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Current student development theories are mostly grounded in the experiences of domestic students in North America. The increasing portion of the international students in the post-secondary student population has created a glaring gap for a unique theory of international student development. A unique theory for international student development, with a focus on their intercultural learning experiences, will serve as a necessary theoretical foundation for international student programmes and services that are offered in most hosting universities of international students as an overlay on top of general student services. Through a critical review of existing literature, this paper endeavours to develop a coherent theory of international student development that endorses a critical and post-structural approach to the key issues of intercultural identity, intercultural competence and intercultural adaptation for international students. [ABSTRACT FROM AUTHOR]

Forkhead box O3a (FOXO3a)-mediated mitochondrial dysfunction plays a pivotal effect on cardiac hypertrophy and heart failure (HF). However, the role and underlying mechanisms of FOXO3a, regulated by breviscapine (BRE), on mitochondrial function in HF therapy remain unclear. This study reveals that BRE-induced nuclear translocation of FOXO3a facilitates mitofusin-1 (MFN-1)-dependent mitochondrial fusion in cardiac hypertrophy and HF. BRE effectively promotes cardiac function and ameliorates cardiac remodeling in pressure overload-induced mice. In addition, BRE mitigates phenylephrine (PE)-induced cardiac hypertrophy in cardiomyocytes and fibrosis remodeling in fibroblasts by inhibiting ROS production and promoting mitochondrial fusion, respectively. Transcriptomics analysis underscores the close association between the FOXO pathway and the protective effect of BRE against HF, with FOXO3a emerging as a potential target of BRE. BRE potentiates the nuclear translocation of FOXO3a by attenuating its phosphorylation, other than its acetylation in cardiac hypertrophy. Mechanistically, over-expression of FOXO3a significantly inhibits cardiac hypertrophy and mitochondrial injury by promoting MFN-1-mediated mitochondrial fusion. Furthermore, BRE demonstrates its ability to substantially curb cardiac hypertrophy, reduce mitochondrial ROS production, and enhance MFN-1-mediated mitochondrial fusion through a FOXO3a-dependent mechanism. In conclusion, nuclear FOXO3a translocation induced by BRE presents a successful therapeutic avenue for addressing cardiac hypertrophy and HF through promoting MFN-1-dependent mitochondrial fusion. [Display omitted] • Breviscapine protects against pathological cardiac hypertrophy and heart failure. • The FOXO3a/MFN-1 signaling is partly involved in the mitochondrial dysfunction in cardiac hypertrophy. • Nuclear FOXO3a translocation by breviscapine promotes MFN-1 mediated mitochondrial fusion. [ABSTRACT FROM AUTHOR]

During the Early-Middle Ordovician, the Upper Yangtze Platform experienced extensive development of a distinctive set of mixed siliciclastic-carbonate deposits known as the Meitan Formation. To conduct a comprehensive study of the relationship between mixed sedimentation and sea-level changes, the Hailong section, situated at the southwest margin of the Upper Yangtze Platform in SW China, was selected as the study area due to its typical mixed sedimentary sequence. This section was effectively compared with sections in other regions. Clustering analysis of the point-count groups from the Honghuayuan and Meitan Formations revealed nine microfacies that developed during this period. Such a diverse range of microfacies provides the evidence of frequent sea-level changes in the Yangtze Platform throughout this period. Specifically, two sea-level rises were identified during the early TS.2b and early TS.3b, with the early TS.2b event occurring globally. Furthermore, four sea-level falls were observed in the late TS.2b, TS.2c, TS.3a, and late TS.3b periods. The late TS.2b sea-level fall was globally significant. From TS.2c onwards, distinct variations in sea-level changes among the Yangtze Platform, North China, Baltoscandia, Australia, and North America emerged due to alterations in the paleogeographic pattern. By comparing the sea-level curves in the Upper Yangtze Platform with the diversity curves of chitinozoans, acritarchs, and brachiopods, it became evident that environmental changes played a crucial role in the Great Ordovician Biodiversification Event (GOBE), especially during the Floian. The rising sea level and increased detrital materials fostered the development of diverse habitats, prompting organisms to adapt to varying environments. In general, rising sea levels favored increased brachiopod diversity, while falling sea levels favored enhanced planktonic diversity among chitinous and acritarch species. By shedding new light on the relationship between Ordovician sea-level changes and biodiversification in the Yangtze region, this study offers a fresh perspective on the subject from the microfacies analysis. [ABSTRACT FROM AUTHOR]

Fractures are crucial as main natural gas transport channels in tight sandstone reservoirs. In order to reveal the correlation between the combination of fractures in Block Keshen 2 and sandstone, we have collected drilling core data, logging curve data, imaging logging data, and rock thin-section data from the Bashjiqike Formation in the Keshen 2 area, and by classifying and statistically analyzing the different influencing factors of fractures, we have established a correlation between the development of fractures and sandstone thickness, lithology, and sedimentary microfacies. The results reveal the following: (1) frequent vertical superposition and lateral migration occur in the sedimentary sand bodies of the Bashijiqike Formation. Three types of patterns of sand bodies have been identified according to the changes in microfacies. Type I refers to the patterns of sand bodies developed in main subaqueous distributary channels, type II refers to the patterns of sand bodies developed in secondary subaqueous distributary channels or mouth bars, and type III refers to the patterns of sand bodies developed in isolated subaqueous distributary channels; (2) three types of fracture patterns have been described in the various sand bodies of the Bashijiqike Formation in the Keshen area, including high–medium-angle branch-like fracture patterns, medium-angle reticular fracture patterns, and isolated fractures; (3) the coupling relationship among sedimentary microfacies, sand body patterns, and fracture patterns has been established. The high–medium-angle branch-like fracture patterns mainly develop in the main underwater distributary channel and the type I sand body patterns. The medium-angle reticular fracture patterns mainly develop in the secondary underwater distributary channel and mouth bars, as well as the type II sand body patterns. Isolated fractures can occur in all sedimentary microfacies but are sporadically distributed within the three types of sand body patterns. The research results present the regularity of fracture development in fractured reservoirs, which can be applied to oil and gas fields with the same background, providing certain geological evidence for exploration and development. [ABSTRACT FROM AUTHOR]

Reidentifying an occluded person across nonoverlapping cameras is still a challenging task. In this work, we propose a novel pose-guided part-based adaptive pyramid neural network for occluded person reidentification. Firstly, to alleviate the impact of occlusion, we utilize pose landmarks to generate pose-guided attention maps. The attention maps will help the model focus on the nonoccluded regions. Secondly, we use pyramid pooling to extract multiscale features in order to address the scale variation problem. The generated pyramid features are then multiplied by attention maps to achieve pose-guided adaptive pyramid features. Thirdly, we propose a pose-guided body part partition scheme to deal with the alignment problem. Accordingly, the adaptive pyramid features are divided into partitions and fed into individual fully connected layers. In the end, all the part-based matching scores are fused with a weighted sum rule for person reidentification. The effectiveness of our method is clearly validated by the experimental results on two popular occluded and holistic datasets, i.e., Occluded-DukeMTMC and the Market-1501. [ABSTRACT FROM AUTHOR]

Mammals' aging is correlated with the accumulation of somatic heteroplasmic mitochondrial DNA (mtDNA) mutations. Whether and how aging accumulated mtDNA mutations modulate fertility remains unknown. Here, we analyzed oocyte quality of young (≤30 years old) and elder (≥38 years old) female patients and show the elder group had lower blastocyst formation rate and more mtDNA point mutations in oocytes. To test the causal role of mtDNA point mutations on infertility, we used polymerase gamma (POLG) mutator mice. We show that mtDNA mutation levels inversely correlate with fertility, interestingly mainly affecting not male but female fertility. mtDNA mutations decrease female mice's fertility by reducing ovarian primordial and mature follicles. Mechanistically, accumulation of mtDNA mutations decreases fertility by impairing oocyte's NADH/NAD+ redox state, which could be rescued by nicotinamide mononucleotide treatment. For the first time, we answer the fundamental question of the causal effect of age‐accumulated mtDNA mutations on fertility and its sex dependence, and show its distinct metabolic controlling mechanism. [ABSTRACT FROM AUTHOR]

1. While it is clear that land‐use change significantly impacts the taxonomic dimension of soil biodiversity, how the functional dimension responds to land‐use change is less well understood. 2. This study examined how the transformation of primary forests into rubber tree monocultures impacts individual termite species and how this change is reflected in termite taxonomic and functional α‐diversity (within site) and β‐diversity (among sites). 3. Overall, individual species responded strongly to land‐use change, whereby only 11 of the 27 species found were able to tolerate both habitats. These differences caused a 27% reduction in termite taxonomic richness and reduced taxonomic β‐diversity in rubber plantations compared with primary forests. The study also revealed that the forest conversion led to a shift in some termite species with smaller body size, shorter legs and smaller mandibular traits. Primary forests exhibited higher functional richness and functional β‐diversity of termite species, indicating that functional traits of termite species in rubber plantations are more evenly distributed. 4. The present study suggests that forest conversion does not merely decrease taxonomic diversity of termites, but also exerts functional trait filtering within some termite species. The results affirm the need for biodiversity assessments that combine taxonomic and functional indicators when monitoring the impact of land‐use change. [ABSTRACT FROM AUTHOR]

Dolomitization of reservoir reefs is common at platform margins of the Changxing Formation in northeastern Sichuan Basin, southwestern China. We carried out a research on these variously dolomitized reef microfacies based on sedimentology and petrology theories and geochemical technologies. The results show that the reservoir reefs at the platform margins of the formation can be divided into several microfacies: reef flats/caps, reef cores, reef bases, etc. The reef flats contain mostly crystal grain dolomites, the reef cores are made up of largely (calcite) reef dolomites, and the reef bases are generally dolomite limestone/calcite dolomites. Samples taken from different microfacies of the reefs were measured and showed a relatively high content of Fe and Sr and low content of Mn, with Mn/Sr ranging between 0.057 and 2. Samples from the east flank of the Kaijiang–Liangping trough and the Exi–Chengkou trough have higher Fe and Mn contents and Mn/Sr ratios than those from the west flank of the Kaijiang–Liangping trough. Dolomites in reef flats have the highest Fe and Mn contents and Mn/Sr ratios, followed by dolomites from reef cores, and those from reef bases are found to have the lowest Fe and Mn contents. Isotopic analyses of the samples from different microfacies of the reefs indicate more negative δ13C and δ18O values than that of limestone in seawater during the Changxing deposition period. The δ18O values were increasingly more negative in the order of reef flat–reef core–reef base. Based on the study, we propose that the dolomitization processes the reefs at different platform margins experienced have the following features: (1) Meteoric water affected dolomites at the eastern flank of the Kaijiang–Liangping and Exi–Chengkou troughs more than those of the west flank of the Kaijiang–liangping trough. From the microfacies perspective, the influence of meteoric water decreases from reef flats to cores and then to bases. Apart from meteoric water, the dolomitization was also under control of seawater at the same period. (2) Meteoric water dolomitization is closely linked to sedimentary microfacies. Reef flats and cores with better porosity and permeability are more dolomitized than reef bases containing mostly micrite with bioclastics. (3) Dolomitization processes driven both by early mixing of water and "juiced" marine fluids during the shallow burial and compaction stage were all completed before the first stage of hydrocarbon emplacement. Hydrothermal dolomitization occurred locally and its contribution to the whole reef dolomitization of the formation may be negligible. [ABSTRACT FROM AUTHOR]

In the past decade, there has been a rapid increase in the number of Chinese international students studying overseas. There has also been a corresponding increase in the media stories about their cross-cultural difficulties. Reported in this study is a reflective inquiry into my work as an international student advisor with a large number of Chinese students in a top Canadian university. Through five composite stories, I hope to present a few areas of challenges Chinese students experience and reflect on how advisors can better support them from the intercultural perspective. I also hope to engage other advisors through this study in exploring ways to contribute to the field of international education as frontline practitioners. [ABSTRACT FROM AUTHOR]

This study focuses on the analysis of the sedimentary facies of the Middle–Late Permian, including the Qixia, Maokou, Wujiaoping/Longtan, and Changxing/Dalong Formations, in the Sichuan Basin, southwest China. Integrating drilling data and field outcrop data, various sedimentary facies indicators were employed to define eight sedimentary facies types in the Sichuan Basin during the Middle–Late Permian, namely, mixed tidal flat, tidal flat, restricted platform, open platform, platform margin, slope, basin, and volcanic facies. Detailed facies analysis was conducted on selected well logs, and sedimentary facies distribution maps were compiled for different time intervals, establishing depositional models. During the Qixia to Maokou stages, an extensive open platform was developed in the Sichuan Basin, accompanied by shallow intra-platform shoals. Towards the west along the Dayi–Ya'an line, platform margins were developed, followed by slope facies and basin facies in a northwest direction. During the Changxing stage, the Kaijiang–Liangping fault block subsided, forming the "Kaijiang-Liangping" paleochannel, which controls reef–shoal deposition in the region. This study provides comprehensive insights into the sedimentary facies characteristics and depositional environments of the Middle–Late Permian in the Sichuan Basin, contributing to the understanding of the regional sedimentary history and geological evolution. [ABSTRACT FROM AUTHOR]

Discussed in this article are the different governance models in international student services in Canadian and Chinese universities. Informing this study were 39 international student service providers from 38 top Chinese universities while interacting with their Canadian counterparts in a professional development program in Canada. The derived comparative data serve to show that a reactive decentralized model is used in international student services in Canada, while practiced in China is a more centralized proactive model. Although both models are rooted in their own social and cultural contexts, mutual learning is possible to some extent. The article ends with some discussion about possible ways Canadian universities can borrow from the Chinese system. [ABSTRACT FROM AUTHOR]

Background: Systemic lupus erythematosus (SLE) is a complex heterogeneous systemic autoimmune disease. Previous studies have shown that SLE may be related to diffuse large B cell lymphoma (DLBCL), but the mechanism of their relationship is still unclear. The present study aimed to explore the common genetic molecular mechanisms, core shared genes, and miRNAs between SLE and DLBCL as well as to investigate the diagnostic markers of DLBCL. Methods: The SLE and DLBCL microarray data were downloaded from the comprehensive Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was used to identify co-expression modules. Four core shared genes were screened out by various algorithms and validated in other cohorts. Finally, we constructed a common core gene-miRNA network using the human microRNA disease database (HMDD) and TarBase. Results: Using WGCNA, four modules were identified as important modules for SLE and DLBCL. Enrichment analysis of the shared genes showed that the highly activated NF-κB pathway was a common feature of the pathophysiology. Four core shared genes, namely, PSMB10, PSMB4, TAF10, and NFΚBIA, were screened out. These core shared genes were significantly upregulated in both diseases, and they may be potential diagnostic markers of DLBCL. The core gene-miRNA network showed that miR-155–5p, regulating the shared NF-κB pathway, may play an important role in the susceptibility of SLE patients to DLBCL. Conclusion: The present study revealed that NF-κB pathway in SLE may be a crucial susceptible factor for DLBCL. In addition, we identified PSMB10, PSMB4, TAF10, NFΚBIA and miR-155 involved in the common pathogenesis as potential biomarkers and therapeutic targets for DLBCL. [ABSTRACT FROM AUTHOR]

Ethnopharmacological relevance Ainsliaea fragrans Champ. (A. fragrans) is used to treat infection of the lower genital tract in gynecology, such as cervicitis and pelvic inflammatory disease. This study analyzed the therapeutic efficiency of A. fragrans on cervicitis and the inhibition mechanism of AF-p2 in MALP-2-stimulated RAW264.7 cells. Materials and methods The anti- Ureaplasma urealyticum (Uu) activity of A. fragrans and AF-p2 were determined by antimicrobial susceptibility testing. The activity of A. fragrans extracts (AFext) was evaluated in female BALB/c mice with cervicitis induced by Uu. Furthermore, the therapeutic mechanism of AFext and AF-p2 on myeloid differentiation factor 88 (MyD88) pathway were studied in macrophage activating lipopeptide-2 (MALP-2) irritated RAW264.7 cells. Results AFext could suppress the proliferation of Uu in vitro , including the azithromycin resistant strains. Meanwhile, AFext prevented cervicitis caused by Uu infection in BALB/c mice. Moreover, both AFext and AF-p2 could significantly suppress the nitric oxide (NO) production as well as other proinflammatory cytokines (IL-1β,IL-6,TNF-α) in MALP-2 stimulated RAW264.7 cells. Moreover, AF-p2 also down-regulated iNOS, p65, Iκ-Bα, MyD88 and cyclooxygenase-2 (COX-2) levels in RAW264.7 cells. Conclusion This study indicated that AFext had a therapeutic effect in cervicitis induced by Uu infection. Furthermore, the lead compound AF-p2 showed an anti-infectious effect in MALP-2 irritated RAW264.7 cells through downregulating MyD88-NF-κB signaling pathway. Image 1 [ABSTRACT FROM AUTHOR]

Taking the Zhongqiu 1 Gas Field in the Tarim Basin as an example, the heterogeneity of large-scale mono-block gas fields and their primary controlling factors have been analyzed. Based on drilling core data, well log data, scanning electron microscopy, thin-section analysis, and mercury injection experiments, combining sedimentological interpretation, research on the reservoir characteristics and variability was carried out. The results showed that: (1) The lithologic characteristics showed obvious variations among wells in the Zhongqiu 1 gas field. Specifically, the main lithology developed in the Zhongqiu 1 well is feldspar lithic sandstone, while the remaining wells predominantly consist of lithic feldspar sandstone. These differences in rock composition maturity reveal that a higher proportion of stable mineral components leads to poorer reservoir properties; (2) the main factors controlling oil and gas productivity include the variations in petrology, mineralogy, and diagenetic process characteristics. The high content of unstable mineral components and constructive diagenesis could increase reservoir porosity together. (3) Sedimentary facies of the Bashijiqike Formation in the Zhongqiu 1 Gas Field played a dominant role in the reservoir distribution. The division of sedimentary facies zones reflects variations in material composition and grain size, serving as the main material basis for reservoirs. Differences in mineral composition reflect the sedimentary environment of the reservoir. Additionally, mineral composition indicates the relationship between diagenetic processes and reservoir evolution. The high feldspar content in well ZQ1 corresponded to relatively favorable reservoir properties. The dominant feldspar type was plagioclase, suggesting that early-stage chemical weathering had undergone significant alteration. The above conclusions provided a microscopic perspective to explain the differences in oil and gas production capacity of large delta-front gas fields, serving as a geological basis for the exploration and exploitation of similar fields. [ABSTRACT FROM AUTHOR]

The Ordovician-Silurian (O S) transition witnessed dramatic tectonic, climatic, marine, and biological coevolution, during which organic-rich black shale was widely deposited and is considered an important source rock. However, the potential links between the differential enrichment pattern of organic matter and climate fluctuations and paleoenvironmental evolution during this period are still unclear. In this paper, the Late Ordovician-early Silurian black shale in a JieLong (JL) section in South China was identified by graptolitic fossils, total organic carbon (TOC) content, X-ray diffraction (XRD), scanning electron microscopy (SEM) and geochemical analysis. The results show that the provenances of sedimentary rocks are all granodiorite-like. According to the variations in the TOC content and geochemical indicators, four layers are delineated. Under warm and humid climatic conditions, sea level rise and unstable seasonal upwelling led to Unit 1 organic matter enrichment controlled by high primary productivity, anoxic conditions and effective smectite production. Unit 2 organic matter burial was controlled by cold, arid and oxic environmental conditions, but primary productivity was still relatively high. After the end of the glacial period, warm and humid climatic conditions and rapid transgression were the main factors affecting the burial of organic matter in Unit 3. Under hot and humid climate conditions, higher terrigenous detrital inputs and unfavourable preservation environments, the dilution of organic matter in Unit 4 was accelerated. The corrected chemical index of alteration (CIA corr) values show that the study area experienced a climate change of alternating cold and warm conditions in response to the climate fluctuation during the glacial-interglacial period. The CIA corr value is negatively correlated with the TOC content, while the generation of available clay minerals (smectite) in warm and humid climates is usually consistent with the enhanced burial flux of organic matter, supporting the important role of climate fluctuations in the accumulation of organic matter. Finally, a comparison of the data from the present study with geochemical data from different profiles in South China reveals the role of climatic fluctuations during the O S transition in controlling paleoenvironmental evolution and organic matter enrichment, while such a heterogeneous factor is usually associated with global or regional geological events. Our study highlights this differential enrichment mechanism as a combined response of multiple factors and provides important implications for glacial-interglacial organic matter enrichment mechanisms. • Rapid changes of weathering indices imply climatic fluctuations during the Late Ordovician-Early Silurian. • Four different patterns were established for organic matter accumulation across the O/S. • Climate fluctuations and the heterogeneity nature of ocean systems explain the regional variations of OM accumulation. [ABSTRACT FROM AUTHOR]

This study investigated, in detail, the characteristics of the Late Triassic fine-grained sediments in the third member of the Xujiahe Formation (Xu-3 Member), in the Western Sichuan Depression, and the paleoenvironmental evolution during their deposition through petrological interpretation, mineralogical composition characterization, and element geochemical analysis. According to the mineralogical composition, the Xu-3 Member can be divided into two petrological types, namely clayey fine-grained felsic sedimentary rocks and lime fine-grained felsic sedimentary rocks. The main mineral components are siliceous, clay, and carbonate minerals. Through the cluster analysis of major elements, all samples could be divided into two types with different major elemental characteristics. Trace elements exhibited distinct Sr depletion, relative enrichment of large ion lithophile elements, and high field strength elements. Two REE enrichment patterns were observed, which could be attributed to differences in the provenance area and tectonic background. The paleoclimate of the sedimentary area was warm and humid, but it was hotter and drier in the southern and central parts of the depression. The change trend of paleo-productivity was consistent with the paleoclimate. The waters in the sedimentary environment were mainly brackish water to saline water, with fresh water in the southern part of the depression. The paleo-redox conditions of the waters were mainly sub-oxidation to sub-reduction, but the southern part of the depression was more oxidative. The provenance area experienced a moderate degree of chemical weathering under a warm and humid paleoclimate, same as the depositional area. However, the depositional environments differed between the northern and south-central parts of the depression. [ABSTRACT FROM AUTHOR]

• We identified aberrantly activated and differentiated CD4+ and γδ T cells as the immunological mechanisms both in psoriasis and IBD, and IL17 and TNF signaling as the common pathogenesis. • We also found that hub shared genes, LCN2, CXCL1 and PI3, which are involved in psoriasis and IBD, are potential therapeutic targets. Psoriasis and inflammatory bowel disease (IBD) have a similar etiology, including abnormal activation of T cells. Differentially expressed genes (DEGs) analysis was used to search for shared genes. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis were then performed. Secondly, single-cell RNA analysis (scRNA-seq) and immune infiltration were employed to explore the immune imbalance of the diseases. By weighted gene co expression network analysis (WGCNA), we obtained hub shared genes. Furthermore, we analyzed the diagnostic performance and immune association with the hub genes. Finally, functional enrichment of miRNAs related to hub shared genes was carried out. Single-cell analysis showed a high proportion of T cells among infiltrated immune cells and immune infiltration showed CD4+ T and γδ T cells were significantly elevated in diseases. Hub shared genes, LCN2, CXCL1 and PI3 had excellent diagnostic properties and were positively correlated with neutrophils, CD4+ T and γδ T cells. IL17 and TNF signaling pathway were the common pathway. In conclusion, CD4+ and γδ T cells and hub shared genes may play a crucial part in common mechanism between psoriasis and IBD. Moreover, hub shared genes may be potential diagnostic markers. [ABSTRACT FROM AUTHOR]

Systemic Lupus Erythematosus (SLE) is an autoimmune disease with multi-organ involvement, and some studies have found that SLE has a reduced risk of breast cancer (BRCA). So, we tried to find prognostic genes for BRCA related to SLE by integrated analysis and machine learning. First, we downloaded 2 SLE datasets from Gene Expression Omnibus (GEO) and BRCA data from the Cancer Genome Atlas (TCGA). Subsequently, we performed differentially expressed genes (DEGs) and functional enrichment analysis by Metascape in SLE. Genes that were differentially expressed in both datasets were the validated DEGs. And after constructing PPI network, genes with nodes >30 were intersected with survival genes in BRCA to obtain candidate genes. Then, the candidate genes were validated by lasso regression in both training and validation sets to obtain prognostic genes. Afterwards, we investigated the diagnostic potential of prognostic genes for SLE and the predictive efficacy for BRCA prognosis. Moreover, GSEA analysis and immune infiltration were performed for SLE and BRCA. Finally, we constructed a prognostic gene-miRNAs network and did functional enrichment of the shared genes. DEGs for SLE were mainly enriched with neutrophil degranulation and IFN pathways. After the lasso model of BRCA was established, IRF7, IFI35 and EIF2AK2, were identified as prognostic genes for BRCA related to SLE and had good predictive ability for the prognosis of BRCA. Prognostic genes had excellent diagnostic potential for SLE, with IFI35 and EIF2AK2 positively associated with SLE activity and IRF7 positively associated with IFI35. GSEA showed that both SLE and BRCA were associated with ubiquitinated degradation. Immune infiltrates suggest that plasma cells, dendritic cells (DC), neutrophils and monocyte were elevated in SLE. DC, NK and CD8+ T cells were elevated in the BRCA low-risk group. Finally, 5 shared miRNAs were confirmed, which were mainly enriched in the IFN pathway. IRF7, IFI35 and EIF2AK2, were identified as prognostic genes for BRCA related to SLE. IFN pathway played an important role in the etiology of SLE and the prognosis of BRCA. [ABSTRACT FROM AUTHOR]