1. Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan.
- Author
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Lin, Yi-Tsung, Chuang, Chien, Chou, Sheng-Hua, Juan, Chih-Han, Yang, Tsuey-Ching, Kreiswirth, Barry N., and Chen, Liang
- Subjects
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KLEBSIELLA pneumoniae , *WHOLE genome sequencing , *SEQUENCE analysis , *BLOOD sampling , *PLASMIDS - Abstract
The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring blaOXA-48. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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