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Your search keyword '"Lima, Barbara A. S."' showing total 7 results
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7 results on '"Lima, Barbara A. S."'

1. Multiplexed Microsphere-Based Flow Cytometric Assay to Assess Strain Transcending Antibodies to Plasmodium vivax Duffy Binding Protein II Reveals an Efficient Tool to Identify Binding-Inhibitory Antibody Responders

Author

Alves, Jéssica R. S., primary, de Araújo, Fernanda F., additional, Pires, Camilla V., additional, Teixeira-Carvalho, Andréa, additional, Lima, Barbara A. S., additional, Torres, Letícia M., additional, Ntumngia, Francis B., additional, Adams, John H., additional, Kano, Flora S., additional, and Carvalho, Luzia H., additional

Published
2021
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2. Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA

Author

Mitran, Catherine J., primary, Mena, Angie, additional, Gnidehou, Sedami, additional, Banman, Shanna, additional, Arango, Eliana, additional, Lima, Barbara A. S., additional, Lugo, Hazel, additional, Ganesan, Aravindhan, additional, Salanti, Ali, additional, Mbonye, Anthony K., additional, Ntumngia, Francis, additional, Barakat, Khaled, additional, Adams, John H., additional, Kano, Flora S., additional, Carvalho, Luzia H., additional, Maestre, Amanda E., additional, Good, Michael F., additional, and Yanow, Stephanie K., additional

Published
2019
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3. Blood-stage Plasmodium vivax antibody dynamics in a low transmission setting: A nine year follow-up study in the Amazon region

Author

Pires, Camilla V., primary, Alves, Jessica R. S., additional, Lima, Barbara A. S., additional, Paula, Ruth B., additional, Costa, Helena L., additional, Torres, Leticia M., additional, Sousa, Taís N., additional, Soares, Irene S., additional, Sanchez, Bruno A. M., additional, Fontes, Cor J. F., additional, Ntumngia, Francis B., additional, Adams, John H., additional, Kano, Flora S., additional, and Carvalho, Luzia H., additional

Published
2018
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4. Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA

Author

Gnidehou, Sédami, primary, J. Mitran, Catherine, additional, Arango, Eliana, additional, Banman, Shanna, additional, Mena, Angie, additional, Medawar, Evelyn, additional, Lima, Barbara A S, additional, Doritchamou, Justin, additional, Rajwani, Jahanara, additional, Jin, Albert, additional, Gavina, Kenneth, additional, Ntumngia, Francis, additional, Duffy, Patrick, additional, Narum, David, additional, Ndam, Nicaise Tuikue, additional, Nielsen, Morten A, additional, Salanti, Ali, additional, Kano, Flora S, additional, Carvalho, Luzia H, additional, Adams, John H, additional, Maestre, Amanda, additional, Good, Michael F, additional, and Yanow, Stephanie K, additional

Published
2018
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5. The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

Author

Kano, Flora S., primary, Souza-Silva, Flávia A., additional, Torres, Leticia M., additional, Lima, Barbara A. S., additional, Sousa, Taís N., additional, Alves, Jéssica R. S., additional, Rocha, Roberto S., additional, Fontes, Cor J. F., additional, Sanchez, Bruno A. M., additional, Adams, John H., additional, Brito, Cristiana F. A., additional, Pires, Douglas E. V., additional, Ascher, David B., additional, Sell, Ana Maria, additional, and Carvalho, Luzia H., additional

Published
2016
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6. Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.

Author

Gnidehou, Sédami, Mitran, Catherine J, Arango, Eliana, Banman, Shanna, Mena, Angie, Medawar, Evelyn, Lima, Barbara A S, Doritchamou, Justin, Rajwani, Jahanara, Jin, Albert, Gavina, Kenneth, Ntumngia, Francis, Duffy, Patrick, Narum, David, Ndam, Nicaise Tuikue, Nielsen, Morten A, Salanti, Ali, Kano, Flora S, Carvalho, Luzia H, and Adams, John H

Subjects
PLASMODIUM vivax, IMMUNE recognition, CARRIER proteins, PLASMODIUM falciparum, CELL surface antigens, MALARIA in pregnancy
Abstract

Background: In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. We observed previously that men and children in Colombia also had antibodies to VAR2CSA, but the origin of these antibodies was unknown. Here, we tested whether infection with Plasmodium vivax is an alternative mechanism of acquisition of VAR2CSA antibodies.Methods: We analyzed sera from nonpregnant Colombians and Brazilians exposed to P. vivax and monoclonal antibodies raised against P. vivax Duffy binding protein (PvDBP). Cross-reactivity to VAR2CSA was characterized by enzyme-linked immunosorbent assay, immunofluorescence assay, and flow cytometry, and antibodies were tested for inhibition of parasite binding to CSA.Results: Over 50% of individuals had antibodies that recognized VAR2CSA. Affinity-purified PvDBP human antibodies and a PvDBP monoclonal antibody recognized VAR2CSA, showing that PvDBP can give rise to cross-reactive antibodies. Importantly, the monoclonal antibody inhibited parasite binding to CSA, which is the primary in vitro correlate of protection from placental malaria.Conclusions: These data suggest that PvDBP induces antibodies that functionally recognize VAR2CSA, revealing a novel mechanism of cross-species immune recognition to falciparum malaria. [ABSTRACT FROM AUTHOR]

Published
2019
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7. Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivaxPvDBP and Plasmodium falciparumVAR2CSA

Author

Mitran, Catherine J., Mena, Angie, Gnidehou, Sedami, Banman, Shanna, Arango, Eliana, Lima, Barbara A. S., Lugo, Hazel, Ganesan, Aravindhan, Salanti, Ali, Mbonye, Anthony K., Ntumngia, Francis, Barakat, Khaled, Adams, John H., Kano, Flora S., Carvalho, Luzia H., Maestre, Amanda E., Good, Michael F., and Yanow, Stephanie K.

Abstract

In this work, we describe a molecular mechanism of heterologous immunity between two distant species of Plasmodium. Our results suggest a mechanism that subverts the classic parasite strategy of presenting highly polymorphic epitopes in surface antigens to evade immunity to that parasite. This alternative immune pathway can be exploited to protect pregnant women from falciparum placental malaria by designing vaccines to cryptic epitopes that elicit broadly inhibitory antibodies against variant parasite strains.

Published
2019
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