoli (2), Simona Bonavita (3), Rita Cittadella (2), Carlo Caltagirone (4), Maria Carolina Fazio (5), Paolo Girlanda (5), Francesco Pira (6), Maria Liguori (7), Giancarlo Logroscino (8), Alessandra Lugaresi (9), Ugo Nocentini (4), Arturo Reggio (6), Giuseppe Salemi (1), Paolo Serra (2), Gioacchino Tedeschi (3), Lucia Toma (9), Maria Trojano (7), Paola Valentino (10), Aldo Quattrone (2,10,11) Keywords: multiple sclerosis; APOE polymorphism; APOE promoter; MS progression Abstract: Objective: To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS. Methods: We investigated 428 subjects affected by clinically defined MS, with a disease duration of at least three years. We collected data concerning the age at onset of MS, clinical type, disease duration and disability according to the expanded disability status scale (EDSS). We also calculated the progression index (PI) to evaluate disease progression. APOE genotyping and the --491 A/T polymorphism of the APOE promoter were determined. Results: No association was observed between the APOE [epsilon]4 allele and clinical characteristics of our study population. We also investigated the --491 A/T APOE promoter polymorphism in 236 MS subjects and did not find any association between the --491 A/T polymorphism and the selected clinical variables. Conclusions: In our population the APOE [epsilon]4 allele and the --491 A/T APOE promoter polymorphism are not associated with a more rapid course of MS. Author Affiliation: (1) Institute of Neuropsychiatry, University of Palermo, Palermo, Italy (2) Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone (Cosenza), Italy (3) Dept. of Neurological Sciences, 2nd University of Naples, Naples, Italy (4) Cattedra di Neurologia and I.R.C.C.S., Fondazione 'S. Lucia', University of Rome 'Tor Vergata', Rome, Italy (5) Dept. of Neurosciences, Psychiatry and Anaesthesiology, University of Messina, Messina, Italy (6) Dept. of Neurological Sciences, University of Catania, Catania, Italy (7) Dept. of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy (8) Dept. of Neurology, Ospedale Miulli, Bari, Italy (9) Dept. of Oncology &amp Neuroscience, University of Chieti 'Gabriele d'Annunzio', Chieti, Italy (10) Institute of Neurology, University Magna Graecia, Catanzaro, Italy (11) Clinica Neurologica, Policlinico Mater Domini, Via T. Campanella, 88100, Catanzaro, Italy Article History: Received Date: 10/10/2002 Accepted Date: 08/05/2003

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results