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29 results on '"Lin, Yufu"'

1. Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer

Author

Sun Xun, Yuan Yitao, Li Suyao, Gan Lu, Xu Midie, Li Qingguo, Liu Mengling, Hu Keshu, Nan Ke, Zhang Jiayu, Dong Yu, Lin Yufu, Zhang Xiuping, Hou Pengcong, and Liu Tianshu

Subjects
colorectal cancer, lncRNA, PCAT6, metastasis, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Approximately 20% of colorectal cancer (CRC) patients are first diagnosed with metastatic colorectal cancer (mCRC) because they develop symptoms at an advanced stage. Despite advancements in treatment, patients with metastatic disease still experience inferior survival rates. Our objective is to investigate the association between long noncoding RNAs (lncRNAs) and prognosis and to explore their role in mCRC. In this study, we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas (TCGA) data, and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center. Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis. Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential use as a prognostic biomarker.

Published
2024
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4. Investigation of experimental observables in search of the chiral magnetic effect in heavy-ion collisions in the STAR experiment

Author

Choudhury, Subikash, Dong, Xin, Drachenberg, Jim, Dunlop, James, Esumi, ShinIchi, Feng, Yicheng, Finch, Evan, Hu, Yu, Jia, Jiangyong, Lauret, Jerome, Li, Wei, Liao, Jinfeng, Lin, Yufu, Lisa, Mike, Niida, Takafumi, Ray, Robert Lanny, Sergeeva, Masha, Shen, Diyu, Shi, Shuzhe, Sorensen, Paul, Tang, Aihong, Tribedy, Prithwish, Van Buren, Gene, Voloshin, Sergei, Wang, Fuqiang, Wang, Gang, Xu, Haojie, Xu, Zhiwan, Yao, Nanxi, and Zhao, Jie

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, chiral magnetic effect, anisotropic flow, heavy-ion collisions, quark-gluon plasma, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

The chiral magnetic effect (CME) is a novel transport phenomenon, arising from the interplay between quantum anomalies and strong magnetic fields in chiral systems. In high-energy nuclear collisions, the CME may survive the expansion of the quark-gluon plasma fireball and be detected in experiments. Over the past two decades, experimental searches for the CME have attracted extensive interest at the Relativistic Heavy Ion Collider (RHIC) and the Large Hadron Collider (LHC). The main goal of this study is to investigate three pertinent experimental approaches: the correlator, the R correlator, and the signed balance functions. We exploit simple Monte Carlo simulations and a realistic event generator (EBE-AVFD) to verify the equivalence of the core components among these methods and to ascertain their sensitivities to the CME signal and the background contributions for the isobar collisions at the RHIC.

Published
2022

5. Investigation of Experimental Observables in Search of the Chiral Magnetic Effect in Heavy-ion Collisions in the STAR experiment

Author

Choudhury, Subikash, Dong, Xin, Drachenberg, Jim, Dunlop, James, Esumi, ShinIchi, Feng, Yicheng, Finch, Evan, Hu, Yu, Jia, Jiangyong, Lauret, Jerome, Li, Wei, Liao, Jinfeng, Lin, Yufu, Lisa, Mike, Niida, Takafumi, Ray, Robert Lanny, Sergeeva, Masha, Shen, Diyu, Shi, Shuzhe, Sorensen, Paul, Tang, Aihong, Tribedy, Prithwish, Van Buren, Gene, Voloshin, Sergei, Wang, Fuqiang, Wang, Gang, Xu, Haojie, Xu, Zhiwan, Yao, Nanxi, and Zhao, Jie

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The chiral magnetic effect (CME) is a novel transport phenomenon, arising from the interplay between quantum anomalies and strong magnetic fields in chiral systems. In high-energy nuclear collisions, the CME may survive the expansion of the quark-gluon plasma fireball and be detected in experiments. Over the past decade, the experimental searches for the CME have aroused extensive interest at the Relativistic Heavy Ion Collider (RHIC) and the Large Hadron Collider (LHC). The main goal of this article is to investigate three pertinent experimental approaches: the $\gamma$ correlator, the $R$ correlator and the signed balance functions. We will exploit both simple Monte Carlo simulations and a realistic event generator (EBE-AVFD) to verify the equivalence in the kernel-component observables among these methods and to ascertain their sensitivities to the CME signal for the isobaric collisions at RHIC., Comment: 18 pages, 8 figures, 2 tables. Extended the discussion on R observable with the consideration of multiplicity fluctuation as used in practice

Published
2021
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6. Intermittency analysis of proton numbers in heavy-ion collisions at energies available at the BNL Relativistic Heavy Ion Collider

Author

Wu, Jin, Lin, Yufu, Li, Zhiming, Luo, Xiaofeng, and Wu, Yuanfang

Subjects
Nuclear Theory, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

Local density fluctuations near the QCD critical point has been suggested to exhibit a power-law behavior which can be probed by an intermittency analysis on scaled factorial moment (SFM) in relativistic heavy-ion collisions. The collision energy and centrality dependence of the second-order SFMs are systematically investigated in Au $+$ Au collisions at $\sqrt{s_{NN}}$ = 7.7, 11.5, 19.6, 27, 39, 62.4, and 200 GeV within the UrQMD model. We estimate the noncritical background in the measurement of intermittency and propose a cumulative variable method to effectively remove the background contributions. We further study the effect of particle detection efficiency by implementing the RHIC (STAR) experimental tracking efficiencies in the UrQMD events. A cell-by-cell method is proposed for experimental application of efficiency corrections on SFM. This work can provide a guidance of background subtraction and efficiency correction for the experimental measurement of intermittency in the search of the QCD critical point in heavy-ion collisions., Comment: Replaced with the published version

Published
2021
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7. Revisit the Chiral Magnetic Effect Expectation in Isobaric Collisions at the Relativistic Heavy Ion Collider

Author

Feng, Yicheng, Lin, Yufu, Zhao, Jie, and Wang, Fuqiang

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Isobaric $^{96}_{44}$Ru+$^{96}_{44}$Ru and $^{96}_{40}$Zr+$^{96}_{40}$Zr collisions at $\sqrt{s_{_{NN}}}=200$ GeV have been conducted at the Relativistic Heavy Ion Collider to circumvent the large flow-induced background in searching for the chiral magnetic effect (CME), predicted by the topological feature of quantum chromodynamics (QCD). Considering that the background in isobar collisions is approximately twice that in Au+Au collisions (due to the smaller multiplicity) and the CME signal is approximately half (due to the weaker magnetic field), we caution that the CME may not be detectable with the collected isobar data statistics, within $\sim$2$\sigma$ significance, if the axial charge per entropy density ($n_5/s$) and the QCD vacuum transition probability are system independent. This expectation is generally verified by the Anomalous-Viscous Fluid Dynamics (AVFD) model. While our estimate provides an approximate "experimental" baseline, theoretical uncertainties on the CME remain large., Comment: 6 pages, 1 multi-panel figure. v2: version after addressing referee comments. Corrected a factor 2 error in the quoted multiplicity; corrected a factor 2 error in the A-dependence exponent of the magnetic field; conclusions unchanged. v3: match published version

Published
2021
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8. Negative correlation between acetyl-CoA acyltransferase 2 and cetuximab resistance in colorectal cancer

Author

Yuan Yitao, Sun Xun, Liu Mengling, Li Suyao, Dong Yu, Hu Keshu, Zhang Jiayu, Xu Bei, Ma Sining, Jiang Hesheng, Hou Pengcong, Lin Yufu, Gan Lu, and Liu Tianshu

Subjects
colorectal cancer, cetuximab resistance, ACAA2, Kras mutation, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

The emergence of anti-EGFR therapy has revolutionized the treatment of colorectal cancer (CRC). However, not all patients respond consistently well. Therefore, it is imperative to conduct further research to identify the molecular mechanisms underlying the development of cetuximab resistance in CRC. In this study, we find that the expressions of many metabolism-related genes are downregulated in cetuximab-resistant CRC cells compared to their sensitive counterparts. Specifically, acetyl-CoA acyltransferase 2 (ACAA2), a key enzyme in fatty acid metabolism, is downregulated during the development of cetuximab resistance. Silencing of ACAA2 promotes proliferation and increases cetuximab tolerance in CRC cells, while overexpression of ACAA2 exerts the opposite effect. RTK-Kras signaling might contribute to the downregulation of ACAA2 expression in CRC, and ACAA2 predicts CRC prognosis in patients with Kras mutations. Collectively, our data suggest that modulating ACAA2 expression contributes to secondary cetuximab resistance in Kras wild-type CRC patients. ACAA2 expression is related to Kras mutation and demonstrates a prognostic role in CRC patients with Kras mutation. Thus, ACAA2 is a potential target in CRC with Kras mutation.

Published
2023
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9. Measurement of the charge separation along the magnetic field with Signed Balance Function in 200 GeV Au + Au collisions at STAR

Author

Lin, Yufu

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

Experimental searches for Chiral Magnetic Effect (CME) in heavy-ion collisions have been going on for a decade, and so far there is no conclusive evidence for its existence. Recently, the Signed Balance Function (SBF), based on the idea of examining the momentum ordering of charged pairs along the in- and out-of-plane directions, has been proposed as a probe of CME. In this approach, a pair of observables is invoked: one is $r_{\mathrm{rest}}$, the out-of-plane to in-plane ratio of $\Delta B$ measured in pair's rest frame, where $\Delta B$ is the difference between signed balance functions; The other is a double ratio, $R_{\mathrm{B}} = r_{\mathrm{rest}}/r_{\mathrm{lab}}$, where $r_{\mathrm{lab}}$ is a measurement similar to $r_{\mathrm{rest}}$ but measured in the laboratory frame. These two observables give opposite responses to the CME-driven charge separation compared to the background correlations arising from resonance flow and global spin alignment. Both $r_{\mathrm{rest}}$ and $R_{\mathrm{B}}$ being larger than unity can be regarded as a case in favor of the existence of CME. It is found experimentally that $r_{\mathrm{rest}}$, $r_{\mathrm{lab}}$ and $R_{\mathrm{B}}$ are larger than unity in Au+Au collisions at 200 GeV, and larger than realistic model calculations with no CME implemented. These findings are difficult to be explained by a background-only scenario., Comment: 4 pages, 6 figures, Proceedings of 28th International Conference on Ultrarelativistic Nucleus-Nucleus Collisions (Quark Matter 2019) A typo has been corrected

Published
2020
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10. Probing QCD critical fluctuations from intermittency analysis in relativistic heavy-ion collisions

Author

Wu, Jin, Lin, Yufu, Wu, Yuanfang, and Li, Zhiming

Subjects
Nuclear Theory, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

It is shown that intermittency, a self-similar correlation with respect to the size of the phase space volume, is sensitive to critical density fluctuations of baryon numbers in a system belonging to the three-dimensional (3D) Ising universality class. The relation between intermittency index and relative baryon density fluctuation is obtained. We thus suggest that measuring the intermittency in relativistic heavy-ion collisions could be used as a good probe of density fluctuations associated with the QCD critical phenomena. From recent preliminary results on neutron density fluctuations in central Au + Au collisions at $\sqrt{s_{NN}}$ = 7.7, 11.5, 19.6, 27, 39, 62.4 and 200 GeV at RHIC/STAR, the collision energy dependence of intermittency index is extracted and shows a non-monotonic behavior with a peak at around 20 - 27 GeV, indicating that the strength of intermittency becomes the largest in this energy region. The transport UrQMD model without implementing critical physics cannot describe the observed behavior., Comment: Replaced with the published version

Published
2019
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11. Poisson baseline of net-charge fluctuations in the relativistic heavy ion collisions

Author

Pan, Xue, Lin, Yufu, Chen, Lizhu, Xu, Mingmei, and Wu, Yuanfang

Subjects
Nuclear Theory, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

Taking doubly charged particles, positive-negative charge pair production and the effects of volume fluctuations into account, the Poisson baseline of the fluctuations of net-charge is studied. Within the Poisson baseline, the cumulants of net-charge are derived. Comparing to the Skellam baseline of net-charge, we infer that doubly charged particles broaden the distributions of net-charge, while positive-negative charge pairs narrow the distributions. Using the ratios of doubly charged particles and positive-negative charge pairs from neutral resonance decays to the total positive charges from THERMINATOR 2, the first four orders of moments and the corresponding moment products are calculated in the Poisson baseline for Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV at RHIC/STAR. We find that the standard deviation is mainly influenced by the resonance decay, while the third and fourth order moments and corresponding moment products are mainly modified and fit the data of RHIC/STAR much better after including the effects of volume fluctuations., Comment: 6 pages, 2 figures, to be published by Chinese Physics C

Published
2018
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12. Correlation functions of net-proton multiplicity distributions in Au + Au collisions at energies available at the BNL Relativistic Heavy Ion Collider from a multiphase transport model

Author

Lin, Yufu, Chen, Lizhu, and Li, Zhiming

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Experiment
Abstract

Fluctuations of conserved quantities are believed to be sensitive observables to probe the signature of the QCD phase transition and critical point. It was argued recently that measuring the genuine correlation functions (CFs) could provide cleaner information on possible nontrivial dynamics in heavy-ion collisions.With the AMPT (a multiphase transport) model, the centrality and energy dependence of various orders of CFs of net protons in Au + Au collisions at $\sqrt{s_\mathrm{NN}}$=7.7, 11.5, 19.6, 27, 39, 62.4 and 200 GeV are investigated. The model results show that the number of antiprotons is important and should be taken into account in the calculation of CFs at high energy and/or in peripheral collisions. It is also found that the contribution of antiprotons is more important for higher order correlations than for lower ones. The CFs of antiprotons and mixed correlations play roles comparable to those of protons at high energies. Finally, we make comparisons between the model calculation and experimental data measured in the STAR experiment at the BNL Relativistic Heavy Ion Collider., Comment: Replaced with the published version

Published
2017
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13. An ultrasonic approach for characterising subsurface fractures in concrete.

Author

Wang, Ding, Yang, Cheng, Lin, Yufu, and Lü, Liangjie

Subjects
RAYLEIGH waves, CONCRETE fractures, NONDESTRUCTIVE testing, ULTRASONIC waves, ANISOTROPY
Abstract

An ultrasonic Rayleigh wave detection method is proposed to determine the geometrical characteristics of subsurface small-scale fractures in concrete. A three-dimensional observation system, including an inclined wedge ultrasonic device, is used to obtain the Rayleigh wave wide-angle data to exhibit the azimuth-dependent scattered wave field. The anisotropic characteristics of Rayleigh wave transmission coefficient are used to determine the distribution range and dip angle of fractures. Fracture models in concrete with different dip angles are designed, and the dip angle is correlated with the degree of attenuation (transmission coefficient) anisotropy. The transmission coefficient characteristics are presented in a random observing system. A focusing approach can be adopted to distinguish the subsurface fracture and to verify the reliability and flexibility of the surface wave approach in practice. The tendencies of experimental results are consistent with patterns obtained from numerical simulation. The proposed method has important application prospects for the non-destructive testing of complex invisible fractures in concrete. [ABSTRACT FROM AUTHOR]

Published
2024
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14. GloEC: a hierarchical-aware global model for predicting enzyme function.

Author

Huang, Yiran, Lin, Yufu, Lan, Wei, Huang, Cuiyu, and Zhong, Cheng

Subjects
*DIRECTED graphs, *ENZYMES, *BIOTECHNOLOGY, *ANNOTATIONS
Abstract

The annotation of enzyme function is a fundamental challenge in industrial biotechnology and pathologies. Numerous computational methods have been proposed to predict enzyme function by annotating enzyme labels with Enzyme Commission number. However, the existing methods face difficulties in modelling the hierarchical structure of enzyme label in a global view. Moreover, they haven't gone entirely to leverage the mutual interactions between different levels of enzyme label. In this paper, we formulate the hierarchy of enzyme label as a directed enzyme graph and propose a hierarchy-GCN (Graph Convolutional Network) encoder to globally model enzyme label dependency on the enzyme graph. Based on the enzyme hierarchy encoder, we develop an end-to-end hierarchical-aware global model named GloEC to predict enzyme function. GloEC learns hierarchical-aware enzyme label embeddings via the hierarchy-GCN encoder and conducts deductive fusion of label-aware enzyme features to predict enzyme labels. Meanwhile, our hierarchy-GCN encoder is designed to bidirectionally compute to investigate the enzyme label correlation information in both bottom-up and top-down manners, which has not been explored in enzyme function prediction. Comparative experiments on three benchmark datasets show that GloEC achieves better predictive performance as compared to the existing methods. The case studies also demonstrate that GloEC is capable of effectively predicting the function of isoenzyme. GloEC is available at: https://github.com/hyr0771/GloEC. [ABSTRACT FROM AUTHOR]

Published
2024
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16. A prognostic model based on tumor microenvironment and immune cell in colorectal cancer.

Author

Lin, Yufu, Chen, Yabo, Gan, Lu, Li, Zhiyong, and Shen, Feng

Subjects
*COLORECTAL cancer, *PROGNOSTIC models, *GENE regulatory networks, *TUMOR microenvironment, *POLYMERASE chain reaction
Abstract

Colorectal cancer (CRC) is the second leading cause of cancer-related death. Immunotherapy is one of the new options for cancer treatment. This study aimed to develop an immune-related signature associated with CRC. We performed differential analysis to screen out the differentially expressed genes (DEGs) of The Cancer Genome Atlas–Colorectal Cancer (TCGA-CRC) datasets. Weighted gene co-expression network analysis (WGCNA) was performed to obtain the key module genes associated with differential immune cells. The candidate genes were obtained through overlapping key DEGs and key module genes. The univariate and multivariate Cox regression analyses were adopted to build a CRC prognostic signature. We further conducted immune feature estimation and chemotherapy analysis between two risk subgroups. Finally, we verified the expression of immune-related prognostic genes at the transcriptional level. A total of 61 candidate genes were obtained by overlapping key DEGs and key module genes associated with differential immune cells. Then, an immune-related prognostic signature was built based on the three prognostic genes (HAMP, ADAM8, and CD1B). The independent prognostic analysis suggested that age, stage, and RiskScore could be used as independent prognostic factors. Further, we found significantly higher expression of three prognostic genes in the CRC group compared with the normal group. Finally, real-time polymerase chain reaction verified the expression of three genes in patients with CRC. The prognostic signature comprising HAMP, ADAM8, and CD1B based on immune cells was established, providing a theoretical basis and reference value for the research of CRC. [ABSTRACT FROM AUTHOR]

Published
2024
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18. A safe and potent anti-CD19 CAR T cell therapy

Author

Ying, Zhitao, Huang, Xue F., Xiang, Xiaoyu, Liu, Yanling, Kang, Xi, Song, Yuqin, Guo, Xiaokai, Liu, Hanzhi, Ding, Ning, Zhang, Tingting, Duan, Panpan, Lin, Yufu, Zheng, Wen, Wang, Xiaopei, Lin, Ningjing, Tu, Meifeng, Xie, Yan, Zhang, Chen, Liu, Weiping, Deng, Lijuan, Gao, Shunyu, Ping, Lingyan, Wang, Xuejuan, Zhou, Nina, Zhang, Junqing, Wang, Yulong, Lin, Songfeng, Mamuti, Mierzhati, Yu, Xueyun, Fang, Lizhu, Wang, Shuai, Song, Haifeng, Wang, Guan, Jones, Lindsey, Zhu, Jun, and Chen, Si-Yi

Published
2019
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19. Probing the Gluonic Structure of the Deuteron with J/ψ Photoproduction in d+Au Ultraperipheral Collisions

Author

Abdallah, Mohamed, Aboona, Bassam, Adam, Jaroslav, Adamczyk, Leszek, Adams, Joseph, Adkins, Kevin, Agakishiev, Geydar, Aggarwal, Ishu, Aggarwal, Madan, Ahammed, Zubayer, Aitbaev, A., Alekseev, Igor, Anderson, Derek, Aparin, Alexey, Aschenauer, Elke-Caroline, Ashraf, Muhammad Usman, Atetalla, Fareha, Attri, Anjali, Averichev, Georgy, Bairathi, Vipul, Baker, William, Ball Cap, Jonathan Gonzalo, Barish, Kenneth, Behera, Arabinda, Bellwied, Rene, Bhagat, Pratibha, Bhasin, Anju, Bielcik, Jaroslav, Bielcikova, Jana, Bordyuzhin, Igor, Brandenburg, James, Brandin, Andrei, Bunzarov, Ivan, Cai, Xiang-Zhou, Caines, Helen, Calderon de la Barca Sanchez, Manuel, Cebra, Daniel, Chakaberia, Irakli, Chaloupka, Petr, Chan, Brian, Chang, Feng-Han, Chang, Zilong, Chankova-Bunzarova, Nedialka, Chatterjee, Arghya, Chattopadhyay, Subhasis, Chen, Ding, Chen, Jia, Chen, Jinhui, Chen, Xiaolong, Chen, Zhenyu, Cheng, Jianping, Chevalier, Malia, Choudhury, Subikash, Christie, W., Christie, Bill, Chu, Xiaoxuan, Crawford, Hank, Csanad, Mate, Daugherity, Michael, Dedovich, Tatiana, Deppner, Ingo, Derevschikov, Anatoly, Dhamija, Arushi, Di Carlo, Launa, Didenko, Lidia, Dixit, Prabhupada, Dong, Xin, Drachenberg, James, Duckworth, Eddie, Dunlop, James, Elsey, Nicholas, Engelage, Jack, Eppley, Geary, Esumi, ShinIchi, Evdokimov, Olga, Ewigleben, Annika, Eyser, Oleg, Fatemi, Renee, Fawzi, Fares, Fazio, Salvatore, Federic, Pavol, Fedorisin, Jan, Feng, Chan-Jui, Feng, Yicheng, Filip, Peter, Finch, Evan, Fisyak, Yuri, Francisco, Audrey, Fu, Chuan, Fulek, Lukasz, Gagliardi, Carl, Galatyuk, Tatyana, Geurts, Frank, Ghimire, Navagyan, Gibson, Adam, Gopal, Krishan, Gou, Xingrui, Grosnick, David, Gupta, Anik, Guryn, Wlodek, Hamad, Ayman, Hamed, Ahmed, Han, Yiding, Harabasz, Szymon, Harasty, Matthew, Harris, John, Harrison, Hannah, He, Shu, He, Wanbing, He, Xionghong, He, Yang, Heppelmann, Samuel, Heppelmann, Steven, Herrmann, Norbert, Hoffman, Eric, Holub, Lukas, Hu, C., Hu, Q., Hu, Yu, Huang, Hao, Huang, Huan, Huang, Shengli, Huang, Te-Chuan, Huang, Xinjie, Huang, Yan, Humanic, T.J., Igo, George, Isenhower, Donald, Isshiki, M., Jacobs, William, Jena, Chitrasen, Jentsch, Alexander, Ji, Yuanjing, Jia, Jiangyong, Jiang, Kun, Ju, Xinyue, Judd, Eleanor, Kabana, Sonia, Kabir, Md Latiful, Kagamaster, Skipper, Kalinkin, Dmitry, Kang, Kejun, Kapukchyan, David, Kauder, Kolja, Ke, Hongwei, Keane, Declan, Kechechyan, Armen, Kelsey, Matthew, Khyzhniak, Yevheniia, Kikola, Daniel, Kim, Chong, Kimelman, Benjamin, Kincses, Daniel, Kisel, Ivan, Kiselev, Alexander, Knospe, Anders, Ko, Ho San, Kochenda, Leonid, Korobitsin, A., Kosarzewski, Leszek, Kramarik, Lukas, Kravtsov, Petr, Kumar, Lokesh, Kumar, Shyam, Kunnawalkam Elayavalli, Raghav, Kwasizur, Joseph, Lacey, Roy, Lan, Shaowei, Landgraf, Jeffery, Lauret, Jerome, Lebedev, Alexei, Lednicky, Richard, Lee, Jeong-Hun, Leung, Yue-Hang, Lewis, Nicole, Li, Changfeng, Li, Cheng, Li, Wei, Li, Xin, Li, Yuanjing, Liang, Xilin, Liang, Yue, Licenik, Robert, Lin, Ting, Lin, Yufu, Lisa, Mike, Liu, Feng, Liu, Huanzhao, Liu, Hui, Liu, Peifeng, Liu, Tong, Liu, Xiaoyu, Liu, Yanfang, Liu, Zhen, Ljubicic, Tonko, Llope, W.J., Longacre, R.S., Loyd, Erik, Lu, T., Lukow, Nicholas, Luo, Xiaofeng, Ma, Long, Ma, Rongrong, Ma, Yu-Gang, Magdy Abdelwahab Abdelrahman, Niseem, Mallick, Debasish, Manukhov, S.L., Margetis, Spiros, Markert, Christina, Matis, Howard, Mazer, Joel, Minaev, Nikolai, Mioduszewski, Saskia, Mohanty, Bedanga, Mondal, Mriganka, Mooney, Isaac, Morozov, Dmitry, Mukherjee, Ayon, Nagy, Marton, Nam, J.D., Nasim, Md., Nayak, Kishora, Neff, Dylan, Nelson, John, Nemes, Daniel, Nie, Maowu, Nigmatkulov, Grigory, Niida, Takafumi, Nishitani, Risa, Nogach, Larisa, Nonaka, Toshihiro, Nunes, Ana Sofia, Odyniec, Grazyna, Ogawa, Akio, Oh, Saehanseul, Okorokov, Vitalii, Okubo, K., Page, Brian, Pak, Robert, Pan, Jinjin, Pandav, Ashish, Pandey, Ashutosh, Panebratsev, Yuri, Parfenov, Petr, Pinsky, Lawrence, Paul, A., Pawlik, Bogdan, Pawlowska, Diana, Perkins, Chris, Pluta, Jan, Pokhrel, Babu, Ponimatkin, Georgij, Porter, Jeff, Posik, Matthew, Prozorova, Veronika, Pruthi, Navneet Kumar, Przybycien, Mariusz, Putschke, Joern, Qiu, Hao, Quintero, Amilkar, Racz, Cameron, Radhakrishnan, Sooraj, Raha, Nandita, Ray, Lanny, Reed, Rosi, Ritter, Hans Georg, Robotkova, Monika, Rogachevskiy, Oleg, Romero, Juan, Roy, Diptanil, Ruan, Lijuan, Rusnak, Jan, Sahoo, Aswini, Sahoo, Nihar, Sako, Hiroyuki, Salur, Sevil, Samigullin, E., Sandweiss, Jack, Sato, Susumu, Schmidke, Bill, Schmitz, Norbert, Schweid, Benjamin, Seck, Florian, Seger, Janet, Sergeeva, Maria, Seto, Richard, Seyboth, Peter, Shah, Neha, Shahaliev, Ehtiram, Shanmuganathan, Prashanth, Shao, Ming, Shao, Tianhao, Sharma, R., Sheikh, Ashik Ikbal, Shen, Diyu, Shi, Shusu, Shi, Yingying, Shou, Qi-Ye, Sichtermann, Ernst, Sikora, Rafal, Simko, Miroslav, Singh, Jagbir, Singha, Subhash, Sorensen, Paul, Sinha, P., Skoby, Michael, Smirnov, Nikolai, Soehngen, Yannick, Solyst, William, Song, Youqi, Spinka, H.M., Srivastava, Brijesh, Stanislaus, Shirvel, Stefaniak, Maria, Stewart, David, Strikhanov, Mikhail, Stringfellow, Blair, Suaide, Alexandre Alarcon, Sumbera, Michal, Summa, Branden, Sun, Xiangming, Sun, Xu, Sun, Yongjie, Sun, Yuliang, Surrow, Bernd, Svirida, Dmitry, Sweger, Zachary, Szymanski, Pawel, Tang, Aihong, Tang, Zebo, Taranenko, Arkadiy, Tarnowsky, Terry, Thomas, J.H., Timmins, Anthony, Tlusty, David, Todoroki, Takahito, Tokarev, Michael, Tomkiel, Catherine, Trentalange, Steven, Tribble, Robert, Tribedy, Prithwish, Tripathy, Srikanta Kumar, Truhlar, Tomas, Trzeciak, Barbara, Tsai, Oleg, Tu, Zhoudunming (Kong), Ullrich, Thomas, Underwood, Dave, Upsal, Isaac, Van Buren, Gene, Vanek, Jan, Vasiliev, Alexander, Vassiliev, Iouri, Verkest, Veronica, Videbaek, Flemming, Vokal, Stanislav, Voloshin, Sergei, Wang, Fuqiang, Wang, Gang, Wang, Jiansong, Wang, Pengfei, Wang, Xiaofeng, Wang, Yaping, Wang, Yi, Wang, Zhen, Webb, Jason, Weidenkaff, Philipp, Wen, Liwen, Westfall, Gary, Wieman, Howard, Wissink, Scott, Witt, Richard, Wu, Jin, Wu, Junlin, Wu, Yang, Xi, Baoshan, Xiao, Zhigang, Xie, Guannan, Xie, Wei, Xu, Haojie, Xu, Nu, Xu, Qinghua, Xu, Yike, Xu, Zhangbu, Xu, Zhiwan, Yan, Gaoguo, Yang, Chi, Yang, Qian, Yang, Shuai, Yang, Yi, Ye, Zaochen, Ye, Zhenyu, Yi, Li, Yip, Kin, Yu, Yi, Zbroszczyk, Hanna, Zha, Wangmei, Zhang, ChunJian, Zhang, Dingwei, Zhang, Jinlong, Zhang, Xiaoping, Zhao, F., Zhang, Shenghui, Zhang, Song, Zhang, Yapeng, Zhang, Yifei, Zhang, Yu, Zhang, Zhe-Jia, Zhang, Zhengqiao, Zhang, Ziyue, Zhao, Jie, Zhao, M., Zhou, Chensheng, Zhou, Yingjie, Zhu, Xianglei, Zurek, Maria, and Zyzak, Maksym

Subjects
Nuclear Theory, nucl-th, hep-ex, FOS: Physical sciences, nucl-ex, High Energy Physics - Experiment, Nuclear Theory (nucl-th), High Energy Physics - Experiment (hep-ex), Nuclear Physics - Theory, High Energy Physics::Experiment, Nuclear Physics - Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment, Particle Physics - Experiment
Abstract

Understanding gluon density distributions and how they are modified in nuclei are among the most important goals in nuclear physics. In recent years, diffractive vector meson production measured in ultra-peripheral collisions (UPCs) at heavy-ion colliders has provided a new tool for probing the gluon density. In this Letter, we report the first measurement of $J/\psi$ photoproduction off the deuteron in UPCs at the center-of-mass energy $\sqrt{s_{_{\rm NN}}}=200~\rm GeV$ in d$+$Au collisions. The differential cross section as a function of momentum transfer $-t$ is measured. In addition, data with a neutron tagged in the deuteron-going Zero-Degree Calorimeter is investigated for the first time, which is found to be consistent with the expectation of incoherent diffractive scattering at low momentum transfer. Theoretical predictions based on the Color Glass Condensate saturation model and the gluon shadowing model are compared with the data quantitatively. A better agreement with the saturation model has been observed. With the current measurement, the results are found to be directly sensitive to the gluon density distribution of the deuteron and the deuteron breakup, which provides insights into the nuclear gluonic structure., Comment: Final published version Phys. Rev. Lett. 128, 122303

Published
2021

24. Chimeric antigen receptor-modified T cells directed against CD19 in patients with relapsed or refractory CD19-positive B-cell lymphomas: interim analysis of a phase 1 study

Author

Ying, Zhitao, primary, Xiang, Xiaoyu, additional, Song, Yuqin, additional, Ding, Ning, additional, Lin, Yufu, additional, Zheng, Wen, additional, Wang, Xiaopei, additional, Lin, Ningjing, additional, Tu, Meifeng, additional, Xie, Yan, additional, Zhang, Chen, additional, Liu, Weiping, additional, Deng, Lijuan, additional, Liu, Yanling, additional, Yue, Yunqiang, additional, Yu, Xueyun, additional, Liu, Hanzhi, additional, Duan, Panpan, additional, Mamuti, Mierzhati, additional, Guo, Xiaokai, additional, Chen, Feng, additional, Wu, Xiaoyan, additional, Zhang, Junqing, additional, Zhang, Tingting, additional, Huang, Xue F, additional, Jones, Lindsey, additional, Kang, Xi, additional, Chen, Si-Yi, additional, and Zhu, Jun, additional

Published
2017
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27. Probing Extreme Electromagnetic Fields with the Breit-Wheeler Process

Author

Adam, Jaroslav, Adamczyk, Leszek, Adams, Joseph, Adkins, Kevin, Agakishiev, Geydar, Aggarwal, Madan, Ahammed, Zubayer, Alekseev, Igor, Anderson, Derek, Aparin, Alexey, Aschenauer, Elke-Caroline, Ashraf, Muhammad Usman, Atetalla, Fareha, Attri, Anjali, Averichev, Georgy, Bairathi, Vipul, Barish, Kenneth, Behera, Arabinda, Bellwied, Rene, Bhasin, Anju, Bielcik, Jaroslav, Bielcikova, Jana, Bland, Leslie, Bordyuzhin, Igor, Brandenburg, James, Brandin, Andrei, Butterworth, Joseph, Caines, Helen, Calderon La Barca Sanchez, Manuel, Cebra, Daniel, Chakaberia, Irakli, Chaloupka, Petr, Brian Chan, Chang, Feng-Han, Chang, Zilong, Chankova-Bunzarova, Nedialka, Chatterjee, Arghya, Chen, Ding, Chen, Jinhui, Chen, Xiaolong, Chen, Zhenyu, Cheng, Jianping, Cherney, Mike, Chevalier, Malia, Choudhury, Subikash, Christie, Bill, Crawford, Hank, Csanad, Mate, Daugherity, Michael, Dedovich, Tatiana, Deppner, Ingo, Derevschikov, Anatoly, Didenko, Lidia, Dong, Xin, Drachenberg, James, Dunlop, James, Edmonds, Terrence, Elsey, Nicholas, Engelage, Jack, Eppley, Geary, Esha, Roli, Esumi, Shinichi, Evdokimov, Olga, Ewigleben, Justin, Eyser, Oleg, Fatemi, Renee, Fazio, Salvatore, Federic, Pavol, Fedorisin, Jan, Feng, Chan-Jui, Yicheng Feng, Filip, Peter, Finch, Evan, Fisyak, Yuri, Francisco, Audrey, Fulek, Lukasz, Gagliardi, Carl, Galatyuk, Tatyana, Geurts, Frank, Gibson, Adam, Gopal, Krishan, Grosnick, David, Guryn, Wlodek, Hamad, Ayman, Hamed, Ahmed M., Harris, John, He, Wanbing, He, Xionghong, Heppelmann, Samuel, Heppelmann, Steven, Herrmann, Norbert, Hoffman, Eric, Holub, Lukas, Yifan Hong, Horvat, Stephen, Hu, Yu, Huang, Huan, Huang, Shengli, Huang, Te-Chuan, Huang, Xinjie, Humanic, Tom, Huo, Peng, Igo, George, Isenhower, Donald, Jacobs, William, Chitrasen Jena, Jentsch, Alexander, Ji, Yuanjing, Jia, Jiangyong, Jiang, Kun, Jowzaee, Sedigheh, Ju, Xinyue, Judd, Eleanor, Kabana, Sonya, Kabir, Md Latiful, Kagamaster, Skipper, Kalinkin, Dmitry, Kang, Kejun, Kapukchyan, David, Kauder, Kolja, Ke, Hongwei, Keane, Declan, Kechechyan, Armen, Kelsey, Matthew, Khyzhniak, Yevheniia, Kikola, Daniel, Kim, Chong, Kimelman, Benjamin, Dániel Kincses, Kinghorn, Todd, Kisel, Ivan, Kiselev, Alexander, Kisiel, Adam, Klein, S. R., Michal Kocan, Kochenda, Leonid, Kosarzewski, Leszek, Kramarik, Lukas, Kravtsov, Peter, Krueger, Keith, Kulathunga Mudiyanselage, Nalinda, Kumar, Lokesh, Kunnawalkam Elayavalli, Raghav, Kwasizur, Joseph, Lacey, Roy, Lan, Shaowei, Landgraf, Jeffery, Lauret, Jerome, Lebedev, Alexei, Lednicky, Richard, Lee, Jeong-Hun, Leung, Yue-Hang, Li, Cheng, Li, Wei, Li, Xin, Li, Yuanjing, Liang, Yue, Licenik, Robert, Lin, Ting, Lin, Yufu, Lisa, Mike, Liu, Feng, Liu, Huanzhao, Liu, Peifeng, Peng Liu, Liu, Tong, Liu, Xiaoyu, Liu, Yanfang, Liu, Zhen, Ljubicic, Tonko, Llope, Wj, Longacre, Ron, Lukow, Nicholas, Luo, Siwei, Luo, Xiaofeng, Ma, Guo-Liang, Ma, Long, Ma, Rongrong, Ma, Yu-Gang, Magdy Abdelwahab Abdelrahman, Niseem, Majka, Richard, Mallick, Debasish, Margetis, Spiros, Markert, Christina, Matis, Howard, Mazer, Joel, Minaev, Nikolai, Mioduszewski, Saskia, Mohanty, Bedanga, Mooney, Isaac, Zuzana Moravcova, Morozov, Dmitry, Nagy, Marton, Nam, Jae, Nasim, Md, Nayak, Kishora, Neff, Dylan, Nelson, John, Nemes, Daniel, Nie, Maowu, Nigmatkulov, Grigory, Niida, Takafumi, Nogach, Larisa, Nonaka, Toshihiro, Odyniec, Grazyna, Ogawa, Akio, Oh, Saehanseul, Okorokov, Vitalii, Page, Brian, Pak, Robert, Pandav, Ashish, Panebratsev, Yuri, Pawlik, Bogdan, Pawlowska, Diana, Pei, Hua, Perkins, Chris, Pinsky, Lawrence, Pinter, Roland Laszlo, Pluta, Jan, Porter, Jeff, Posik, Matthew, Pruthi, Navneet Kumar, Przybycien, Mariusz, Putschke, Joern, Qiu, Hao, Quintero, Amilkar, Radhakrishnan, Sooraj, Ramachandran, Suvarna, Ray, Lanny, Reed, Rosi, Ritter, Hans Georg, Roberts, Jay, Rogachevskiy, Oleg, Romero, Juan, Ruan, Lijuan, Rusnak, Jan, Sahoo, Nihar, Hiroyuki Sako, Salur, Sevil, Sandweiss, Jack, Sato, Susumu, Schmidke, Bill, Schmitz, Norbert, Schweid, Benjamin, Seck, Florian, Seger, Janet, Sergeeva, Maria, Seto, Richard, Seyboth, Peter, Shah, Neha, Shahaliev, Ehtiram, Shanmuganathan, Prashanth, Shao, Ming, Shen, Fuwang, Shen, Wen-Qing, Shi, Shusu, Shou, Qi-Ye, Sichtermann, Ernst, Sikora, Rafal, Simko, Miroslav, Singh, Jagbir, Singha, Subhash, Smirnov, Nikolai, Solyst, William, Sorensen, Paul, Spinka, Hal, Srivastava, Brijesh, Stanislaus, Shirvel, Stefaniak, Maria, Stewart, David, Strikhanov, Mikhail, Stringfellow, Blair, Suaide, Alexandre Alarcon, Sumbera, Michal, Summa, Branden, Sun, Xiangming, Sun, Yongjie, Sun, Yuliang, Surrow, Bernd, Svirida, Dmitry, Szymanski, Pawel, Tang, Aihong, Tang, Zebo, Taranenko, Arkadiy, Tarnowsky, Terry, Thomas, Jim, Timmins, Anthony, Tlusty, David, Tokarev, Michael, Tomkiel, Catherine, Trentalange, Steven, Tribble, Robert, Tribedy, Prithwish, Tripathy, Srikanta Kumar, Tsai, Oleg, Tu, Zhoudunming, Ullrich, Thomas, Underwood, Dave, Upsal, Isaac, Buren, Gene, Vanek, Jan, Vasiliev, Alexander, Vassiliev, Iouri, Videbaek, Flemming, Vokal, Stanislav, Voloshin, Sergei, Wang, Fuqiang, Wang, Gang, Jian-Song Wang, Wang, Pengfei, Wang, Yaping, Wang, Yi, Wang, Zhen, Webb, Jason, Weidenkaff, Philipp, Wen, Liwen, Westfall, Gary, Wieman, Howard, Wissink, Scott, Witt, Richard, Wu, Yang, Xiao, Zhigang, Xie, Guannan, Xie, Wei, Xu, Haojie, Xu, Nu, Xu, Qinghua, Xu, Yi-Fei, Xu, Yike, Xu, Zhangbu, Xu, Zhiwan, Yang, Chi, Yang, Qian, Yang, Shuai, Yang, Yi, Yang, Zhenzhen, Ye, Zaochen, Ye, Zhenyu, Yi, Li, Yip, Kin, Zbroszczyk, Hanna, Zha, Wangmei, Zhang, Dingwei, Zhang, Shenghui, Zhang, Song, Zhang, Xiaoping, Zhang, Yifei, Zhang, Zhe-Jia, Zhang, Zhengqiao, Zhao, Jie, Zhong, Chen, Zhou, Chensheng, Zhu, Xianglei, Zhu, Zhanwen, Zurek, Maria, and Zyzak, Maksym

28. Clinical treatment strategy and follow-up of lymphoepithelioma-like carcinoma: a retrospective study.

Author

Zhang S, Lin Y, Li Z, Wang Z, Luo R, and Zhang X

Abstract

Aim: To investigate the clinical features, diagnosis and treatment of lymphoepithelioma-like carcinoma (LELC). Materials & methods: The clinical data of 114 LELC patients were retrospectively analyzed. Results: Ninety-eight patients (86.0%) were Epstein-Barr virus-encoded small RNA (EBER) positive detected by situ hybridization. A 67.1% (51/76) patients had PD-L1 expression. The 5-year overall survival rate of EBER negative patients was 51.6% while the rate of positive patients was 84.8% ( p  = 0.015). The 5-year progression free survival rate of EBER negative patients was 40.2% while the rate of positive patients was 70.2% ( p  = 0.004). Conclusion: The progression of LELC is relatively slow and present a better prognosis. The occurrence of tumor is closely related to Epstein-Barr virus infection and PD-L1 is highly expressed in tumor cells.

Published
2024
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29. Pathologic Complete Response After Gastric Artery Chemoembolization Combined With Tislelizumab for Neoadjuvant Therapy of Locally Advanced Gastric Cancer: A Case Report.

Author

Lin Y, Chen Y, Lin S, Zheng J, Zhang X, and Gan L

Subjects
Humans, Neoadjuvant Therapy, Gastric Artery pathology, Immune Checkpoint Inhibitors therapeutic use, Pathologic Complete Response, Stomach Neoplasms therapy, Antibodies, Monoclonal, Humanized
Abstract

Gastric cancer is the most common type of gastrointestinal cancer in China which about 80% of patients are locally advanced or advanced when diagnosed. Surgery along brings high recurrence rate for locally advanced gastric cancer (LAGC), and neoadjuvant therapies are needed. The use of programmed cell death-1 (PD-1)/programmed death-ligand 1 inhibitor nowadays improved the disease-free survival for LAGC, however, only <35% of patients achieved pathologic complete response (pCR) after neoadjuvant therapy nowadays. Therefore, new regimens are needed to be investigated. Gastric artery chemoembolization is applied to metastasis gastric cancer and researches showed interventional therapy can enhance the antitumor effect of PD-1 inhibitor. Here, for the first time, we combined gastric artery chemoembolization with tislelizumab (a PD-1 inhibitor) for neoadjuvant therapy of a patient with LAGC. The patient achieved pCR after a D2 resection and tumor regression grade score was 1. After surgery, the patient received tislelizumab 200 mg per 3 weeks, and showed no sign of recurrence after 6 months of follow-up. The study indicated the use of tislelizumab and gastric artery chemoembolization for neoadjuvant therapy may bring a better pCR rate and prognosis of LAGC., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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