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13 results on '"Lin, Hui-Ran"'

7. CASC15Gene Polymorphisms and Glioma Susceptibility in Chinese Children

Author

Lin, Hui-ran, Chen, Yong-ping, Chen, Hui-tong, Liu, Xiao-ping, Zhou, Jing-ying, Huang, Xiao-kai, Yuan, Li, and Zhuo, Zhen-jian

Abstract

Objective: Gliomas are the most common tumors in the central nervous system. The cancer susceptibility candidate 15 (CASC15) gene has been reported to be a susceptibility gene for several types of cancer. No studies have been carried out on the predisposing effect of CASC15gene single nucleotide polymorphisms (SNPs) on glioma risk. Methods: In order to determine whether CASC15gene SNPs are involved in glioma susceptibility, the first association study in a relatively large sample, which consisted of 171 patients and 228 healthy controls recruited from China, was performed. The contribution of SNPs (rs6939340 A>G, rs4712653 T>C and rs9295536 C>A) to the risk of glioma was evaluated by multinomial logistic regression, based on the calculation of the odds ratio (OR) and 95% confidence interval (CI). Results: In the single locus and combined analysis, it was revealed that the genetic risk score had no significant associations between CASC15gene SNPs and glioma risk. However, in the stratified analysis, a significant decrease in risk of glioma was observed in subjects of <60 months old with the rs4712653 TT genotype, when compared to those with the CC/CT genotype (OR=0.12, 95% CI=0.02–0.91, P=0.041). Conclusion: The present study provides referential evidence on the association between the genetic predisposition of the CASC15gene and glioma risk in Chinese children. However, more well-designed case-control studies and functional experiments are needed to further explore the role of CASC15gene SNPs.

Published
2022
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8. Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis

Author

Xu, Nan, additional, Wu, Xue, additional, Luo, Hui-Juan, additional, Xu, Fang-Fang, additional, Huang, Qiong-Hui, additional, Wu, Jia-Zhen, additional, Gan, Yu-Xuan, additional, Li, Min-Yao, additional, Lai, Zheng-Quan, additional, Lin, Hui-Ran, additional, Chen, Jian-Nan, additional, Su, Zi-Ren, additional, Ai, Wei-Peng, additional, and Liu, Yu-Hong, additional

Published
2020
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12. Novel betulin derivative induces anti-proliferative activity by G2/M phase cell cycle arrest and apoptosis in Huh7 cells.

Author

Zhuo, Zhen-Jian, Xiao, Min-Jie, Lin, Hui-Ran, Luo, Jing, and Wang, Tao

Subjects
LIVER cancer, BETULIN, CELL cycle, APOPTOSIS, BCL-2 proteins, MITOCHONDRIA, THERAPEUTICS
Abstract

Betulin (BT) has been identified to exhibit potential benefits for treating hepatocellular carcinoma (HCC). The results of the present study demonstrated that a new semisynthetic derivative of BT, 3,28-di-(2-nitroxy-acetyl)-oxy-BT, may effectively decrease the viability of Huh7 cells. Mechanistic studies revealed that 3,28-di-(2-nitroxy-acetyl)-oxy-BT inhibited the transition between G2 and M phase of the cell cycle by regulating cell cycle regulatory proteins. Additional study revealed that 3,28-di-(2-nitroxy-acetyl)-oxy-BT may trigger Huh7 cells to undergo caspase-dependent apoptosis as an increased proportion of cells were identified in the sub-G1 phase, which may b e a result of p oly(ADP-ribose) polymerase cleavage and caspase activation. Furthermore, 3,28-di-(2-nitroxy-acetyl)-oxy-BT-induced apoptosis was mitochondrion-mediated. The results of the present study demonstrated that Bcl-2-associated X protein translocated to the mitochondria from the cytosol following 3,28-di-(2-nitroxy-acetyl)-oxy-BT treatment. Notably, the phosphoinositide 3-kinase/protein kinase B signaling pathway was involved in 3,28-di-(2-nitroxy-acetyl)-oxy-BT-treated Huh7 cells. Therefore, the results of the present study demonstrated that 3,28-di-(2-nitroxy-acetyl)-oxy-BT may inhibit HCC, which may be a possible application to treat HCC. [ABSTRACT FROM AUTHOR]

Published
2018
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13. Novel betulin derivative induces anti-proliferative activity by G 2 /M phase cell cycle arrest and apoptosis in Huh7 cells.

Author

Zhuo ZJ, Xiao MJ, Lin HR, Luo J, and Wang T

Abstract

Betulin (BT) has been identified to exhibit potential benefits for treating hepatocellular carcinoma (HCC). The results of the present study demonstrated that a new semisynthetic derivative of BT, 3,28-di-(2-nitroxy-acetyl)-oxy-BT, may effectively decrease the viability of Huh7 cells. Mechanistic studies revealed that 3,28-di-(2-nitroxy-acetyl)-oxy-BT inhibited the transition between G 2 and M phase of the cell cycle by regulating cell cycle regulatory proteins. Additional study revealed that 3,28-di-(2-nitroxy-acetyl)-oxy-BT may trigger Huh7 cells to undergo caspase-dependent apoptosis as an increased proportion of cells were identified in the sub-G 1 phase, which may be a result of poly(ADP-ribose) polymerase cleavage and caspase activation. Furthermore, 3,28-di-(2-nitroxy-acetyl)-oxy-BT-induced apoptosis was mitochondrion-mediated. The results of the present study demonstrated that Bcl-2-associated X protein translocated to the mitochondria from the cytosol following 3,28-di-(2-nitroxy-acetyl)-oxy-BT treatment. Notably, the phosphoinositide 3-kinase/protein kinase B signaling pathway was involved in 3,28-di-(2-nitroxy-acetyl)-oxy-BT-treated Huh7 cells. Therefore, the results of the present study demonstrated that 3,28-di-(2-nitroxy-acetyl)-oxy-BT may inhibit HCC, which may be a possible application to treat HCC.

Published
2018
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