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1,158 results on '"Lin, Ching-Heng"'

8. SEAGLE: A Scalable Exact Algorithm for Large-Scale Set-Based GxE Tests in Biobank Data

Author

Chi, Jocelyn T., Ipsen, Ilse C. F., Hsiao, Tzu-Hung, Lin, Ching-Heng, Wang, Li-San, Lee, Wan-Ping, Lu, Tzu-Pin, and Tzeng, Jung-Ying

Subjects
Statistics - Computation, Statistics - Methodology
Abstract

The explosion of biobank data offers immediate opportunities for gene-environment (GxE) interaction studies of complex diseases because of the large sample sizes and the rich collection in genetic and non-genetic information. However, the extremely large sample size also introduces new computational challenges in GxE assessment, especially for set-based GxE variance component (VC) tests, which are a widely used strategy to boost overall GxE signals and to evaluate the joint GxE effect of multiple variants from a biologically meaningful unit (e.g., gene). In this work, we focus on continuous traits and present SEAGLE, a Scalable Exact AlGorithm for Large-scale set-based GxE tests, to permit GxE VC tests for biobank-scale data. SEAGLE employs modern matrix computations to achieve the same "exact" results as the original GxE VC tests without imposing additional assumptions or relying on approximations. SEAGLE can easily accommodate sample sizes in the order of $10^5$, is implementable on standard laptops, and does not require specialized computing equipment. We demonstrate SEAGLE's performance through extensive simulations. We illustrate its utility by conducting genome-wide gene-based GxE analysis on the Taiwan Biobank data to explore the interaction of gene and physical activity status on body mass index.

Published
2021

33. Association between HNF4A rs1800961 polymorphisms and gallstones in a Taiwanese population.

Author

Lin, Ying‐Cheng, Chen, I‐Chieh, Chen, Yen‐Ju, Lin, Ching‐Tsai, Chang, Jui‐Chun, Wang, Tsai‐Jung, Chen, Yi‐Ming, and Lin, Ching‐Heng

Subjects
TAIWANESE people, GALLSTONES, HEPATOCYTE nuclear factors, GENOME-wide association studies, SMOKING statistics, ASIANS
Abstract

Background and Aim: A large genetic effect of a novel gallstone‐associated genetic variant, the hepatocyte nuclear factor 4α (HNF4A) rs1800961 polymorphism, has been identified through recent genome‐wide association studies. However, this effect has not been validated in Asian populations. We investigated the association between the rs1800961 variant and gallstones among a Taiwanese population. Methods: A total of 20 405 participants aged between 30 and 70 years voluntarily enrolled in the Taiwan Biobank. Self‐report questionnaires, physical examinations, biochemical tests, and genotyping were used for analysis. The association of the HNF4A rs1800961 variant and other metabolic risks with gallstone disease was analyzed using multiple logistic regression models. Results: The minor T allele of HNF4A rs1800961 was associated with an increased risk of gallstone, and the association remained significant even after adjustment for other risk factors including age, body mass index (BMI), diabetes, hyperlipidemia, hypertension, and cigarette smoking (adjusted odds ratio [OR] = 1.90, 95% confidence interval [CI] = 1.31 to 2.75) in male participants. When further stratified by BMI and age, the lithogenic effect was the most significant in male participants with obesity (adjusted OR = 3.55, 95% CI = 1.92 to 6.56) and who were younger (adjusted OR = 2.45, 95% CI = 1.49 to 4.04). Conclusion: The novel gallstone‐associated HNF4A rs1800961 variant was associated with the risk of gallstone in the Taiwanese men. Screening for the rs1800961 polymorphism may be particularly useful in assessing the risk of gallstone formation in younger or obese men. [ABSTRACT FROM AUTHOR]

Published
2024
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34. The impact of sodium‐glucose co‐transporter‐2 inhibitors on dementia and cardiovascular events in diabetic patients with atrial fibrillation.

Author

Chen, Yun‐Yu, Chang, Hao‐Chih, Lin, Yenn‐Jiang, Chien, Kuo‐Liong, Hsieh, Yu‐Cheng, Chung, Fa‐Po, Lin, Ching‐Heng, Lip, Gregory Y. H., and Chen, Shih‐Ann

Subjects
ATRIAL fibrillation, PEOPLE with diabetes, DEMENTIA, DEMENTIA patients, VASCULAR dementia, DABIGATRAN
Abstract

Aims: The effectiveness of sodium‐glucose co‐transporter‐2 inhibitors (SGLT2i) on incident dementia in patients with diabetes and atrial fibrillation (AF) remains unknown. This study aimed to investigate the association between SGLT2i and the risk of incident dementia in diabetic patients with AF, and to explore the interactions with oral anticoagulants or dipeptidyl peptidase‐4 inhibitors (DPP4i). Materials and Methods: We conducted a cohort study using Taiwan's National Health Insurance Research Database. Patients with diabetes and AFwithout a prior history of established cardiovascular diseases, were identified. Using propensity score matching, 810 patients receiving SGLT2i were matched with 1620 patients not receiving SGLT2i. The primary outcome was incident dementia, and secondary outcomes included composite cardiovascular events and mortality. Results: After up to 5 years of follow‐up, SGLT2i use was associated with a significantly lower risk of incident dementia (hazard: 0.71, 95% confidence interval: 0.51–0.98), particularly vascular dementia (HR: 0.44, 95% CI: 0.24–0.82). SGLT2i was related to reduced risks of AF‐related hospitalisation (HR: 0.72, 95% CI: 0.56–0.93), stroke (HR: 0.75, 95% CI: 0.60–0.94), and all‐cause death (HR: 0.33, 95% CI: 0.24–0.44). The protective effects were consistent irrespective of the concurrent use of non‐vitamin K antagonist oral anticoagulants (NOACs) or DPP4i. Conclusions: In diabetic patients with AF, SGLT2i was associated with reduced risks of incident dementia, AF‐related hospitalisation, stroke, and all‐cause death. The protective effects were independent of either concurrent use of NOACs or DPP4i. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Machine learning-based prediction of acute mortality in emergency department patients using twelve-lead electrocardiogram

Author

Chang, Po-Cheng, primary, Liu, Zhi-Yong, additional, Huang, Yu-Chang, additional, Hsu, Yu-Chun, additional, Chen, Jung-Sheng, additional, Lin, Ching-Heng, additional, Tsai, Richard, additional, Chou, Chung-Chuan, additional, Wen, Ming-Shien, additional, Wo, Hung-Ta, additional, Lee, Wen-Chen, additional, Liu, Hao-Tien, additional, Wang, Chun-Chieh, additional, and Kuo, Chang-Fu, additional

Published
2023
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