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Audible noise is one of the key factors affecting the selection of overhead transmission line conductors and the design of poles. Based on the line sound source model, a three-dimensional prediction method for AC transmission line noise is proposed, and the method is used for example analysis. The results show that: due to the influence of the line-height, at the same horizontal distance from the line the ground noise near the center of the file distance is the largest, which gradually decreases towards the end of the file distance, but the influence decreases with the increase of the horizontal distance; the noise along the line increases with the height and then decreases, and the maximum value appears at the high level of the line; in the line noise prediction work, it needs to take account of the influence of adjacent cross-line noise and ground factor. Compared with the measured values of the 1,000 kV UHVAC lines of the Anhui-East Power Transmission project, the predicted values of the proposed method are 0.9 dB(A) and 0.4 dB(A) larger at 10 m and 20 m outside the projection of the side phase conductors respectively, and the predicted results are consistent with the measured results.

Background Radiation-induced colorectal fibrosis (RICF) is a common pathological alteration among patients with rectal cancer undergoing neoadjuvant chemoradiotherapy (nCRT). Anastomotic stenosis (AS) causes symptoms and negatively impacts patients' quality of life and long-term survival. In this study, we aimed to evaluate the fibrosis signature of RICF and develop a nomogram to predict the risk of AS in patients with rectal cancer undergoing nCRT. Methods Overall, 335 pairs of proximal and distal margins were collected and randomly assigned at a 7:3 ratio to the training and testing cohorts. The RICF score was established to evaluate the fibrosis signature in the anastomotic margins. A nomogram based on the RICF score for AS was developed and evaluated by using the area under the curve, decision curve analysis, and the DeLong test. Results The training cohort included 235 patients (161 males [68.51%]; mean age, 59.61 years) with an occurrence rate of AS of 17.4%, whereas the testing cohort included 100 patients (72 males [72.00%]; mean age, 57.17 years) with an occurrence rate of AS of 11%. The RICF total score of proximal and distal margins was significantly associated with AS (odds ratio, 3.064; 95% confidence interval [CI], 2.200–4.268; P  <   0.001). Multivariable analysis revealed that the RICF total score, neoadjuvant radiotherapy, and surgical approach were independent predictors for AS. The nomogram demonstrated good discrimination in the training cohort (area under the receiver-operating characteristic curve, 0.876; 95% CI, 0.816–0.937), with a sensitivity of 68.3% (95% CI, 51.9%–81.9%) and a specificity of 85.5% (95% CI, 78.7%–89.3%). Similar results were observed in the testing cohort. Conclusions This study results suggest that the RICF total score of anastomotic margins is an independent predictor for AS. The prediction model developed based on the RICF total score may be useful for individualized AS risk prediction in patients with rectal cancer undergoing nCRT and sphincter-preserving surgery. [ABSTRACT FROM AUTHOR]

The impulsive vibration induced by human running and jumping, object falling, striking during decoration, etc., significantly disturbs the learning, work, and life of people through building structure transmission. To study the influence of impulsive vibration in buildings, a vacant frame building was selected as a tested building. The vibration at each floor besides hitting spot would be measured when a solid metal ball falling freely hit the first floor of this building. The vibration response at each floor caused by the excitation above was simulated through a finite element method. The parameters of the simulation model were optimized according to measured results. Furthermore, the influence of building structure, the total amount of stories, and slab dimension on the transmission of vibration from 1 Hz to 80 Hz which can be perceived by human bodies was quantitatively studied. Results showed that the vertical weighted vibration acceleration level at each floor linearly decreased with the increase of the logarithm of the distance between each floor and the hitting spot. A prediction model of vertical weighted vibration acceleration level from 1 Hz to 80 Hz induced by the impulsive vibration in buildings was developed according to simulation results. The corrections relating to the number of story, building structure, slab span, slab length-to-width ratio, and slab thickness were respectively introduced in the model which can predict the vertical weighted vibration acceleration level at each floor above the hitting spot. The results of this study can provide a basis for the prediction and control of impulsive vibration caused by an impact source with great stiffness in buildings. [ABSTRACT FROM AUTHOR]

A survey of community annoyance induced by aircraft noise exposure was carried out around Hangzhou Xiaoshan International Airport. To investigate the relationship curves between aircraft noise and the percentage of "highly annoyed" persons in China and also to get annoyance threshold of aircraft noise in China. Noise annoyance induced by aircraft noise exposure was assessed by 764 local residents around the airport using the International Commission on Biological Effect of Noise (ICBEN) scale. The status quo of aircraft noise pollution was measured by setting up 39 monitoring points. The interpolation was used to estimate the weighted effective continuous perceived noise levels (LWECPN) in different areas around the airport, and the graph of equal noise level contour was drawn. The membership function was used to calculate the annoyance threshold of aircraft noise. Data were analyzed using SPSS 16.0 and Origin 8.0. The results showed that if LWECPN was 64.3 dB (Ldn was 51.4 dB), then 15% respondents were highly annoyed. If LWECPN was 68.1 dB (Ldn was 55.0 dB), then 25% respondents were highly annoyed. The annoyance threshold of aircraft noise (LWECPN) was 73.7 dB, while the annoyance threshold of a single flight incident instantaneous noise level (LAmax) was 72.9 dB. People around the airport had felt annoyed before the aircraft noise LWECPN reached the standard limit.

Background: Long non-coding RNAs (lncRNAs) are increasingly observed as regulatory factors for the initiation and progression of varying kinds of cancers. However, studies on lncRNAs in non-small cell lung cancer (NSCLC) progression are currently lacking., Objectives: We intended to determine the role of lncRNA LINC00472 and its downstream regulatory mechanism in NSCLC, thus providing novel ideas for targeted therapies for NSCLC., Material and Methods: The target signaling axis comprising the lncRNA/microRNA/mRNA was identified through bioinformatics analysis. Subcellular localization of LINC00472 was assessed with fluorescence in situ hybridization (FISH). Cellular function experiments were conducted to examine the proliferation, migration, invasion, and apoptosis of NSCLC cells, and dual-luciferase and RNA binding protein immunoprecipitation assays were performed to validate the binding relationship. Quantitative real-time polymerase chain reaction (qPCR) and western blot were utilized to assess the expression levels of the investigated gene and protein, respectively., Results: The LINC00472 expression was markedly decreased in NSCLC tissues and cells. The FISH, combined with nuclear-cytoplasm separation assay, demonstrated that LINC00472 was mainly located in the cytoplasm. The overexpression of LINC00472 restrained proliferation and metastasis of NSCLC in vitro. The LINC00472 could target and repress miR-1275 level, and overexpression of LINC00472 reduced the miR-1275-dependent malignant cell phenotype in NSCLC. Further study revealed that HOXA2 was a downstream target of miR-1275 and was negatively modulated by miR-1275. Rescue assays exhibited that the overexpression of miR-1275 or inhibition of HOXA2 reversed the impact of LINC00472 overexpression on the malignant progression of NSCLC cells. The LINC00472 repressed the epithelial-mesenchymal transition (EMT) of NSCLC cells through miR-1275/HOXA2., Conclusions: The LINC00472 functioned as a competing endogenous RNA to modulate HOXA2 level by sponging miR-1275 in NSCLC. Simultaneously, the LINC00472/miR-1275/HOXA2 axis may be a possible therapeutic target and biomarker for NSCLC.

Liver cancer is a prevalent type of tumor worldwide. CRISPR-Cas9 technology can be utilized to identify therapeutic targets for novel therapeutic approaches. In this study, our goal was to identify key genes related to the survival of hepatocellular carcinoma (HCC) cells by analyzing the DepMap database based on CRISPR-Cas9. We screened candidate genes associated with HCC cell survival and proliferation from DepMap and identified their expression levels in HCC from the TCGA database. To develop a prognostic risk model based on these candidate genes, we performed WGCNA, functional pathway enrichment analysis, protein interaction network construction, and LASSO analysis. Our findings show that 692 genes were critical for HCC cell proliferation and survival, and among them, 571 DEGs were identified in HCC tissues. WGCNA categorized these 584 genes into three modules, and the blue module consisting of 135 genes was positively linked to the tumor stage. Using the MCODE approach in Cytoscape, we identified ten hub genes in the PPI network, and through Cox univariate analysis and Lasso analysis, we developed a prognostic model consisting of three genes (SFPQ, SSRP1, and KPNB1). Furthermore, knocking down SFPQ inhibited HCC cell proliferation, migration, and invasion. In conclusion, we identified three core genes (SFPQ, SSRP1, and KPNB1) that are essential for the proliferation and survival of HCC cells. These genes were used to develop a prognostic risk model, and knockdown of SFPQ was found to inhibit the proliferation, migration, and invasion of HCC cells., Competing Interests: None., (AJCR Copyright © 2023.)