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Your search keyword '"Lin, Xiao-sheng"' showing total 12 results
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12 results on '"Lin, Xiao-sheng"'

6. Reduced NM23 Protein Level Correlates With Worse Clinicopathologic Features in Colorectal Cancers

Author

Yang, Tian, Chen, Bo-Zan, Li, Dan-Feng, Wang, Huai-Ming, Lin, Xiao-Sheng, Wei, Hong-Fa, and Zeng, Yong-Ming

Subjects
Survival Rate, Lymphatic Metastasis, Humans, NM23 Nucleoside Diphosphate Kinases, Neoplasm Grading, Colorectal Neoplasms, Systematic Review and Meta-Analysis, Research Article, Neoplasm Staging
Abstract

The clinical value of a prominent metastasis suppressor, nonmetastatic protein 23 (NM23), remains controversial. In this study, we examined the correlation between NM23 protein levels and the clinicopathologic features of colorectal cancers (CRC), and assessed the overall prognostic value of NM23 for CRC. Embase, PubMed, Web of Science, and other scientific literature databases were exhaustively searched to identify relevant studies published prior to June 31, 2015. The methodological qualities of selected studies were scored based on the critical appraisal skills program (CASP) criteria, as independently assessed by 2 reviewers. NM23 protein levels in tumor tissues of CRC patients were examined in relation to Dukes stage, differentiation grade, T-stage, lymph node metastasis status, and overall survival (OS). STATA software version 12.0 (Stata Corp, College Station, TX) was used for statistical analysis of data pooled from selected studies. Nineteen cohort studies met the inclusion criteria for present study and contained a combined total of 2148 study subjects. Pooled odd ratios (ORs) for NM23 expression revealed that reduced NM23 protein levels in CRC tumor tissues correlated with Dukes stage C and D (OR = 1.89, 95% CI: 1.06–3.39, P = 0.032), poor differentiation grades (OR = 1.41, 95% CI: 1.03–1.94, P = 0.032), and positive lymph node metastasis status (OR = 3.21, 95% CI: 1.95–5.29, P

Published
2016

9. Updated incidence rates and risk factors of esophageal cancer in Nan'ao Island, a coastal high-risk area in southern China

Author

Tan, Hua-Zhen, primary, Lin, Wen-Jie, additional, Huang, Jin-Qu, additional, Dai, Meng, additional, Fu, Jian-Hua, additional, Huang, Qing-Hua, additional, Chen, Wei-Min, additional, Xu, Yi-Long, additional, Ye, Ting-Ting, additional, Lin, Ze-Ying, additional, Lin, Xiao-Sheng, additional, Cai, Jian-Xiong, additional, Dong, Yu-Hao, additional, Luo, Hai-Yu, additional, Chen, Shuo-Hang, additional, Huang, Yong-Lin, additional, Yang, Jing, additional, Lin, An-Xin, additional, Yuan, Xin-Qiang, additional, Chen, Sheng-Ying, additional, Wang, Kai-Song, additional, Zhuang, Cai-Yu, additional, Wang, Si-Chao, additional, Lin, Li-Ling, additional, Zou, Xin-Fei, additional, Song, Zhan-Hui, additional, Fang, Xiao-Hong, additional, Chen, Tong, additional, Zhang, Ju-Hong, additional, Li, Kai-Qin, additional, Chen, Li-Hang, additional, Lin, Xiao-Peng, additional, Lin, Jing-Mei, additional, Lin, Jia-Na, additional, Lin, Pei-Le, additional, Chen, Jie-Ting, additional, Lin, Kai-Miao, additional, Hong, Xiao-Chun, additional, Wang, Li-Dong, additional, Xu, Li-Yan, additional, Li, En-Min, additional, and Zhang, Jian-Jun, additional

Published
2016
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11. UPF1: a potential biomarker in human cancers.

Author

Chen BL, Wang HM, Lin XS, and Zeng YM

Subjects
Alternative Splicing, Animals, Biomarkers, Tumor genetics, Carcinogenesis, Disease Progression, Down-Regulation, Epigenesis, Genetic, Genomics, Humans, Mice, Neoplasms genetics, Nonsense Mediated mRNA Decay, Prognosis, RNA, Messenger metabolism, Signal Transduction, Biomarkers, Tumor metabolism, Neoplasms metabolism, RNA Helicases biosynthesis, RNA Helicases genetics, Trans-Activators biosynthesis, Trans-Activators genetics
Abstract

Recently, Up-frameshift protein 1 (UPF1) is reported to be downregulated in various cancers and its low expression is closely correlated with poor prognosis. UPF1 is well known as a master regulator of nonsense-mediated mRNA decay (NMD), which serves as a highly conserved mRNA surveillance process protecting cells from aberrant toxic transcripts. Due to dysfunction of UPF1, NMD fails to proceed, which contributes to tumor initiation and progression. This review shows a brief summary of the aberrant expression, functional roles and molecular mechanisms of UPF1 during tumorigenesis. Increasing evidence has indicated that UPF1 could serve as a potential biomarker for cancer diagnosis and treatment for future clinical applications in cancer., (© 2021 The Author(s). Published by BRI.)

Published
2021
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12. Updated incidence rates and risk factors of esophageal cancer in Nan'ao Island, a coastal high-risk area in southern China.

Author

Tan HZ, Lin WJ, Huang JQ, Dai M, Fu JH, Huang QH, Chen WM, Xu YL, Ye TT, Lin ZY, Lin XS, Cai JX, Dong YH, Luo HY, Chen SH, Huang YL, Yang J, Lin AX, Yuan XQ, Chen SY, Wang KS, Zhuang CY, Wang SC, Lin LL, Zou XF, Song ZH, Fang XH, Chen T, Zhang JH, Li KQ, Chen LH, Lin XP, Lin JM, Lin JN, Lin PL, Chen JT, Lin KM, Hong XC, Wang LD, Xu LY, Li EM, and Zhang JJ

Subjects
Adult, Age Distribution, Aged, Aged, 80 and over, Case-Control Studies, China epidemiology, Drinking Water, Female, Food Preservation, Fruit, Humans, Incidence, Male, Middle Aged, Odds Ratio, Protective Factors, Risk Factors, Sex Distribution, Vegetables, Adenocarcinoma epidemiology, Alcohol Drinking epidemiology, Carcinoma, Squamous Cell epidemiology, Diet statistics & numerical data, Esophageal Neoplasms epidemiology
Abstract

Esophageal cancer (EC) is one of the most common cancers in China. The purpose of this study was to investigate the updated incidence rates and risk factors of EC in Nan'ao Island, where the EC incidence rate was chronically the highest in southern China. To calculate the annual incidence rate, data on 338 EC cases from Nan'ao Cancer Registry system diagnosed during 2005-2011 were collected. A case-control study was conducted to explore the EC risk factors. One hundred twenty-five alive EC patients diagnosed during 2005-2011 and 250 controls were enrolled into the case-control study. A pre-test questionnaire on demography, dietary factors, drinking water treatment, and behavioral factors was applied to collect information of all participants. The average EC incidence rates during 2005-2011 were 66.09/105, 94.62/105, 36.83/105 for both genders, males and females, respectively, in Nan'ao Island. The EC incidence rate in males was 2.40- to 4.55-fold higher than that in females in the period from 2006 to 2011 (P < 0.05). Considering the onset age, males tend to be much younger than females and reached peak incidence rate at a younger age (P < 0.05). Drinking water treatment by filter (odds ratio [OR] = 0.28, 95% confidence interval [95% CI] = 0.13-0.58) and fruit consumption (OR = 0.55, 95% CI = 0.32-0.94) reduced the risk for EC. On the contrary, the pickled vegetables consumption (OR = 2.64, 95% CI = 1.46-4.76) and liquor drinking (OR = 2.32, 95% CI = 1.21-4.44) increased the risk for EC. These results may be of importance for future research on EC etiology and prevention strategies., (© 2016 International Society for Diseases of the Esophagus.)

Published
2017
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