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15 results on '"Lim, G.K."'

7. Long-term immunogenicity and efficacy of a reduced dose of plasma-based hepatitis B vaccine in young adults

Author

Goh, K.T., Oon, C.J., Heng, B.H., and Lim, G.K.

Subjects
Hepatitis B vaccine -- Evaluation, Vaccines -- Dosage and administration
Abstract

A cohort of seronegative preclinical medical and dental students and another cohort of seronegative national service recruits who were immunized intramuscularly with a reduced dose (10 mg) of plasmabased hepatitis B vaccine (Merck, Sharp & Dohme) at the start of the study and at 1 month and 6 months thereafter were followed up for 5 years and 6 years, respectively. Among the medical and dental students, antibody to hepatitis B surface antigen (antin-HBs) ([greater than or equal to10]mlU/ml)was detected in 81% of the vaccinees at the end of the 5-year follow-up and the geometric mean titre (GMT) had dropped from 412.6 mlU/ml one year after completion of vaccination to 174.9 mlU/ml after 5 years. Antibody to hepatitis B core antigen (anti-HBc) was detected in 0.4-1.0% of the vaccinees but none was positive for hepatitis B surface antigen (HBsAg) during the follow-up period. Among the national servicemen, the anti-HBs seroconversion rate and GMT were considerably lower than those of the preclinical medical and dental students. At the end of the 6-year follow-up, 55% of the vaccinees were positive for anti-HBs ([greater than or equal to]10 mlU/ml) and the GMT had dropped from 80.7 mlU/ml one year after completion of vaccination to 30.4 mlUml after 6 years. Anti-HBc was detected in 8 (2.7%) and transient Hbs antigenaemia in 2 (0.7%) of 293 vaccinees after 4 years. However, none of the 196 vaccinees followed up at 6 years was HbsAg-positive compared with 8 (4.2%) of 191 seronegative national service recruits who were not vaccinated, giving a vaccine efficacy of 100% in the prevention of the chronic HBsAg carrier state., Introduction When hepatitis B vaccine first became commercially available, it was extremely expensive. Clinical trials on the immunogenicity of reduced doses of the vaccine were therefore conducted in several ocentres. [...]

Published
1995

9. An extra Saturday off will hamper productivity

Author

Lim, G.K.

Subjects
General interest
Abstract

MALAYSIA cannot afford to have government servants taking an extra Saturday off even if they work a few minutes more each day to compensate for the day off. We are [...]

Published
2000

13. The effects of DMAEMA polyelectrolyte and TiO2photocatalyst on the tartrazine quenching of N-doped carbon dot immobilized in PVA/microfibrillated cellulose film

Author

Ng, H.K. Melvin, Lim, G.K., and Leo, C.P.

Abstract

The quenching of carbon dots (CDs) is affected by surface functional groups and other factors. Since CDs were also immobilized into thin films as a sensor, the effects of film properties on their photoluminescence should be investigated. In this work, N-doped CDs (NCDs) were immobilized in polyvinyl alcohol (PVA) thin films for tartrazine detection. Using a microwave-assisted hydrothermal method, amorphous NCDs were successfully produced. NCDs were blended into the PVA dope solution containing microfibrillated cellulose (MFC). An excessive amount of NCDs caused the undesired interaction and mutual reabsorption between the NCDs, resulting in self-quenching. Dimethylaminoethyl acrylate (DMAEMA) was added as copolymer to reduce the swelling ratio by about 50%. The reduction of water uptake subsequently reduced the tartrazine adsorption and the quenching of NCDs. Contradictory, the addition of TiO2nanoparticles improved the tartrazine adsorption and the NCDs quenching. The thin film also exhibits photocatalytic properties for analyte removal. The linear ΔFand the unchanged absorbance spectra of PVA/DM3/NCD/TiO2thin film indicate dynamic quenching at low tartrazine concentration (< 10 µM), attaining a limit of detection of 4.66 µM. The overlapping spectrum between the analyte absorbance and NCDs film emission spectra showed possible inner filter effects or fluorescence resonance energy transfer quenching mechanism.

Published
2021
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14. Mutation 'Hot Spot' in HLA Class I-Restricted T Cell Epitope on Hepatitis B Virus Surface Antigen in Chronic Carriers and Patients with Hepatocellular Carcinoma.

Author

Lim, G.K.

Subjects
*GENETIC mutation, *HEPATITIS B virus, *LIVER cancer
Abstract

Presents an abstract of the study on 'Mutation 'Hot Spot' in HLA Class I-Restricted T Cell Epitope on Hepatitis B Virus Surface Antigen in Chronic Carriers and Patients With Hepatocellular Carcinoma,' by W.N. Chen, C.J. Oon and G.K. Lim presented at the Asian Pacific Association for the Study of the Liver Commemorative International Congress in Singapore.

Published
2001

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