Search

Your search keyword '"Lin, Wuu-Jyh"' showing total 192 results
Start Over Author "Lin, Wuu-Jyh"
192 results on '"Lin, Wuu-Jyh"'

20. Design of PET Radiopharmaceuticals for Brain Imaging

Author

Hsu Jyh Ping, Lin Wuu Jyh, Li Ming Hsin, Shiue Chyng, Lin Jiang Jen, Farn Shiou Shiow, Lo Pro Long, Chang Kang Wei, Luo Tsai Yueh, Chen Jenn Tzong, Duh Ting Shien, and Chen Dow Che

Subjects
Drug pharmacokinetics, Positron, Neuroimaging, medicine.diagnostic_test, In vivo, business.industry, Positron emission tomography, Medicine, General Medicine, business, Nuclear medicine, Structural imaging
Abstract

Positron Emission Tomography (PET) is a multidisciplinary science. In contrast to CT and MRI, which are structural imaging techniques, PET is based on the characteristics of positron emitterslabeled radiopharmaceuticals and has been applied to study human pathophysiology in vivo non-invasively.

Published
2019

24. Evaluation of the Biological Behavior of a Gold Nanocore-Encapsulated Human Serum Albumin Nanoparticle (Au@HSANP) in a CT-26 Tumor/Ascites Mouse Model after Intravenous/Intraperitoneal Administration

Author

Chen, Chao-Cheng, primary, Li, Jia-Je, additional, Guo, Nai-Hua, additional, Chang, Deng-Yuan, additional, Wang, Chung-Yih, additional, Chen, Jenn-Tzong, additional, Lin, Wuu-Jyh, additional, Chi, Kwan-Hwa, additional, Lee, Yi-Jang, additional, Liu, Ren-Shyan, additional, Chen, Chuan-Lin, additional, and Wang, Hsin-Ell, additional

Published
2019
Full Text
View/download PDF

27. Molecular imaging, pharmacokinetics, and dosimetry of [sup.111]In-AMBA in human prostate tumor-bearing mice

Author

Ho, Chung-Li, Liu, I-Hsiang, Wu, Yu-Hsien, Chen, Liang-Cheng, Chen, Chun-Lin, Lee, Wan-Chi, Chuang, Cheng-Hui, Lee, Te-Wei, Lin, Wuu-Jyh, Shen, Lie-Hang, and Chang, Chih-Hsien

Subjects
Tumors -- Physiological aspects -- Development and progression, Prostate cancer -- Physiological aspects -- Development and progression, Pharmacokinetics -- Research, Radiation -- Measurement, Diagnostic imaging -- Methods, Biotechnology industry, High technology industry
Abstract

Molecular imaging with promise of personalized medicine can provide patient-specific information noninvasively, thus enabling treatment to be tailored to the specific biological attributes of both the disease and the patient. This study was to investigate the characterization of DO3A-C[H.sub.2]CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-N[H.sub.2] (AMBA) in vitro, MicroSPECT/CT imaging, and biological activities of [sup.111]In-AMBA in PC-3 prostate tumor-bearing SCID mice. The uptake of [sup.111]In-AMBA reached highest with 3.87 ± 0.65% ID/g at 8h. MicroSPECT/CT imaging studies suggested that the uptake of [sup.111]In-AMBA was clearly visualized between 8 and 48 h postinjection. The distribution half-life ([t.sub.1/2a]) and the elimination half-life ([t.sub.1/2])of [sup.111]In-AMBA in mice were 1.53 h and 30.7 h, respectively. The [C.sub.m]ax and AUC of [sup.111]In-AMBA were 7.57% ID/g and 66.39 h* % ID/g, respectively. The effective dose appeared to be 0.11 mSv/[MBq.sup.-1]. We demonstrated a good uptake of [sup.111]In-AMBA in the GRPR-overexpressed PC-3 tumor-bearing SCID mice. [sup.111]In-AMBA is a safe, potential molecular image-guided diagnostic agent for human GRPR-positive tumors, ranging from simple and straightforward biodistribution studies to improve the efficacy of combined modality anti- cancer therapy., 1. Introduction Prostate cancer is estimated to rank first in number of cancer cases and second in number of deaths due to cancer among men in the Western world [1]. [...]

Published
2011
Full Text
View/download PDF

28. Development of single vial kits for preparation of 68Ga‐labelled hexavalent lactoside for PET imaging of asialoglycoprotein receptor.

Author

Yu, Hung‐Man, Chan, Chen‐Hsin, Chen, Jyun‐Hong, Chien, Chuan‐Yi, Wang, Ping‐Yen, Juan, Wei‐Cheng, Yang, Chun‐Hung, Hsia, Hao‐Ting, Wang, Mei‐Hui, and Lin, Wuu‐Jyh

Subjects
ASIALOGLYCOPROTEIN receptors, RADIOLABELING, RADIOCHEMISTRY, LIVER, POSITRON emission tomography
Abstract

The aim of this study was to formulate and evaluate the freeze‐dried kit of NOTA‐hexavalent lactoside (NOTA‐HL) for the preparation of 68Ga‐labeled glycoligand for PET imaging of the asialoglycoprotein receptor (ASGPR). 68GaCl3 was obtained from a commercial 68Ge/68Ga generator. Single‐vial kits of HL were formulated. Optimization of radiolabeling with 68Ga, various evaluations of NOTA‐HL kits, and in vitro stability study of 68Ga‐HL were carried out. PET/CT imaging of normal mice injected with 68Ga‐NOTA‐HL was performed. NOTA‐HL kit was successfully formulated. High radiochemical yields (>95%) were obtained by 68Ga radiolabeling. The NOTA‐HL kits were stable for at least 12 months, and 68Ga‐NOTA‐HL exhibited good in vitro stability. PET studies in normal mice revealed high specific accumulation of activity in the liver. The NOTA‐HL kit was developed for fast 68Ga labeling. 68Ga‐NOTA‐HL showed high specific uptake in liver. The availability of ready‐to‐use NOTA‐HL kits combined with 68Ge/68Ga generators would provide an efficient approach for PET imaging of ASGPR. The freeze‐dried kit of NOTA‐hexavalent lactoside (NOTA‐HL) was formulated for the preparation of 68Ga‐NOTA‐HL for PET imaging of the asialoglycoprotein receptor (ASGPR). High radiochemical yields (>95%) were obtained. The NOTA‐HL kits were stable for at least 12 months, and 68Ga‐NOTA‐HL exhibited good in vitro stability. PET studies in normal mice revealed high specific accumulation of activity in the liver. The availability of ready‐to‐use NOTA‐HL kits combined with 68Ge/68Ga generators would provide an efficient approach for PET imaging of ASGPR. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

34. Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3′-Deoxy-3′-[18F]-fluorothymidine PET

Author

Chan, Pei-Chia, primary, Wu, Chun-Yi, additional, Chou, Lin-Shan, additional, Ho, Chung-Hsien, additional, Chang, Chi-Wei, additional, Chiou, Shih-Hwa, additional, Lin, Wuu-Jyh, additional, Chen, Fu-Du, additional, Chang, C. Allen, additional, Hwang, Jeng-Jong, additional, Liu, Ren-Shyan, additional, and Wang, Hsin-Ell, additional

Published
2014
Full Text
View/download PDF

48. Study of [18F]FLT and [123I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes

Author

Huang, Ho-Lien, primary, Chiang, Li-Wu, additional, Chen, Jia-Rong, additional, Yang, Wen K., additional, Jeng, Kee-Ching, additional, Chen, Jenn-Tzong, additional, Duh, Ting-Shien, additional, Lin, Wuu-Jyh, additional, Farn, Shiou-Shiow, additional, Chiang, Chi-Shiun, additional, Huang, Chia-Wen, additional, Lin, Kun-I, additional, and Yu, Chung-Shan, additional

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results