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Your search keyword '"Lim, Hye-Sun"' showing total 262 results
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262 results on '"Lim, Hye-Sun"'

16. Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-κB in HaCaT cells

Author

Jeong, Soo-Jin, Lim, Hye-Sun, Seo, Chang-Seob, Kim, Jung-Hoon, Jin, Seong- Eun, Yoo, Sae-Rom, and Shin, Hyeun-Kyoo

Subjects
Medicine, Primitive -- Research, Peonies -- Health aspects, Folk medicine -- Research, Pharmacology, Experimental, Medicine, Botanic -- Research, Medicinal plants -- Health aspects, Medicine, Herbal -- Research, Biological sciences, Health, Science and technology
Abstract

ABSTRACT A traditional herbal formula Jakyakgamcho-tang (JYGCT; Paeonia lactiflora and Glycyrrhiza uralensis) has been used for treatment of backache, muscle pain, acute abdominal pain, neuralgia, bronchial asthma, and painful peripheral [...]

Published
2015
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33. Structural behaviour of prestressed concrete beams with high-strength stirrups.

Author

Lee, Jung-Yoon, Lim, Hye-Sun, and Kim, Changhyuk

Subjects
*PRESTRESSED concrete beams, *TRANSVERSE reinforcements, *HIGH strength concrete, *PRESTRESSED concrete, *TRANSVERSE strength (Structural engineering), *STIRRUPS
Abstract

Many studies related to high-strength concrete material have been conducted, but relatively few studies have considered high-strength steel reinforcement. Four current design codes – ACI 318-14, Eurocode 2, CSA A23.3-04, and JSCE-07 – limit the yield strength of transverse reinforcement to control diagonal crack width, and to ensure yielding of transverse reinforcement prior to brittle failure mode. ACI, Eurocode 2 and CSA A23.3-04 limit the yield strength of transverse reinforcement to 420, 600, and 500 MPa, respectively; while JSCE-07 limits the yield strength to 800 MPa, when the compressive strength of concrete is higher than 60 MPa. The implementation of high-strength transverse reinforcement in prestressed concrete (PSC) and reinforced concrete (RC) beams has been determined in this study. A total of 16 beams were strengthened using higher yield strength stirrups than the code limitations, and were monotonically loaded to failure. All the beams were designed to experience shear failure prior to flexural failure. Most of the test results showed yielding of the stirrups, and narrower crack width than the code limitations even though the specimens were strengthened with higher than 420 MPa stirrups. The test results imply the feasibility of using high-strength stirrups for PSC beams with regard to serviceability. [ABSTRACT FROM AUTHOR]

Published
2022
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41. A water extract of Samchulkunbi-tang attenuates airway inflammation by inhibiting inos and MMP-9 activities in an ovalbumin-induced murine asthma model

Author

Lee Mee Young, Shin In Sik, Lim Hye Sun, and Shin Hyeun Kyoo

Subjects
Samchulkunbi-tang, Asthma, Cytokines, iNOS, MMP-9, Inflammation, Other systems of medicine, RZ201-999
Abstract

Abstract Background In this study, we investigated the effect of Samchulkunbi-tang water extract (SCTE) in an established mouse model of ovalbumin (OVA)-induced allergic asthma. The effects of SCTE on the production of Th1 and Th2 cytokines, eotaxin, and total and OVA-specific immunoglobulin E, inducible nitric oxide synthase expression, and matrix metalloproteinase-9 activity were measured. Methods Mice were sensitized on days 0 and 14 with an intraperitoneal injection of 20 μg ovalbumin (OVA) emulsified in 2 mg aluminum hydroxide in 200 μL PBS buffer. On days 21, 22, and 23, mice received an airway exposure to OVA (1%, w/v, in PBS) for 1 h. SCTE was administered orally to mice at doses of 200 and 400 mg/kg per day from days 18 to 23. Results SCTE reduced the number of inflammatory cells, cytokines, and chemokines in bronchoalveolar lavage fluids and iNOS expression and MMP-9 activity in mouse lung tissue. Histological studies using hematoxylin & eosin and periodic acid-schiff staining showed that SCTE substantially inhibited OVA-induced inflammatory cell infiltration in lung tissue and goblet cell hyperplasia in the airway. SCTE also reduced IL-4 and IL-13 expression in concanavalin-A-stimulated splenocytes. These results were similar to those obtained with montelukast as a positive control. Conclusions Collectively, these results suggest that SCTE may be an effective oral treatment for allergic airway inflammation by virtue of its anti-inflammatory activity.

Published
2012
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