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Your search keyword '"Lin, Ming-Hong"' showing total 242 results
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242 results on '"Lin, Ming-Hong"'

19. The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

Author

Lin, Ming-Hong, primary, Cheng, Po-Ching, additional, Hsiao, Pi-Jung, additional, Chen, Szu-Chia, additional, Hung, Chih-Hsing, additional, Kuo, Chao-Hung, additional, Huang, Shau-Ku, additional, and Clair Chiou, Hsin-Ying, additional

Published
2023
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42. The efficacy of culture‐guided versus empirical therapy with high‐dose proton pump inhibitor as third‐line treatment of Helicobacter pylori infection: A real‐world clinical experience.

Author

Wang, Jiunn‐Wei, Hsu, Ping‐I, Lin, Ming‐Hong, Kao, John, Tsay, Feng‐Woei, Wu, I‐Ting, Shie, Chang‐Bih, and Wu, Deng‐Chyang

Subjects
PROTON pump inhibitors, HELICOBACTER pylori infections, MICROBIAL sensitivity tests, PROTON therapy, HELICOBACTER pylori, AMOXICILLIN
Abstract

Background and Aim: Most consensuses recommend culture‐guided therapy as third‐line Helicobacter pylori treatment. This study aimed to investigate the efficacies of culture‐guided therapy and empirical therapy with high‐dose proton pump inhibitor (PPI) in the H. pylori third‐line treatment. Methods: Between August 2012 and October 2021, H. pylori‐infected patients with at least two failed eradication attempts received anti‐H. pylori therapy according to the results of antimicrobial sensitivity tests plus high‐dose rabeprazole and/or bismuth. They were categorized into three groups: patients who had positive results of culture with equal to or more than three susceptible antibiotics were treated by culture‐guided non‐bismuth quadruple therapy, patients who had positive results of culture with one or two susceptible antibiotics were treated by culture‐guided bismuth‐containing therapy, and patients who had a negative result of culture were treated by an empirical therapy with high‐dose rabeprazole plus amoxicillin, tetracycline and levofloxacin. A post‐treatment assessment was conducted at week 8. Results: We recruited 126 patients. The eradication rates of culture‐guided non‐bismuth quadruple therapy (n = 50), culture‐guided bismuth‐containing therapy (n = 46) and empirical therapy (n = 30) were 84.0%, 87.0%, and 66.7% (95% confidence interval: 73.8–94.2%, 77.3–96.7%, and 49.8–83.6%), respectively. Overall, culture‐guided therapy achieved a higher eradication rate than empirical therapy (85.4% vs 66.7%; 95% confidence interval, 0.4% to 37.0%, P = 0.022). Conclusions: Culture‐guided therapy with high‐dose PPI achieves a higher eradication rate than empirical therapy with high‐dose PPI in the third‐line treatment of H. pylori infection. The eradication rate of rescue therapy with bismuth plus two susceptible antibiotics is not inferior to that with three susceptible antibiotics. [ABSTRACT FROM AUTHOR]

Published
2022
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44. Hyperbaric Oxygen Therapy Alleviates the Autoimmune Encephalomyelitis via the Reduction of IL-17a and GM-Csf Production of Autoreactive T Cells as Well as Boosting the Immunosuppressive IL-10 in the Central Nervous System Tissue Lesions

Author

Chiou, Hsin-Ying Clair, primary, Huang, Shu-Hung, additional, Hung, Chih-Hsing, additional, Tsai, Su-Min, additional, Kuo, Hui-Ru, additional, Huang, Yu-Rui, additional, Wang, Jiunn-Wei, additional, Chen, Szu-Chia, additional, Kuo, Chao-Hung, additional, Wu, Deng-Chyang, additional, Huang, Shau-Ku, additional, Hsu, Shih-Hsien, additional, and Lin, Ming-Hong, additional

Published
2021
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47. WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism

Author

Wang, Li-Ting, primary, Lin, Ming-Hong, additional, Liu, Kwei-Yan, additional, Chiou, Shyh-Shin, additional, Wang, Shen-Nien, additional, Chai, Chee-Yin, additional, Tseng, Li-Wen, additional, Chiou, Hsin-Ying Clair, additional, Wang, Hsueh-Chun, additional, Yokoyama, Kazunari K., additional, Hsu, Shih-Hsien, additional, and Huang, Shau-Ku, additional

Published
2021
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49. Kinetic Alterations in Resurgent Sodium Currents of Mutant Na v 1.4 Channel in Two Patients Affected by Paramyotonia Congenita.

Author

Lee, Ming-Jen, Lin, Pi-Chen, Lin, Ming-Hong, Chiou, Hsin-Ying Clair, Wang, Kai, and Huang, Chiung-Wei

Subjects
MYOTONIA congenita, SODIUM channels, ACTION potentials, MOLECULAR pathology, GENETIC mutation, MISSENSE mutation, MUSCLE weakness, FACIAL muscles
Abstract

Simple Summary: Paramyotonia congenita (PMC) is a rare muscle disorder that causes myotonia and weakness of facial and limb muscles. The electromyography in PMC shows continual spontaneous, high-frequency spike potentials in skeletal muscles. Genetic mutations in the Nav1.4 channel that cause hyperexcitability of muscle fibers are responsible for PMC. However, the genotype–phenotype relationship is highly diversified, and the molecular pathology remains unclear. Here, we investigated the electrophysiology in the Nav1.4 channel with mutations, p.V781I and p.A1737T, which were found in two Taiwanese patients. We identified the distinct changes in gating mechanisms altered by mutations which may underlie the clinical phenotype. Paramyotonia congenita (PMC) is a rare skeletal muscle disorder characterized by muscle stiffness upon repetitive exercise and cold exposure. PMC was reported to be caused by dominant mutations in the SCN4A gene encoding the α subunit of the Nav1.4 channel. Recently, we identified two missense mutations of the SCN4A gene, p.V781I and p.A1737T, in two PMC families. To evaluate the changes in electrophysiological properties caused by the mutations, both mutant and wild-type (WT) SCN4A genes were expressed in CHO-K1 and HEK-293T cells. Then, whole-cell patch-clamp recording was employed to study the altered gating of mutant channels. The activation curve of transient current showed a hyperpolarizing shift in both mutant Nav1.4 channels as compared to the WT channel, whereas there was a depolarizing shift in the fast inactivation curve. These changes confer to an increase in window current in the mutant channels. Further investigations demonstrated that the mutated channel proteins generate significantly larger resurgent currents as compared to the WT channel and take longer to attain the peak of resurgent current than the WT channel. In conclusion, the current study demonstrates that p.V781I and p.A1737T mutations in the Nav1.4 channel increase both the sustained and the resurgent Na+ current, leading to membrane hyperexcitability with a lower firing threshold, which may influence the clinical phenotype. [ABSTRACT FROM AUTHOR]

Published
2022
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