Search

Your search keyword '"Lin, Siou-Hong"' showing total 4 results
Start Over Author "Lin, Siou-Hong"
4 results on '"Lin, Siou-Hong"'

4. Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection.

Author

Chiao SH, Lin SH, Shen CI, Liao JW, Bau IJ, Wei JC, Tseng LP, Hsu SH, Lai PS, Lin SZ, Lin JJ, and Su HL

Subjects
Aluminum Silicates toxicity, Analysis of Variance, Animals, Anti-Bacterial Agents toxicity, Chickens, Clay, Drug Stability, Intestinal Mucosa metabolism, Intestines chemistry, Materials Testing, Metal Nanoparticles toxicity, Sepsis drug therapy, Sepsis microbiology, Sepsis prevention & control, Silver toxicity, Survival Analysis, Aluminum Silicates pharmacology, Anti-Bacterial Agents pharmacology, Metal Nanoparticles administration & dosage, Salmonella Infections drug therapy, Salmonella enterica drug effects, Silver pharmacology
Abstract

Developing effective and safe drugs is imperative for replacing antibiotics and controlling multidrug-resistant microbes. Nanoscale silicate platelet (NSP) and its nanohybrid, silver nanoparticle/NSP (AgNP/NSP), have been developed, and the nanohybrids show a strong and general antibacterial activity in vitro. Here, their efficacy for protecting Salmonella-infected chicks from fatality and septicemia was evaluated. Both orally administrated NSP and AgNP/NSP, but not AgNPs alone, effectively reduced the systemic Salmonella infection and mortality. In addition, quantitative Ag analyses demonstrated that Ag deposition from AgNP/NSP in the intestines was less than that from conventional AgNPs, indicating that the presence of NSP for immobilizing AgNPs reduced Ag accumulation in tissue and improved the safety of AgNPs. These in vivo results illustrated that both NSP and AgNP/NSP nanohybrid represent potential agents for controlling enteric bacterial infections.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results