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203 results on '"Lin, Wea‐Lung"'

1. Radiomic biomarkers for platinum‐refractory head and neck cancer in the era of immunotherapy

Author

Lu, Hsueh‐Ju, primary, Shen, Chao‐Yu, additional, Chiu, Yu‐Wei, additional, Lin, Wea‐Lung, additional, Peng, Chih‐Yu, additional, Tseng, Hsien‐Chun, additional, Hsin, Chung‐Han, additional, Chuang, Chun‐Yi, additional, Chen, Chun‐Chia, additional, Wu, Ming‐Fang, additional, Huang, Wei‐Shiou, additional, and Shen, Wei‐Chih, additional

Published
2024
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11. Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury

Author

Hus, Cheng-chin, Lin, Ko-yen, Wang, Zhi-hong, Lin, Wea-lung, and Yin, Mei-chin

Subjects
Liver diseases -- Risk factors -- Care and treatment -- Prevention -- Research -- Complications and side effects, Reishi -- Usage -- Health aspects -- Chemical properties -- Research, Acetaminophen -- Complications and side effects -- Research -- Usage, Biological sciences, Health, Science and technology
Abstract

Abstract In vivo preventive effects of Gunoderma amboinense against acetaminophen-induced hepatotoxicity in Balb/cA mice were studied. G. amboinense powder at 1% and 2% was mixed with standard diet and supplied [...]

Published
2008

34. Protective Effects of Morus Root Extract (MRE) Against Lipopolysaccharide-Activated RAW264.7 Cells and CCl4-Induced Mouse Hepatic Damage.

Author

Tseng, Tsui-Hwa, Lin, Wea-Lung, Chang, Che-Kai, Lee, Ko-Chao, Tung, Shui-Yi, and Kuo, Hsing-Chun

Subjects
*OXIDATIVE stress, *HERBAL medicine, *LIPOPOLYSACCHARIDES, *MACROPHAGES, *MEDICAL sciences
Abstract

Background/Aims: Inflammation is one of the main contributors to chronic diseases such as cancer. It is of great value to identify the potential activity of various medicinal plants for regulating or blocking uncontrolled chronic inflammation. We investigated whether the root extract of Morus australis possesses antiinflammatory and antioxidative stress potential and hepatic protective activity. Methods: The microwave-assisted extractionwere was used to prepare the ethanol extract from the dried root of Morus australis (MRE), including polyphenolic and flavonoid contents. Lipopolysaccharide (LPS)-stimulated RAW264.7 cells was examined the anti-inflammatory and anti-oxidative potential of MRE. CCl4-induced mouse hepatic damage were performed to detect the hepatic protective potential in vivo. Immunohistochemistry (IHC) and western blot assays were used to detect target proteins. Results: MRE contained approximately 23% phenolic compounds and 3% flavonoids. The major flavonoid component of MRE was morusin. MRE and morusin inhibited lipopolysaccharide-induced production of nitrite and prostaglandin E2 in RAW264.7 cells. MRE and morusin also suppressed the formation of intracellular reactive oxygen species and the expression of iNOS and COX-2. In an in vivo study, a thiobarbituric acid reactive substances assay showed that MRE inhibited CCl4-induced oxidative stress and expression of nitrotyrosine. MRE also decreased CCl4-induced hepatic iNOS and COX-2 expression, as well as CCl4-induced hepatic inflammation and necrosis in mice. Conclusion: MRE exhibited antiinflammatory and hepatic protective activity. [ABSTRACT FROM AUTHOR]

Published
2018
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35. Steatocystoma multiplex as initial impression of non-small cell lung cancer with complete response to gefitinib

Author

Tsai, Ming-Hung, Hsiao, Yu-Ping, Lin, Wea-Lung, and Tseng, Szu-Wen

Subjects
integumentary system, Case Report, respiratory tract diseases
Abstract

Cutaneous metastases are rare and seldom present at the time of first diagnosis of cancer. Data from various studies show that 1-12% of lung cancer patients experience tumor spread to the skin. The scalp, chest, and abdomen are favored sites of skin metastases from lung cancers, but metastases to multiple skin sites in a single patient are rarely reported. We describe a 56-year-old lung adenocarcinoma patient, initially diagnosed with steatocystoma multiplex who responded well to gefitinib treatment. The efficacy of conventional chemotherapy for cutaneous metastases has been limited because of the relatively poor blood supply to the skin. It has been demonstrated that tyrosine kinase inhibitor (TKI), gefitinib, has significant clinical benefit in lung cancer patients with epidermal growth factor receptor (EGFR) mutation even in metastases to the brain. However, the therapeutic response to gefitinib in patients with skin metastases is seldom mentioned in the literature. We report one case of lung adenocarcinoma with multiple skin metastases that were successfully treated with gefitinib.

Published
2014

38. Monoclonal antibody Cam 5.2 targeted mainly CK8, but not CK18 — Comment on: 'Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation - report of a unique case. Int J Clin Exp Pathol. 2010 May 5; 3 (5):534-40.'

Author

Leei, Chang Kuang, Lin, Wea-Lung, and Han, Chih-Ping

Subjects
Fatal Outcome, Biomarkers, Tumor, Humans, Female, Liposarcoma, Middle Aged, Letter to the Editor, Carcinoma, Renal Cell, Immunohistochemistry, Nephrectomy, Kidney Neoplasms
Abstract

Sarcomatous transformation of chromophobe renal cell carcinoma (CRCC) is a well recognized phenomenon. Of the published cases with sarcomatous transformation of CRCC, none have shown liposarcomatous differentiation. Out of a cohort of 250 cases of CRCC, 19 (7.6%) showed sarcomatous differentiation. In one case (female, age 46 years), the sarcomatous component of the tumor displayed histological features of a pleomorphic liposar-coma. Light microscopic examination revealed a biphasic pattern with a chromophobe renal cell carcinoma(CRCC) and a high-grade sarcomatous component containing large pleomorphic lipoblasts. In several areas both components were intermingled. The conventional CRCC component showed classic histological features with calcifications, medium-sized polygonal cells arranged in solid-alveolar structures with raisinoid nuclei, pale-eosinophilic flocculent cytoplasm with perinuclear haloes. In addition, a microcystic-adenomatous component had luminal spaces filled with erythrocytes. The CRCC was positive with Hale's colloidal iron-stain whereas the sarcomatous component was negative. The CRCC component was diffusely positive for cytokeratin 7, parvalbumin and racemase but negative for cy-tokeratin 20, vimentin, CD10, carboanhydrase IX and S100-protein. The pleomorphic liposarcomatous component displayed immunereactivity for CD10, vimentin, racemase and focally for carboanhydrase IX. The proliferative activity (Mib-1/Ki-67) was 5% in the CRCC and 30% in the pleomorphic liposarcomatous component. No immunereactivity for MDM2 or CDK4 was detected.This is the first reported case of a sarcomatoid CRCC where the sarcomatous component displayed features of a pleomorphic liposarcoma. The patient died from widespread metastatic disease 12 months after nephrectomy.

Published
2010

45. Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression.

Author

Tseng, Tsui‐Hwa, Chien, Ming‐Hsien, Lin, Wea‐Lung, Wen, Yu‐Ching, Chow, Jyh‐Ming, Chen, Chi‐Kuan, Kuo, Tsang‐Chih, and Lee, Wei‐Jiunn

Subjects
BREAST cancer, CANCER prevention, TUMOR growth prevention, APIGENIN, CYCLINS, HISTONE acetylation
Abstract

ABSTRACT Apigenin (4′,5,7-trihydroxyflavone), a flavonoid commonly found in fruits and vegetables, has anticancer properties in various malignant cancer cells. However, the molecular basis of the anticancer effect remains to be elucidated. In this study, we investigated the cellular mechanisms underlying the induction of cell cycle arrest by apigenin. Our results showed that apigenin at the nonapoptotic induction concentration inhibited cell proliferation and induced cell cycle arrest at the G2/M phase in the MDA-MB-231 breast cancer cell line. Immunoblot analysis indicated that apigenin suppressed the expression of cyclin A, cyclin B, and cyclin-dependent kinase-1 (CDK1), which control the G2-to-M phase transition in the cell cycle. In addition, apigenin upregulated p21WAF1/CIP1 and increased the interaction of p21WAF1/CIP1 with proliferating cell nuclear antigen (PCNA), which inhibits cell cycle progression. Furthermore, apigenin significantly inhibited histone deacetylase (HDAC) activity and induced histone H3 acetylation. The subsequent chromatin immunoprecipitation (ChIP) assay indicated that apigenin increased acetylation of histone H3 in the p21WAF1/CIP1 promoter region, resulting in the increase of p21WAF1/CIP1 transcription. In a tumor xenograft model, apigenin effectively delayed tumor growth. In these apigenin-treated tumors, we also observed reductions in the levels of cyclin A and cyclin B and increases in the levels of p21WAF1/CIP1 and acetylated histone H3. These findings demonstrate for the first time that apigenin can be used in breast cancer prevention and treatment through epigenetic regulation. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 434-444, 2017. [ABSTRACT FROM AUTHOR]

Published
2017
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47. The Expression of Ribonucleotide Reductase M2 in the Carcinogenesis of Uterine Cervix and Its Relationship with Clinicopathological Characteristics and Prognosis of Cancer Patients

Author

Su, Ying-Fang, primary, Wu, Tzu-Fan, additional, Ko, Jiunn-Liang, additional, Tsai, Hsiu-Ting, additional, Tee, Yi-Torng, additional, Chien, Ming-Hsien, additional, Chou, Chi-Hung, additional, Lin, Wea-Lung, additional, Low, Hui-Ying, additional, Chou, Ming-Yung, additional, Yang, Shun-Fa, additional, and Wang, Po-Hui, additional

Published
2014
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