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2. Reticulocyte Binding Protein Homologue 5 is a target of balancing selection in the Plasmodium falciparum population of Papua New Guinea

Author

Naung, Myo T., primary, Martin, Elijah, additional, Wong, Wilson, additional, Razook, Zahra, additional, Utama, Digjaya, additional, Guy, Andrew J., additional, Harrison, Shannon Takala, additional, Cowman, Alan F., additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Laman, Moses, additional, Mueller, Ivo, additional, and Barry, Alyssa E., additional

Published
2023
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3. Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial

Author

Hockham, Carinna, Kotwal, Sradha, Wilcox, Arlen, Bassi, Abhinav, McGree, James, Pollock, Carol, Burrell, Louise M., Bathla, Nikita, Kunigari, Mallikarjuna, Rathore, Vinay, John, Michael, Lin, Enmoore, Jenkins, Christine, Ritchie, Angus, McLachlan, Andrew, Snelling, Thomas, Jones, Mark, Jha, Vivekanand, and Jardine, Meg

Published
2021
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4. Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis

Author

Paramsothy, Sudarshan, Nielsen, Shaun, Kamm, Michael A., Deshpande, Nandan P., Faith, Jeremiah J., Clemente, Jose C., Paramsothy, Ramesh, Walsh, Alissa J., van den Bogaerde, Johan, Samuel, Douglas, Leong, Rupert W.L., Connor, Susan, Ng, Watson, Lin, Enmoore, Borody, Thomas J., Wilkins, Marc R., Colombel, Jean-Frederic, Mitchell, Hazel M., and Kaakoush, Nadeem O.

Published
2019
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5. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Band, Gavin, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Clarke, Geraldine, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, deVries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hubbart, Christina, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jeffreys, Anna, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Le, Si, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Ly, Alioune, Macharia, Alexander, MacInnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Kevin, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, McCreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Peshu, Norbert, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Rowlands, Kate, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, SanJoaquin, Miguel, Sepúlveda, Nuno, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Uyoga, Sophie, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, Ndila, Carolyne M, Macharia, Alexander W, Nyutu, Gideon, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Clark, Taane G, Kariuki, Silvia, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, and Williams, Thomas N

Published
2018
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9. Additional file 4 of Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial

Author

Hockham, Carinna, Kotwal, Sradha, Wilcox, Arlen, Bassi, Abhinav, McGree, James, Pollock, Carol, Burrell, Louise M., Bathla, Nikita, Kunigari, Mallikarjuna, Rathore, Vinay, John, Michael, Lin, Enmoore, Jenkins, Christine, Ritchie, Angus, McLachlan, Andrew, Snelling, Thomas, Jones, Mark, Jha, Vivekanand, and Jardine, Meg

Abstract

Additional file 4. CLARITY Trial Results Template.

Published
2021
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10. Additional file 3 of Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial

Author

Hockham, Carinna, Kotwal, Sradha, Wilcox, Arlen, Bassi, Abhinav, McGree, James, Pollock, Carol, Burrell, Louise M., Bathla, Nikita, Kunigari, Mallikarjuna, Rathore, Vinay, John, Michael, Lin, Enmoore, Jenkins, Christine, Ritchie, Angus, McLachlan, Andrew, Snelling, Thomas, Jones, Mark, Jha, Vivekanand, and Jardine, Meg

Abstract

Additional file 3. CLARITY SPIRIT Fillable Checklist.

Published
2021
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11. Additional file 1 of Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial

Author

Hockham, Carinna, Kotwal, Sradha, Wilcox, Arlen, Bassi, Abhinav, McGree, James, Pollock, Carol, Burrell, Louise M., Bathla, Nikita, Kunigari, Mallikarjuna, Rathore, Vinay, John, Michael, Lin, Enmoore, Jenkins, Christine, Ritchie, Angus, McLachlan, Andrew, Snelling, Thomas, Jones, Mark, Jha, Vivekanand, and Jardine, Meg

Abstract

Additional file 1. CLARITY Trial Team.

Published
2021
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12. Additional file 5 of Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial

Author

Hockham, Carinna, Kotwal, Sradha, Wilcox, Arlen, Bassi, Abhinav, McGree, James, Pollock, Carol, Burrell, Louise M., Bathla, Nikita, Kunigari, Mallikarjuna, Rathore, Vinay, John, Michael, Lin, Enmoore, Jenkins, Christine, Ritchie, Angus, McLachlan, Andrew, Snelling, Thomas, Jones, Mark, Jha, Vivekanand, and Jardine, Meg

Abstract

Additional file 5. CLARITY WHO Trial Registration Data.

Published
2021
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13. Additional file 2 of Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trial

Author

Hockham, Carinna, Kotwal, Sradha, Wilcox, Arlen, Bassi, Abhinav, McGree, James, Pollock, Carol, Burrell, Louise M., Bathla, Nikita, Kunigari, Mallikarjuna, Rathore, Vinay, John, Michael, Lin, Enmoore, Jenkins, Christine, Ritchie, Angus, McLachlan, Andrew, Snelling, Thomas, Jones, Mark, Jha, Vivekanand, and Jardine, Meg

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDSOCIETY, ComputingMilieux_LEGALASPECTSOFCOMPUTING, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Additional file 2. CLARITY Participant Information and Informed Consent Document (in English).

Published
2021
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15. Metagenomic Hi-C of a Healthy Human Fecal Microbiome Transplant Donor

Author

DeMaere, Matthew Z., primary, Liu, Michael Y. Z., additional, Lin, Enmoore, additional, Djordjevic, Steven P., additional, Charles, Ian G., additional, Worden, Paul, additional, Burke, Catherine M., additional, Monahan, Leigh G., additional, Gardiner, Melissa, additional, Borody, Thomas J., additional, and Darling, Aaron E., additional

Published
2020
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16. Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants

Author

Tessema, Sofonias K., primary, Nakajima, Rie, additional, Jasinskas, Algis, additional, Monk, Stephanie L., additional, Lekieffre, Lea, additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Proietti, Carla, additional, Siba, Peter, additional, Felgner, Philip L., additional, Doolan, Denise L., additional, Mueller, Ivo, additional, and Barry, Alyssa E., additional

Published
2019
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19. A global network for investigating the genomic epidemiology of malaria

Author

Achidi, Eric Akum, Agbenyega, Tsiri, Allen, Stephen, Amodu, Olukemi, Bojang, Kalifa, Conway, David, Corran, Patrick, Deloukas, Panos, Djimde, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Drakeley, Chris, Duffy, Patrick, Dunstan, Sarah, Evans, Jennifer, Farrar, Jeremy, Fernando, Deepika, Hien, Tran Tinh, Horstmann, Rolf, Ibrahim, Muntaser, Karunaweera, Nadira, Kokwaro, Gilbert, Koram, Kojo, Kwiatkowski, Dominic, Lemnge, Martha, Makani, Julie, Marsh, Kevin, Michon, Pascal, Modiano, David, Molyneux, Malcolm E., Mueller, Ivo, Mutabingwa, Theonest, Peshu, Norbert, Plowe, Chris, Puijalon, Odile, Ragoussis, Jiannis, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Rogers, Jane, Sakuntabhai, Anavaj, Singhasivanon, Pratap, Sirima, Sodiomon, Sirugo, Giorgio, Tall, Adama, Taylor, Terrie, Thera, Mahamadou, Troye-Blomberg, Marita, Williams, Tom, Wilson, Michael, Amenga-Etego, Lucas, Apinjoh, Tobias O., Bougouma, Edith, Dewasurendra, Rajika, Diakite, Mahamadou, Enimil, Anthony, Hussein, Ayman, Ishengoma, Deus, Jallow, Muminatou, Lin, Enmoore, Ly, Alioune, Mangano, Valentina D., Manjurano, Alphaxard, Manning, Laurens, Ndila, Carolyne M., Nyirongo, Vysaul, Oluoch, Tom, Quyen, Nguyen T. N., Suriyaphol, Prapat, Toure, Ousman, Kwiatkowski, Dominic, Alcock, Daniel, Auburn, Sarah, Barnwell, David, Bull, Susan, Campino, Susana, deVries, Jantina, Elzein, Abier, Evans, Julie, Fitzpatrick, Kathryn, Ghansah, Anita, Green, Angie, Hart, Lee, Hilton, Eliza, Hubbart, Christina, Hughes, Catherine, Jeffreys, Anna E., Kivinen, Katja, MacInnis, Bronwyn, Manske, Magnus, Maslen, Gareth, McCreight, Marilyn, Mendy, Alieu, Moyes, Catherine, Nyika, Aceme, Potter, Claire, Risley, Paul, Rowlands, Kate, SanJoaquin, Miguel, Small, Kerrin, Somaskantharajah, Elilan, Stevens, Marryat, Teo, YikYing, Watson, Renee, Carucci, Dan, Cook, Katharine, Doyle, Alan, Duombo, Ogobara, Gottlieb, Michael, Kwiatkowski, Dominic, Rockett, Kirk A., Vanderwal, Aaron, Clark, Taane, Parker, Michael, and Wrigley, Rebecca

Published
2008
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20. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Ndila, Carolyne M, Uyoga, Sophie, Macharia, Alexander W, Nyutu, Gideon, Peshu, Norbert, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Sepúlveda, Nuno, Clark, Taane G, Band, Gavin, Clarke, Geraldine, Rowlands, Kate, Hubbart, Christina, Jeffreys, Anna, Kariuki, Silvia, Marsh, Kevin, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, Williams, Thomas N, Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, Devries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Si, Le, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Alioune, Ly, Macharia, Alexander, Macinnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, Mccreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, Sanjoaquin, Miguel, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford, London School of Hygiene and Tropical Medicine (LSHTM), The Wellcome Trust Sanger Institute [Cambridge], St Mary's Hospital, Imperial College, TNW and MM are funded through awards from the Wellcome Trust (grants 091758 and 202800 [to TNW] and grant 088634 [to MM]) and DPK and TGC receive support from the Medical Research Council (grant G19/9 [to DPK] and grants MR/K000551/1, MR/M01360X/1, MR/N010469/1, and MC_PC_15103 [to TGC]). The research leading to these results received funding from the European Community's Seventh Framework Programme (FP7/2007-2013, under grant agreement 242095) and from the Medical Research Council (grant G0600718). MalariaGEN is supported by the Wellcome Trust (WT077383/Z/05/Z) and by the Foundation for the National Institutes of Health (grant 566) as part of the Bill & Melinda Gates' Grand Challenges in Global Health Initiative. The Resource Centre for Genomic Epidemiology of Malaria is supported by the Wellcome Trust (grant 090770/Z/09/Z). Support was also provided by the Medical Research Council (grant G0600718). The Wellcome Trust also provides core awards to the Wellcome Trust Centre for Human Genetics (grant 090532/Z/09/Z) and to the Wellcome Trust Sanger Institute (grant 098051). This work forms part of a larger collaboration with the MalariaGEN Consortium, whose members are listed at http://www.malariagen.net/projects/host/consortium-members. This paper is published with permission from the Director of the Kenya Medical Research Institute (KEMRI)., MalariaGEN Consortium (Anavaj Sakuntabhai), and European Project: 242095,EC:FP7:HEALTH,FP7-HEALTH-2009-single-stage,EVIMALAR(2009)

Subjects
Case-Control Studies, Child, Child, Preschool, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Kenya, Malaria, Male, Polymorphism, Genetic, Hematology, macromolecular substances, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Article, Genetic, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, parasitic diseases, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Polymorphism, Preschool
Abstract

Summary Background Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress. Methods We did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward of Kilifi County Hospital. We included as controls infants born in the local community between Aug 1, 2006, and Sept 30, 2010, who were part of a genetics study. We tested for associations between a range of candidate malaria-protective genes and risk for severe malaria and its specific phenotypes. We used a permutation approach to account for multiple comparisons between polymorphisms and severe malaria. We judged p values less than 0·005 significant for the primary analysis of the association between candidate genes and severe malaria. Findings Between June 11, 1995, and June 12, 2008, 2244 children with severe malaria were recruited to the study, and 3949 infants were included as controls. Overall, 263 (12%) of 2244 children with severe malaria died in hospital, including 196 (16%) of 1233 with cerebral malaria. We investigated 121 polymorphisms in 70 candidate severe malaria-associated genes. We found significant associations between risk for severe malaria overall and polymorphisms in 15 genes or locations, of which most were related to red blood cells: ABO, ATP2B4, ARL14, CD40LG, FREM3, INPP4B, G6PD, HBA (both HBA1 and HBA2), HBB, IL10, LPHN2 (also known as ADGRL2), LOC727982, RPS6KL1, CAND1, and GNAS. Combined, these genetic associations accounted for 5·2% of the variance in risk for developing severe malaria among individuals in the general population. We confirmed established associations between severe malaria and sickle-cell trait (odds ratio [OR] 0·15, 95% CI 0·11–0·20; p=2·61 × 10−58), blood group O (0·74, 0·66–0·82; p=6·26 × 10−8), and –α3·7-thalassaemia (0·83, 0·76–0·90; p=2·06 × 10−6). We also found strong associations between overall risk of severe malaria and polymorphisms in both ATP2B4 (OR 0·76, 95% CI 0·63–0·92; p=0·001) and FREM3 (0·64, 0·53–0·79; p=3·18 × 10−14). The association with FREM3 could be accounted for by linkage disequilibrium with a complex structural mutation within the glycophorin gene region (comprising GYPA, GYPB, and GYPE) that encodes for the rare Dantu blood group antigen. Heterozygosity for Dantu was associated with risk for severe malaria (OR 0·57, 95% CI 0·49–0·68; p=3·22 × 10−11), as was homozygosity (0·26, 0·11–0·62; p=0·002). Interpretation Both ATP2B4 and the Dantu blood group antigen are associated with the structure and function of red blood cells. ATP2B4 codes for plasma membrane calcium-transporting ATPase 4 (the major calcium pump on red blood cells) and the glycophorins are ligands for parasites to invade red blood cells. Future work should aim at uncovering the mechanisms by which these polymorphisms can result in severe malaria protection and investigate the implications of these associations for wider health. Funding Wellcome Trust, UK Medical Research Council, European Union, and Foundation for the National Institutes of Health as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative.

Published
2018

22. Protective Immunity Against Severe Malaria is Associated with a Repertoire of Antibodies to Conserved PfEMP1 Variants

Author

Tessema, Sofonias K., primary, Nakajima, Rie, additional, Jasinskas, Algis, additional, Monk, Stephanie L., additional, Lekieffre, Lea, additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Proietti, Carla, additional, Siba, Peter, additional, Felgner, Philip L., additional, Doolan, Denise L., additional, Mueller, Ivo, additional, and Barry, Alyssa, additional

Published
2019
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23. Protective immunity against severe malaria is associated with antibodies to a conserved repertoire of PfEMP1 variants

Author

Tessema, Sofonias K., primary, Nakajima, Rie, additional, Jasinskas, Algis, additional, Monk, Stephanie L., additional, Lekieffre, Lea, additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Proietti, Carla, additional, Siba, Peter, additional, Felgner, Philip L., additional, Doolan, Denise L., additional, Mueller, Ivo, additional, and Barry, Alyssa E., additional

Published
2018
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24. Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping

Author

Kiniboro Benson, Lin Enmoore, Valsangiacomo Francesca, Schoepflin Sonja, Mueller Ivo, and Felger Ingrid

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The diversity of genotyping markers of Plasmodium falciparum depends on transmission intensity. It has been reported that the diversity of the merozoite surface protein 2 (msp2) is greater in areas of high compared to low endemicity, however, results for msp1 were inconsistent. These previous reports relied on low resolution genotyping techniques. Methods In the present study, a high-resolution capillary electrophoresis-based technique was applied to genotype samples from areas of different endemicity in Papua New Guinea and Tanzania. For both endemic settings, the diversity of msp1 and msp2 was investigated; the mean multiplicity of infection (MOI) and the FST values were determined to investigate whether more accurate sizing generates different results. Results and Conclusion The results of the present study confirmed previous reports of a higher mean MOI for both marker genes and increased genetic diversity in areas of higher endemicity as estimated by the total number of distinct alleles for msp2. For msp1 a minor increase in diversity was observed. Measures of between population variance in allele frequencies (FST) indicated little genetic differentiation for both marker genes between the two populations from different endemic settings. MOI adjusted for the probability of multiple infections sharing the same allele was estimated by using the msp2 allele frequency distribution and the distribution of observed numbers of concurrent infections. For the high-resolution typing technique applied in this study, this adjustment made little difference to the estimated mean MOI compared to the observed mean MOI.

Published
2009
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25. Safety and outcomes of 177Lu‐DOTATATE for neuroendocrine tumours: experience in New South Wales, Australia.

Author

Lin, Enmoore, Chen, Tina, Little, Alana, Holliday, Laura, Roach, Paul, Butler, Patrick, Hosking, Erika, Bailey, Elizabeth, Elison, Barry, and Currow, David

Subjects
*THERAPEUTIC use of amino acids, *PEPTIDES, *AUDITING, *CHEMICAL elements, *MEDICAL quality control, *NEUROENDOCRINE tumors, *ORGANOMETALLIC compounds, *REGRESSION analysis, *SURVIVAL analysis (Biometry), *TREATMENT effectiveness, *DESCRIPTIVE statistics, *KAPLAN-Meier estimator, *THERAPEUTICS
Abstract

Background: Peptide receptor radionuclide therapy with 177Lu‐DOTATATE is a promising treatment for inoperable or metastatic neuroendocrine tumours (NET). In 2015, the NSW Ministry of Health provided funding for 177Lu‐DOTATATE treatment of NET under an evaluation framework. Aims: To examine the safety and outcomes of NET patients treated with 177Lu‐DOTATATE under the evaluation framework and assess the statewide implementation of the NSW Lutate therapy referral and protocol for neuroendocrine cancer patients. Methods: A quality of care clinical audit was conducted on all NET patients treated with 177Lu‐DOTATATE from October 2010 to October 2015 at St George Hospital, and from August 2013 to March 2017 at Royal North Shore Hospital. Percentage of patients who met protocol selection criteria was calculated. Survival was estimated using the Kaplan–Meier method. Adjusted regression analyses assessed associations between key clinical factors and outcomes. Results: A total of 279 patients was treated. Statewide protocol implementation led to an increase from 60.5 to 83.8% in patients meeting selection criteria. Estimated median overall survival was significantly longer for patients who met selection criteria compared with those who did not (50.7 vs 34.2 months) (P = 0.018). This was driven by the significantly worse overall survival in patients who failed exclusion criteria (P < 0.001). 177Lu‐DOTATATE was well tolerated with haematological, renal and hepatic treatment‐related serious adverse events experienced by 9.7, 0.4 and 0.4% of patients respectively. Conclusions: 177Lu‐DOTATATE is a promising treatment for advanced NET. Superior survival in patients who met selection criteria emphasise the importance of protocol adherence. [ABSTRACT FROM AUTHOR]

Published
2019
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27. 130 - In Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis, Fusobacterium is Associated with Lack of Remission, while Metabolic Shifts to Starch Degradation and Short Chain Fatty Acid Production are Associated with Remission – Results from the Randomized Controlled Focus Study

Author

Paramsothy, Sudarshan, primary, Kamm, Michael A., additional, Nielsen, Shaun, additional, Deshpande, Nandan, additional, Faith, Jeremiah, additional, Clemente, José C., additional, Paramsothy, Ramesh, additional, Walsh, Alissa, additional, van den Bogaerde, Johan, additional, Samuel, Douglas, additional, Leong, Rupert W., additional, Connor, Susan J., additional, Ng, Wa Sang Watson, additional, Lin, Enmoore, additional, Wilkins, Marc, additional, Colombel, Jean Frederic, additional, Borody, Thomas J., additional, Mitchell, Hazel M., additional, and Kaakoush, Nadeem O., additional

Published
2018
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28. Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study

Author

Rosanas-Urgell, Anna, Lin, Enmoore, Manning, Laurens, Rarau, Patricia, Laman, Moses, Senn, Nicolas, Grimberg, Brian T., Tavul, Livingstone, Stanisic, Danielle I., Robinson, Leanne J., Aponte, John J., Dabod, Elijah, Reeder, John C., Siba, Peter, Zimmerman, Peter A., Davis, Timothy M.E., King, Christopher L., Michon, Pascal, and Mueller, Ivo

Subjects
Malaria -- Physiological aspects -- Risk factors, Plasmodium -- Physiological aspects -- Health aspects, Hemolytic anemia -- Physiological aspects -- Development and progression, Biological sciences
Abstract

Background: The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4Δ1D27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against P. vivax infection and disease. Methods and Findings: The association between SAO and P. vivax infection was examined through genotyping of 1,975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea. SAO was associated with a statistically significant 46% reduction in the incidence of clinical P. vivax episodes (adjusted incidence rate ratio [IRR] = 0.54, 95% CI 0.40-0.72, p90% binding inhibition) P. vivax Duffy binding protein-specific binding inhibitory antibodies were observed significantly more often in sera from SAO than non-SAO children (SAO, 22.2%;non-SAO, 6.7%;p = 0.008). Conclusions: In three independent studies, we observed strong associations between SAO and protection against P. vivax malaria by a mechanism that is independent of the Duffy antigen. P. vivax malaria may have contributed to shaping the unique host genetic adaptations to malaria in Asian and Oceanic populations., Introduction The populations of the southwest Pacific are highly diverse and exhibit a range of unique red blood cell (RBC) polymorphisms. Within Papua New Guinea (PNG), a variety of RBC [...]

Published
2012
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29. Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Author

França, Camila Tenorio, primary, White, Michael T, additional, He, Wen-Qiang, additional, Hostetler, Jessica B, additional, Brewster, Jessica, additional, Frato, Gabriel, additional, Malhotra, Indu, additional, Gruszczyk, Jakub, additional, Huon, Christele, additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Yadava, Anjali, additional, Siba, Peter, additional, Galinski, Mary R, additional, Healer, Julie, additional, Chitnis, Chetan, additional, Cowman, Alan F, additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Tham, Wai-Hong, additional, Fairhurst, Rick M, additional, Rayner, Julian C, additional, King, Christopher L, additional, and Mueller, Ivo, additional

Published
2017
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31. Patterns of protective associations differ for antibodies to P. falciparum ‐infected erythrocytes and merozoites in immunity against malaria in children

Author

Chan, Jo‐Anne, primary, Stanisic, Danielle I, additional, Duffy, Michael F, additional, Robinson, Leanne J, additional, Lin, Enmoore, additional, Kazura, James W, additional, King, Christopher L, additional, Siba, Peter M, additional, Fowkes, Freya JI, additional, Mueller, Ivo, additional, and Beeson, James G, additional

Published
2017
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32. Author response: Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

Author

França, Camila Tenorio, primary, White, Michael T, additional, He, Wen-Qiang, additional, Hostetler, Jessica B, additional, Brewster, Jessica, additional, Frato, Gabriel, additional, Malhotra, Indu, additional, Gruszczyk, Jakub, additional, Huon, Christele, additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Yadava, Anjali, additional, Siba, Peter, additional, Galinski, Mary R, additional, Healer, Julie, additional, Chitnis, Chetan, additional, Cowman, Alan F, additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Tham, Wai-Hong, additional, Fairhurst, Rick M, additional, Rayner, Julian C, additional, King, Christopher L, additional, and Mueller, Ivo, additional

Published
2017
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34. An Antibody Screen of a Plasmodium vivax Antigen Library Identifies Novel Merozoite Proteins Associated with Clinical Protection

Author

França, Camila T., primary, Hostetler, Jessica B., additional, Sharma, Sumana, additional, White, Michael T., additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Waltmann, Andreea, additional, Darcy, Andrew W., additional, Li Wai Suen, Connie S. N., additional, Siba, Peter, additional, King, Christopher L., additional, Rayner, Julian C., additional, Fairhurst, Rick M., additional, and Mueller, Ivo, additional

Published
2016
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35. 600 Multi Donor Intense Faecal Microbiota Transplantation is an Effective Treatment for Resistant Ulcerative Colitis: A Randomised Placebo-Controlled Trial

Author

Paramsothy, Sudarshan, primary, Kamm, Michael A., additional, Walsh, Alissa, additional, van den Bogaerde, Johan, additional, Samuel, Douglas, additional, Leong, Rupert W., additional, Connor, Susan J., additional, Ng, Wa Sang Watson, additional, Paramsothy, Ramesh, additional, Kaakoush, Nadeem, additional, Mitchell, Hazel M., additional, Xuan, Wei, additional, Lin, Enmoore, additional, and Borody, Thomas, additional

Published
2016
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36. Donor Recruitment for Fecal Microbiota Transplantation

Author

Paramsothy, Sudarshan, primary, Borody, Thomas J., additional, Lin, Enmoore, additional, Finlayson, Sarah, additional, Walsh, Alissa J., additional, Samuel, Douglas, additional, van den Bogaerde, Johan, additional, Leong, Rupert W. L., additional, Connor, Susan, additional, Ng, Watson, additional, Mitchell, Hazel M., additional, Kaakoush, Nadeem, additional, and Kamm, Michael A., additional

Published
2015
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38. Acquisition of Antibodies against Plasmodium falciparum Merozoites and Malaria Immunity in Young Children and the Influence of Age, Force of Infection, and Magnitude of Response

Author

Stanisic, Danielle I., primary, Fowkes, Freya J. I., additional, Koinari, Melanie, additional, Javati, Sarah, additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Richards, Jack S., additional, Robinson, Leanne J., additional, Schofield, Louis, additional, Kazura, James W., additional, King, Christopher L., additional, Zimmerman, Peter, additional, Felger, Ingrid, additional, Siba, Peter M., additional, Mueller, Ivo, additional, and Beeson, James G., additional

Published
2015
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40. Naturally Acquired Immune Responses to P. vivax Merozoite Surface Protein 3α and Merozoite Surface Protein 9 Are Associated with Reduced Risk of P. vivax Malaria in Young Papua New Guinean Children

Author

Stanisic, Danielle I., primary, Javati, Sarah, additional, Kiniboro, Benson, additional, Lin, Enmoore, additional, Jiang, Jianlin, additional, Singh, Balwan, additional, Meyer, Esmeralda V. S., additional, Siba, Peter, additional, Koepfli, Cristian, additional, Felger, Ingrid, additional, Galinski, Mary R., additional, and Mueller, Ivo, additional

Published
2013
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43. Pharmacokinetics of Lamivudine and Lamivudine-Triphosphate after Administration of 300 Milligrams and 150 Milligrams Once Daily to Healthy Volunteers: Results of the ENCORE 2 Study

Author

Else, Laura J., primary, Jackson, Akil, additional, Puls, Rebekah, additional, Hill, Andrew, additional, Fahey, Paul, additional, Lin, Enmoore, additional, Amara, Alieu, additional, Siccardi, Marco, additional, Watson, Victoria, additional, Tjia, John, additional, Emery, Sean, additional, Khoo, Saye, additional, Back, David J., additional, and Boffito, Marta, additional

Published
2012
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44. Features and Prognosis of Severe Malaria Caused by Plasmodium falciparum, Plasmodium vivax and Mixed Plasmodium Species in Papua New Guinean Children

Author

Manning, Laurens, primary, Laman, Moses, additional, Law, Irwin, additional, Bona, Cathy, additional, Aipit, Susan, additional, Teine, David, additional, Warrell, Jonathan, additional, Rosanas-Urgell, Anna, additional, Lin, Enmoore, additional, Kiniboro, Benson, additional, Vince, John, additional, Hwaiwhanje, Ilomo, additional, Karunajeewa, Harin, additional, Michon, Pascal, additional, Siba, Peter, additional, Mueller, Ivo, additional, and Davis, Timothy M. E., additional

Published
2011
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48. Differential Patterns of Infection and Disease with P. falciparum and P. vivax in Young Papua New Guinean Children

Author

Lin, Enmoore, primary, Kiniboro, Benson, additional, Gray, Laurie, additional, Dobbie, Stuart, additional, Robinson, Leanne, additional, Laumaea, Annemarie, additional, Schöpflin, Sonja, additional, Stanisic, Danielle, additional, Betuela, Inoni, additional, Blood-Zikursh, Melinda, additional, Siba, Peter, additional, Felger, Ingrid, additional, Schofield, Louis, additional, Zimmerman, Peter, additional, and Mueller, Ivo, additional

Published
2010
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