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1,348 results on '"Liguori, Rocco"'

9. Respiratory function in a large cohort of treatment-naïve adult spinal muscular atrophy patients: a cross-sectional study

Author

Vicino, Alex, Bello, Luca, Bonanno, Silvia, Govoni, Alessandra, Cerri, Federica, Ferraro, Manfredi, Capece, Giuliana, Gadaleta, Giulio, Meneri, Megi, Vacchiano, Veria, Ricci, Giulia, D'Errico, Eustachio, Tramacere, Irene, Banfi, Paolo, Bortolani, Sara, Zanin, Riccardo, Maioli, Maria Antonietta, Silvestrini, Mauro, Previtali, Stefano Carlo, Berardinelli, Angela, Turri, Mara, Coccia, Michela, Mantegazza, Renato, Liguori, Rocco, Filosto, Massimiliano, Siciliano, Gabriele, Simone, Isabella Laura, Mongini, Tiziana, Comi, Giacomo, Pegoraro, Elena, and Maggi, Lorenzo

Published
2023
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10. Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort study

Author

Ferri, Laura, Gessani, Annalisa, Liguori, Rocco, Cortelli, Pietro, Michelucci, Roberto, Salvi, Fabrizio, Bartolomei, Ilaria, Borghi, Anna Maria, Zini, Andrea, Rinaldi, Rita, Tugnoli, Valeria, Pugliatti, Maura, Codeluppi, Luca, Valzania, Franco, Stragliati, Filippo, Nuredini, Andi, Romano, Sonia, D'Orsi, Alessandro, Parrino, Liborio, Medici, Doriana, Pilurzi, Giovanna, Terlizzi, Emilio, Guidetti, Donata, De Pasqua, Silvia, Santangelo, Mario, De Massis, Paola, Gizzi, Matteo, Casmiro, Mario, Querzani, Pietro, Morresi, Simonetta, Vitiello, Maria, Longoni, Marco, Patuelli, Alberto, Malagù, Susanna, Bianchi, Francesca, Dossi, Marco Currò, Ganino, Cristiana, Zucchi, Elisabetta, Musazzi, Umberto Maria, Fedele, Guido, Martinelli, Ilaria, Gianferrari, Giulia, Simonini, Cecilia, Fini, Nicola, Ghezzi, Andrea, Caputo, Maria, Sette, Elisabetta, Vacchiano, Veria, Zinno, Lucia, Anceschi, Pietro, Canali, Elena, Vinceti, Marco, Ferro, Salvatore, and Mandrioli, Jessica

Published
2023
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13. Anti-LGI1 encephalitis following COVID-19 vaccination: a case series

Author

Asioli, Gian Maria, Muccioli, Lorenzo, Barone, Valentina, Giacomozzi, Sebastiano, Rossi, Simone, Silvestri, Tania, Spinardi, Luca, Mastrangelo, Vincenzo, Bernabè, Giorgia, Leta, Chiara, Brutto, Mariachiara, Faggiano, Chiara, Liguori, Rocco, Bisulli, Francesca, Longoni, Marco, Tinuper, Paolo, Guarino, Maria, and Cortelli, Pietro

Published
2022
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15. Chromatic Pupillometry Findings in Alzheimers Disease.

Author

Romagnoli, Martina, Stanzani Maserati, Michelangelo, De Matteis, Maddalena, Capellari, Sabina, Carbonelli, Michele, Amore, Giulia, Cantalupo, Gaetano, Zenesini, Corrado, Liguori, Rocco, Sadun, Alfredo, Carelli, Valerio, Park, Jason, and La Morgia, Chiara

Subjects
Alzheimer’s disease, chromatic pupillometry, melanopsin retinal ganglion cells, post-illumination pupil response, pupil, pupillary light reflex
Abstract

Intrinsically photosensitive melanopsin retinal ganglion cells (mRGCs) are crucial for non-image forming functions of the eye, including the photoentrainment of circadian rhythms and the regulation of the pupillary light reflex (PLR). Chromatic pupillometry, using light stimuli at different wavelengths, makes possible the isolation of the contribution of rods, cones, and mRGCs to the PLR. In particular, post-illumination pupil response (PIPR) is the most reliable pupil metric of mRGC function. We have previously described, in post-mortem investigations of AD retinas, a loss of mRGCs, and in the remaining mRGCs, we demonstrated extensive morphological abnormalities. We noted dendrite varicosities, patchy distribution of melanopsin, and reduced dendrite arborization. In this study, we evaluated, with chromatic pupillometry, the PLR in a cohort of mild-moderate AD patients compared to controls. AD and controls also underwent an extensive ophthalmological evaluation. In our AD cohort, PIPR did not significantly differ from controls, even though we observed a higher variability in the AD group and 5/26 showed PIPR values outside the 2 SD from the control mean values. Moreover, we found a significant difference between AD and controls in terms of rod-mediated transient PLR amplitude. These results suggest that in the early stage of AD there are PLR abnormalities that may reflect a pathology affecting mRGC dendrites before involving the mRGC cell body. Further studies, including AD cases with more severe and longer disease duration, are needed to further explore this hypothesis.

Published
2020

18. Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix® Cohort

Author

Mutti, Carlotta, Brunetti, Valerio, Figorilli, Michela, Liguori, Claudio, Pizza, Fabio, Proserpio, Paola, Sacco, Tommaso, Pedrazzi, Giuseppe, Lecomte, Isabelle, Blanchard, Nora, Agostoni, Elio Clemente, Bonanni, Enrica, Centonze, Diego, Cicolin, Alessandro, Della Marca, Giacomo, Ferini-Strambi, Luigi, Ferri, Raffaele, Gigli, Gian Luigi, Izzi, Francesca, Liguori, Rocco, Lodi, Raffaele, Nobili, Lino, Parrino, Liborio, Placidi, Fabio, Puligheddu, Monica, Romigi, Andrea, Savarese, Maria Antonietta, Terzaghi, Michele, and Plazzi, Giuseppe

Published
2022
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23. Clinical, prognostic and pathophysiological implications of MOG-IgG detection in the CSF: the importance of intrathecal MOG-IgG synthesis

Author

Greco, Giacomo, primary, Risi, Mario, additional, Masciocchi, Stefano, additional, Businaro, Pietro, additional, Rigoni, Eleonora, additional, Zardini, Elisabetta, additional, Scaranzin, Silvia, additional, Morandi, Chiara, additional, Diamanti, Luca, additional, Foiadelli, Thomas, additional, Giannoccaro, Maria Pia, additional, Morelli, Luana, additional, Liguori, Rocco, additional, Barone, Paolo, additional, Tozzo, Alessandra, additional, Passarini, Alice, additional, Gelibter, Stefano, additional, Patti, Francesco, additional, Banfi, Paola, additional, Simone, Anna Maria, additional, Bisecco, Alvino, additional, Ruggieri, Martino, additional, Maimone, Davide, additional, Bruno, Giorgia, additional, Siliquini, Sabrina, additional, Bova, Stefania, additional, Di Filippo, Massimiliano, additional, Lanzillo, Roberta, additional, Gallo, Antonio, additional, Colombo, Elena, additional, Franciotta, Diego, additional, and Gastaldi, Matteo, additional

Published
2024
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26. Identifying and predicting amyotrophic lateral sclerosis clinical subgroups: a population-based machine-learning study

Author

Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Canosa, Antonio, Manera, Umberto, Vasta, Rosario, Palumbo, Francesca, Bombaci, Alessandro, Grassano, Maurizio, Brunetti, Maura, Casale, Federico, Fuda, Giuseppe, Salamone, Paolina, Iazzolino, Barbara, Peotta, Laura, Cugnasco, Paolo, De Marco, Giovanni, Torrieri, Maria Claudia, Gallone, Salvatore, Barberis, Marco, Sbaiz, Luca, Gentile, Salvatore, Mauro, Alessandro, Mazzini, Letizia, De Marchi, Fabiola, Corrado, Lucia, D'Alfonso, Sandra, Bertolotto, Antonio, Imperiale, Daniele, De Mattei, Marco, Amarù, Salvatore, Comi, Cristoforo, Labate, Carmelo, Poglio, Fabio, Ruiz, Luigi, Testa, Lucia, Rota, Eugenia, Ghiglione, Paolo, Launaro, Nicola, Di Sapio, Alessia, Mandrioli, Jessica, Fini, Nicola, Martinelli, Ilaria, Zucchi, Elisabetta, Gianferrari, Giulia, Simonini, Cecilia, Meletti, Stefano, Liguori, Rocco, Vacchiano, Veria, Salvi, Fabrizio, Bartolomei, Ilaria, Michelucci, Roberto, Cortelli, Pietro, Rinaldi, Rita, Borghi, Anna Maria, Zini, Andrea, Sette, Elisabetta, Tugnoli, Valeria, Pugliatti, Maura, Canali, Elena, Codeluppi, Luca, Valzania, Franco, Zinno, Lucia, Pavesi, Giovanni, Medici, Doriana, Pilurzi, Giovanna, Terlizzi, Emilio, Guidetti, Donata, De Pasqua, Silvia, Santangelo, Mario, De Massis, Patrizia, Bracaglia, Martina, Casmiro, Mario, Querzani, Pietro, Morresi, Simonetta, Longoni, Marco, Patuelli, Alberto, Malagù, Susanna, Currò Dossi, Marco, Vidale, Simone, Ferro, Salvatore, Faghri, Faraz, Brunn, Fabian, Dadu, Anant, Nalls, Michael A, Campbell, Roy H, and Traynor, Bryan J

Published
2022
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27. Co‐occurrence of glial fibrillary acidic protein astrocytopathy in a patient with Leber's hereditary optic neuropathy due to DNAJC30 mutations.

Author

Giannoccaro, Maria Pia, Morelli, Luana, Ricciardiello, Fortuna, Donadio, Vincenzo, Bartiromo, Fiorina, Tonon, Caterina, Carbonelli, Michele, Amore, Giulia, Carelli, Valerio, Liguori, Rocco, and La Morgia, Chiara

Abstract

Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease characterized by visual loss, and rarely associated with extraocular manifestations including multiple sclerosis‐like lesions. The association of LHON and neuromyelitis optica spectrum disorders has rarely been reported. Here is reported a case of glial fibrillary acidic protein astrocytopathy presenting with area postrema syndrome in a patient with previously diagnosed recessive LHON due to mutations in the nuclear gene DNAJC30. This case emphasizes the necessity of extensive investigations for other treatable conditions in patients with LHON and otherwise unexplained extraocular involvement and the possibility that also visual symptoms can respond to immune therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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28. FADD gene pathogenic variants causing recurrent febrile infection‐related epilepsy syndrome: Case report and literature review.

Author

Giovannini, Giada, Giannoccaro, Maria Pia, Cioclu, Maria Cristina, Orlandi, Niccolò, Liguori, Rocco, and Meletti, Stefano

Subjects
LITERATURE reviews, EPILEPSY, GENETIC variation, CEREBRAL atrophy, STATUS epilepticus, SYMPTOMS
Abstract

FIRES and NORSE are clinical presentations of disease processes that, to date, remain unexplained without an established etiology in many cases. Neuroinflammation is thought to have paramount importance in the genesis of these conditions. We hereby report the clinical, EEG, brain MRI, and genetic findings of a nuclear family with recurrent febrile‐related encephalopathy with refractory de novo Status Epilepticus. Whole‐exome sequencing (WES) revealed a homozygous p.C105W pathogenic variant of FADD gene (FAS‐associated protein with death domain, FADD), known to cause ultrarare forms of autosomal recessive immunodeficiency that could be associated with variable degrees of lymphoproliferation, cerebral atrophy, and cardiac abnormalities. The FADD‐related conditions disrupt FAS‐mediated apoptosis and can cause a clinical picture with the characteristics of FIRES. This observation is important because, on one hand, it increases the number of reported patients with FADD deficiency, showing that this disorder may present variable expressivity, and on the other hand, it demonstrates a genetic cause of FIRES involving a cell‐mediated inflammation regulatory pathway. This finding supports early treatment with immunomodulatory therapy and could represent a new avenue of research in the field of new onset refractory status epilepticus and related conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Motor unit number estimation via MScanFit MUNE in spinal muscular atrophy.

Author

Vacchiano, Veria, Morabito, Francesca, Faini, Claudia, Nocera, Giovanna, Not, Riccardo, Scarpini, Gaia, Romagnoli, Martina, Pini, Antonella, and Liguori, Rocco

Abstract

Introduction/Aims: MScanFit MUNE (MScanFit) is a novel tool to derive motor unit number estimates (MUNEs) from compound muscle action potential (CMAP) scans. Few studies have explored its utility in 5q spinal muscular atrophy (SMA5q) patients, assessing only the abductor pollicis brevis (APB) muscle. We aimed to assess different distal muscles in pediatric and adult SMA5q patients, further evaluating clinical‐electrophysiological correlations. Methods: We analyzed MScanFit parameters reflecting the extent of denervation (MUNE; N50) and parameters of collateral reinnervation in APB, abductor digiti minimi (ADM), and tibialis anterior (TA) muscles. SMA patients were clinically evaluated using standardized motor function clinical scales, including the Hammersmith Functional Motor Scale – Expanded and the Revised Upper Limb Module. Results: A total of 23 SMA5q (9 SMA type 2 and 14 SMA type 3) and 12 age‐matched healthy controls (HCs) were enrolled. SMA patients showed lower MUNE and N50 values and higher parameters of collateral sprouting in all muscles compared to HC (p <.001). SMA type 2 patients demonstrated lower MUNE and higher collateral reinnervation values in APB and TA compared to SMA type 3 (p <.05). Walker patients showed higher values of MUNE and N50, and lower parameters of reinnervation in all muscles compared to sitters (p <.05). MScanFit parameters showed strong correlations (Rho‐values ranging from.72 to.83) with clinical measurements. MUNE values were abnormal in muscles that were not clinically affected. Discussion: MScanFit parameters showed promise as an outcome measure. Further studies, particularly longitudinal ones, are needed to evaluate MScanFit in measuring response to treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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31. HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease

Author

Yogeshwar, Selina M, primary, Muñiz-Castrillo, Sergio, additional, Sabater, Lidia, additional, Peris-Sempere, Vicente, additional, Mallajosyula, Vamsee, additional, Luo, Guo, additional, Yan, Han, additional, Yu, Eric, additional, Zhang, Jing, additional, Lin, Ling, additional, Fagundes Bueno, Flavia, additional, Ji, Xuhuai, additional, Picard, Géraldine, additional, Rogemond, Véronique, additional, Pinto, Anne Laurie, additional, Heidbreder, Anna, additional, Höftberger, Romana, additional, Graus, Francesc, additional, Dalmau, Josep, additional, Santamaria, Joan, additional, Iranzo, Alex, additional, Schreiner, Bettina, additional, Giannoccaro, Maria Pia, additional, Liguori, Rocco, additional, Shimohata, Takayoshi, additional, Kimura, Akio, additional, Ono, Yoya, additional, Binks, Sophie, additional, Mariotto, Sara, additional, Dinoto, Alessandro, additional, Bonello, Michael, additional, Hartmann, Christian J, additional, Tambasco, Nicola, additional, Nigro, Pasquale, additional, Prüss, Harald, additional, McKeon, Andrew, additional, Davis, Mark M, additional, Irani, Sarosh R, additional, Honnorat, Jérôme, additional, Gaig, Carles, additional, Finke, Carsten, additional, and Mignot, Emmanuel, additional

Published
2024
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36. Intravenous immunoglobulin therapy in COVID-19-related encephalopathy

Author

Muccioli, Lorenzo, Pensato, Umberto, Bernabè, Giorgia, Ferri, Lorenzo, Tappatà, Maria, Volpi, Lilia, Cani, Ilaria, Henry, Olivia J., Ceccaroni, Francesca, Cevoli, Sabina, Stofella, Gloria, Pasini, Elena, Fornaro, Giacomo, Tonon, Caterina, Vidale, Simone, Liguori, Rocco, Tinuper, Paolo, Michelucci, Roberto, Cortelli, Pietro, and Bisulli, Francesca

Published
2021
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38. Next-generation sequencing application to investigate skeletal muscle channelopathies in a large cohort of Italian patients

Author

Brugnoni, Raffaella, Maggi, Lorenzo, Canioni, Eleonora, Verde, Federico, Gallone, Annamaria, Ariatti, Alessandra, Filosto, Massimiliano, Petrelli, Cristina, Logullo, Francesco Ottavio, Esposito, Marcello, Ruggiero, Lucia, Tonin, Paola, Riguzzi, Pietro, Pegoraro, Elena, Torri, Francesca, Ricci, Giulia, Siciliano, Gabriele, Silani, Vincenzo, Merlini, Luciano, De Pasqua, Silvia, Liguori, Rocco, Pini, Antonella, Mariotti, Caterina, Moroni, Isabella, Imbrici, Paola, Desaphy, Jean-Francois, Mantegazza, Renato, and Bernasconi, Pia

Published
2021
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41. Sulcal Morphometry Predicts Mild Cognitive Impairment Conversion to Alzheimer's Disease.

Author

Sighinolfi, Giovanni, Mitolo, Micaela, Pizzagalli, Fabrizio, Stanzani-Maserati, Michelangelo, Remondini, Daniel, Rochat, Magali Jane, Cantoni, Elena, Venturi, Greta, Vornetti, Gianfranco, Bartiromo, Fiorina, Capellari, Sabina, Liguori, Rocco, Tonon, Caterina, Testa, Claudia, and Lodi, Raffaele

Subjects
MILD cognitive impairment, ALZHEIMER'S disease, MORPHOMETRICS, NEUROPSYCHOLOGICAL tests, SHORT-term memory, INSPECTION & review
Abstract

Background: Being able to differentiate mild cognitive impairment (MCI) patients who would eventually convert (MCIc) to Alzheimer's disease (AD) from those who would not (MCInc) is a key challenge for prognosis. Objective: This study aimed to investigate the ability of sulcal morphometry to predict MCI progression to AD, dedicating special attention to an accurate identification of sulci. Methods: Twenty-five AD patients, thirty-seven MCI and twenty-five healthy controls (HC) underwent a brain-MR protocol (1.5T scanner) including a high-resolution T1-weighted sequence. MCI patients underwent a neuropsychological assessment at baseline and were clinically re-evaluated after a mean of 2.3 years. At follow-up, 12 MCI were classified as MCInc and 25 as MCIc. Sulcal morphometry was investigated using the BrainVISA framework. Consistency of sulci across subjects was ensured by visual inspection and manual correction of the automatic labelling in each subject. Sulcal surface, depth, length, and width were retrieved from 106 sulci. Features were compared across groups and their classification accuracy in predicting MCI conversion was tested. Potential relationships between sulcal features and cognitive scores were explored using Spearman's correlation. Results: The width of sulci in the temporo-occipital region strongly differentiated between each pair of groups. Comparing MCIc and MCInc, the width of several sulci in the bilateral temporo-occipital and left frontal areas was significantly altered. Higher width of frontal sulci was associated with worse performances in short-term verbal memory and phonemic fluency. Conclusions: Sulcal morphometry emerged as a strong tool for differentiating HC, MCI, and AD, demonstrating its potential prognostic value for the MCI population. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Melanopsin retinal ganglion cell loss in Alzheimer disease

Author

La Morgia, Chiara, Ross‐Cisneros, Fred N, Koronyo, Yosef, Hannibal, Jens, Gallassi, Roberto, Cantalupo, Gaetano, Sambati, Luisa, Pan, Billy X, Tozer, Kevin R, Barboni, Piero, Provini, Federica, Avanzini, Pietro, Carbonelli, Michele, Pelosi, Annalisa, Chui, Helena, Liguori, Rocco, Baruzzi, Agostino, Koronyo‐Hamaoui, Maya, Sadun, Alfredo A, and Carelli, Valerio

Subjects
Neurosciences, Neurodegenerative, Alzheimer's Disease, Eye Disease and Disorders of Vision, Aging, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Sleep Research, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Neurological, Eye, Actigraphy, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Axons, Chronobiology Disorders, Female, Humans, Male, Middle Aged, Optic Nerve, Retinal Ganglion Cells, Rod Opsins, Tomography, Optical Coherence, Clinical Sciences, Neurology & Neurosurgery
Abstract

ObjectiveMelanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction.MethodsWe assessed retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in 21 mild-moderate AD patients, and in a subgroup of 16 we evaluated rest-activity circadian rhythm by actigraphy. We studied postmortem mRGCs by immunohistochemistry in retinas, and axons in optic nerve cross-sections of 14 neuropathologically confirmed AD patients. We coimmunostained for retinal amyloid β (Aβ) deposition and melanopsin to locate mRGCs. All AD cohorts were compared with age-matched controls.ResultsWe demonstrated an age-related optic neuropathy in AD by OCT, with a significant reduction of RNFL thickness (p = 0.038), more evident in the superior quadrant (p = 0.006). Axonal loss was confirmed in postmortem AD optic nerves. Abnormal circadian function characterized only a subgroup of AD patients. Sleep efficiency was significantly reduced in AD patients (p = 0.001). We also found a significant loss of mRGCs in postmortem AD retinal specimens (p = 0.003) across all ages and abnormal mRGC dendritic morphology and size (p = 0.003). In flat-mounted AD retinas, Aβ accumulation was remarkably evident inside and around mRGCs.InterpretationWe show variable degrees of rest-activity circadian dysfunction in AD patients. We also demonstrate age-related loss of optic nerve axons and specifically mRGC loss and pathology in postmortem AD retinal specimens, associated with Aβ deposition. These results all support the concept that mRGC degeneration is a contributor to circadian rhythm dysfunction in AD.

Published
2016

46. Correlations Between Cardiac Magnetic Resonance and Myocardial Histologic Findings in Fabry Disease

Author

Ditaranto, Raffaello, primary, Leone, Ornella, additional, Lovato, Luigi, additional, Niro, Fabio, additional, Cenacchi, Giovanna, additional, Papa, Valentina, additional, Baldovini, Chiara, additional, Ferracin, Manuela, additional, Salamon, Irene, additional, Kurdi, Hibba, additional, Parisi, Vanda, additional, Capelli, Irene, additional, Pession, Andrea, additional, Liguori, Rocco, additional, Potena, Luciano, additional, Seri, Marco, additional, Martin Suarez, Sofia, additional, Galiè, Nazzareno, additional, Moon, James C., additional, and Biagini, Elena, additional

Published
2023
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48. Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort study

Author

Zucchi, Elisabetta, primary, Musazzi, Umberto Maria, additional, Fedele, Guido, additional, Martinelli, Ilaria, additional, Gianferrari, Giulia, additional, Simonini, Cecilia, additional, Fini, Nicola, additional, Ghezzi, Andrea, additional, Caputo, Maria, additional, Sette, Elisabetta, additional, Vacchiano, Veria, additional, Zinno, Lucia, additional, Anceschi, Pietro, additional, Canali, Elena, additional, Vinceti, Marco, additional, Ferro, Salvatore, additional, Mandrioli, Jessica, additional, Ferri, Laura, additional, Gessani, Annalisa, additional, Liguori, Rocco, additional, Cortelli, Pietro, additional, Michelucci, Roberto, additional, Salvi, Fabrizio, additional, Bartolomei, Ilaria, additional, Borghi, Anna Maria, additional, Zini, Andrea, additional, Rinaldi, Rita, additional, Tugnoli, Valeria, additional, Pugliatti, Maura, additional, Codeluppi, Luca, additional, Valzania, Franco, additional, Stragliati, Filippo, additional, Nuredini, Andi, additional, Romano, Sonia, additional, D'Orsi, Alessandro, additional, Parrino, Liborio, additional, Medici, Doriana, additional, Pilurzi, Giovanna, additional, Terlizzi, Emilio, additional, Guidetti, Donata, additional, De Pasqua, Silvia, additional, Santangelo, Mario, additional, De Massis, Paola, additional, Gizzi, Matteo, additional, Casmiro, Mario, additional, Querzani, Pietro, additional, Morresi, Simonetta, additional, Vitiello, Maria, additional, Longoni, Marco, additional, Patuelli, Alberto, additional, Malagù, Susanna, additional, Bianchi, Francesca, additional, Dossi, Marco Currò, additional, and Ganino, Cristiana, additional

Published
2023
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49. Multiple intra‐axial lesions in a 57‐year‐old male with a history of B‐cell chronic lymphocytic leukemia.

Author

Asioli, Sofia, Cardisciani, Lina, Martinoni, Matteo, Tonon, Caterina, Liguori, Rocco, Zinzani, Pierluigi, Di Sciascio, Luisa, and Sabattini, Elena

Subjects
DIFFUSE large B-cell lymphomas, T-cell lymphoma, T-cell receptor genes, INAPPROPRIATE ADH syndrome, ETIOLOGY of diseases
Abstract

This article discusses the case of a 57-year-old male with a history of B-cell chronic lymphocytic leukemia who developed multiple intra-axial lesions in the brain. The patient experienced symptoms such as headache, fever, seizures, and coma. Imaging scans revealed edematous lesions with contrast enhancement. A biopsy confirmed the diagnosis of peripheral T-cell lymphoma, Not Otherwise Specified (NOS) consistent with Primary CNS T-cell lymphoma. The article highlights the importance of distinguishing this type of lymphoma from other intra-axial tumors and discusses the prognosis and potential treatment options. [Extracted from the article]

Published
2024
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