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4. Self-assembled poly(ε-caprolactone)-g-chondroitin sulfate copolymers as an intracellular doxorubicin delivery carrier against lung cancer cells.

Author

Lin YJ, Liu YS, Yeh HH, Cheng TL, and Wang LF

Subjects
Animals, Body Weight drug effects, Cell Line, Tumor, Cell Survival drug effects, Chondroitin Sulfates chemistry, Doxorubicin chemistry, Doxorubicin pharmacokinetics, Drug Carriers administration & dosage, Drug Carriers chemistry, Female, Lung Neoplasms metabolism, Lung Neoplasms pathology, Mice, Mice, Nude, Micelles, Microscopy, Confocal, Nanoparticles administration & dosage, Nanoparticles chemistry, Polyesters chemistry, Tissue Distribution, Xenograft Model Antitumor Assays, Chondroitin Sulfates administration & dosage, Doxorubicin administration & dosage, Lung Neoplasms drug therapy, Polyesters administration & dosage
Abstract

The aim of this study was to utilize self-assembled polycaprolactone (PCL)-grafted chondroitin sulfate (CS) as an anticancer drug carrier. We separately introduced double bonds to the hydrophobic PCL and the hydrophilic CS. The modified PCL was reacted with the modified CS through a radical reaction (CSMA-g-PCL). The copolymer without doxorubicin (DOX) was noncytotoxic in CRL-5802 and NCI-H358 cells at a concentration ranging from 5-1000 μg/mL and DOX-loaded CSMA-g-PCL (Micelle DOX) had the lowest inhibitory concentration of 50% cell growth values against the NCI-H358 cells among test samples. The cellular uptake of Micelle DOX into the cells was confirmed by flow cytometric data and confocal laser scanning microscopic images. The in vivo tumor-targeting efficacy of Micelle DOX was realized using an NCI-H358 xenograft nude mouse model. The mice administered with Micelle DOX showed suppressed growth of the NCI-H358 lung tumor compared with those administered with phosphate-buffered saline and free DOX.

Published
2012
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