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This article discusses a case series study that examined the efficacy of topical crisaborole in treating facial dermatitis in patients with atopic dermatitis who were also receiving dupilumab treatment. The study included eight patients who experienced facial dermatitis after starting dupilumab treatment. After four weeks of topical crisaborole treatment, all patients showed clinical improvement in facial and neck erythema. The study suggests that topical crisaborole may be a potential treatment option for dupilumab facial dermatitis, although further research is needed to validate its effectiveness. [Extracted from the article]

Abstract: Anisotropic microstructure is becoming a critical issue in microbumps used in 3-D integrated circuit packaging. We report here an experimental approach for controlling the microstructure of η-Cu6Sn5 intermetallic compound in microbumps by using 〈111〉 oriented and nanotwinned Cu pads as the under-bump-metallization. By electroplating arrays of large numbers of 〈111〉 oriented and nanotwinned Cu pads and by electroplating the Sn2.3Ag solder on the pads, we form η-Cu6Sn5 in the reflow at 260°C for 1min. The η-Cu6Sn5 showed a highly preferential growth along the 〈0001〉 direction. As reflow time is extended, the preferred texture of η-Cu6Sn5 changed to { }. The results indicate that we can control the uniform microstructure of η-Cu6Sn5 intermetallic by controlling the microstructure of the Cu under-bump-metallization. [Copyright &y& Elsevier]