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8 results on '"Lim, Chun You"'

1. Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis

Author

Chan, Jia Jia, Zhang, Bin, Chew, Xiao Hong, Salhi, Adil, Kwok, Zhi Hao, Lim, Chun You, Desi, Ng, Subramaniam, Nagavidya, Siemens, Angela, Kinanti, Tyas, Ong, Shane, Sanchez-Mejias, Avencia, Ly, Phuong Thao, An, Omer, Sundar, Raghav, Fan, Xiaonan, Wang, Shi, Siew, Bei En, Lee, Kuok Chung, Chong, Choon Seng, Lieske, Bettina, Cheong, Wai-Kit, Goh, Yufen, Fam, Wee Nih, Ooi, Melissa G., Koh, Bryan T. H., Iyer, Shridhar Ganpathi, Ling, Wen Huan, Chen, Jianbin, Yoong, Boon-Koon, Chanwat, Rawisak, Bonney, Glenn Kunnath, Goh, Brian K. P., Zhai, Weiwei, Fullwood, Melissa J., Wang, Wilson, Tan, Ker-Kan, Chng, Wee Joo, Dan, Yock Young, Pitt, Jason J., Roca, Xavier, Guccione, Ernesto, Vardy, Leah A., Chen, Leilei, Gao, Xin, Chow, Pierce K. H., Yang, Henry, and Tay, Yvonne

Published
2022
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3. Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis

Author

Desi, Ng, Tong, Qing Yun, Teh, Velda, Chan, Jia Jia, Zhang, Bin, Tabatabaeian, Hossein, Tan, Hui Qing, Kapeli, Katannya, Jin, Wenhao, Lim, Chun You, Kwok, Zhi Hao, Tan, Hwee Tong, Wang, Shi, Siew, Bei-En, Lee, Kuok-Chung, Chong, Choon-Seng, Tan, Ker-Kan, Yang, Henry, Kappei, Dennis, Yeo, Gene W., Chung, Maxey Ching Ming, and Tay, Yvonne

Published
2022
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4. MiR-138 is a potent regulator of the heterogenous MYC transcript population in cancers

Author

Desi, Ng, primary, Teh, Velda, additional, Tong, Qing Yun, additional, Lim, Chun You, additional, Tabatabaeian, Hossein, additional, Chew, Xiao Hong, additional, Sanchez-Mejias, Avencia, additional, Chan, Jia Jia, additional, Zhang, Bin, additional, Pitcheshwar, Priyankaa, additional, Siew, Bei-En, additional, Wang, Shi, additional, Lee, Kuok-Chung, additional, Chong, Choon-Seng, additional, Cheong, Wai-Kit, additional, Lieske, Bettina, additional, Tan, Ian Jse-Wei, additional, Tan, Ker-Kan, additional, and Tay, Yvonne, additional

Published
2021
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6. A comprehensive expression landscape of RNA-binding proteins (RBPs) across 16 human cancer types.

Author

Zhang, Bin, Babu, Kamesh R., Lim, Chun You, Kwok, Zhi Hao, Li, Jia, Zhou, Siqin, Yang, Henry, and Tay, Yvonne

Abstract

RNA-binding proteins (RBPs) are key regulators of posttranscriptional processes such as RNA maturation, localization, turnover and translation. Despite their dysregulation in various diseases including cancer, the landscape of RBP expression in human cancer has not been well elucidated. Here, we built a comprehensive expression landscape of 1504 RBPs across 16 human cancer types, which revealed that RBPs are predominantly upregulated in tumours and this phenomenon is affected by the tumour immune subtypes and microenvironment. Across different cancer types, 109 RBPs are consistently upregulated while 41 RBPs are consistently downregulated. These up-regulated and down-regulated RBPs show distinct molecular characteristics and prognostic effects, whereas their dysregulation is mediated by distinct cis/trans-regulatory mechanisms. Finally, we validated one candidate PABPC1L that might promote colon tumorigenesis by regulating mRNA splicing. In summary, we built a comprehensive expression landscape of RBPs across different cancer types and identified consistently dysregulated RBPs which could be novel targets for developing broad-spectrum anticancer agents. [ABSTRACT FROM AUTHOR]

Published
2020
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8. MiR-138 is a potent regulator of the heterogenous MYCtranscript population in cancers

Author

Desi, Ng, Teh, Velda, Tong, Qing Yun, Lim, Chun You, Tabatabaeian, Hossein, Chew, Xiao Hong, Sanchez-Mejias, Avencia, Chan, Jia Jia, Zhang, Bin, Pitcheshwar, Priyankaa, Siew, Bei-En, Wang, Shi, Lee, Kuok-Chung, Chong, Choon-Seng, Cheong, Wai-Kit, Lieske, Bettina, Tan, Ian Jse-Wei, Tan, Ker-Kan, and Tay, Yvonne

Abstract

3′UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported microRNA-oncogene target interactions may not be present in cancer cells. One of the most well-studied oncogenes is the transcription factor MYC, which is overexpressed in more than half of all cancers. MYCoverexpression is not always accompanied by underlying genetic aberrations. In this study, we demonstrate that the MYC3′UTR is shortened in colorectal cancer (CRC). Using unbiased computational and experimental approaches, we identify and validate microRNAs that target the MYCcoding region. In particular, we show that miR-138 inhibits MYC expression and suppresses tumor growth of CRC and hepatocellular carcinoma (HCC) cell lines. Critically, the intravenous administration of miR-138 significantly impedes MYC-driven tumor growth in vivo. Taken together, our results highlight the previously uncharacterized shortening of the MYC3′UTR in cancer, and identify miR-138 as a potent regulator of the heterogenous MYCtranscript population.

Published
2021
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