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29. Isolation and characterization of high-CO2 sensitive Nannochloropsis salina mutant.

Author

Lim, Jong-Min, Jung, Sokyong, Min, Sung Ran, and Jeong, Won-Joong

Subjects
*ALGAL growth, *ALGAE physiology, *HOMEOSTASIS, *CARBON cycle, *ALGAL cells, *BICARBONATE ions, *BIOMASS production, *PHOTOSYNTHETICALLY active radiation (PAR)
Abstract

Carbon acquisition and utilization are fundamental processes required for the growth and metabolism of algae, eukaryotic organisms that play a crucial role in global carbon cycling and contribute to the primary productivity of aquatic ecosystems. Algal cells rely on carbonic anhydrases (CAs) to facilitate the acquisition of inorganic carbon (Ci) and its conversion into bicarbonate ions (HCO3−) for various cellular processes. Understanding the molecular mechanisms that underlie Ci regulation is vital for unraveling the adaptation of algae to different CO2 conditions and enhancing the production of algal biomass. In this study, we characterized mutant algae showing robust growth under low CO2 conditions but impaired growth in high CO2 environments. Our investigation revealed a significant reduction in intracellular Ci content in the mutant, suggesting a disruption in Ci regulatory mechanisms. Through molecular analysis, we identified the pKIWI502 gene homolog as one of the mutated loci, which played a critical role in Ci regulation and was responsible for the mutant phenotype. Introduction of the intact pKIWI502 gene into mutant algae resulted in the recovery of high-CO2 sensitivity and the restoration of intracellular Ci content. These findings highlight the possible role of the pKIWI502 homolog in pH homeostasis and Ci regulation, and provide insights into the molecular basis of the mutant phenotype. Furthermore, our study improves the understanding of algal physiology and offers potential strategies for enhancing algal biomass production and carbon capture technologies. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Effects of β-glucan from Aureobasidium pullulans in a Streptozotocininduced Rat Diabetes Model

Author

Jung Go-Woon, Choi Jae-Suk, Kwang Ku Sae, Sohn Jae-Hak, Lim Jong-Min, and Wan Kim Joo

Subjects
chemistry.chemical_classification, Aureobasidium pullulans, Nutrition and Dietetics, Diabetes model, biology, Chemistry, Public Health, Environmental and Occupational Health, biology.organism_classification, Food Science, Glucan, Microbiology
Abstract

Background: The alleviating effects of diabetic nephropathy and hepatopathy of β-glucan were evaluated in this study. Objective: The anti-diabetic effects of β -glucan from Aureobasidium pullulans were assessed in a streptozotocin (STZ)-induced rat diabetes model at 62.5 and 125 mg/kg doses. In addition, the possibility of changes in the effects of β-glucan according to the severity of diabetes was also assessed at one dosage (62.5 mg/kg): severe, >360 mg/dL; slight, 130-200 mg/dL. Methods: Test articles were administered orally to STZ-induced diabetic rats from 21 days after STZ dosing for 4 weeks. Each of five or six female rats per group was selected using blood glucose levels at 21 days after STZ dosing. Changes in body weight were recorded during the study, along with blood glucose, blood urea nitrogen, creatinine, and serum aspartate aminotransferase and alanine aminotransferase levels. On the day of sacrifice, livers and kidneys were weighed and observed microscopically for changes in the percentage of degenerative regions and numbers of degenerative tubules in the kidney. Results: β-glucan showed no hypoglycemic effects in the STZ-induced diabetic rat model. However, it had favorable effects on decreasing diabetic complications related to diabetic nephropathy and hepatopathy. Conclusion: Based on the results of this study, it was concluded that β-glucan showed favorable effects in decreasing diabetic complications in STZ-induced rat diabetes model.

Published
2020

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