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11 results on '"Lin, Jaymie Siqi"'

2. RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis

Author

Song, Yangyang, primary, An, Omer, additional, Ren, Xi, additional, Chan, Tim Hon Man, additional, Tay, Daryl Jin Tai, additional, Tang, Sze Jing, additional, Han, Jian, additional, Hong, HuiQi, additional, Ng, Vanessa Hui En, additional, Ke, Xinyu, additional, Shen, Haoqing, additional, Pitcheshwar, Priyankaa, additional, Lin, Jaymie Siqi, additional, Leong, Ka Wai, additional, Molias, Fernando Bellido, additional, Yang, Henry, additional, Kappei, Dennis, additional, and Chen, Leilei, additional

Published
2021
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3. Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression

Author

Han, Jian, primary, An, Omer, additional, Hong, HuiQi, additional, Chan, Tim Hon Man, additional, Song, Yangyang, additional, Shen, Haoqing, additional, Tang, Sze Jing, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Tay, Daryl Jin Tai, additional, Molias, Fernando Bellido, additional, Pitcheshwar, Priyankaa, additional, Tan, Hui Qing, additional, Yang, Henry, additional, and Chen, Leilei, additional

Published
2020
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4. Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers

Author

Irudayaswamy, Antony, primary, Muthiah, Mark, additional, Zhou, Lei, additional, Hung, Hau, additional, Jumat, Nur Halisah Bte, additional, Haque, Jamil, additional, Teoh, Narcissus, additional, Farrell, Geoffrey, additional, Riehle, Kimberly J., additional, Lin, Jaymie Siqi, additional, Su, Lin Lin, additional, Chan, Jerry Ky, additional, Choolani, Mahesh, additional, Wong, Peng Cheang, additional, Wee, Aileen, additional, Lim, Seng Gee, additional, Campbell, Jean, additional, Fausto, Nelson, additional, and Dan, Yock Young, additional

Published
2017
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5. An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

Author

Qi, Lihua, primary, Song, Yangyang, additional, Chan, Tim Hon Man, additional, Yang, Henry, additional, Lin, Chi Ho, additional, Tay, Daryl Jin Tai, additional, Hong, HuiQi, additional, Tang, Sze Jing, additional, Tan, Kar Tong, additional, Huang, Xi Xiao, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Maury, Julien Jean Pierre, additional, Tenen, Daniel G., additional, and Chen, Leilei, additional

Published
2017
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6. ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer

Author

Chan, Tim Hon Man, primary, Qamra, Aditi, additional, Tan, Kar Tong, additional, Guo, Jing, additional, Yang, Henry, additional, Qi, Lihua, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Song, Yangyang, additional, Hong, Huiqi, additional, Tay, Su Ting, additional, Liu, Yujing, additional, Lee, Jeeyun, additional, Rha, Sun Yong, additional, Zhu, Feng, additional, So, Jimmy Bok Yan, additional, Teh, Bin Tean, additional, Yeoh, Khay Guan, additional, Rozen, Steve, additional, Tenen, Daniel G., additional, Tan, Patrick, additional, and Chen, Leilei, additional

Published
2016
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7. An RNA editing/binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

Author

Qi, Lihua, primary, Song, Yangyang, additional, Chan, Tim Hon Man, additional, Yang, Henry, additional, Lin, Chi Ho, additional, Tay, Daryl Jin Tai, additional, Hong, HuiQi, additional, Lin, Jaymie Siqi, additional, Ng, Vanessa Hui En, additional, Maury, Julien Jean Pierre, additional, Tenen, Daniel G., additional, and Chen, Leilei, additional

Published
2016
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9. Long-Term Fate of Human Fetal Liver Progenitor Cells Transplanted in Injured Mouse Livers.

Author

Irudayaswamy, Antony, Muthiah, Mark, Zhou, Lei, Hung, Hau, Jumat, Nur Halisah Bte, Haque, Jamil, Teoh, Narcissus, Farrell, Geoffrey, Riehle, Kimberly J., Lin, Jaymie Siqi, Su, Lin Lin, Chan, Jerry Ky, Choolani, Mahesh, Wong, Peng Cheang, Wee, Aileen, Lim, Seng Gee, Campbell, Jean, Fausto, Nelson, and Dan, Yock Young

Abstract

Liver progenitor cells have the potential to repair and regenerate a diseased liver. The success of any translational efforts, however, hinges on thorough understanding of the fate of these cells after transplant, especially in terms of long-term safety and efficacy. Here, we report transplantation of a liver progenitor population isolated from human fetal livers into immune-permissive mice with follow-up up to 36 weeks after transplant. We found that human progenitor cells engraft and differentiate into functional human hepatocytes in the mouse, producing albumin, alpha-1-antitrypsin, and glycogen. They create tight junctions with mouse hepatocytes, with no evidence of cell fusion. Interestingly, they also differentiate into functional endothelial cell and bile duct cells. Transplantation of progenitor cells abrogated carbon tetrachloride-induced fibrosis in recipient mice, with downregulation of procollagen and anti-smooth muscle actin. Paradoxically, the degree of engraftment of human hepatocytes correlated negatively with the anti-fibrotic effect. Progenitor cell expansion was most prominent in cirrhotic animals, and correlated with transcript levels of pro-fibrotic genes. Animals that had resolution of fibrosis had quiescent native progenitor cells in their livers. No evidence of neoplasia was observed, even up to 9 months after transplantation. Human fetal liver progenitor cells successfully attenuate liver fibrosis in mice. They are activated in the setting of liver injury, but become quiescent when injury resolves, mimicking the behavior of de novo progenitor cells. Our data suggest that liver progenitor cells transplanted into injured livers maintain a functional role in the repair and regeneration of the liver. S tem C ells 2018;36:103-113 [ABSTRACT FROM AUTHOR]

Published
2018
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11. Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression.

Author

Jian Han, An, Omer, HuiQi Hong, Hon Man Chan, Tim, Yangyang Song, Haoqing Shen, Sze Jing Tang, Lin, Jaymie Siqi, Hui En Ng, Vanessa, Jin Tai Tay, Daryl, Molias, Fernando Bellido, Pitcheshwar, Priyankaa, Hui Qing Tan, Yang, Henry, and Leilei Chen

Subjects
*CANCER invasiveness, *RNA splicing, *RNA, *RNA-binding proteins, *ALTERNATIVE RNA splicing, *GREEN fluorescent protein, *TRANSFER RNA, *ISOMERASES
Abstract

In this article, author uncover death associated protein 3 (DAP3) as a potent repressor of editing and a strong oncogene in cancer. It discusses the suppression of adenosine-to-inosine RNA editome by death associated protein 3 (DAP3) promotes cancer progression. It mentions the negative regulation of editing mechanism by which DAP3 promotes cancer development.

Published
2020
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