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34 results on '"Lim, Byeonghwa"'

3. Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery

Author

Hu, Xinghao, Lim, Byeonghwa, Torati, Sri Ramulu, Ding, Junjia, Novosad, Valentine, Im, Mi‐Young, Reddy, Venu, Kim, Kunwoo, Jung, Eunjoo, Shawl, Asif Iqbal, Kim, Eunjoo, and Kim, CheolGi

Subjects
Engineering, Nanotechnology, Bioengineering, Biotechnology, Humans, MCF-7 Cells, Magnetics, Microfluidics, Robotics, THP-1 Cells, biofunctionalization, cells sorting, lab-on-a-chip, microparticles manipulation, microrobots, Nanoscience & Nanotechnology
Abstract

The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte, and their simultaneous on-chip separation and trapping, still remain challenging. Here, a universal micromagnet junction for self-navigating gates of microrobotic particles to deliver the biomolecules to specific sites using a remote magnetic field is described. In the proposed concept, the nonmagnetic gap between the lithographically defined donor and acceptor micromagnets creates a crucial energy barrier to restrict particle gating. It is shown that by carefully designing the geometry of the junctions, it becomes possible to deliver multiple protein-functionalized carriers in high resolution, as well as MCF-7 and THP-1 cells from the mixture, with high fidelity and trap them in individual apartments. Integration of such junctions with magnetophoretic circuitry elements could lead to novel platforms without retrieving for the synchronous digital manipulation of particles/biomolecules in microfluidic multiplex arrays for next-generation biochips.

Published
2018

7. Magnetically Selective Versatile Transport of Microrobotic Carriers.

Author

Hu, Xinghao, Kim, Keonmok, Ali, Abbas, Kim, Hyeonseol, Kang, Yumin, Yoon, Jonghwan, Torati, Sri Ramulu, Reddy, Venu, Im, Mi‐Young, Lim, Byeonghwa, and Kim, CheolGi

Subjects
IMMOBILIZED cells, MAGNETIC fields, MAGNETIC nanoparticles
Abstract

Field‐driven transport systems offer great promise for use as biofunctionalized carriers in microrobotics, biomedicine, and cell delivery applications. Despite the construction of artificial microtubules using several micromagnets, which provide a promising transport pathway for the synchronous delivery of microrobotic carriers to the targeted location inside microvascular networks, the selective transport of different microrobotic carriers remains an unexplored challenge. This study demonstrated the selective manipulation and transport of microrobotics along a patterned micromagnet using applied magnetic fields. Owing to varied field strengths, the magnetic beads used as the microrobotic carriers with different sizes revealed varied locomotion, including all of them moving along the same direction, selective rotation, bidirectional locomotion, and all of them moving in a reversed direction. Furthermore, cells immobilized with magnetic beads and nanoparticles also revealed varied locomotion. It is expected that such steering strategies of microrobotic carriers can be used in microvascular channels for the targeted delivery of drugs or cells in an organized manner. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Microstructures: Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery (Small 25/2018)

Author

Hu, Xinghao, primary, Lim, Byeonghwa, additional, Torati, Sri Ramulu, additional, Ding, Junjia, additional, Novosad, Valentine, additional, Im, Mi-Young, additional, Reddy, Venu, additional, Kim, Kunwoo, additional, Jung, Eunjoo, additional, Shawl, Asif Iqbal, additional, Kim, Eunjoo, additional, and Kim, CheolGi, additional

Published
2018
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34. Surface-Driven Particle Dynamics: Sequential Synchronization of Colloidal Flow Attempted in a Static Fluidic Environment.

Author

Kim H, Ali A, Kang Y, Lim B, and Kim C

Abstract

The collective behavior of colloids in microsystems is characterized by precise micro-object control, broadening the applications of cargo manipulation in drug delivery, microfluidics, and nanotechnology. To further investigate this potential, we introduce a cargo-manipulating platform that utilizes micromagnetic patterns and fluid flow rather than conventional fluidic components. This platform, called the flowless micropump, comprises an encapsulating fluid system within a chip, containing both actuation particles (2.8 μm in diameter) and control targets, thereby eliminating external interactions. This platform enables two distinct modes of cargo manipulation: direct control of nonmagnetic cargo (e.g., MCF-7 and THP-1 cells) and indirect manipulation of particles (e.g., polymer particles) through secondary localized fluid flow. Direct manipulation is achieved via coordinated particle collisions, facilitated by an optimized guiding wall with a height of 25 μm. Conversely, indirect manipulation allows for high-speed control and mode change of individual targets. These manipulation events are achieved using two patterned structures: railway-track and connected half-disk (conductor) patterns. By employing a conductor pattern in conjunction with a railway-track pattern, precise and agile control of microcargo (MCF-7 and THP-1 cells and polymer bead clusters) was achieved at frequencies of 1-3 Hz and a magnetic field strength of 10 mT. This study establishes a programmable platform for designing flowless micropumps with diverse functionalities for various experimental purposes. By using colloidal flow and localized fluid flow generated by the shape of magnetic patterns and semi-three-dimensional (3D) structures, this platform holds significant promise for applications in drug screening, cell-cell interaction studies, and organoid-on-chip research.

Published
2025
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