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2. Telephone Versus Internet Administration of Self-Report Measures of Social Anxiety, Depressive Symptoms, and Insomnia: Psychometric Evaluation of a Method to Reduce the Impact of Missing Data

Author

Hedman, Erik, Ljótsson, Brjánn, Blom, Kerstin, El Alaoui, Samir, Kraepelien, Martin, Rück, Christian, Andersson, Gerhard, Svanborg, Cecilia, Lindefors, Nils, and Kaldo, Viktor

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundInternet-administered self-report measures of social anxiety, depressive symptoms, and sleep difficulties are widely used in clinical trials and in clinical routine care, but data loss is a common problem that could render skewed estimates of symptom levels and treatment effects. One way of reducing the negative impact of missing data could be to use telephone administration of self-report measures as a means to complete the data missing from the online data collection. ObjectiveThe aim of the study was to compare the convergence of telephone and Internet administration of self-report measures of social anxiety, depressive symptoms, and sleep difficulties. MethodsThe Liebowitz Social Anxiety Scale-Self-Report (LSAS-SR), Montgomery-Åsberg Depression Rating Scale-Self-Rated (MADRS-S), and the Insomnia Severity Index (ISI) were administered over the telephone and via the Internet to a clinical sample (N=82) of psychiatric patients at a clinic specializing in Internet-delivered treatment. Shortened versions of the LSAS-SR and the ISI were used when administered via telephone. ResultsAs predicted, the results showed that the estimates produced by the two administration formats were highly correlated (r=.82-.91; P

Published
2013
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3. A 5-Year Follow-up of Internet-Based Cognitive Behavior Therapy for Social Anxiety Disorder

Author

Hedman, Erik, Furmark, Tomas, Carlbring, Per, Ljótsson, Brjánn, Rück, Christian, Lindefors, Nils, and Andersson, Gerhard

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundInternet-based cognitive behavior therapy (CBT) has been shown to be a promising method to disseminate cognitive behavior therapy for social anxiety disorder (SAD). Several trials have demonstrated that Internet-based CBT can be effective for SAD in the shorter term. However, the long-term effects of Internet-based CBT for SAD are less well known. ObjectiveOur objective was to investigate the effect of Internet-based CBT for SAD 5 years after completed treatment. MethodWe conducted a 5-year follow-up study of 80 persons with SAD who had undergone Internet-based CBT. The assessment comprised a diagnostic interview and self-report questionnaires. The main outcome measure was the Liebowitz Social Anxiety Scale-Self-Report (LSAS-SR). Additional measures of social anxiety were the Social Interaction Anxiety Scale (SIAS) and the Social Phobia Scale (SPS). Attrition rates were low: 89% (71/80) of the participants completed the diagnostic interview and 80% (64/80) responded to the questionnaires. ResultsMixed-effect models analysis showed a significant effect of time on the three social anxiety measures, LSAS-SR, SIAS, and SPS (F3,98-102 = 16.05 - 29.20, P < .001) indicating improvement. From baseline to 5-year follow-up, participants’ mean scores on the LSAS-SR were reduced from 71.3 (95% confidence interval [CI] 66.1-76.5) to 40.3 (95% CI 35.2 - 45.3). The effect sizes of the LSAS-SR were large (Cohen’s d range 1.30 - 1.40, 95% CI 0.77 - 1.90). Improvements gained at the 1-year follow-up were sustained 5 years after completed treatment. ConclusionsInternet-based CBT for SAD is a treatment that can result in large and enduring effects. Trial registration Clinicaltrials.gov NCT01145690; http://clinicaltrials.gov/ct2/show/NCT01145690 (Archived by WebCite at http://www.webcitation.org/5ygRxDLfK)

Published
2011
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8. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

Author

Forstner, Andreas J., Awasthi, Swapnil, Wolf, Christiane, Maron, Eduard, Erhardt, Angelika, Czamara, Darina, Eriksson, Elias, Lavebratt, Catharina, Allgulander, Christer, Friedrich, Nina, Becker, Jessica, Hecker, Julian, Rambau, Stefanie, Conrad, Rupert, Geiser, Franziska, McMahon, Francis J., Moebus, Susanne, Hess, Timo, Buerfent, Benedikt C., Hoffmann, Per, Herms, Stefan, Heilmann-Heimbach, Stefanie, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Weber, Heike, Alpers, Georg W., Arolt, Volker, Fehm, Lydia, Fydrich, Thomas, Gerlach, Alexander L., Hamm, Alfons, Kircher, Tilo, Pané-Farré, Christiane A., Pauli, Paul, Rief, Winfried, Ströhle, Andreas, Plag, Jens, Lang, Thomas, Wittchen, Hans-Ulrich, Mattheisen, Manuel, Meier, Sandra, Metspalu, Andres, Domschke, Katharina, Reif, Andreas, Hovatta, Iiris, Lindefors, Nils, Andersson, Evelyn, Schalling, Martin, Mbarek, Hamdi, Milaneschi, Yuri, de Geus, Eco J. C., Boomsma, Dorret I., Penninx, Brenda W. J. H., Thorgeirsson, Thorgeir E., Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, Müller-Myhsok, Bertram, Hansen, Thomas Folkmann, Børglum, Anders D., Werge, Thomas, Mortensen, Preben Bo, Nordentoft, Merete, Hougaard, David M., Hultman, Christina M., Sullivan, Patrick F., Nöthen, Markus M., Woldbye, David P. D., Mors, Ole, Binder, Elisabeth B., Rück, Christian, Ripke, Stephan, Deckert, Jürgen, and Schumacher, Johannes

Published
2021
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9. Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis

Author

Schiele, Miriam A., Reif, Andreas, Lin, Jiaxi, Alpers, Georg W., Andersson, Evelyn, Andersson, Gerhard, Arolt, Volker, Bergström, Jan, Carlbring, Per, Eley, Thalia C., Esquivel, Gabriel, Furmark, Tomas, Gerlach, Alexander L., Hamm, Alfons, Helbig-Lang, Sylvia, Hudson, Jennifer L., Lang, Thomas, Lester, Kathryn J., Lindefors, Nils, Lonsdorf, Tina B., Pauli, Paul, Richter, Jan, Rief, Winfried, Roberts, Susanna, Rück, Christian, Schruers, Koen R.J., Thiel, Christiane, Wittchen, Hans-Ulrich, Domschke, Katharina, Weber, Heike, and Lueken, Ulrike

Published
2021
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16. Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)

Author

Boberg, Julia, primary, Kaldo, Viktor, additional, Mataix-Cols, David, additional, Crowley, James J, additional, Roelstraete, Bjorn, additional, Halvorsen, Matthew, additional, Forsell, Erik, additional, Isacsson, Nils H, additional, Sullivan, Patrick F, additional, Svanborg, Cecilia, additional, Andersson, Evelyn H, additional, Lindefors, Nils, additional, Kravchenko, Olly, additional, Mattheisen, Manuel, additional, Danielsdottir, Hilda B, additional, Ivanova, Ekaterina, additional, Boman, Magnus, additional, Fernández de la Cruz, Lorena, additional, Wallert, John, additional, and Rück, Christian, additional

Published
2023
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19. Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis

Author

Karyotaki, Eirini, Ebert, David Daniel, Donkin, Liesje, Riper, Heleen, Twisk, Jos, Burger, Simone, Rozental, Alexander, Lange, Alfred, Williams, Alishia D., Zarski, Anna Carlotta, Geraedts, Anna, van Straten, Annemieke, Kleiboer, Annet, Meyer, Björn, Ünlü Ince, Burçin B., Buntrock, Claudia, Lehr, Dirk, Snoek, Frank J., Andrews, Gavin, Andersson, Gerhard, Choi, Isabella, Ruwaard, Jeroen, Klein, Jan Philipp, Newby, Jill M., Schröder, Johanna, Laferton, Johannes A.C., Van Bastelaar, Kim, Imamura, Kotaro, Vernmark, Kristofer, Boß, Leif, Sheeber, Lisa B., Kivi, Marie, Berking, Matthias, Titov, Nickolai, Carlbring, Per, Johansson, Robert, Kenter, Robin, Perini, Sarah, Moritz, Steffen, Nobis, Stephanie, Berger, Thomas, Kaldo, Viktor, Forsell, Yvonne, Lindefors, Nils, Kraepelien, Martin, Björkelund, Cecilia, Kawakami, Norito, and Cuijpers, Pim

Published
2018
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20. Genetics of response to cognitive behavior therapy in adults with major depression: a preliminary report

Author

Andersson, Evelyn, Crowley, James J., Lindefors, Nils, Ljótsson, Brjánn, Hedman-Lagerlöf, Erik, Boberg, Julia, El Alaoui, Samir, Karlsson, Robert, Lu, Yi, Mattheisen, Manuel, Kähler, Anna K., Svanborg, Cecilia, Mataix-Cols, David, Mattsson, Simon, Forsell, Erik, Kaldo, Viktor, Schalling, Martin, Lavebratt, Catharina, Sullivan, Patrick F., and Rück, Christian

Published
2019
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23. Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)

Author

Boberg, Julia, Kaldo, Viktor, Mataix-Cols, David, Crowley, James J., Roelstraete, Bjorn, Halvorsen, Matthew, Forsell, Erik, Isacsson, Nils H., Sullivan, Patrick F., Svanborg, Cecilia, Andersson, Evelyn H., Lindefors, Nils, Kravchenko, Olly, Mattheisen, Manuel, Danielsdottir, Hilda B., Ivanova, Ekaterina, Boman, Magnus, Fernández De La Cruz, Lorena, Wallert, John, Rück, Christian, Boberg, Julia, Kaldo, Viktor, Mataix-Cols, David, Crowley, James J., Roelstraete, Bjorn, Halvorsen, Matthew, Forsell, Erik, Isacsson, Nils H., Sullivan, Patrick F., Svanborg, Cecilia, Andersson, Evelyn H., Lindefors, Nils, Kravchenko, Olly, Mattheisen, Manuel, Danielsdottir, Hilda B., Ivanova, Ekaterina, Boman, Magnus, Fernández De La Cruz, Lorena, Wallert, John, and Rück, Christian

Abstract

Purpose Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose of MULTI-PSYCH is to improve risk stratification, outcome prediction and secondary preventive interventions. MULTI-PSYCH is a precision medicine initiative that combines clinical, genetic and nationwide register data. Participants MULTI-PSYCH includes 2668 clinically well-characterised adults with major depressive disorder (MDD) (n=1300), social anxiety disorder (n=640) or panic disorder (n=728) assessed before, during and after 12 weeks of ICBT at the internet psychiatry clinic in Stockholm, Sweden. All patients have been blood sampled and genotyped. Clinical and genetic data have been linked to several Swedish registers containing a wide range of variables from patient birth up to 10 years after the end of ICBT. These variable types include perinatal complications, school grades, psychiatric and somatic comorbidity, dispensed medications, medical interventions and diagnoses, healthcare and social benefits, demographics, income and more. Long-term follow-up data will be collected through 2029. Findings to date Initial uses of MULTI-PSYCH include the discovery of an association between PRS for autism spectrum disorder and response to ICBT, the development of a machine learning model for baseline prediction of remission status after ICBT in MDD and data contributions to genome wide association studies for ICBT outcome. Other projects have been launched or are in the planning phase. Future plans The MULTI-PSYCH cohort provides a unique infrastructure to study not only predictors or short-term treatment outcomes, but also longer term medical and socioeconomic outcomes in patients treated with ICBT for depression or anxiety. MULTI-PSYCH is well positioned for, QC 20231031

Published
2023
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26. A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders

Author

Rayner, Christopher, Coleman, Jonathan R. I., Purves, Kirstin L., Hodsoll, John, Goldsmith, Kimberley, Alpers, Georg W., Andersson, Evelyn, Arolt, Volker, Boberg, Julia, Bögels, Susan, Creswell, Cathy, Cooper, Peter, Curtis, Charles, Deckert, Jürgen, Domschke, Katharina, El Alaoui, Samir, Fehm, Lydia, Fydrich, Thomas, Gerlach, Alexander L., Grocholewski, Anja, Hahlweg, Kurt, Hamm, Alfons, Hedman, Erik, Heiervang, Einar R., Hudson, Jennifer L., Jöhren, Peter, Keers, Robert, Kircher, Tilo, Lang, Thomas, Lavebratt, Catharina, Lee, Sang-hyuck, Lester, Kathryn J., Lindefors, Nils, Margraf, Jürgen, Nauta, Maaike, Pané-Farré, Christiane A., Pauli, Paul, Rapee, Ronald M, Reif, Andreas, Rief, Winfried, Roberts, Susanna, Schalling, Martin, Schneider, Silvia, Silverman, Wendy K., Ströhle, Andreas, Teismann, Tobias, Thastum, Mikael, Wannemüller, Andre, Weber, Heike, Wittchen, Hans-Ulrich, Wolf, Christiane, Rück, Christian, Breen, Gerome, and Eley, Thalia C.

Published
2019
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49. Treatment feasibility of a digital tool for brief self-help behavioural therapy for insomnia (FastAsleep)

Author

Jernelöv, Susanna, Forsell, Erik, Westman, Henrietta, Dufva, Ylva Eriksson, Lindefors, Nils, Kaldo, Viktor, Kraepelien, Martin, Jernelöv, Susanna, Forsell, Erik, Westman, Henrietta, Dufva, Ylva Eriksson, Lindefors, Nils, Kaldo, Viktor, and Kraepelien, Martin

Abstract

Cognitive behavioural therapy for insomnia is efficacious and recommended for insomnia, but availability is scarce. Cognitive behavioural therapy for insomnia self-help interventions could increase availability, especially if unguided. Optimizing cognitive behavioural therapy for insomnia methods and system user-friendliness, we developed a short, digital, self-help programme-FastAsleep-based on the behavioural components of sleep restriction and stimulus control. This study investigated its feasibility and preliminary effects. Thirty media-recruited participants with moderate to severe insomnia were assessed via telephone before using FastAsleep for 4 weeks, and were interviewed afterwards. Self-ratings with web questionnaires were conducted at screening, pre-, mid- and post-treatment, and at 3-month follow-up. Primary outcomes were feasibility (credibility, adherence, system user-friendliness and adverse effects), and secondary outcomes were changes in symptom severity (insomnia, depression and anxiety). Adherence was generally high, participants' feasibility ratings were favourable, and adverse effects matched previously reported levels for cognitive behavioural therapy for insomnia. Symptoms of insomnia decreased after the treatment period (Hedge's g = 1.79, 95% confidence interval = 1.20-2.39), as did symptoms of depression and anxiety. FastAsleep can be considered feasible and promising for alleviating insomnia symptoms among patients fit for self-care. Future controlled trials are needed to establish the efficacy of FastAsleep and its suitability in a stepped care model.

Published
2022
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50. Treatment feasibility of a digital tool for brief self‐help behavioural therapy for insomnia (FastAsleep).

Author

Jernelöv, Susanna, Forsell, Erik, Westman, Henrietta, Eriksson Dufva, Ylva, Lindefors, Nils, Kaldo, Viktor, and Kraepelien, Martin

Subjects
BEHAVIOR therapy, INSOMNIA, DIGITAL technology, HEALTH self-care, COGNITIVE therapy, DROWSINESS, NIGHTMARES
Abstract

Summary: Cognitive behavioural therapy for insomnia is efficacious and recommended for insomnia, but availability is scarce. Cognitive behavioural therapy for insomnia self‐help interventions could increase availability, especially if unguided. Optimizing cognitive behavioural therapy for insomnia methods and system user‐friendliness, we developed a short, digital, self‐help programme—FastAsleep—based on the behavioural components of sleep restriction and stimulus control. This study investigated its feasibility and preliminary effects. Thirty media‐recruited participants with moderate to severe insomnia were assessed via telephone before using FastAsleep for 4 weeks, and were interviewed afterwards. Self‐ratings with web questionnaires were conducted at screening, pre‐, mid‐ and post‐treatment, and at 3‐month follow‐up. Primary outcomes were feasibility (credibility, adherence, system user‐friendliness and adverse effects), and secondary outcomes were changes in symptom severity (insomnia, depression and anxiety). Adherence was generally high, participants' feasibility ratings were favourable, and adverse effects matched previously reported levels for cognitive behavioural therapy for insomnia. Symptoms of insomnia decreased after the treatment period (Hedge's g = 1.79, 95% confidence interval = 1.20–2.39), as did symptoms of depression and anxiety. FastAsleep can be considered feasible and promising for alleviating insomnia symptoms among patients fit for self‐care. Future controlled trials are needed to establish the efficacy of FastAsleep and its suitability in a stepped care model. [ABSTRACT FROM AUTHOR]

Published
2023
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