1. The impact of bacterial colonization on graft success after total pancreatectomy with autologous islet transplantation: considerations for early definitive surgical intervention
- Author
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Victor M. Zaydfudim, Joshua S. Jolissaint, Linda W. Langman, Claire L. DeBolt, Jacob A. Tatum, Andrew Y. Wang, Allison N. Martin, Daniel S. Strand, Reid B. Adams, and Kenneth L. Brayman
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Total pancreatectomy ,medicine.medical_treatment ,Islets of Langerhans Transplantation ,Transplantation, Autologous ,Article ,Islets of Langerhans ,Young Adult ,03 medical and health sciences ,Pancreatectomy ,Postoperative Complications ,0302 clinical medicine ,Bacterial colonization ,Pancreatitis, Chronic ,medicine ,Humans ,Insulin ,Prospective Studies ,Retrospective Studies ,Transplantation ,geography ,geography.geographical_feature_category ,business.industry ,Perioperative ,Middle Aged ,Islet ,medicine.disease ,Autotransplantation ,Surgery ,Diabetes Mellitus, Type 1 ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Pancreatitis ,Female ,030211 gastroenterology & hepatology ,Pancreas ,business ,Follow-Up Studies - Abstract
OBJECTIVE The purpose of this study was to determine whether bacterial contamination of islets affects graft success after total pancreatectomy with islet autotransplantation (TPIAT). BACKGROUND Factors associated with insulin independence after TPIAT are inconclusive. Although bacterial contamination does not preclude transplantation, the impact of bacterial contamination on graft success is unknown. METHODS Patients who received TPIAT at the University of Virginia between January 2007 and January 2016 were reviewed. Patient charts were reviewed for bacterial contamination and patients were prospectively contacted to assess rates of insulin independence. RESULTS There was no significant difference in demographic or perioperative data between patients who achieved insulin independence and those who did not. However, six of 27 patients analyzed (22.2%) grew bacterial contaminants from culture of the final islet preparations. These patients had significantly lower islet yield and C-peptide at most recent follow-up (P
- Published
- 2016
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