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2. Global Longitudinal Strain and Biomarkers of Cardiac Damage and Stress as Predictors of Outcomes After Transcatheter Aortic Valve Implantation

Author

Perry, Andrew S, Stein, Elliot J, Biersmith, Michael, Fearon, William F, Elmariah, Sammy, Kim, Juyong B, Clark, Daniel E, Patel, Jay N, Gonzales, Holly, Baker, Michael, Piana, Robert N, Mallugari, Ravinder R, Kapadia, Samir, Kumbhani, Dharam J, Gillam, Linda, Whisenant, Brian, Quader, Nishath, Zajarias, Alan, Welt, Frederick G, Bavry, Anthony A, Coylewright, Megan, Gupta, Deepak K, Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R

Subjects
Cardiovascular, Clinical Research, Heart Disease, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Aortic Valve, Aortic Valve Stenosis, Biomarkers, Humans, Natriuretic Peptide, Brain, Prospective Studies, Retrospective Studies, Stroke Volume, Transcatheter Aortic Valve Replacement, Troponin, Ventricular Function, Left, aortic stenosis, biomarkers, cardiac remodeling, echocardiography, global longitudinal strain, outcomes, transcatheter aortic valve implantation, Cardiorespiratory Medicine and Haematology
Abstract

Background Global longitudinal strain (GLS) is a sensitive measure of left ventricular function and a risk marker in severe aortic stenosis. We sought to determine whether biomarkers of cardiac damage (cardiac troponin) and stress (NT-proBNP [N-terminal pro-B-type natriuretic peptide]) could complement GLS to identify patients with severe aortic stenosis at highest risk. Methods and Results From a multicenter prospective cohort of patients with symptomatic severe aortic stenosis who underwent transcatheter aortic valve implantation, we measured absolute GLS (aGLS), cardiac troponin, and NT-proBNP at baseline in 499 patients. Left ventricular ejection fraction 2; P≤0.002 for each) when the other biomarker was elevated, but not when the other biomarker was normal (interaction P=0.015). Conclusions Among patients with symptomatic severe aortic stenosis undergoing transcatheter aortic valve implantation, elevations in circulating cardiac troponin and NT-proBNP are more common as GLS worsens. Biomarkers of cardiac damage and stress are independently associated with mortality after transcatheter aortic valve implantation, whereas GLS is not. These findings may have implications for risk stratification of asymptomatic patients to determine optimal timing of valve replacement.

Published
2022

3. Neutrophil‐to‐Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries

Author

Shahim, Bahira, Redfors, Björn, Lindman, Brian R, Chen, Shmuel, Dahlen, Torsten, Nazif, Tamim, Kapadia, Samir, Gertz, Zachary M, Crowley, Aaron C, Li, Ditian, Thourani, Vinod H, Kodali, Susheel K, Zajarias, Alan, Babaliaros, Vasilis C, Guyton, Robert A, Elmariah, Sammy, Herrmann, Howard C, Cohen, David J, Mack, Michael J, Smith, Craig R, Leon, Martin B, and George, Isaac

Subjects
Heart Disease, Clinical Research, Transplantation, Cardiovascular, Aortic Valve, Aortic Valve Stenosis, Heart Valve Prosthesis Implantation, Humans, Lymphocytes, Neutrophils, Registries, Risk Factors, Severity of Illness Index, Treatment Outcome, aortic stenosis, neutrophil-to-lymphocyte ratio, NLR, surgical aortic valve replacement, transcatheter aortic valve replacement, neutrophil‐to‐lymphocyte ratio, Cardiorespiratory Medicine and Haematology
Abstract

Background The neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the prognostic impact of elevated baseline NLR or change in NLR levels during follow-up in patients undergoing transcatheter or surgical aortic valve replacement (TAVR or SAVR) for aortic stenosis. Methods and Results NLR was available in 5881 patients with severe aortic stenosis receiving TAVR or SAVR in PARTNER (Placement of Aortic Transcatheter Valves) I, II, and S3 trials/registries (median [Q1, Q3] NLR, 3.30 [2.40, 4.90]); mean NLR, 4.10; range, 0.5-24.9) and was evaluated as continuous variable and categorical tertiles (low: NLR ≤2.70, n=1963; intermediate: NLR 2.70-4.20, n=1958; high: NLR ≥4.20, n=1960). No patients had known baseline infection. High baseline NLR was associated with increased risk of death or rehospitalization at 3 years (58.4% versus 41.0%; adjusted hazard ratio [aHR], 1.39; 95% CI, 1.18-1.63; P

Published
2022

4. JACC: Advances Expert Panel Perspective: Shared Decision-Making in Multidisciplinary Team-Based Cardiovascular Care

Author

Perpetua, Elizabeth M., Palmer, Roseanne, Le, Viet T., Al-Khatib, Sana M., Beavers, Craig J., Beckman, Joshua A., Bozkurt, Biykem, Coylewright, Megan, Lloyd Doherty, Caroline, Guibone, Kimberly A., Hawkey, Marian, Keegan, Patricia A., Kirkpatrick, James N., Laperle, Jessica, Lauck, Sandra B., Levine, Glenn, Lindman, Brian R., Mack, Michael J., Price, Andrea L., Strong, Susan, Wyman, Janet F., Youmans, Quentin R., and Gulati, Martha

Published
2024
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5. Left Ventricular Hypertrophy and Biomarkers of Cardiac Damage and Stress in Aortic Stenosis

Author

Stein, Elliot J, Fearon, William F, Elmariah, Sammy, Kim, Juyong B, Kapadia, Samir, Kumbhani, Dharam J, Gillam, Linda, Whisenant, Brian, Quader, Nishath, Zajarias, Alan, Welt, Frederick G, Bavry, Anthony A, Coylewright, Megan, Piana, Robert N, Mallugari, Ravinder R, Clark, Daniel E, Patel, Jay N, Gonzales, Holly, Gupta, Deepak K, Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R

Subjects
Cardiovascular, Prevention, Heart Disease, Clinical Research, Patient Safety, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Good Health and Well Being, Aortic Valve, Aortic Valve Stenosis, Biomarkers, Female, Humans, Hypertrophy, Left Ventricular, Male, Natriuretic Peptide, Brain, Peptide Fragments, Risk Factors, biomarkers, left ventricular hypertrophy, mortality, NT-proBNP, transcatheter aortic valve implantation, transcatheter aortic valve replacement, troponin, NT‐proBNP, Cardiorespiratory Medicine and Haematology
Abstract

Background Left ventricular hypertrophy (LVH) is associated with increased mortality risk and rehospitalization after transcatheter aortic valve replacement among those with severe aortic stenosis. Whether cardiac troponin (cTnT) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) risk stratify patients with aortic stenosis and without LVH is unknown. Methods and Results In a multicenter prospective registry of 923 patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, we included 674 with core-laboratory-measured LV mass index, cTnT, and NT-proBNP. LVH was defined by sex-specific guideline cut-offs and elevated biomarker levels were based on age and sex cut-offs. Adjusted Cox proportional hazards models evaluated associations between LVH and biomarkers and all-cause death out to 5 years. Elevated cTnT and NT-proBNP were present in 82% and 86% of patients with moderate/severe LVH, respectively, as compared with 66% and 69% of patients with no/mild LVH, respectively (P

Published
2022

8. Acute Valve Syndrome in Aortic Stenosis

Author

Généreux, Philippe, Pellikka, Patricia A., Lindman, Brian R., Pibarot, Philippe, Garcia, Santiago, Koulogiannis, Konstantinos P., Rodriguez, Evelio, Thourani, Vinod H., Dobbles, Michael, Giustino, Gennaro, Sharma, Rahul P., Cohen, David J., Schwartz, Allan, Leon, Martin B., and Gillam, Linda D.

Published
2024
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9. Baseline pro-inflammatory gene expression in whole blood is related to adverse long-term outcomes after transcatheter aortic valve replacement: a case control study.

Author

Goldwater, Deena S, Leng, Mei, Karlamangla, Arun, Seeman, Teresa, Elashoff, David, Wanagat, Jonathan M, Reuben, David B, Lindman, Brian R, and Cole, Steve

Subjects
Gene expression, Geriatrics, Inflammation, Quality of life, Transcatheter aortic valve replacement, Cardiovascular System & Hematology, Cardiorespiratory Medicine and Haematology
Abstract

BackgroundAge-associated inflammation and immune system dysfunction have been implicated as mechanisms that increase risk for adverse long-term procedural outcomes in older adults. The purpose of this study was to investigate relationships between baseline inflammatory and innate antiviral gene expression and outcomes after transcatheter aortic valve replacement (TAVR) in older adults with severe aortic stenosis.MethodsWe performed a retrospective case-control study comparing pre-procedural pro-inflammatory and Type 1 interferon (IFN) gene expression in 48 controls with favorable outcomes (alive 1 year after TAVR with improved quality of life [QoL]) versus 48 individuals with unfavorable outcomes (dead by 1 year or alive at 1 year but with reduced QoL). Gene expression was evaluated in whole blood via (1) pre-defined composite scores of 19 inflammation-associated genes and 34 Type I IFN response genes, and (2) pro-inflammatory and antiviral transcription factor activity inferred from promotor based bioinformatics analyses of genes showing > 25% difference in average expression levels across groups. All analyses were adjusted for age, gender, body mass index, diabetes, immunosuppression, cardiovascular disease (CVD), and frailty.ResultsRelative to controls, those with unfavorable outcomes demonstrated higher expression of the pro-inflammatory gene composite prior to TAVR (p

Published
2021

10. Effect of a pragmatic home-based mobile health exercise intervention after transcatheter aortic valve replacement: a randomized pilot trial

Author

Lindman, Brian R, Gillam, Linda D, Coylewright, Megan, Welt, Frederick GP, Elmariah, Sammy, Smith, Stephanie A, McKeel, David A, Jackson, Natalie, Mukerjee, Kush, Cloud, Harrison, Hanna, Narden, Purpura, Jenelle, Ellis, Hannah, Martinez, Vong, Selberg, Alexandra M, Huang, Shi, and Harrell, Frank E

Subjects
Public Health, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Comparative Effectiveness Research, Cardiovascular, Clinical Research, Heart Disease, Rehabilitation, Behavioral and Social Science, Transplantation, Physical Rehabilitation, Clinical Trials and Supportive Activities, 6.7 Physical, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Accelerometer, Actigraphy, Aortic stenosis, Cardiac rehabilitation, Frailty, Mobile health, Transcatheter aortic valve replacement
Abstract

AimsImpaired physical function is common in patients undergoing transcatheter aortic valve replacement (TAVR) and associated with worse outcomes. Participation in centre-based cardiac rehabilitation (CR) after cardiovascular procedures is sub-optimal. We aimed to test a home-based mobile health exercise intervention as an alternative or complementary approach.Methods and resultsAt five centres, after a run-in period, eligible individuals treated with TAVR were randomized 1:1 at their 1-month post-TAVR visit to an intervention group [activity monitor (AM) with personalized daily step goal and resistance exercises] or a control group for 6 weeks. Among 50 participants, average age was 76 years, 34% were female, average STS score was 2.91.8, and 40% had Short Physical Performance Battery (SPPB) 9. Daily compliance with wearing the AM and performing exercises averaged 8590%. In the intention to treat population, there was no evidence that the intervention improved the co-primary endpoints: daily steps +769 (95% CI 244 to +1783); SPPB +0.68 (0.27 to 1.53); and Kansas City Cardiomyopathy Questionnaire 1.7 (9.1 to 7.1). The intervention did improve secondary physical activity parameters, including moderate-to-intense daily active minutes (P

Published
2021

11. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints

Author

Arnold, Suzanne, Bapat, Vinayak, Berry, Natalia, Blanke, Philipp, Burkhoff, Daniel, Coylewright, Megan, Duggal, Neal, Galper, Benjamin, George, Isaac, Guerrero, Mayra, Hamid, Nadira, Jagadeesan, Vikrant, Kodali, Susheel, Krucoff, Mitch, Lang, Roberto, Madhavan, Mahesh, McLaughin, Vallerie, Mehran, Roxana, Philippon, Francois, Sethi, Sanjum S., Simonato, Matheus, Smith, Robert, Sodhi, Nishtha, Spertus, John, Stocker, Thomas J., Stone, Gregg, Hahn, Rebecca T., Lawlor, Matthew K., Davidson, Charles J., Badhwar, Vinay, Sannino, Anna, Spitzer, Ernest, Lurz, Philipp, Lindman, Brian R., Topilsky, Yan, Baron, Suzanne J., Chadderdon, Scott, Khalique, Omar K., Tang, Gilbert H.L., Taramasso, Maurizio, Grayburn, Paul A., Badano, Luigi, Leipsic, Jonathon, Lindenfeld, JoAnn, Windecker, Stephan, Vemulapalli, Sreekanth, Redfors, Bjorn, Alu, Maria C., Cohen, David J., Rodés-Cabau, Josep, Ailawadi, Gorav, Mack, Michael, Ben-Yehuda, Ori, Leon, Martin B., and Hausleiter, Jörg

Published
2023
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12. Managing Severe Aortic Stenosis in the COVID-19 Era

Author

Tanguturi, Varsha K, Lindman, Brian R, Pibarot, Philippe, Passeri, Jonathan J, Kapadia, Samir, Mack, Michael J, Inglessis, Ignacio, Langer, Nathan B, Sundt, Thoralf M, Hung, Judy, and Elmariah, Sammy

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Health Services, Prevention, Clinical Research, Heart Disease, 7.1 Individual care needs, Management of diseases and conditions, Good Health and Well Being, Aortic Valve, Aortic Valve Stenosis, Betacoronavirus, COVID-19, Coronavirus Infections, Global Health, Hospital Mortality, Humans, Pandemics, Pneumonia, Viral, Risk Factors, SARS-CoV-2, Transcatheter Aortic Valve Replacement, aortic stenosis, SAVR, TAVR, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

The novel coronavirus disease-2019 (COVID-19) pandemic has created uncertainty in the management of patients with severe aortic stenosis. This population experiences high mortality from delays in treatment of valve disease but is largely overlapping with the population of highest mortality from COVID-19. The authors present strategies for managing patients with severe aortic stenosis in the COVID-19 era. The authors suggest transitions to virtual assessments and consultation, careful pruning and planning of necessary testing, and fewer and shorter hospital admissions. These strategies center on minimizing patient exposure to COVID-19 and expenditure of human and health care resources without significant sacrifice to patient outcomes during this public health emergency. Areas of innovation to improve care during this time include increased use of wearable and remote devices to assess patient performance and vital signs, devices for facile cardiac assessment, and widespread use of clinical protocols for expedient discharge with virtual physical therapy and cardiac rehabilitation options.

Published
2020

13. Associations of Sarcopenia and Body Composition Measures With Mortality After Transcatheter Aortic Valve Replacement

Author

Stein, Elliot J., Neill, Colin, Nair, Sangeeta, Terry, J. Greg, Carr, J. Jeffrey, Fearon, William F., Elmariah, Sammy, Kim, Juyong B., Kapadia, Samir, Kumbhani, Dharam J., Gillam, Linda, Whisenant, Brian, Quader, Nishath, Zajarias, Alan, Welt, Frederick G., Bavry, Anthony A., Coylewright, Megan, Piana, Robert, Mallugari, Ravinder R., Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R.

Published
2024
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15. Lower Blood Pressure After Transcatheter or Surgical Aortic Valve Replacement is Associated with Increased Mortality

Author

Lindman, Brian R, Goel, Kashish, Bermejo, Javier, Beckman, Joshua, O'Leary, Jared, Barker, Colin M, Kaiser, Clayton, Cavalcante, João L, Elmariah, Sammy, Huang, Jian, Hickey, Graeme L, Adams, David H, Popma, Jeffrey J, and Reardon, Michael J

Subjects
Clinical Research, Cardiovascular, Good Health and Well Being, Aged, Aged, 80 and over, Female, Heart Valve Prosthesis Implantation, Humans, Hypotension, Male, Postoperative Complications, Retrospective Studies, Transcatheter Aortic Valve Replacement, aortic valve stenosis, blood pressure, mortality, transcatheter aortic valve implantation, Cardiorespiratory Medicine and Haematology
Abstract

Background Blood pressure (BP) guidelines for patients with aortic stenosis or a history of aortic stenosis treated with aortic valve replacement (AVR) match those in the general population, but this extrapolation may not be warranted. Methods and Results Among patients enrolled in the Medtronic intermediate, high, and extreme risk trials, we included those with a transcatheter AVR (n=1794) or surgical AVR (n=1103) who were alive at 30 days. The associations between early (average of discharge and 30 day post-AVR) systolic BP (SBP) and diastolic BP (DBP) measurements and clinical outcomes between 30 days and 1 year were evaluated. Among 2897 patients, after adjustment, spline curves demonstrated an association between lower SBP (

Published
2019

16. Activin type II receptor signaling in cardiac aging and heart failure

Author

Roh, Jason D, Hobson, Ryan, Chaudhari, Vinita, Quintero, Pablo, Yeri, Ashish, Benson, Mark, Xiao, Chunyang, Zlotoff, Daniel, Bezzerides, Vassilios, Houstis, Nicholas, Platt, Colin, Damilano, Federico, Lindman, Brian R, Elmariah, Sammy, Biersmith, Michael, Lee, Se-Jin, Seidman, Christine E, Seidman, Jonathan G, Gerszten, Robert E, Lach-Trifilieff, Estelle, Glass, David J, and Rosenzweig, Anthony

Subjects
Aging, Heart Disease, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Activin Receptors, Type II, Activins, Adult, Aged, Aged, 80 and over, Animals, Constriction, Pathologic, Disease Models, Animal, Follistatin-Related Proteins, Frailty, Heart Failure, Heart Ventricles, Humans, Ligands, Male, Mice, Inbred C57BL, Middle Aged, Myocardium, Myocytes, Cardiac, Pressure, Proteasome Endopeptidase Complex, Proteolysis, Rats, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Severity of Illness Index, Signal Transduction, Systole, Biological Sciences, Medical and Health Sciences
Abstract

Activin type II receptor (ActRII) ligands have been implicated in muscle wasting in aging and disease. However, the role of these ligands and ActRII signaling in the heart remains unclear. Here, we investigated this catabolic pathway in human aging and heart failure (HF) using circulating follistatin-like 3 (FSTL3) as a potential indicator of systemic ActRII activity. FSTL3 is a downstream regulator of ActRII signaling, whose expression is up-regulated by the major ActRII ligands, activin A, circulating growth differentiation factor-8 (GDF8), and GDF11. In humans, we found that circulating FSTL3 increased with aging, frailty, and HF severity, correlating with an increase in circulating activins. In mice, increasing circulating activin A increased cardiac ActRII signaling and FSTL3 expression, as well as impaired cardiac function. Conversely, ActRII blockade with either clinical-stage inhibitors or genetic ablation reduced cardiac ActRII signaling while restoring or preserving cardiac function in multiple models of HF induced by aging, sarcomere mutation, or pressure overload. Using unbiased RNA sequencing, we show that activin A, GDF8, and GDF11 all induce a similar pathologic profile associated with up-regulation of the proteasome pathway in mammalian cardiomyocytes. The E3 ubiquitin ligase, Smurf1, was identified as a key downstream effector of activin-mediated ActRII signaling, which increased proteasome-dependent degradation of sarcoplasmic reticulum Ca2+ ATPase (SERCA2a), a critical determinant of cardiomyocyte function. Together, our findings suggest that increased activin/ActRII signaling links aging and HF pathobiology and that targeted inhibition of this catabolic pathway holds promise as a therapeutic strategy for multiple forms of HF.

Published
2019

19. Abstract 13362: Proteomic Architecture of Frailty Across the Spectrum of Cardiovascular Disease

Author

Perry, Andrew, Zhao, SHilin, Gajjar, Priya, Murthy, Venkatesh L, Lehallier, Benoit, Miller, Patricia, Nair, Sangeeta, Neill, Colin, Carr, Jeffrey, Fearon, William F, Kapadia, Samir R, Kumbhani, Dharam J, Gillam, Linda D, Lindenfeld, Joann, Farrell, Laurie, Marron, Megan M, Tian, Qu, Newman, Anne, Murabito, Joanne, Gerszten, Robert E, Nayor, Matthew G, Elmariah, Sammy, Lindman, Brian R, and Shah, Ravi V

Published
2023
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22. Association of Depression and Cognitive Dysfunction With Patient-Centered Outcomes After Transcatheter Aortic Valve Replacement

Author

El-Sabawi, Bassim, Cloud, Harrison, Patel, Jay N., Bell, Susan P., Elmariah, Sammy, Fearon, William F., Kim, Juyong B., Piana, Robert N., Kapadia, Samir R., Kumbhani, Dharam J., Gillam, Linda D., Whisenant, Brian K., Quader, Nishath, Zajarias, Alan, Welt, Frederick G., Bavry, Anthony A., Coylewright, Megan, Vatterott, Anna, Jackson, Natalie, Huang, Shi, and Lindman, Brian R.

Published
2023
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28. Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR: An Analysis of the PARTNER Trials and Registries

Author

Gonzales, Holly, Douglas, Pamela S., Pibarot, Philippe, Hahn, Rebecca T., Khalique, Omar K., Jaber, Wael A., Cremer, Paul, Weissman, Neil J., Asch, Federico M., Zhang, Yiran, Gertz, Zachary M., Elmariah, Sammy, Clavel, Marie-Annick, Thourani, Vinod H., Daubert, Melissa, Alu, Maria C., Leon, Martin B., and Lindman, Brian R.

Published
2020
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29. Capillary blood self‐collection for high‐throughput proteomics

Author

El‐Sabawi, Bassim, primary, Huang, Shi, additional, Tanriverdi, Kahraman, additional, Perry, Andrew S., additional, Amancherla, Kaushik, additional, Jackson, Natalie, additional, Hulsey, Jenna, additional, Freedman, Jane E., additional, Shah, Ravi, additional, and Lindman, Brian R., additional

Published
2024
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30. An interactive, online decision aid assessing patient goals and preferences for treatment of aortic stenosis to support physician-led shared decision-making: Early feasibility pilot study

Author

Coylewright, Megan, primary, Otero, Diana, additional, Lindman, Brian R., additional, Levack, Melissa M., additional, Horne, Aaron, additional, Ngo, Long H., additional, Beaudry, Melissa, additional, Col, Hannah V., additional, and Col, Nananda F., additional

Published
2024
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33. 2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons

Author

Nishimura, Rick A., O’Gara, Patrick T., Bavaria, Joseph E., Brindis, Ralph G., Carroll, John D., Kavinsky, Clifford J., Lindman, Brian R., Linderbaum, Jane A., Little, Stephen H., Mack, Michael J., Mauri, Laura, Miranda, William R., Shahian, David M., and Sundt, Thoralf M., III

Published
2019
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34. 2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and The Society of Thoracic Surgeons

Author

Nishimura, Rick A., O’Gara, Patrick T., Bavaria, Joseph E., Brindis, Ralph G., Carroll, John D., Kavinsky, Clifford J., Lindman, Brian R., Linderbaum, Jane A., Little, Stephen H., Mack, Michael J., Mauri, Laura, Miranda, William R., Shahian, David M., and Sundt, Thoralf M., III

Published
2019
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36. Multimarker Approach to Identify Patients With Higher Mortality and Rehospitalization Rate After Surgical Aortic Valve Replacement for Aortic Stenosis

Author

Lindman, Brian R., Clavel, Marie-Annick, Abu-Alhayja'a, Rami, Côté, Nancy, Dagenais, François, Novak, Eric, Voisine, Pierre, Poulin, Anthony, Arsenault, Benoit J., Desmeules, Philippe, Dahou, Abdellaziz, Taster, Lionel, Aldahoun, Khitam, Bossé, Yohan, Mathieu, Patrick, and Pibarot, Philippe

Published
2018
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37. Implications of Concomitant Tricuspid Regurgitation in Patients Undergoing Transcatheter Aortic Valve Replacement for Degenerated Surgical Aortic Bioprosthesis: Insights From the PARTNER 2 Aortic Valve-in-Valve Registry

Author

Sathananthan, Janarthanan, Murdoch, Dale J., Lindman, Brian R., Zajarias, Alan, Jaber, Wael A., Cremer, Paul, Wood, David, Moss, Robert, Cheung, Anson, Ye, Jian, Hahn, Rebecca T., Crowley, Aaron, Leon, Martin B., Mack, Michael J., and Webb, John G.

Published
2018
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39. Incidence and Clinical Significance of Worsening Tricuspid Regurgitation Following Surgical or Transcatheter Aortic Valve Replacement: Analysis From the PARTNER IIA Trial

Author

Cremer, Paul C., Wang, Tom Kai Ming, Rodriguez, L. Leonardo, Lindman, Brian R., Zhang, Yiran, Zajarias, Alan, Hahn, Rebecca T., Lerakis, Stamatios, Malaisrie, S. Chris, Douglas, Pamela S., Pibarot, Philippe, Svensson, Lars G., Kapadia, Samir, Leon, Martin B., and Jaber, Wael A.

Published
2021
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40. ACC/AATS/AHA/ASE/EACTS/HVS/SCA/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for the Treatment of Patients With Severe Aortic Stenosis: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, European Association for Cardio-Thoracic Surgery, Heart Valve Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons

Author

Bonow, Robert O., Brown, Alan S., Gillam, Linda D., Kapadia, Samir R., Kavinsky, Clifford J., Lindman, Brian R., Mack, Michael J., Thourani, Vinod H., Dehmer, Gregory J., Beaver, Thomas M., Bradley, Steven M., Carabello, Blase A., Desai, Milind Y., George, Isaac, Green, Philip, Holmes, David R., Jr, Johnston, Douglas, Leipsic, Jonathon, Mick, Stephanie L., Passeri, Jonathan J., Piana, Robert N., Reichek, Nathaniel, Ruiz, Carlos E., Taub, Cynthia C., Thomas, James D., Turi, Zoltan G., Doherty, John U., Bailey, Steven R., Bhave, Nicole M., Daugherty, Stacie L., Dean, Larry S., Duvernoy, Claire S., Hendel, Robert C., Kramer, Christopher M., Lindsay, Bruce D., Manning, Warren J., Mehrotra, Praveen, Patel, Manesh R., Sachdeva, Ritu, Wann, L. Samuel, Winchester, David E., and Allen, Joseph M.

Published
2018
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41. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints

Author

Hahn, Rebecca T., primary, Lawlor, Matthew K., additional, Davidson, Charles J., additional, Badhwar, Vinay, additional, Sannino, Anna, additional, Spitzer, Ernest, additional, Lurz, Philipp, additional, Lindman, Brian R., additional, Topilsky, Yan, additional, Baron, Suzanne J., additional, Chadderdon, Scott, additional, Khalique, Omar K., additional, Tang, Gilbert H.L., additional, Taramasso, Maurizio, additional, Grayburn, Paul A., additional, Badano, Luigi, additional, Leipsic, Jonathon, additional, Lindenfeld, JoAnn, additional, Windecker, Stephan, additional, Vemulapalli, Sreekanth, additional, Redfors, Bjorn, additional, Alu, Maria C., additional, Cohen, David J., additional, Rodés-Cabau, Josep, additional, Ailawadi, Gorav, additional, Mack, Michael, additional, Ben-Yehuda, Ori, additional, Leon, Martin B., additional, Hausleiter, Jörg, additional, Arnold, Suzanne, additional, Bapat, Vinayak, additional, Berry, Natalia, additional, Blanke, Philipp, additional, Burkhoff, Daniel, additional, Coylewright, Megan, additional, Duggal, Neal, additional, Galper, Benjamin, additional, George, Isaac, additional, Guerrero, Mayra, additional, Hamid, Nadira, additional, Jagadeesan, Vikrant, additional, Kodali, Susheel, additional, Krucoff, Mitch, additional, Lang, Roberto, additional, Madhavan, Mahesh, additional, McLaughin, Vallerie, additional, Mehran, Roxana, additional, Philippon, Francois, additional, Sethi, Sanjum S., additional, Simonato, Matheus, additional, Smith, Robert, additional, Sodhi, Nishtha, additional, Spertus, John, additional, Stocker, Thomas J., additional, and Stone, Gregg, additional

Published
2023
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42. Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints

Author

Hahn, Rebecca T, primary, Lawlor, Matthew K, additional, Davidson, Charles J, additional, Badhwar, Vinay, additional, Sannino, Anna, additional, Spitzer, Ernest, additional, Lurz, Philipp, additional, Lindman, Brian R, additional, Topilsky, Yan, additional, Baron, Suzanne J, additional, Chadderdon, Scott, additional, Khalique, Omar K, additional, Tang, Gilbert H L, additional, Taramasso, Maurizio, additional, Grayburn, Paul A, additional, Badano, Luigi, additional, Leipsic, Jonathon, additional, Lindenfeld, JoAnn, additional, Windecker, Stephan, additional, Vemulapalli, Sreekanth, additional, Redfors, Bjorn, additional, Alu, Maria C, additional, Cohen, David J, additional, Rodés-Cabau, Josep, additional, Ailawadi, Gorav, additional, Mack, Michael, additional, Ben-Yehuda, Ori, additional, Leon, Martin B, additional, and Hausleiter, Jörg, additional

Published
2023
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43. Transcatheter Edge-to-Edge Repair in 5,000 Patients With Secondary Mitral Regurgitation

Author

Goel, Kashish, primary, Lindenfeld, JoAnn, additional, Makkar, Raj, additional, Naik, Hursh, additional, Atmakuri, Satya, additional, Mahoney, Paul, additional, Morse, Michael A., additional, Thourani, Vinod H., additional, Yadav, Pradeep, additional, Batchelor, Wayne, additional, Rogers, Jason, additional, Whisenant, Brian, additional, Rinaldi, Michael, additional, Hermiller, James, additional, Lindman, Brian R., additional, and Barker, Colin M., additional

Published
2023
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44. Transapical Transcatheter Aortic Valve Replacement Is Associated With Increased Cardiac Mortality in Patients With Left Ventricular Dysfunction: Insights From the PARTNER I Trial

Author

Elmariah, Sammy, Fearon, William F., Inglessis, Ignacio, Vlahakes, Gus J., Lindman, Brian R., Alu, Maria C., Crowley, Aaron, Kodali, Susheel, Leon, Martin B., Svensson, Lars, Pibarot, Philippe, Hahn, Rebecca T., Thourani, Vinod H., Palacios, Igor F., Miller, D. Craig, Douglas, Pamela S., and Passeri, Jonathan J.

Published
2017
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48. Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement: An Analysis of the PARTNER 2 Trial and Registry

Author

Salaun, Erwan, Clavel, Marie-Annick, Hahn, Rebecca T., Jaber, Wael A., Asch, Federico M., Rodriguez, Leonardo, Weissman, Neil J., Gertz, Zachary M., Herrmann, Howard C., Dahou, Abdellaziz, Annabi, Mohamed-Salah, Toubal, Oumhani, Bernier, Mathieu, Beaudoin, Jonathan, Leipsic, Jonathon, Blanke, Philipp, Ridard, Carine, Ong, Géraldine, Rodés-Cabau, Josep, Webb, John G., Zhang, Yiran, Alu, Maria C., Douglas, Pamela S., Makkar, Raj, Miller, D. Craig, Lindman, Brian R., Thourani, Vinod H., Leon, Martin B., and Pibarot, Philippe

Published
2020
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