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1. Physical activity in relation to metabolic health and obesity: The Feel4Diabetes study.

Author: Pelekanou, Christina, Anastasiou, Costas A., Mavrogianni, Christina, Cardon, Greet, Liatis, Stavros, Lindstrom, Jaana, Moreno, Luis A., Hilal, Soukaina, Rurik, Imre, Wikström, Katja, Iotova, Violeta, Makrilakis, Konstantinos, and Manios, Yannis
Subjects: ODDS ratio, PHENOTYPES, PHYSICAL training & conditioning, OBESITY, CONFIDENCE intervals
Abstract: Aim: To examine physical activity levels in association with metabolic health and estimate the stability of metabolically healthy obese (MHO) phenotypes over a 2‐year period. Methods: In total, 2848 men and women from families at risk of the development of diabetes were recruited. Participants were classified as obese or non‐obese and metabolic health was defined using five existing definitions. Physical activity was estimated with the International Physical Activity Questionnaire and pedometers. Results: Prevalence of the MHO phenotype varied among definitions (0% to 20.2%). Overall, the MHO were more active than the metabolically unhealthy obese (MUO). Daily sitting hours (odds ratio [OR] = 1.055, 95% confidence interval [CI]: 1.009‐1.104) and daily steps (per 500; OR = 0.934, 95% CI: 0.896‐0.973) were remarkable predictors of metabolic health in individuals with obesity; and likewise, in individuals without obesity. After 2 years, 44.1% of baseline MHO adults transitioned to MUO, while 84.0% of the MUO at baseline remained at the same phenotype. Although physical activity was not a major determinant in phenotype transitioning, daily steps were associated with the maintenance of metabolic health over time in the non‐obese group. Conclusion: A universally accepted definition for MHO is needed. Being physically active can contribute to a metabolically healthy profile even in the presence of obesity; still, MHO is a transient condition and physical activity alone may not be an adequate factor for its maintenance. [ABSTRACT FROM AUTHOR]
Published: 2024
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2. Unraveling the factors associated with digital health intervention uptake

Author: Ruotsalainen, Ilona, primary, Valtanen, Mikko, additional, Karsama, Riikka, additional, Umer, Adil, additional, Liedes, Hilkka, additional, Parikka, Suvi, additional, Lundqvist, Annamari, additional, Aittola, Kirsikka, additional, Manninen, Suvi, additional, Pihlajamaki, Jussi, additional, Vuorinen, Anna-Leena, additional, and Lindstrom, Jaana, additional
Published: 2024
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3. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.

Author: Manning, Alisa, Highland, Heather M, Gasser, Jessica, Sim, Xueling, Tukiainen, Taru, Fontanillas, Pierre, Grarup, Niels, Rivas, Manuel A, Mahajan, Anubha, Locke, Adam E, Cingolani, Pablo, Pers, Tune H, Viñuela, Ana, Brown, Andrew A, Wu, Ying, Flannick, Jason, Fuchsberger, Christian, Gamazon, Eric R, Gaulton, Kyle J, Im, Hae Kyung, Teslovich, Tanya M, Blackwell, Thomas W, Bork-Jensen, Jette, Burtt, Noël P, Chen, Yuhui, Green, Todd, Hartl, Christopher, Kang, Hyun Min, Kumar, Ashish, Ladenvall, Claes, Ma, Clement, Moutsianas, Loukas, Pearson, Richard D, Perry, John RB, Rayner, N William, Robertson, Neil R, Scott, Laura J, van de Bunt, Martijn, Eriksson, Johan G, Jula, Antti, Koskinen, Seppo, Lehtimäki, Terho, Palotie, Aarno, Raitakari, Olli T, Jacobs, Suzanne BR, Wessel, Jennifer, Chu, Audrey Y, Scott, Robert A, Goodarzi, Mark O, Blancher, Christine, Buck, Gemma, Buck, David, Chines, Peter S, Gabriel, Stacey, Gjesing, Anette P, Groves, Christopher J, Hollensted, Mette, Huyghe, Jeroen R, Jackson, Anne U, Jun, Goo, Justesen, Johanne Marie, Mangino, Massimo, Murphy, Jacquelyn, Neville, Matt, Onofrio, Robert, Small, Kerrin S, Stringham, Heather M, Trakalo, Joseph, Banks, Eric, Carey, Jason, Carneiro, Mauricio O, DePristo, Mark, Farjoun, Yossi, Fennell, Timothy, Goldstein, Jacqueline I, Grant, George, Hrabé de Angelis, Martin, Maguire, Jared, Neale, Benjamin M, Poplin, Ryan, Purcell, Shaun, Schwarzmayr, Thomas, Shakir, Khalid, Smith, Joshua D, Strom, Tim M, Wieland, Thomas, Lindstrom, Jaana, Brandslund, Ivan, Christensen, Cramer, Surdulescu, Gabriela L, Lakka, Timo A, Doney, Alex SF, Nilsson, Peter, Wareham, Nicholas J, Langenberg, Claudia, Varga, Tibor V, Franks, Paul W, Rolandsson, Olov, Rosengren, Anders H, and Farook, Vidya S
Subjects: Genetics, Diabetes, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Black or African American, Alleles, Asian People, Case-Control Studies, Diabetes Mellitus, Type 2, Fasting, Finland, Gene Frequency, Genetic Predisposition to Disease, Genotype, Hispanic or Latino, Humans, Insulin, Insulin Resistance, Odds Ratio, Proto-Oncogene Proteins c-akt, White People, Medical and Health Sciences, Endocrinology & Metabolism
Abstract: To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting plasma insulin (FI), a gene in which rare fully penetrant mutations are causal for monogenic glycemic disorders. The low-frequency allele is associated with a 12% increase in FI levels. This variant is present at 1.1% frequency in Finns but virtually absent in individuals from other ancestries. Carriers of the FI-increasing allele had increased 2-h insulin values, decreased insulin sensitivity, and increased risk of type 2 diabetes (odds ratio 1.05). In cellular studies, the AKT2-Thr50 protein exhibited a partial loss of function. We extend the allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis and demonstrate bidirectional effects of variants within the pleckstrin homology domain of AKT2.
Published: 2017

4. Learning from Human Behavior to Improve Preventative Health Information Systems

Author: Martinez, Remberto, Tong, Marcos, Diago, Luis, Lindstrom, Jaana, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Ahram, Tareq, editor, Karwowski, Waldemar, editor, and Taiar, Redha, editor
Published: 2019
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5. Tackling the challenge of cardiovascular diseases and diabetes across Europe: a joint action by more than 300 public health professionals.

Author: Armocida, Benedetta, Formenti, Beatrice, Silano, Marco, Aszalos, Albert, Bueno, Hector, Elyamani, Mounia, Zabala, Ane Fullaondo, Leonardi, Matilde, Lindstrom, Jaana, Michalak, Karolina, Morillo, Bernardino, Nowicki, Michal, Opresnik, Denis, Palmieri, Luigi, Papa, Roberta, Peltonen, Markku, Safadi, Helena, Shchetynina, Hanna, Skogberg, Natalia, and Tolonen, Hanna
Published: 2024
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6. Sugar-sweetened beverage intakes among adults between 1990 and 2018 in 185 countries

Author: Lara-Castor, Laura, Micha, Renata, Cudhea, Frederick, Miller, Victoria, Shi, Peilin, Zhang, Jianyi, Sharib, Julia R., Erndt-Marino, Josh, Cash, Sean B., Mozaffarian, Dariush, Bas, Murat, Ali, Jemal Haidar, Abumweis, Suhad, Krishnan, Anand, Misra, Puneet, Hwalla, Nahla Chawkat, Janakiram, Chandrashekar, Liputo, Nur Indrawaty, Musaiger, Abdulrahman, Pourfarzi, Farhad, Alam, Iftikhar, DeRidder, Karin, Termote, Celine, Memon, Anjum, Turrini, Aida, Lupotto, Elisabetta, Piccinelli, Raffaela, Sette, Stefania, Anzid, Karim, Vossenaar, Marieke, Mazumdar, Paramita, Rached, Ingrid, Rovirosa, Alicia, Zapata, María Elisa, Asayehu, Tamene Taye, Oduor, Francis, Boedecker, Julia, Aluso, Lilian, Ortiz-Ulloa, Johana, Meenakshi, J.V., Castro, Michelle, Grosso, Giuseppe, Waskiewicz, Anna, Khan, Umber S., Thanopoulou, Anastasia, Malekzadeh, Reza, Calleja, Neville, Ocke, Marga, Etemad, Zohreh, Nsour, Mohannad Al, Waswa, Lydiah M., Nurk, Eha, Arsenault, Joanne, Lopez-Jaramillo, Patricio, Sibai, Abla Mehio, Damasceno, Albertino, Arambepola, Carukshi, Lopes, Carla, Severo, Milton, Lunet, Nuno, Torres, Duarte, Tapanainen, Heli, Lindstrom, Jaana, Virtanen, Suvi, Palacios, Cristina, Roos, Eva, Agdeppa, Imelda Angeles, Desnacido, Josie, Capanzana, Mario, Misra, Anoop, Khouw, Ilse, Ng, Shu Wen, Delgado, Edna Gamboa, Caballero, Mauricio, Otero, Johanna, Lee, Hae Jeung, Koksal, Eda, Guessous, Idris, Lachat, Carl, De Henauw, Stefaan, Rahbar, Ali Reza, Tedstone, Alison, Naska, Androniki, Mathee, Angie, Ling, Annie, Tedla, Bemnet, Hopping, Beth, Ginnela, Brahmam, Leclercq, Catherine, Duante, Charmaine, Haerpfer, Christian, Hotz, Christine, Pitsavos, Christos, Rehm, Colin, van Oosterhout, Coline, Cerdena, Corazon, Bradshaw, Debbie, Trichopoulos, Dimitrios, Gauci, Dorothy, Fernando, Dulitha, Sygnowska, Elzbieta, Vartiainen, Erkki, Farzadfar, Farshad, Zajkas, Gabor, Swan, Gillian, Ma, Guansheng, Pekcan, Gulden, Ibrahim, Hajah Masni, Sinkko, Harri, Barbieri, Helene Enghardt, Sioen, Isabelle, Myhre, Jannicke, Gaspoz, Jean Michel, Odenkirk, Jillian, Bundhamcharoen, Kanitta, Nelis, Keiu, Zarina, Khairul, Biro, Lajos, Johansson, Lars, Steingrimsdottir, Laufey, Riley, Leanne, Yap, Mabel, Inoue, Manami, Szabo, Maria, Ovaskainen, Marja Leena, Lee, Meei Shyuan, Chan, Mei Fen, Cowan, Melanie, Kandiah, Mirnalini, Kally, Ola, Jonsdottir, Olof, Palmer, Pam, Vollenweider, Peter, Orfanos, Philippos, Asciak, Renzo, Templeton, Robert, Don, Rokiah, Yaakub, Roseyati, Selamat, Rusidah, Yusof, Safiah, Al-Zenki, Sameer, Hung, Shu Yi, Beer-Borst, Sigrid, Wu, Suh, Lukito, Widjaja, Hadden, Wilbur, Becker, Wulf, Cao, Xia, Ma, Yi, Lai, Yuen, Hjdaud, Zaiton, Ali, Jennifer, Gravel, Ron, Tao, Tina, Veerman, Jacob Lennert, Chiplonkar, Shashi, Arici, Mustafa, Ngoan, Le Tran, Panagiotakos, Demosthenes, Li, Yanping, Trichopoulou, Antonia, Barengo, Noel, Khadilkar, Anuradha, Ekbote, Veena, Mohammadifard, Noushin, Kovalskys, Irina, Laxmaiah, Avula, Rachakulla, Harikumar, Rajkumar, Hemalatha, Meshram, Indrapal, Avula, Laxmaiah, Arlappa, Nimmathota, Hemalatha, Rajkumar, Iacoviello, Licia, Bonaccio, Marialaura, Costanzo, Simona, Martin-Prevel, Yves, Castetbon, Katia, Jitnarin, Nattinee, Hsieh, Yao Te, Olivares, Sonia, Tejeda, Gabriela, Hadziomeragic, Aida, de Moura Souza, Amanda, Pan, Wen Harn, Huybrechts, Inge, de Brauw, Alan, Moursi, Mourad, Maghroun, Maryam, Zeba, Augustin Nawidimbasba, Sarrafzadegan, Nizal, Keinan-Boker, Lital, Goldsmith, Rebecca, Shimony, Tal, Jordan, Irmgard, Mastiholi, Shivanand C., Mwangi, Moses, Kombe, Yeri, Bukania, Zipporah, Alissa, Eman, Al-Daghri, Nasser, Sabico, Shaun, Gulliford, Martin, Diba, Tshilenge S., Oh, Kyungwon, Kweon, Sanghui, Park, Sihyun, Cho, Yoonsu, Al-Hooti, Suad, Luangphaxay, Chanthaly, Douangvichit, Daovieng, Siengsounthone, Latsamy, Marques-Vidal, Pedro, Rybak, Constance, Luke, Amy, Piaseu, Noppawan, Rojroongwasinkul, Nipa, Sundram, Kalyana, Koster, Jeremy, Baykova, Donka, Abedi, Parvin, Sandjaja, Sandjaja, Fadzil, Fariza, Bukhary, Noriklil Bukhary Ismail, Bovet, Pascal, Chen, Yu, Sawada, Norie, Tsugane, Shoichiro, Rangelova, Lalka, Petrova, Stefka, Duleva, Vesselka, Lindroos, Anna Karin, Sipinen, Jessica Petrelius, Moraeus, Lotta, Bergman, Per, Siamusantu, Ward, Szponar, Lucjan, Chang, Hsing Yi, Sekiyama, Makiko, Le Nguyen Bao, Khanh, Nagalla, Balakrishna, Polasa, Kalpagam, Boindala, Sesikeran, El Ati, Jalila, Silva, Ivonne Ramirez, Dommarco, Juan Rivera, Barquera, Simon, Rodríguez-Ramírez, Sonia, Illescas-Zarate, Daniel, Sanchez-Romero, Luz Maria, Ikeda, Nayu, Zaghloul, Sahar, Houshiar-rad, Anahita, Mohammadi-Nasrabadi, Fatemeh, Abdollahi, Morteza, Chuah, Khun Aik, Mahdy, Zaleha Abdullah, Eldridge, Alison, Ding, Eric L., Kruger, Herculina, Henjum, Sigrun, Fernandez, Anne, Suarez-Ortegon, Milton Fabian, Al-Hamad, Nawal, Janská, Veronika, Tayyem, Reema, Mirmiran, Parvin, Kelishadi, Roya, Lemming, Eva Warensjo, Richter, Almut, Mensink, Gert, Wieler, Lothar, Hoffman, Daniel, Salanave, Benoit, Il Kim, Cho, Kuriyan-Raj, Rebecca, Swaminathan, Sumathi, Garriguet, Didier, Dastgiri, Saeed, Vaask, Sirje, Karupaiah, Tilakavati, Zohoori, Fatemeh Vida, Esteghamati, Alireza, Hashemian, Maryam, Noshad, Sina, Mwaniki, Elizabeth, Yakes-Jimenez, Elizabeth, Chileshe, Justin, Mwanza, Sydney, Marques, Lydia Lera, Preston, Alan Martin, Aguero, Samuel Duran, Oleas, Mariana, Posada, Luz, Ochoa, Angelica, Shamsuddin, Khadijah, Shariff, Zalilah Mohd, Jan Bin Jan Mohamed, Hamid, Manan, Wan, Nicolau, Anca, Tudorie, Cornelia, Poh, Bee Koon, Abbott, Pamela, Pakseresht, Mohammadreza, Sharma, Sangita, Strand, Tor, Alexy, Ute, Nöthlings, Ute, Carmikle, Jan, Brown, Ken, Waidyatilaka, Indu, Lanerolle, Pulani, Jayawardena, Ranil, Long, Julie M., Hambidge, Michael, Krebs, Nancy F., Haque, Aminul, Keding, Gudrun B., Korkalo, Liisa, Erkkola, Maijaliisa, Freese, Riitta, Eleraky, Laila, Stuetz, Wolfgang, Thorsdottir, Inga, Gunnarsdottir, Ingibjorg, Serra-Majem, Lluis, Moy, Foong Ming, Anderson, Simon, Jeewon, Rajesh, Zugravu, Corina Aurelia, Adair, Linda, Skeaff, Sheila, Marchioni, Dirce, Fisberg, Regina, Henry, Carol, Ersino, Getahun, Zello, Gordon, Meyer, Alexa, Elmadfa, Ibrahim, Mitchell, Claudette, Balfour, David, Geleijnse, Johanna M., Manary, Mark, El-kour, Tatyana, Nikiema, Laetitia, Mirzaei, Masoud, Hakeem, Rubina, Lara-Castor, Laura, Micha, Renata, Cudhea, Frederick, Miller, Victoria, Shi, Peilin, Zhang, Jianyi, Sharib, Julia R., Erndt-Marino, Josh, Cash, Sean B., Mozaffarian, Dariush, Bas, Murat, Ali, Jemal Haidar, Abumweis, Suhad, Krishnan, Anand, Misra, Puneet, Hwalla, Nahla Chawkat, Janakiram, Chandrashekar, Liputo, Nur Indrawaty, Musaiger, Abdulrahman, Pourfarzi, Farhad, Alam, Iftikhar, DeRidder, Karin, Termote, Celine, Memon, Anjum, Turrini, Aida, Lupotto, Elisabetta, Piccinelli, Raffaela, Sette, Stefania, Anzid, Karim, Vossenaar, Marieke, Mazumdar, Paramita, Rached, Ingrid, Rovirosa, Alicia, Zapata, María Elisa, Asayehu, Tamene Taye, Oduor, Francis, Boedecker, Julia, Aluso, Lilian, Ortiz-Ulloa, Johana, Meenakshi, J.V., Castro, Michelle, Grosso, Giuseppe, Waskiewicz, Anna, Khan, Umber S., Thanopoulou, Anastasia, Malekzadeh, Reza, Calleja, Neville, Ocke, Marga, Etemad, Zohreh, Nsour, Mohannad Al, Waswa, Lydiah M., Nurk, Eha, Arsenault, Joanne, Lopez-Jaramillo, Patricio, Sibai, Abla Mehio, Damasceno, Albertino, Arambepola, Carukshi, Lopes, Carla, Severo, Milton, Lunet, Nuno, Torres, Duarte, Tapanainen, Heli, Lindstrom, Jaana, Virtanen, Suvi, Palacios, Cristina, Roos, Eva, Agdeppa, Imelda Angeles, Desnacido, Josie, Capanzana, Mario, Misra, Anoop, Khouw, Ilse, Ng, Shu Wen, Delgado, Edna Gamboa, Caballero, Mauricio, Otero, Johanna, Lee, Hae Jeung, Koksal, Eda, Guessous, Idris, Lachat, Carl, De Henauw, Stefaan, Rahbar, Ali Reza, Tedstone, Alison, Naska, Androniki, Mathee, Angie, Ling, Annie, Tedla, Bemnet, Hopping, Beth, Ginnela, Brahmam, Leclercq, Catherine, Duante, Charmaine, Haerpfer, Christian, Hotz, Christine, Pitsavos, Christos, Rehm, Colin, van Oosterhout, Coline, Cerdena, Corazon, Bradshaw, Debbie, Trichopoulos, Dimitrios, Gauci, Dorothy, Fernando, Dulitha, Sygnowska, Elzbieta, Vartiainen, Erkki, Farzadfar, Farshad, Zajkas, Gabor, Swan, Gillian, Ma, Guansheng, Pekcan, Gulden, Ibrahim, Hajah Masni, Sinkko, Harri, Barbieri, Helene Enghardt, Sioen, Isabelle, Myhre, Jannicke, Gaspoz, Jean Michel, Odenkirk, Jillian, Bundhamcharoen, Kanitta, Nelis, Keiu, Zarina, Khairul, Biro, Lajos, Johansson, Lars, Steingrimsdottir, Laufey, Riley, Leanne, Yap, Mabel, Inoue, Manami, Szabo, Maria, Ovaskainen, Marja Leena, Lee, Meei Shyuan, Chan, Mei Fen, Cowan, Melanie, Kandiah, Mirnalini, Kally, Ola, Jonsdottir, Olof, Palmer, Pam, Vollenweider, Peter, Orfanos, Philippos, Asciak, Renzo, Templeton, Robert, Don, Rokiah, Yaakub, Roseyati, Selamat, Rusidah, Yusof, Safiah, Al-Zenki, Sameer, Hung, Shu Yi, Beer-Borst, Sigrid, Wu, Suh, Lukito, Widjaja, Hadden, Wilbur, Becker, Wulf, Cao, Xia, Ma, Yi, Lai, Yuen, Hjdaud, Zaiton, Ali, Jennifer, Gravel, Ron, Tao, Tina, Veerman, Jacob Lennert, Chiplonkar, Shashi, Arici, Mustafa, Ngoan, Le Tran, Panagiotakos, Demosthenes, Li, Yanping, Trichopoulou, Antonia, Barengo, Noel, Khadilkar, Anuradha, Ekbote, Veena, Mohammadifard, Noushin, Kovalskys, Irina, Laxmaiah, Avula, Rachakulla, Harikumar, Rajkumar, Hemalatha, Meshram, Indrapal, Avula, Laxmaiah, Arlappa, Nimmathota, Hemalatha, Rajkumar, Iacoviello, Licia, Bonaccio, Marialaura, Costanzo, Simona, Martin-Prevel, Yves, Castetbon, Katia, Jitnarin, Nattinee, Hsieh, Yao Te, Olivares, Sonia, Tejeda, Gabriela, Hadziomeragic, Aida, de Moura Souza, Amanda, Pan, Wen Harn, Huybrechts, Inge, de Brauw, Alan, Moursi, Mourad, Maghroun, Maryam, Zeba, Augustin Nawidimbasba, Sarrafzadegan, Nizal, Keinan-Boker, Lital, Goldsmith, Rebecca, Shimony, Tal, Jordan, Irmgard, Mastiholi, Shivanand C., Mwangi, Moses, Kombe, Yeri, Bukania, Zipporah, Alissa, Eman, Al-Daghri, Nasser, Sabico, Shaun, Gulliford, Martin, Diba, Tshilenge S., Oh, Kyungwon, Kweon, Sanghui, Park, Sihyun, Cho, Yoonsu, Al-Hooti, Suad, Luangphaxay, Chanthaly, Douangvichit, Daovieng, Siengsounthone, Latsamy, Marques-Vidal, Pedro, Rybak, Constance, Luke, Amy, Piaseu, Noppawan, Rojroongwasinkul, Nipa, Sundram, Kalyana, Koster, Jeremy, Baykova, Donka, Abedi, Parvin, Sandjaja, Sandjaja, Fadzil, Fariza, Bukhary, Noriklil Bukhary Ismail, Bovet, Pascal, Chen, Yu, Sawada, Norie, Tsugane, Shoichiro, Rangelova, Lalka, Petrova, Stefka, Duleva, Vesselka, Lindroos, Anna Karin, Sipinen, Jessica Petrelius, Moraeus, Lotta, Bergman, Per, Siamusantu, Ward, Szponar, Lucjan, Chang, Hsing Yi, Sekiyama, Makiko, Le Nguyen Bao, Khanh, Nagalla, Balakrishna, Polasa, Kalpagam, Boindala, Sesikeran, El Ati, Jalila, Silva, Ivonne Ramirez, Dommarco, Juan Rivera, Barquera, Simon, Rodríguez-Ramírez, Sonia, Illescas-Zarate, Daniel, Sanchez-Romero, Luz Maria, Ikeda, Nayu, Zaghloul, Sahar, Houshiar-rad, Anahita, Mohammadi-Nasrabadi, Fatemeh, Abdollahi, Morteza, Chuah, Khun Aik, Mahdy, Zaleha Abdullah, Eldridge, Alison, Ding, Eric L., Kruger, Herculina, Henjum, Sigrun, Fernandez, Anne, Suarez-Ortegon, Milton Fabian, Al-Hamad, Nawal, Janská, Veronika, Tayyem, Reema, Mirmiran, Parvin, Kelishadi, Roya, Lemming, Eva Warensjo, Richter, Almut, Mensink, Gert, Wieler, Lothar, Hoffman, Daniel, Salanave, Benoit, Il Kim, Cho, Kuriyan-Raj, Rebecca, Swaminathan, Sumathi, Garriguet, Didier, Dastgiri, Saeed, Vaask, Sirje, Karupaiah, Tilakavati, Zohoori, Fatemeh Vida, Esteghamati, Alireza, Hashemian, Maryam, Noshad, Sina, Mwaniki, Elizabeth, Yakes-Jimenez, Elizabeth, Chileshe, Justin, Mwanza, Sydney, Marques, Lydia Lera, Preston, Alan Martin, Aguero, Samuel Duran, Oleas, Mariana, Posada, Luz, Ochoa, Angelica, Shamsuddin, Khadijah, Shariff, Zalilah Mohd, Jan Bin Jan Mohamed, Hamid, Manan, Wan, Nicolau, Anca, Tudorie, Cornelia, Poh, Bee Koon, Abbott, Pamela, Pakseresht, Mohammadreza, Sharma, Sangita, Strand, Tor, Alexy, Ute, Nöthlings, Ute, Carmikle, Jan, Brown, Ken, Waidyatilaka, Indu, Lanerolle, Pulani, Jayawardena, Ranil, Long, Julie M., Hambidge, Michael, Krebs, Nancy F., Haque, Aminul, Keding, Gudrun B., Korkalo, Liisa, Erkkola, Maijaliisa, Freese, Riitta, Eleraky, Laila, Stuetz, Wolfgang, Thorsdottir, Inga, Gunnarsdottir, Ingibjorg, Serra-Majem, Lluis, Moy, Foong Ming, Anderson, Simon, Jeewon, Rajesh, Zugravu, Corina Aurelia, Adair, Linda, Skeaff, Sheila, Marchioni, Dirce, Fisberg, Regina, Henry, Carol, Ersino, Getahun, Zello, Gordon, Meyer, Alexa, Elmadfa, Ibrahim, Mitchell, Claudette, Balfour, David, Geleijnse, Johanna M., Manary, Mark, El-kour, Tatyana, Nikiema, Laetitia, Mirzaei, Masoud, and Hakeem, Rubina
Abstract: Sugar-sweetened beverages (SSBs) are associated with cardiometabolic diseases and social inequities. For most nations, recent estimates and trends of intake are not available; nor variation by education or urbanicity. We investigated SSB intakes among adults between 1990 and 2018 in 185 countries, stratified subnationally by age, sex, education, and rural/urban residence, using data from the Global Dietary Database. In 2018, mean global SSB intake was 2.7 (8 oz = 248 grams) servings/week (95% UI 2.5-2.9) (range: 0.7 (0.5-1.1) in South Asia to 7.8 (7.1-8.6) in Latin America/Caribbean). Intakes were higher in male vs. female, younger vs. older, more vs. less educated, and urban vs. rural adults. Variations by education and urbanicity were largest in Sub-Saharan Africa. Between 1990 and 2018, SSB intakes increased by +0.37 (+0.29, +0.47), with the largest increase in Sub-Saharan Africa. These findings inform intervention, surveillance, and policy actions worldwide, highlighting the growing problem of SSBs for public health in Sub-Saharan Africa.
Published: 2023

7. Learning from Human Behavior to Improve Preventative Health Information Systems

Author: Martinez, Remberto, primary, Tong, Marcos, additional, Diago, Luis, additional, and Lindstrom, Jaana, additional
Published: 2018
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8. Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity

Author: Miller, Victoria, Webb, Patrick, Cudhea, Frederick, Zhang, Jianyi, Reedy, Julia, Shi, Peilin, Erndt-Marino, Josh, Coates, Jennifer, Micha, Renata, Mozaffarian, Dariush, Bas, Murat, Ali, Jemal Haidar, Abumweis, Suhad, Krishnan, Anand, Misra, Puneet, Hwalla, Nahla Chawkat, Janakiram, Chandrashekar, Liputo, Nur Indrawaty, Musaiger, Abdulrahman, Pourfarzi, Farhad, Alam, Iftikhar, DeRidder, Karin, Termote, Celine, Memon, Anjum, Turrini, Aida, Lupotto, Elisabetta, Piccinelli, Raffaela, Sette, Stefania, Anzid, Karim, Vossenaar, Marieke, Mazumdar, Paramita, Rached, Ingrid, Rovirosa, Alicia, Zapata, María Elisa, Asayehu, Tamene Taye, Oduor, Francis, Boedecker, Julia, Aluso, Lilian, Ortiz-Ulloa, Johana, Meenakshi, J.V., Castro, Michelle, Grosso, Giuseppe, Waskiewicz, Anna, Khan, Umber S., Thanopoulou, Anastasia, Malekzadeh, Reza, Calleja, Neville, Ocke, Marga, Etemad, Zohreh, Nsour, Mohannad Al, Waswa, Lydiah M., Nurk, Eha, Arsenault, Joanne, Lopez-Jaramillo, Patricio, Sibai, Abla Mehio, Damasceno, Albertino, Arambepola, Carukshi, Lopes, Carla, Severo, Milton, Lunet, Nuno, Torres, Duarte, Tapanainen, Heli, Lindstrom, Jaana, Virtanen, Suvi, Palacios, Cristina, Roos, Eva, Agdeppa, Imelda Angeles, Desnacido, Josie, Capanzana, Mario, Misra, Anoop, Khouw, Ilse, Ng, Swee Ai, Delgado, Edna Gamboa, Caballero, Mauricio, Otero, Johanna, Lee, Hae-Jeung, Koksal, Eda, Guessous, Idris, Lachat, Carl, De Henauw, Stefaan, Rahbar, Ali Reza, Tedstone, Alison, Naska, Androniki, Mathee, Angie, Ling, Annie, Tedla, Bemnet, Hopping, Beth, Ginnela, Brahmam, Leclercq, Catherine, Duante, Charmaine, Haerpfer, Christian, Hotz, Christine, Pitsavos, Christos, Rehm, Colin, van Oosterhout, Coline, Cerdena, Corazon, Bradshaw, Debbie, Trichopoulos, Dimitrios, Gauci, Dorothy, Fernando, Dulitha, Sygnowska, Elzbieta, Vartiainen, Erkki, Farzadfar, Farshad, Zajkas, Gabor, Swan, Gillian, Ma, Guansheng, Pekcan, Gulden, Ibrahim, Hajah Masni, Sinkko, Harri, Barbieri, Helene Enghardt, Sioen, Isabelle, Myhre, Jannicke, Gaspoz, Jean-Michel, Odenkirk, Jillian, Bundhamcharoen, Kanitta, Nelis, Keiu, Zarina, Khairul, Biro, Lajos, Johansson, Lars, Steingrimsdottir, Laufey, Riley, Leanne, Yap, Mabel, Inoue, Manami, Szabo, Maria, Ovaskainen, Marja-Leena, Lee, Meei-Shyuan, Chan, Mei Fen, Cowan, Melanie, Kandiah, Mirnalini, Kally, Ola, Jonsdottir, Olof, Palmer, Pam, Vollenweider, Peter, Orfanos, Philippos, Asciak, Renzo, Templeton, Robert, Don, Rokiah, Yaakub, Roseyati, Selamat, Rusidah, Yusof, Safiah, Al-Zenki, Sameer, Hung, Shu-Yi, Beer-Borst, Sigrid, Wu, Suh, Lukito, Widjaja, Hadden, Wilbur, Becker, Wulf, Cao, Xia, Ma, Yi, Lai, Yuen, Hjdaud, Zaiton, Ali, Jennifer, Gravel, Ron, Tao, Tina, Veerman, Jacob Lennert, Chiplonkar, Shashi, Arici, Mustafa, Ngoan, Le Tran, Panagiotakos, Demosthenes, Li, Yanping, Trichopoulou, Antonia, Barengo, Noel, Khadilkar, Anuradha, Ekbote, Veena, Mohammadifard, Noushin, Kovalskys, Irina, Laxmaiah, Avula, Rachakulla, Harikumar, Rajkumar, Hemalatha, Meshram, Indrapal, Avula, Laxmaiah, Arlappa, Nimmathota, Hemalatha, Rajkumar, lacoviello, Licia, Bonaccio, Marialaura, Costanzo, Simona, Martin-Prevel, Yves, Castetbon, Katia, Jitnarin, Nattinee, Hsieh, Yao-Te, Olivares, Sonia, Tejeda, Gabriela, Hadziomeragic, Aida, de Moura Souza, Amanda, Pan, Wen-Harn, Huybrechts, Inge, de Brauw, Alan, Moursi, Mourad, Maghroun, Maryam, Zeba, Augustin Nawidimbasba, Sarrafzadegan, Nizal, Keinan-Boker, Lital, Goldsmith, Rebecca, Shimony, Tal, Jordan, Irmgard, Mastiholi, Shivanand C., Mwangi, Moses, Kombe, Yeri, Bukania, Zipporah, Alissa, Eman, Al-Daghri, Nasser, Sabico, Shaun, Gulliford, Martin, Diba, Tshilenge S., Oh, Kyungwon, Kweon, Sanghui, Park, Sihyun, Cho, Yoonsu, Al-Hooti, Suad, Luangphaxay, Chanthaly, Douangvichit, Daovieng, Siengsounthone, Latsamy, Marques-Vidal, Pedro, Rybak, Constance, Luke, Amy, Piaseu, Noppawan, Rojroongwasinkul, Nipa, Sundram, Kalyana, Baykova, Donka, Abedi, Parvin, Sandjaja, Sandjaja, Fadzil, Fariza, Bukhary, Noriklil Bukhary Ismail, Bovet, Pascal, Chen, Yu, Sawada, Norie, Tsugane, Shoichiro, Rangelova, Lalka, Petrova, Stefka, Duleva, Vesselka, Lindroos, Anna Karin, Sipinen, Jessica Petrelius, Moraeus, Lotta, Bergman, Per, Siamusantu, Ward, Szponar, Lucjan, Chang, Hsing-Yi, Sekiyama, Makiko, Le Nguyen Bao, Khanh, Nagalla, Balakrishna, Polasa, Kalpagam, Boindala, Sesikeran, El Ati, Jalila, Silva, Ivonne Ramirez, Dommarco, Juan Rivera, Barquera, Simon, Ramírez, Sonia Rodríguez, Illescas-Zarate, Daniel, Sanchez-Romero, Luz Maria, Ikeda, Nayu, Zaghloul, Sahar, Houshiar-rad, Anahita, Mohammadi-Nasrabadi, Fatemeh, Abdollahi, Morteza, Chuah, Khun-Aik, Mahdy, Zaleha Abdullah, Eldridge, Alison, Ding, Eric L., Kruger, Herculina, Henjum, Sigrun, Fernandez, Anne, Suarez-Ortegon, Milton Fabian, Hamad, Nawal Al, Janská, Veronika, Tayyem, Reema, Mirmiran, Parvin, Kelishadi, Roya, Lemming, Eva Warensjo, Richter, Almut, Mensink, Gert, Wieler, Lothar, Hoffman, Daniel, Salanave, Benoit, Kim, Cho-il, Kuriyan-Raj, Rebecca, Swaminathan, Sumathi, Garriguet, Didier, Dastgiri, Saeed, Vaask, Sirje, Karupaiah, Tilakavati, Zohoori, Fatemeh Vida, Esteghamati, Alireza, Hashemian, Maryam, Noshad, Sina, Mwaniki, Elizabeth, Yakes-Jimenez, Elizabeth, Chileshe, Justin, Mwanza, Sydney, Marques, Lydia Lera, Preston, Alan Martin, Aguero, Samuel Duran, Oleas, Mariana, Posada, Luz, Ochoa, Angelica, Shamsuddin, Khadijah, Shariff, Zalilah Mohd, Jan Bin Jan Mohamed, Hamid, Manan, Wan, Nicolau, Anca, Tudorie, Cornelia, Poh, Bee Koon, Abbott, Pamela, Pakseresht, Mohammadreza, Sharma, Sangita, Strand, Tor Arne, Alexy, Ute, Nöthlings, Ute, Carmikle, Jan, Brown, Ken, Koster, Jeremy, Waidyatilaka, Indu, Lanerolle, Pulani, Jayawardena, Ranil, Long, Julie M., Hambidge, K. Michael, Krebs, Nancy F., Haque, Aminul, Keding, Gudrun B., Korkalo, Liisa, Erkkola, Maijaliisa, Freese, Riitta, Eleraky, Laila, Stuetz, Wolfgang, Thorsdottir, Inga, Gunnarsdottir, Ingibjorg, Serra-Majem, Lluis, Moy, Foong Ming, Anderson, Simon, Jeewon, Rajesh, Zugravu, Corina Aurelia, Adair, Linda, Ng, Shu Wen, Skeaff, Sheila, Marchioni, Dirce, Fisberg, Regina, Henry, Carol, Ersino, Getahun, Zello, Gordon, Meyer, Alexa, Elmadfa, Ibrahim, Mitchell, Claudette, Balfour, David, Geleijnse, Johanna M., Manary, Mark, El-kour, Tatyana, Nikiema, Laetitia, Mirzaei, Masoud, and Hakeem, Rubina
Abstract: Animal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the world’s child population. Mean ASF intake was 1.9 servings per day, representing 16% of children consuming at least three daily servings. Intake was similar between boys and girls, but higher among urban children with educated parents. Consumption varied by age from 0.6 at
Published: 2023

9. Incident type 2 diabetes attributable to suboptimal diet in 184 countries

Author: O’Hearn, Meghan, Lara-Castor, Laura, Cudhea, Frederick, Miller, Victoria, Reedy, Julia, Shi, Peilin, Zhang, Jianyi, Wong, John B., Economos, Christina D., Micha, Renata, Mozaffarian, Dariush, Bas, Murat, Ali, Jemal Haidar, Abumweis, Suhad, Krishnan, Anand, Misra, Puneet, Hwalla, Nahla Chawkat, Janakiram, Chandrashekar, Liputo, Nur Indrawaty, Musaiger, Abdulrahman, Pourfarzi, Farhad, Alam, Iftikhar, DeRidder, Karin, Termote, Celine, Memon, Anjum, Turrini, Aida, Lupotto, Elisabetta, Piccinelli, Raffaela, Sette, Stefania, Anzid, Karim, Vossenaar, Marieke, Mazumdar, Paramita, Rached, Ingrid, Rovirosa, Alicia, Zapata, María Elisa, Asayehu, Tamene Taye, Oduor, Francis, Boedecker, Julia, Aluso, Lilian, Ortiz-Ulloa, Johana, Meenakshi, J.V., Castro, Michelle, Grosso, Giuseppe, Waskiewicz, Anna, Khan, Umber S., Thanopoulou, Anastasia, Malekzadeh, Reza, Calleja, Neville, Ocke, Marga, Etemad, Zohreh, Nsour, Mohannad Al, Waswa, Lydiah M., Nurk, Eha, Arsenault, Joanne, Lopez-Jaramillo, Patricio, Sibai, Abla Mehio, Damasceno, Albertino, Arambepola, Carukshi, Lopes, Carla, Severo, Milton, Lunet, Nuno, Torres, Duarte, Tapanainen, Heli, Lindstrom, Jaana, Virtanen, Suvi, Palacios, Cristina, Roos, Eva, Agdeppa, Imelda Angeles, Desnacido, Josie, Capanzana, Mario, Misra, Anoop, Khouw, Ilse, Ng, Swee Ai, Delgado, Edna Gamboa, Caballero, Mauricio, Otero, Johanna, Lee, Hae-Jeung, Koksal, Eda, Guessous, Idris, Lachat, Carl, De Henauw, Stefaan, Rahbar, Ali Reza, Tedstone, Alison, Naska, Androniki, Mathee, Angie, Ling, Annie, Tedla, Bemnet, Hopping, Beth, Ginnela, Brahmam, Leclercq, Catherine, Duante, Charmaine, Haerpfer, Christian, Hotz, Christine, Pitsavos, Christos, Rehm, Colin, van Oosterhout, Coline, Cerdena, Corazon, Bradshaw, Debbie, Trichopoulos, Dimitrios, Gauci, Dorothy, Fernando, Dulitha, Sygnowska, Elzbieta, Vartiainen, Erkki, Farzadfar, Farshad, Zajkas, Gabor, Swan, Gillian, Ma, Guansheng, Pekcan, Gulden, Ibrahim, Hajah Masni, Sinkko, Harri, Barbieri, Helene Enghardt, Sioen, Isabelle, Myhre, Jannicke, Gaspoz, Jean-Michel, Odenkirk, Jillian, Bundhamcharoen, Kanitta, Nelis, Keiu, Zarina, Khairul, Biro, Lajos, Johansson, Lars, Steingrimsdottir, Laufey, Riley, Leanne, Yap, Mabel, Inoue, Manami, Szabo, Maria, Ovaskainen, Marja-Leena, Lee, Meei-Shyuan, Chan, Mei Fen, Cowan, Melanie, Kandiah, Mirnalini, Kally, Ola, Jonsdottir, Olof, Palmer, Pam, Vollenweider, Peter, Orfanos, Philippos, Asciak, Renzo, Templeton, Robert, Don, Rokiah, Yaakub, Roseyati, Selamat, Rusidah, Yusof, Safiah, Al-Zenki, Sameer, Hung, Shu-Yi, Beer-Borst, Sigrid, Wu, Suh, Lukito, Widjaja, Hadden, Wilbur, Becker, Wulf, Cao, Xia, Ma, Yi, Lai, Yuen, Hjdaud, Zaiton, Ali, Jennifer, Gravel, Ron, Tao, Tina, Veerman, Jacob Lennert, Chiplonkar, Shashi, Arici, Mustafa, Ngoan, Le Tran, Panagiotakos, Demosthenes, Li, Yanping, Trichopoulou, Antonia, Barengo, Noel, Khadilkar, Anuradha, Ekbote, Veena, Mohammadifard, Noushin, Kovalskys, Irina, Laxmaiah, Avula, Rachakulla, Harikumar, Rajkumar, Hemalatha, Meshram, Indrapal, Avula, Laxmaiah, Arlappa, Nimmathota, Hemalatha, Rajkumar, lacoviello, Licia, Bonaccio, Marialaura, Costanzo, Simona, Martin-Prevel, Yves, Castetbon, Katia, Jitnarin, Nattinee, Hsieh, Yao-Te, Olivares, Sonia, Tejeda, Gabriela, Hadziomeragic, Aida, de Moura Souza, Amanda, Pan, Wen-Harn, Huybrechts, Inge, de Brauw, Alan, Moursi, Mourad, Maghroun, Maryam, Zeba, Augustin Nawidimbasba, Sarrafzadegan, Nizal, Keinan-Boker, Lital, Goldsmith, Rebecca, Shimony, Tal, Jordan, Irmgard, Mastiholi, Shivanand C., Mwangi, Moses, Kombe, Yeri, Bukania, Zipporah, Alissa, Eman, Al-Daghri, Nasser, Sabico, Shaun, Gulliford, Martin, Diba, Tshilenge S., Oh, Kyungwon, Kweon, Sanghui, Park, Sihyun, Cho, Yoonsu, Al-Hooti, Suad, Luangphaxay, Chanthaly, Douangvichit, Daovieng, Siengsounthone, Latsamy, Marques-Vidal, Pedro, Rybak, Constance, Luke, Amy, Piaseu, Noppawan, Rojroongwasinkul, Nipa, Sundram, Kalyana, Baykova, Donka, Abedi, Parvin, Sandjaja, Sandjaja, Fadzil, Fariza, Bukhary, Noriklil Bukhary Ismail, Bovet, Pascal, Chen, Yu, Sawada, Norie, Tsugane, Shoichiro, Rangelova, Lalka, Petrova, Stefka, Duleva, Vesselka, Lindroos, Anna Karin, Sipinen, Jessica Petrelius, Moraeus, Lotta, Bergman, Per, Siamusantu, Ward, Szponar, Lucjan, Chang, Hsing-Yi, Sekiyama, Makiko, Le Nguyen Bao, Khanh, Nagalla, Balakrishna, Polasa, Kalpagam, Boindala, Sesikeran, El Ati, Jalila, Silva, Ivonne Ramirez, Dommarco, Juan Rivera, Barquera, Simon, Rodríguez-Ramírez, Sonia, Illescas-Zarate, Daniel, Sanchez-Romero, Luz Maria, Ikeda, Nayu, Zaghloul, Sahar, Houshiar-rad, Anahita, Mohammadi-Nasrabadi, Fatemeh, Abdollahi, Morteza, Chuah, Khun-Aik, Mahdy, Zaleha Abdullah, Eldridge, Alison, Ding, Eric L., Kruger, Herculina, Henjum, Sigrun, Fernandez, Anne, Suarez-Ortegon, Milton Fabian, Al-Hamad, Nawal, Janská, Veronika, Tayyem, Reema, Mirmiran, Parvin, Kelishadi, Roya, Lemming, Eva Warensjo, Richter, Almut, Mensink, Gert, Wieler, Lothar, Hoffman, Daniel, Salanave, Benoit, Kim, Cho-il, Kuriyan-Raj, Rebecca, Swaminathan, Sumathi, Garriguet, Didier, Dastgiri, Saeed, Vaask, Sirje, Karupaiah, Tilakavati, Zohoori, Fatemeh Vida, Esteghamati, Alireza, Hashemian, Maryam, Noshad, Sina, Mwaniki, Elizabeth, Yakes-Jimenez, Elizabeth, Chileshe, Justin, Mwanza, Sydney, Marques, Lydia Lera, Preston, Alan Martin, Aguero, Samuel Duran, Oleas, Mariana, Posada, Luz, Ochoa, Angelica, Shamsuddin, Khadijah, Shariff, Zalilah Mohd, Jan Bin Jan Mohamed, Hamid, Manan, Wan, Nicolau, Anca, Tudorie, Cornelia, Poh, Bee Koon, Abbott, Pamela, Pakseresht, Mohammadreza, Sharma, Sangita, Strand, Tor Arne, Alexy, Ute, Nöthlings, Ute, Carmikle, Jan, Brown, Ken, Koster, Jeremy, Waidyatilaka, Indu, Lanerolle, Pulani, Jayawardena, Ranil, Long, Julie M., Hambidge, K. Michael, Krebs, Nancy F., Haque, Aminul, Keding, Gudrun B., Korkalo, Liisa, Erkkola, Maijaliisa, Freese, Riitta, Eleraky, Laila, Stuetz, Wolfgang, Thorsdottir, Inga, Gunnarsdottir, Ingibjorg, Serra-Majem, Lluis, Moy, Foong Ming, Anderson, Simon, Jeewon, Rajesh, Zugravu, Corina Aurelia, Adair, Linda, Ng, Shu Wen, Skeaff, Sheila, Marchioni, Dirce, Fisberg, Regina, Henry, Carol, Ersino, Getahun, Zello, Gordon, Meyer, Alexa, Elmadfa, Ibrahim, Mitchell, Claudette, Balfour, David, Geleijnse, Johanna M., Manary, Mark, El-kour, Tatyana, Nikiema, Laetitia, Mirzaei, Masoud, and Hakeem, Rubina
Abstract: The global burden of diet-attributable type 2 diabetes (T2D) is not well established. This risk assessment model estimated T2D incidence among adults attributable to direct and body weight-mediated effects of 11 dietary factors in 184 countries in 1990 and 2018. In 2018, suboptimal intake of these dietary factors was estimated to be attributable to 14.1 million (95% uncertainty interval (UI), 13.8–14.4 million) incident T2D cases, representing 70.3% (68.8–71.8%) of new cases globally. Largest T2D burdens were attributable to insufficient whole-grain intake (26.1% (25.0–27.1%)), excess refined rice and wheat intake (24.6% (22.3–27.2%)) and excess processed meat intake (20.3% (18.3–23.5%)). Across regions, highest proportional burdens were in central and eastern Europe and central Asia (85.6% (83.4–87.7%)) and Latin America and the Caribbean (81.8% (80.1–83.4%)); and lowest proportional burdens were in South Asia (55.4% (52.1–60.7%)). Proportions of diet-attributable T2D were generally larger in men than in women and were inversely correlated with age. Diet-attributable T2D was generally larger among urban versus rural residents and higher versus lower educated individuals, except in high-income countries, central and eastern Europe and central Asia, where burdens were larger in rural residents and in lower educated individuals. Compared with 1990, global diet-attributable T2D increased by 2.6 absolute percentage points (8.6 million more cases) in 2018, with variation in these trends by world region and dietary factor. These findings inform nutritional priorities and clinical and public health planning to improve dietary quality and reduce T2D globally. publishedVersion
Published: 2023

10. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)

Author: Ngandu, Tiia, Lehtisalo, Jenni, Korkki, Saana, Solomon, Alina, Coley, Nicola, Antikainen, Riitta, Backman, Lars, Hanninen, Tuomo, Lindstrom, Jaana, Laatikainen, Tiina, Paajanen, Teemu, Havulinna, Satu, Peltonen, Markku, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, Kivipelto, Miia, Ngandu, Tiia, Lehtisalo, Jenni, Korkki, Saana, Solomon, Alina, Coley, Nicola, Antikainen, Riitta, Backman, Lars, Hanninen, Tuomo, Lindstrom, Jaana, Laatikainen, Tiina, Paajanen, Teemu, Havulinna, Satu, Peltonen, Markku, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, and Kivipelto, Miia
Abstract: Introduction Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses). Methods FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores. Results Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function. Discussion Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.
Published: 2022
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11. Diabetes Care

Author: QIAN, Frank, ARDISSON KORAT, Andres V., IMAMURA, Fumiaki, MARKLUND, Matti, TINTLE, Nathan, VIRTANEN, Jyrki K., ZHOU, Xia, BASSETT, Julie K., LAI, Heidi, HIRAKAWA, Yoichiro, CHIEN, Kuo-Liong, WOOD, Alexis C., LANKINEN, Maria, MURPHY, Rachel A., SAMIERI, Cecilia, PERTIWI, Kamalita, DE MELLO, Vanessa D., GUAN, Weihua, FOROUHI, Nita G., WAREHAM, Nick, HU, InterAct Consortium Frank B, RISERUS, Ulf, LIND, Lars, HARRIS, William S., SHADYAB, Aladdin H., ROBINSON, Jennifer G., STEFFEN, Lyn M., HODGE, Allison, GILES, Graham G., NINOMIYA, Toshiharu, UUSITUPA, Matti, TUOMILEHTO, Jaakko, LINDSTROM, Jaana, LAAKSO, Markku, SISCOVICK, David S., HELMER, Catherine, GELEIJNSE, Johanna M., WU, Jason H. Y., FRETTS, Amanda, LEMAITRE, Rozenn N., MICHA, Renata, MOZAFFARIAN, Dariush, SUN, Qi, FATTY, Acids, and OUTCOMES RESEARCH, Consortium
Published: 2021

12. Cost-effectiveness analysis of a school- and community-based intervention to promote a healthy lifestyle and prevent type 2 diabetes in vulnerable families across Europe: the Feel4Diabetes-study

Author: Willems, Ruben Tsoutsoulopoulou, Konstantina Brondeel, Ruben and Cardon, Greet Makrilakis, Konstantinos Liatis, Stavros and Lindstrom, Jaana Kivela, Jemina Gonzalez-Gil, Esther M. and Gimenez-Legarre, Natalia Usheva, Natalya Iotova, Violeta and Tankova, Tsvetalina Antal, Emese Rurik, Imre Timpel, Patrick and Schwarz, Peter E. H. Manios, Yannis Annemans, Lieven
Subjects: health care economics and organizations
Abstract: The Feel4Diabetes-study implemented a school- and community-based intervention to promote healthy lifestyle and prevent type 2 diabetes mellitus (T2DM) in six European countries. The intervention included a special focus on families at increased T2DM risk. The current study evaluates the intervention's cost-effectiveness. A Markov-type health economic model was developed to predict the incidence of T2DM and its complications. Incremental cost-effectiveness ratios (lifetime horizon, societal perspective) were calculated based on the overall intervention effect on health behaviour, and stratified for low- and high-risk families. Sensitivity analyses captured input parameters uncertainty. A budget impact analysis was performed. The increase in children's water consumption and physical activity led to a modest gain in quality adjusted life years (QALYs) at a low intervention cost and budget impact. Medical cost savings due to avoided illness could only be achieved on the very long-term (>30 years). The intervention in its entirety was cost-effective (more QALYs at a reasonable investment) in Belgium, Finland, Bulgaria, and Hungary, while being dominant (net savings and more QALYs) in Greece and Spain. Results were cost-effective for the low-risk families, who only received the school- and community-based intervention component. Results for the high-risk families were only cost-effective (with considerable uncertainty) in Greece and Spain, but not when the intervention would need to be repeated. The Feel4Diabetes-intervention is potentially cost-effective, especially in countries with a high overweight and obesity prevalence, at a limited budget impact. The incremental financial investments to reach and support high -risk families did not result in the hoped-for health benefits.
Published: 2021

13. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes : An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Author: Qian, Frank, Korat, Andres V. Ardisson, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K., Zhou, Xia, Bassett, Julie K., Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C., Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Pertiwi, Kamalita, de Mello, Vanessa D., Guan, Weihua, Forouhi, Nita G., Wareham, Nick, Hu, Frank B., Risérus, Ulf, Lind, Lars, Harris, William S., Shadyab, Aladdin H., Robinson, Jennifer G., Steffen, Lyn M., Hodge, Allison, Giles, Graham G., Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindstrom, Jaana, Laakso, Markku, Siscovick, David S., Helmer, Catherine, Geleijnse, Johanna M., Wu, Jason H. Y., Fretts, Amanda, Lemaitre, Rozenn N., Micha, Renata, Mozaffarian, Dariush, Sun, Qi, Qian, Frank, Korat, Andres V. Ardisson, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K., Zhou, Xia, Bassett, Julie K., Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C., Lankinen, Maria, Murphy, Rachel A., Samieri, Cecilia, Pertiwi, Kamalita, de Mello, Vanessa D., Guan, Weihua, Forouhi, Nita G., Wareham, Nick, Hu, Frank B., Risérus, Ulf, Lind, Lars, Harris, William S., Shadyab, Aladdin H., Robinson, Jennifer G., Steffen, Lyn M., Hodge, Allison, Giles, Graham G., Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindstrom, Jaana, Laakso, Markku, Siscovick, David S., Helmer, Catherine, Geleijnse, Johanna M., Wu, Jason H. Y., Fretts, Amanda, Lemaitre, Rozenn N., Micha, Renata, Mozaffarian, Dariush, and Sun, Qi
Abstract: OBJECTIVE Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a pre-specified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.
Published: 2021
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14. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Author: Manning, Alisa K, Hivert, Marie-France, Scott, Robert A, Grimsby, Jonna L, Bouatia-Naji, Nabila, Chen, Han, Rybin, Denis, Liu, Ching-Ti, Bielak, Lawrence F, Prokopenko, Inga, Amin, Najaf, Barnes, Daniel, Cadby, Gemma, Hottenga, Jouke-Jan, Ingelsson, Erik, Jackson, Anne U, Johnson, Toby, Kanoni, Stavroula, Ladenvall, Claes, Lagou, Vasiliki, Lahti, Jari, Lecoeur, Cecile, Liu, Yongmei, Martinez-Larrad, Maria Teresa, Montasser, May E, Navarro, Pau, Perry, John R B, Rasmussen-Torvik, Laura J, Salo, Perttu, Sattar, Naveed, Shungin, Dmitry, Strawbridge, Rona J, Tanaka, Toshiko, van Duijn, Cornelia M, An, Ping, de Andrade, Mariza, Andrews, Jeanette S, Aspelund, Thor, Atalay, Mustafa, Aulchenko, Yurii, Balkau, Beverley, Bandinelli, Stefania, Beckmann, Jacques S, Beilby, John P, Bellis, Claire, Bergman, Richard N, Blangero, John, Boban, Mladen, Boehnke, Michael, Boerwinkle, Eric, Bonnycastle, Lori L, Boomsma, Dorret I, Borecki, Ingrid B, Böttcher, Yvonne, Bouchard, Claude, Brunner, Eric, Budimir, Danijela, Campbell, Harry, Carlson, Olga, Chines, Peter S, Clarke, Robert, Collins, Francis S, Corbatón-Anchuelo, Arturo, Couper, David, de Faire, Ulf, Dedoussis, George V, Deloukas, Panos, Dimitriou, Maria, Egan, Josephine M, Eiriksdottir, Gudny, Erdos, Michael R, Eriksson, Johan G, Eury, Elodie, Ferrucci, Luigi, Ford, Ian, Forouhi, Nita G, Fox, Caroline S, Franzosi, Maria Grazia, Franks, Paul W, Frayling, Timothy M, Froguel, Philippe, Galan, Pilar, de Geus, Eco, Gigante, Bruna, Glazer, Nicole L, Goel, Anuj, Groop, Leif, Gudnason, Vilmundur, Hallmans, Göran, Hamsten, Anders, Hansson, Ola, Harris, Tamara B, Hayward, Caroline, Heath, Simon, Hercberg, Serge, Hicks, Andrew A, Hingorani, Aroon, Hofman, Albert, Hui, Jennie, Hung, Joseph, Jarvelin, Marjo-Riitta, Jhun, Min A, Johnson, Paul C D, Jukema, J Wouter, Jula, Antti, Kao, W H, Kaprio, Jaakko, Kardia, Sharon L R, Keinanen-Kiukaanniemi, Sirkka, Kivimaki, Mika, Kolcic, Ivana, Kovacs, Peter, Kumari, Meena, Kuusisto, Johanna, Kyvik, Kirsten Ohm, Laakso, Markku, Lakka, Timo, Lannfelt, Lars, Lathrop, G Mark, Launer, Lenore J, Leander, Karin, Li, Guo, Lind, Lars, Lindstrom, Jaana, Lobbens, Stéphane, Loos, Ruth J F, Luan, Jian'an, Lyssenko, Valeriya, Mägi, Reedik, Magnusson, Patrik K E, Marmot, Michael, Meneton, Pierre, Mohlke, Karen L, Mooser, Vincent, Morken, Mario A, Miljkovic, Iva, Narisu, Narisu, O'Connell, Jeff, Ong, Ken K, Oostra, Ben A, Palmer, Lyle J, Palotie, Aarno, Pankow, James S, Peden, John F, Pedersen, Nancy L, Pehlic, Marina, Peltonen, Leena, Penninx, Brenda, Pericic, Marijana, Perola, Markus, Perusse, Louis, Peyser, Patricia A, Polasek, Ozren, Pramstaller, Peter P, Province, Michael A, Räikkönen, Katri, Rauramaa, Rainer, Rehnberg, Emil, Rice, Ken, Rotter, Jerome I, Rudan, Igor, Ruokonen, Aimo, Saaristo, Timo, Sabater-Lleal, Maria, Salomaa, Veikko, Savage, David B, Saxena, Richa, Schwarz, Peter, Seedorf, Udo, Sennblad, Bengt, Serrano-Rios, Manuel, Shuldiner, Alan R, Sijbrands, Eric J G, Siscovick, David S, Smit, Johannes H, Small, Kerrin S, Smith, Nicholas L, Smith, Albert Vernon, Stančáková, Alena, Stirrups, Kathleen, Stumvoll, Michael, Sun, Yan V, Swift, Amy J, Tönjes, Anke, Tuomilehto, Jaakko, Trompet, Stella, Uitterlinden, Andre G, Uusitupa, Matti, Vikström, Max, Vitart, Veronique, Vohl, Marie-Claude, Voight, Benjamin F, Vollenweider, Peter, Waeber, Gerard, Waterworth, Dawn M, Watkins, Hugh, Wheeler, Eleanor, Widen, Elisabeth, Wild, Sarah H, Willems, Sara M, Willemsen, Gonneke, Wilson, James F, Witteman, Jacqueline C M, Wright, Alan F, Yaghootkar, Hanieh, Zelenika, Diana, Zemunik, Tatijana, Zgaga, Lina, Wareham, Nicholas J, McCarthy, Mark I, Barroso, Ines, Watanabe, Richard M, Florez, Jose C, Dupuis, Josée, Meigs, James B, and Langenberg, Claudia
Published: 2012
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15. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Author: Surendran, Praveen, Feofanova, Elena V., Lahrouchi, Najim, Ntalla, Ioanna, Karthikeyan, Savita, Cook, James, Chen, Lingyan, Mifsud, Borbala, Yao, Chen, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Thorleifsson, Gudmar, Liu, Dajiang J., Prins, Bram P., Stewart, Isobel D., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Auer, Paul L., Bielak, Lawrence F., Bis, Joshua C., Braithwaite, Vickie S., Brody, Jennifer A., Daw, E. Warwick, Warren, Helen R., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Fauman, Eric B., Fava, Cristiano, Ferreira, Teresa, Foley, Christopher N., Franceschini, Nora, Gao, He, Giannakopoulou, Olga, Giulianini, Franco, Gudbjartsson, Daniel F., Guo, Xiuqing, Harris, Sarah E., Havulinna, Aki S., Helgadottir, Anna, Huffman, Jennifer E., Hwang, Shih-Jen, Kanoni, Stavroula, Kontto, Jukka, Larson, Martin G., Li-Gao, Ruifang, Lindstrom, Jaana, Lotta, Luca A., Lu, Yingchang, Luan, Jian'an, Mahajan, Anubha, Malerba, Giovanni, Masca, Nicholas G. D., Mei, Hao, Menni, Cristina, Mook-Kanamori, Dennis O., Mosen-Ansorena, David, Muller-Nurasyid, Martina, Pare, Guillaume, Paul, Dirk S., Perola, Markus, Poveda, Alaitz, Rauramaa, Rainer, Richard, Melissa, Richardson, Tom G., Sepulveda, Nuno, Sim, Xueling, Smith, Albert, V, Smith, Jennifer A., Staley, James R., Stanakova, Alena, Sulem, Patrick, Theriault, Sebastien, Thorsteinsdottir, Unnur, Trompet, Stella, Varga, Tibor V., Edwards, Digna R. Velez, Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Yao, Jie, Young, Robin, Yu, Bing, Zhang, Weihua, Zhao, Jing-Hua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Blankenberg, Stefan, Bonnycastle, Lori L., Bork-Jensen, Jette, Brandslund, Ivan, Braund, Peter S., Burgess, Stephen, Cho, Kelly, Christensen, Cramer, Connell, John, de Mutsert, Renee, Dominiczak, Anna F., Dorr, Marcus, Eiriksdottir, Gudny, Farmaki, Aliki-Eleni, Gaziano, J. Michael, Grarup, Niels, Grove, Megan L., Hallmans, Göran, Hansen, Torben, Have, Christian T., Heiss, Gerardo, Jorgensen, Marit E., Jousilahti, Pekka, Kajantie, Eero, Kamat, Mihir, Karajamaki, AnneMari, Karpe, Fredrik, Koistinen, Heikki A., Kovesdy, Csaba P., Kuulasmaa, Kari, Laatikainen, Tiina, Lannfelt, Lars, Lee, I-Te, Lee, Wen-Jane, Linneberg, Allan, Martin, Lisa W., Moitry, Marie, Nadkarni, Girish, Neville, Matt J., Palmer, Colin N. A., Papanicolaou, George J., Pedersen, Oluf, Peters, James, Poulter, Neil, Rasheed, Asif, Rasmussen, Katrine L., Rayner, N. William, Magi, Reedik, Renström, Frida, Rettig, Rainer, Rossouw, Jacques, Schreiner, Pamela J., Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan, V, Sundstrom, Johan, Thorgeirsson, Gudmundur, Esko, Tonu, Trabetti, Elisabetta, Tsao, Philip S., Tuomi, Tiinamaija, Turner, Stephen T., Tzoulaki, Ioanna, Vaartjes, Ilonca, Vergnaud, Anne-Claire, Willer, Cristen J., Wilson, Peter W. F., Witte, Daniel R., Yonova-Doing, Ekaterina, Zhang, He, Aliya, Naheed, Almgren, Peter, Amouyel, Philippe, Asselbergs, Folkert W., Barnes, Michael R., Blakemore, Alexandra, I, Boehnke, Michael, Bots, Michiel L., Bottinger, Erwin P., Buring, Julie E., Chambers, John C., Chen, Yii-Der Ida, Chowdhury, Rajiv, Conen, David, Correa, Adolfo, Smith, George Davey, de Boer, Rudolf A., Deary, Ian J., Dedoussis, George, Deloukas, Panos, Di Angelantonio, Emanuele, Elliott, Paul, Felix, Stephan B., Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Franks, Stephen, Frossard, Philippe, Gambaro, Giovanni, Gaunt, Tom R., Groop, Leif, Gudnason, Vilmundur, Harris, Tamara B., Hayward, Caroline, Hennig, Branwen J., Herzig, Karl-Heinz, Ingelsson, Erik, Tuomilehto, Jaakko, Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Kardia, Sharon L. R., Kee, Frank, Kooner, Jaspal S., Kooperberg, Charles, Launer, Lenore J., Lind, Lars, Loos, Ruth J. F., Majumder, Abdulla Al Shafi, Laakso, Markku, McCarthy, Mark, I, Melander, Olle, Mohlke, Karen L., Murray, Alison D., Nordestgaard, Borge Gronne, Orho-Melander, Marju, Packard, Chris J., Padmanabhan, Sandosh, Palmas, Walter, Polasek, Ozren, Porteous, David J., Prentice, Andrew M., Province, Michael A., Relton, Caroline L., Rice, Kenneth, Ridker, Paul M., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome, I, Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sattar, Naveed, Sheu, Wayne H-H, Smith, Blair H., Soranzo, Nicole, Spector, Timothy D., Starr, John M., Sebert, Sylvain, Taylor, Kent D., Lakka, Timo A., Timpson, Nicholas J., Tobin, Martin D., van der Harst, Pim, van der Meer, Peter, Ramachandran, Vasan S., Verweij, Niek, Virtamo, Jarmo, Volker, Uwe, Weir, David R., Zeggini, Eleftheria, Charchar, Fadi J., Wareham, Nicholas J., Langenberg, Claudia, Tomaszewski, Maciej, Butterworth, Adam S., Caulfield, Mark J., Danesh, John, Edwards, Todd L., Holm, Hilma, Hung, Adriana M., Lindgren, Cecilia M., Liu, Chunyu, Manning, Alisa K., Morris, Andrew P., Morrison, Alanna C., O'Donnell, Christopher J., Psaty, Bruce M., Saleheen, Danish, Stefansson, Kari, Boerwinkle, Eric, Chasman, Daniel, I, Levy, Daniel, Newton-Cheh, Christopher, Munroe, Patricia B., Howson, Joanna M. M., Surendran, Praveen, Feofanova, Elena V., Lahrouchi, Najim, Ntalla, Ioanna, Karthikeyan, Savita, Cook, James, Chen, Lingyan, Mifsud, Borbala, Yao, Chen, Kraja, Aldi T., Cartwright, James H., Hellwege, Jacklyn N., Giri, Ayush, Tragante, Vinicius, Thorleifsson, Gudmar, Liu, Dajiang J., Prins, Bram P., Stewart, Isobel D., Cabrera, Claudia P., Eales, James M., Akbarov, Artur, Auer, Paul L., Bielak, Lawrence F., Bis, Joshua C., Braithwaite, Vickie S., Brody, Jennifer A., Daw, E. Warwick, Warren, Helen R., Drenos, Fotios, Nielsen, Sune Fallgaard, Faul, Jessica D., Fauman, Eric B., Fava, Cristiano, Ferreira, Teresa, Foley, Christopher N., Franceschini, Nora, Gao, He, Giannakopoulou, Olga, Giulianini, Franco, Gudbjartsson, Daniel F., Guo, Xiuqing, Harris, Sarah E., Havulinna, Aki S., Helgadottir, Anna, Huffman, Jennifer E., Hwang, Shih-Jen, Kanoni, Stavroula, Kontto, Jukka, Larson, Martin G., Li-Gao, Ruifang, Lindstrom, Jaana, Lotta, Luca A., Lu, Yingchang, Luan, Jian'an, Mahajan, Anubha, Malerba, Giovanni, Masca, Nicholas G. D., Mei, Hao, Menni, Cristina, Mook-Kanamori, Dennis O., Mosen-Ansorena, David, Muller-Nurasyid, Martina, Pare, Guillaume, Paul, Dirk S., Perola, Markus, Poveda, Alaitz, Rauramaa, Rainer, Richard, Melissa, Richardson, Tom G., Sepulveda, Nuno, Sim, Xueling, Smith, Albert, V, Smith, Jennifer A., Staley, James R., Stanakova, Alena, Sulem, Patrick, Theriault, Sebastien, Thorsteinsdottir, Unnur, Trompet, Stella, Varga, Tibor V., Edwards, Digna R. Velez, Veronesi, Giovanni, Weiss, Stefan, Willems, Sara M., Yao, Jie, Young, Robin, Yu, Bing, Zhang, Weihua, Zhao, Jing-Hua, Zhao, Wei, Evangelou, Evangelos, Aeschbacher, Stefanie, Asllanaj, Eralda, Blankenberg, Stefan, Bonnycastle, Lori L., Bork-Jensen, Jette, Brandslund, Ivan, Braund, Peter S., Burgess, Stephen, Cho, Kelly, Christensen, Cramer, Connell, John, de Mutsert, Renee, Dominiczak, Anna F., Dorr, Marcus, Eiriksdottir, Gudny, Farmaki, Aliki-Eleni, Gaziano, J. Michael, Grarup, Niels, Grove, Megan L., Hallmans, Göran, Hansen, Torben, Have, Christian T., Heiss, Gerardo, Jorgensen, Marit E., Jousilahti, Pekka, Kajantie, Eero, Kamat, Mihir, Karajamaki, AnneMari, Karpe, Fredrik, Koistinen, Heikki A., Kovesdy, Csaba P., Kuulasmaa, Kari, Laatikainen, Tiina, Lannfelt, Lars, Lee, I-Te, Lee, Wen-Jane, Linneberg, Allan, Martin, Lisa W., Moitry, Marie, Nadkarni, Girish, Neville, Matt J., Palmer, Colin N. A., Papanicolaou, George J., Pedersen, Oluf, Peters, James, Poulter, Neil, Rasheed, Asif, Rasmussen, Katrine L., Rayner, N. William, Magi, Reedik, Renström, Frida, Rettig, Rainer, Rossouw, Jacques, Schreiner, Pamela J., Sever, Peter S., Sigurdsson, Emil L., Skaaby, Tea, Sun, Yan, V, Sundstrom, Johan, Thorgeirsson, Gudmundur, Esko, Tonu, Trabetti, Elisabetta, Tsao, Philip S., Tuomi, Tiinamaija, Turner, Stephen T., Tzoulaki, Ioanna, Vaartjes, Ilonca, Vergnaud, Anne-Claire, Willer, Cristen J., Wilson, Peter W. F., Witte, Daniel R., Yonova-Doing, Ekaterina, Zhang, He, Aliya, Naheed, Almgren, Peter, Amouyel, Philippe, Asselbergs, Folkert W., Barnes, Michael R., Blakemore, Alexandra, I, Boehnke, Michael, Bots, Michiel L., Bottinger, Erwin P., Buring, Julie E., Chambers, John C., Chen, Yii-Der Ida, Chowdhury, Rajiv, Conen, David, Correa, Adolfo, Smith, George Davey, de Boer, Rudolf A., Deary, Ian J., Dedoussis, George, Deloukas, Panos, Di Angelantonio, Emanuele, Elliott, Paul, Felix, Stephan B., Ferrieres, Jean, Ford, Ian, Fornage, Myriam, Franks, Paul W., Franks, Stephen, Frossard, Philippe, Gambaro, Giovanni, Gaunt, Tom R., Groop, Leif, Gudnason, Vilmundur, Harris, Tamara B., Hayward, Caroline, Hennig, Branwen J., Herzig, Karl-Heinz, Ingelsson, Erik, Tuomilehto, Jaakko, Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Kardia, Sharon L. R., Kee, Frank, Kooner, Jaspal S., Kooperberg, Charles, Launer, Lenore J., Lind, Lars, Loos, Ruth J. F., Majumder, Abdulla Al Shafi, Laakso, Markku, McCarthy, Mark, I, Melander, Olle, Mohlke, Karen L., Murray, Alison D., Nordestgaard, Borge Gronne, Orho-Melander, Marju, Packard, Chris J., Padmanabhan, Sandosh, Palmas, Walter, Polasek, Ozren, Porteous, David J., Prentice, Andrew M., Province, Michael A., Relton, Caroline L., Rice, Kenneth, Ridker, Paul M., Rolandsson, Olov, Rosendaal, Frits R., Rotter, Jerome, I, Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Sattar, Naveed, Sheu, Wayne H-H, Smith, Blair H., Soranzo, Nicole, Spector, Timothy D., Starr, John M., Sebert, Sylvain, Taylor, Kent D., Lakka, Timo A., Timpson, Nicholas J., Tobin, Martin D., van der Harst, Pim, van der Meer, Peter, Ramachandran, Vasan S., Verweij, Niek, Virtamo, Jarmo, Volker, Uwe, Weir, David R., Zeggini, Eleftheria, Charchar, Fadi J., Wareham, Nicholas J., Langenberg, Claudia, Tomaszewski, Maciej, Butterworth, Adam S., Caulfield, Mark J., Danesh, John, Edwards, Todd L., Holm, Hilma, Hung, Adriana M., Lindgren, Cecilia M., Liu, Chunyu, Manning, Alisa K., Morris, Andrew P., Morrison, Alanna C., O'Donnell, Christopher J., Psaty, Bruce M., Saleheen, Danish, Stefansson, Kari, Boerwinkle, Eric, Chasman, Daniel, I, Levy, Daniel, Newton-Cheh, Christopher, Munroe, Patricia B., and Howson, Joanna M. M.
Abstract: Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets., Errata: Surendran, P., Feofanova, E.V., Lahrouchi, N. et al. Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics 53, 762 (2021). https://doi.org/10.1038/s41588-021-00832-z
Published: 2020
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16. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the finnish diabetes prevention study

Author: Lindstrom, Jaana, Ilanne-Parikka, Pirjo, Peltonen, Markku, Aunola, Sirkka, Eriksson, Johan G., Hemio, Katri, Hamalainen, Helena, Harkonen, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Laakso, Mauri, Louheranta, Anne, Mannelin, Marjo, Paturi, Merja, Sundvall, Jouko, Valle, Timo T., Uusitupa, Matti, and Tuomilehto, Jaako
Subjects: Type 2 diabetes -- Prevention, Diabetes -- Health aspects, Quality of life -- Analysis, Finns -- Health aspects
Published: 2006

17. Effect of occupational complexity on cognitive change during a multidomain lifestyle intervention: The FINGER trial

Author: Rydström, Anders, primary, Darin‐Mattsson, Alexander, additional, Kåreholt, Ingemar, additional, Ngandu, Tiia, additional, Solomon, Alina, additional, Lehtisalo, Jenni, additional, Antikainen, Riitta, additional, Bäckman, Lars, additional, Hänninen, Tuomo, additional, Laatikainen, Tiina, additional, Levälahti, Esko, additional, Lindstrom, Jaana, additional, Paajanen, Teemu, additional, Havulinna, Satu, additional, Peltonen, Markku, additional, Soininen, Hilkka, additional, Neely, Anna Stigsdotter, additional, Strandberg, Timo, additional, Tuomilehto, Jaakko, additional, Kivipelto, Miia, additional, and Mangialsche, Francesca, additional
Published: 2020
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18. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

Author: Tuomilehto, Jaakko, Lindstrom, Jaana, Eriksson, Johan G., Valle, Timo T., Hamalainen, Helena, Ilanne-Parikka, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Laakso, Mauri, Louheranta, Anne, Rastas, Merja, Salminen, Virpi, and Uusitupa, Matti
Subjects: Type 2 diabetes -- Prevention, Life style -- Health aspects
Abstract: People who have a high risk of developing type 2, or adult onset, diabetes can cut their risk in half just by changing their lifestyle. This was the conclusion of a study of 522 overweight people with an abnormal glucose tolerance test. Half received counseling to eat a low-fat, high-fiber diet, lose weight, and get more exercise.
Published: 2001

19. Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the Finnish Diabetes Prevention Study

Author: de Mello, Vanessa D.F., Lindstrom, Jaana, Eriksson, Johan, Ilanne-Parikka, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Sundvall, Jouko, Laakso, Markku, Tuomilehto, Jaakko, and Uusitupa, Matti
Subjects: Dextrose, Diabetes -- Research, Insulin -- Research, Glucose, Type 2 diabetes -- Research -- Development and progression, Health
Abstract: OBJECTIVE--We investigated the effect of early-phase insulin secretion on the incidence of type 2 diabetes in individuals with impaired glucose tolerance (IGT) participating in the Finnish Diabetes Prevention Study (DPS). [...]
Published: 2012
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20. Socio-Demographic Characteristics and Body Weight Perceptions of Study Participants Benefitting Most from the Feel4Diabetes Program Based on Their Anthropometric and Glycaemic Profile Changes

Author: Moschonis, George, primary, Karatzi, Kalliopi, additional, Apergi, Kyriaki, additional, Liatis, Stavros, additional, Kivelä, Jemina, additional, Wikström, Katja, additional, Ayala-Marín, Alelí M., additional, Mateo-Gallego, Rocio, additional, Tsochev, Kaloyan, additional, Chakarova, Nevena, additional, Antal, Emese, additional, Rurik, Imre, additional, Iotova, Violeta, additional, Cardon, Greet, additional, Lindstrom, Jaana, additional, Moreno, Luis A., additional, Makrilakis, Konstantinos, additional, and Manios, Yannis, additional
Published: 2020
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21. Employment and Chronic Diseases: Suggested Actions for The Implementation of Inclusive Policies for The Participation of People with Chronic Diseases in the Labour Market

Author: Silvaggi, Fabiola, primary, Eigenmann, Michela, additional, Scaratti, Chiara, additional, Guastafierro, Erika, additional, Toppo, Claudia, additional, Lindstrom, Jaana, additional, Rantala, Eeva, additional, Imaz-Iglesia, Iñaki, additional, Barnfield, Andrew, additional, Maassen, Alison, additional, and Leonardi, Matilde, additional
Published: 2020
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22. Long-term benefits from lifestyle interventions for type 2 diabetes prevention: time to expand the efforts

Author: Tuomilehto, Jaakko, Schwarz, Peter, and Lindstrom, Jaana
Subjects: Medical research, Medicine, Experimental, Type 2 diabetes -- Research, Physical fitness -- Research, Health
Abstract: The potential to prevent type 2 diabetes in high-risk individuals by lifestyle intervention was established in several clinical trials. These studies had a strong focus on increased physical activity and [...]
Published: 2011
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23. Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes prevention study

Author: Uusitupa, Maiti I., Stancakova, Alena, Peltonen, Markku, Eriksson, Johan G., Lindstrom, Jaana, Aunola, Sirkka, Ilanne-Parikka, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Tuomilehto, Jaakko, and Laakso, Markku
Subjects: Genetic research, Dextrose, Diabetes -- Research, Glucose, Type 2 diabetes -- Prevention -- Genetic aspects, Weight loss -- Prevention -- Genetic aspects, Health
Abstract: OBJECTIVE--We aimed to investigate the influence of positive family history (FH+) of diabetes and 19 known genetic risk loci on the effectiveness of lifestyle changes and their predictive value on [...]
Published: 2011
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24. Leisure-time physical activity and the metabolic syndrome in the Finnish Diabetes Prevention Study

Author: Ilanne-Parikka, Pirjo, Laaksonen, David E., Eriksson, Johan G., Lakka, Timo A., Lindstrom, Jaana, Peltonen, Markku, Aunola, Sirkka, Keinanen-Kiukaanniemi, Sirkka, Uusitupa, Matti, and Tuomilehto, Jaakko
Subjects: Cholesterol -- Analysis, Dextrose -- Analysis, Diabetes -- Research, Glucose -- Analysis, Weight training -- Analysis
Abstract: OBJECTIVE--To assess the effects of leisure-time physical activity (LTPA) and resistance training on metabolic syndrome (MetS) and its components in a post hoc analysis of the Finnish Diabetes Prevention Study, [...]
Published: 2010
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25. Sleep duration, lifestyle intervention, and incidence of type 2 diabetes in impaired glucose tolerance: the Finnish diabetes prevention study

Author: Tuomilehto, Henri, Peltonen, Markku, Partinen, Markku, Lavigne, Gilles, Eriksson, Johan G., Herder, Christian, Aunola, Sirkka, Keinanen-Kiukaanniemi, Sirkka, Ilanne-Parikka, Pirjo, Uusitupa, Matti, Tuomilehto, Jaakko, and Lindstrom, Jaana
Subjects: Diabetes therapy -- Analysis, Dextrose -- Analysis, Diabetes -- Research, Glucose -- Analysis, Type 2 diabetes -- Prevention -- Analysis, Health
Abstract: OBJECTIVE--Both short and long sleep duration have frequently been found to be associated with an increased risk for diabetes. The aim of the present exploratory analysis was to examine the [...]
Published: 2009
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26. Determinants for the effectiveness of lifestyle intervention in the Finnish diabetes prevention study

Author: Lindstrom, Jaana, Peltonen, Markku, Eriksson, Johan G., Aunola, Sirkka, Hamalainen, Helena, Ilanne-Parikka, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Uusitupa, Matti, and Tuomilehto, Jaakko
Subjects: Life style -- Health aspects -- Research, Type 2 diabetes -- Risk factors -- Care and treatment -- Prevention -- Research, Health, Care and treatment, Prevention, Research, Risk factors, Health aspects
Abstract: OBJECTIVE--Intensive lifestyle intervention significantly reduced diabetes incidence among the participants in the Finnish Diabetes Prevention Study. We investigated whether and to what extent risk factors for type 2 diabetes and [...]
Published: 2008

27. Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study

Author: Herder, Christian, Peltonen, Markku, Koenig, Wolfgang, Kraft, Ilka, Muller-Scholze, Sylvia, Martin, Stephan, Lakka, Timo, Ilanne-Parikka, Pirjo, Eriksson, Johan G., Hamalainen, Helena, Keinanen-Kiukaanniemi, Sirkka, Valle, Timo T., Uusitupa, Matti, Lindstrom, Jaana, Kolb, Hubert, and Tuomilehto, Jaakko
Subjects: Type 2 diabetes -- Prevention -- Risk factors -- Health aspects, Weight loss -- Health aspects -- Risk factors -- Prevention, Health, Prevention, Risk factors, Health aspects
Abstract: The Finnish DPS (Diabetes Prevention Study) demonstrated that lifestyle intervention, aimed at increasing physical activity, improving diet, and decreasing body weight, reduced the incidence of type 2 diabetes in individuals with overweight and impaired glucose tolerance by 58%. Here, we studied which immunological markers at baseline predicted subsequent type 2 diabetes and whether there are immunologically defined subsets of subjects who are more or less responsive to the protective effects of lifestyle intervention. We randomly assigned 522 participants to a control group (n = 257) or a lifestyle intervention group (n = 265). Immunological parameters at baseline included high-sensitivity C-reactive protein (CRP), serum amyloid A, interleukin-6, regulated on activation normal T-cell expressed and secreted (RANTES), macrophage migration inhibitory factor (MIF), and soluble intercellular adhesion molecule. In the control group, CRP was the best immunological predictor for progression to overt type 2 diabetes. In the intervention group, progression to type 2 diabetes was significantly higher in subjects with the highest RANTES concentrations and was lower in subjects with the highest MIF levels. Ratios of RANTES to MIF in the upper tertile were highly predictive of incident type 2 diabetes in the intervention group (P = 0.006), whereas the association was less pronounced in the control group (P = 0.088). Thus, systemic concentrations of immune mediators appear to be associated with the progression to type 2 diabetes and the prevention of type 2 diabetes by lifestyle changes., Type 2 diabetes is one of the most prevalent chronic diseases, and its complications, including cardiovascular disease, nephropathy, neuropathy, and retinopathy, cause substantial human and economic burdens (1,2). Thus, the [...]
Published: 2006

28. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: The Finnish Diabetes Prevention Study

Author: Laukkanen, Olli, Lindstrom, Jaana, Eriksson, Johan, Valle, Timo T., Hamalainen, Helena, Ilanne-Parikka, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Tuomilehto, Jaakko, Uusitupa, Matti, and Laakso, Markku
Subjects: Type 2 diabetes -- Genetic aspects, Type 2 diabetes -- Risk factors, Glucose metabolism -- Observations, Gene mutations -- Observations, Health
Abstract: Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1[alpha]], HNF4A, GIP, and GLP1R) are associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in participants of the Finnish Diabetes Prevention Study. With the exception of SLC2A2, other genes were not associated with the risk of type 2 diabetes. All four SNPs of SLC2A2 predicted the conversion to diabetes, and rs5393 (AA genotype) increased the risk of type 2 diabetes in the entire study population by threefold (odds ratio 3.04, 95% CI 1.34-6.88, P = 0.008). The risk for type 2 diabetes in the AA genotype carriers was increased in the control group (5.56 [1.78-17.39], P = 0.003) but not in the intervention group. We conclude that the SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with IGT., Defective insulin secretion is a key feature in the pathogenesis of type 2 diabetes in addition to insulin resistance. Therefore, variants in the genes regulating insulin secretion are plausible candidate [...]
Published: 2005

29. Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study

Author: Laaksonen, David E., Lindstrom, Jaana, Lakka, Timo A., Eriksson, Johan G., Niskanen, Leo, Wikstrom, Katja, Aunola, Sirkka, Keinanen-Kiukaanniemi, Sirkka, Laakso, Mauri, Yalle, Time T., Ilanne-Parikka, Pirjo, Louheranta, Anne, Hamalainen, Helena, Rastas, Merja, Salminen, Virpi, Cepaitis, Zygimantas, Hakumaki, Martti, Kaikkonen, Hannu, Harkonen, Pirjo, Sundvall, Jouko, Tuomilehto, Jaakko, and Uusitupa, Matti
Subjects: Aerobic exercises -- Health aspects, Type 2 diabetes -- Prevention, Type 2 diabetes -- Risk factors, Health
Abstract: Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.260.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals., Epidemiological studies have suggested that moderate-to-vigorous leisure-time physical activity (LTPA) protects against the development of type 2 diabetes (1-6) as well as the metabolic syndrome (7), which commonly precedes diabetes [...]
Published: 2005

30. Increased concentrations of glycogen synthase protein in skeletal muscle of patients with NIDDM

Author: Lofman, Monika, Yki-Jarvinen, Hannele, Parkkonen, Maija, Lindstrom, Jaana, Koranyi, Laslzo, Schalin-Jantti, Camilla, and Groop, Leif
Subjects: Glycogen -- Synthesis, Insulin -- Analysis, Enzyme activation -- Usage, Biological sciences
Abstract: Muscle biopsies are taken before and after a 4-h euglycemic hyperinsulinemic clamp to measure glycogen synthase activity and glycogen protein synthase concentrations in patients with non-insulin-dependent diabetes mellitus (NIDDM), and the results show the reduction of non-oxidative glucose metabolism by 64%. These findings indicate the glycogen synthase protein amount in the patient's skeletal muscle. The increase in glycogen synthase protein compensates for a functional defect in the insulin activation enzyme.
Published: 1995

31. Prevalence of the metabolic syndrome and its components: findings from a Finnish general population sample and the Diabetes Prevention Study cohort

Author: Ilanne-Parikka, Pirjo, Eriksson, Johan G., Lindstrom, Jaana, Hamalainen, Helena, Keinanen-Kiukaanniemi, Sirkka, Laakso, Mauri, Louheranta, Anne, Mannelin, Marjo, Rastas, Merja, Salminen, Virpi, Aunola, Sirkka, Sundvall, Jouko, Valle, Timo, Lahtela, Jorma, Uusitupa, Matti, and Tuomilehto, Jaakko
Subjects: Baby boom generation -- Health aspects -- Research, Glucose intolerance -- Causes of -- Research, Metabolic syndrome X -- Research, Type 2 diabetes -- Causes of -- Research, Health, Research, Causes of, Health aspects
Abstract: OBJECTIVE--To assess the prevalence of the metabolic syndrome (MetS) in two independent Finnish study cohorts. RESEARCH D|SIGN AND METHODS--The prevalence of the MetS by modified World Health Organization criteria was [...]
Published: 2004

32. Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation

Author: Hu, Gang, Lindstrom, Jaana, Valle, Timo T., Eriksson, Johan G., Jousilahti, Pekka, Silventoinen, Karri, Qiao, Qing, and Tuomilehto, Jaakko
Subjects: Type 2 diabetes -- Prevention, Exercise -- Health aspects, Obesity, Body mass index, Health
Published: 2004

33. The Finnish Diabetes Prevention Study (DPS): lifestyle intervention and 3-year results on diet and physical activity

Author: Lindstrom, Jaana, Louheranta, Anne, Mannelin, Marjo, Rastas, Merja, Salminen, Virpi, Eriksson, Johan, Uusitupa, Matti, and Tuomilehto, Jaakko
Subjects: Type 2 diabetes -- Prevention -- Diet therapy, Health, Prevention, Diet therapy
Abstract: OBJECTIVE--To describe the 1) lifestyle intervention used in the Finnish Diabetes Prevention Study, 2) short and long-term changes in diet and exercise behavior, and 3) effect of the intervention on [...]
Published: 2003

34. Long-term improvement in insulin sensitivity by changing lifestyles of people with impaired glucose tolerance: 4-year results from the Finnish Diabetes Prevention Study

Author: Uusitupa, Matti, Lindi, Virpi, Louheranta, Anne, Salopuro, Titta, Lindstrom, Jaana, and Tuomileheto, Jaakko
Subjects: Insulin resistance -- Physiological aspects -- Development and progression -- Genetic aspects -- Environmental aspects, Type 2 diabetes -- Development and progression -- Genetic aspects -- Environmental aspects -- Physiological aspects, Health, Physiological aspects, Development and progression, Genetic aspects, Environmental aspects
Abstract: Lifestyle interventions reduce the incidence of type 2 diabetes among individuals with impaired glucose tolerance (IGT). However, it is unknown whether this is due to improved insulin sensitivity or insulin secretion. We investigated at baseline insulin sensitivity and insulin secretion applying frequently sampled intravenous glucose tolerance test (FSIGT) in 87 of 101 obese middle-aged subjects with IGT randomized into an intervention or a control group in the Finnish Diabetes Prevention Study. FSIGT was repeated after 4 years in 52 people. There were no significant differences in any of the baseline anthropometric or metabolic characteristics between the groups. The 4-year weight and waist circumference decreases were greater in the intervention than in the control group (P = 0.043 and P = 0.025, respectively). At 4-year examination, insulin sensitivity ([S.sub.i]) tended to be higher in the intervention group (the difference between the mean values 36%; P = 0.067, and P = 0.136 after adjustment for age, sex, BMI, and baseline [S.sub.i] value). There was strong correlation between the 4-year changes in [S.sub.i] and weight (r = -0.628 and r = -0.710, for intervention and control groups; P < 0.001 for both). In the entire group, [S.sub.i] improved by 64% in the highest tertile of weight loss but deteriorated by 24% in those who gained weight (lowest tertile). Acute insulin response declined significantly in the control group. In conclusion, [S.sub.i] markedly improved by weight reduction during the 4-year follow-up of individuals with IGT. Insulin secretion remained constant for years in individuals with IGT who were able to lose weight. Diabetes 52:2532-2538, 2003, Both genetic and environmental factors contribute to the development of type 2 diabetes (1-5). The two major pathogenetic factors involved in disturbed glucose metabolism and ultimately leading to overt diabetes [...]
Published: 2003

35. Promoter polymorphisms of the TNF-[alpha] (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. (Brief Genetics Report)

Author: Kubaszek, Agata, Pihlajamaki, Jussi, Komarovski, Vladislav, Lindi, Virpi, Lindstrom, Jaana, Eriksson, Johan, Valle, Timo T., Hamalainen, Helena, Ilanne-Parikka, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Tuomilehto, Jaakko, Uusitupa, Matti, and Laakso, Markku
Subjects: Type 2 diabetes -- Genetic aspects, Type 2 diabetes -- Development and progression, Glucose intolerance -- Complications, Tumor necrosis factor -- Physiological aspects, Health
Abstract: High levels of cytokines are risk factors for type 2 diabetes. Therefore, we investigated whether the promoter polymorphisms of the tumor necrosis factor-[alpha] (TNF-[alpha]; G-308A) and interleukin 6 (IL-6; C-174G) genes predict the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in the Finnish Diabetes Prevention Study. Altogether, 490 overweight subjects with IGT whose DNA was available were randomly divided into one of the two treatment assignments: the control group and the intensive, individualized diet and exercise intervention group. The -308A allele of the TNF-[alpha] gene was associated with an approximate twofold higher risk for type 2 diabetes compared with the G-308G genotype (odds ratio 1.80, 95% CI 1.05-3.09; P = 0.034). Subjects with both the A allele of the TNF-[alpha] gene and the C-174C genotype of the IL-6 gene had a 2.2-fold (CI 1.02-4.85, P = 0.045) higher risk of developing type 2 diabetes than subjects without the risk genotypes. We conclude that the -308A allele of the promoter polymorphism (G-308A) of the TNF-[alpha] gene is a predictor for the conversion from IGT to type 2 diabetes. Furthermore, this polymorphism seems to have a gene-gene interaction with the C-174C genotype of the IL-6 gene., The major known risk factors for developing type 2 diabetes include a previous history of abnormal glucose tolerance, hyperinsulinemia, obesity, hypertension, physical inactivity, and a family history of diabetes (1). [...]
Published: 2003

36. The diabetes risk score: a practical tool to predict type 2 diabetes risk. (Original Article: Epidemiology/Health Services/Psychosocial Research)

Author: Lindstrom, Jaana and Tuomilehto, Jaakko
Subjects: Health risk assessment -- Physiological aspects -- Psychological aspects, Type 2 diabetes -- Prevention -- Risk factors, Health, Psychological aspects, Prevention, Physiological aspects, Risk factors
Abstract: OBJECTIVE -- Interventions to prevent type 2 diabetes should be directed toward individuals at increased risk for the disease. To identify such individuals without laboratory tests, we developed the Diabetes [...]
Published: 2003

37. Association of the Pro12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study

Author: Lindi, Virpi I., Uusitupa, Matti I.J., Lindstrom, Jaana, Louheranta, Anne, Eriksson, Johan G., Valle, Timo T., Hamalainen, Helena, Ilanne-Parikka, Pirjo, Keinanen-Kiukaanniemi, Sirkka, Laakso, Markku, and Tuomilehto, Jaakko
Subjects: Glucose intolerance -- Complications and side effects -- Development and progression, Fiber in human nutrition -- Health aspects, Low-fat diet -- Health aspects, Diabetes -- Health aspects -- Complications and side effects -- Development and progression, Type 2 diabetes -- Development and progression -- Complications and side effects, Health, Complications and side effects, Development and progression, Health aspects
Abstract: The association of the Pro12Ala polymorphism of the PPAR-γ2 gene with the incidence of type 2 diabetes was investigated in 522 subjects with impaired glucose tolerance (IGT) participating in the Finnish Diabetes Prevention Study. Subjects were randomized to either an intensive diet and exercise group or a control group. By 3 years of intervention, the odds ratio of the development of type 2 diabetes for subjects with the Ala12 allele was 2.11-fold compared with that for subjects with the Pro12Pro genotype (95% CI 1.20-3.72). The risk for type 2 diabetes increased also in subjects who gained weight or belonged to the control group. In the intervention group, subjects with the Ala12Ala genotype lost more weight during the follow-up than subjects with other genotypes (Pro12Pro vs. Ala12Ala P = 0.043), and none of subjects with the Ala12Ala genotype developed type 2 diabetes in this group. In conclusion, the Ala12 allele may predispose to the development of type 2 diabetes in obese subjects with IGT. However, beneficial changes in diet, increases in physical activity, and weight loss may reverse, to some extent, the diabetogenic impact of the Ala12 allele, possibly due to an improved insulin sensitivity., Type 2 diabetes is preceded by impaired glucose tolerance (IGT) that can last for years before the diagnosis of diabetes. Two earlier intervention studies suggest that it is possible to [...]
Published: 2002

38. Determinants of weight outcomes in type 2 diabetes prevention intervention in primary health care setting (the DE-PLAN project)

Author: Gilis-Januszewska, Aleksandra, Piwońska-Solska, Beata, Lindstrom, Jaana, Wójtowicz, Ewa, Tuomilehto, Jaakko, Schwarz, Peter, Kissimova-Skarbek, Katarzyna, Szybiński, Zbigniew, Windak, Adam, and Hubalewska-Dydejczyk, Alicja
Subjects: Adult, Male, Lifestyle intervention, Weight loss, medicine.medical_specialty, Multivariate analysis, Psychological intervention, 030209 endocrinology & metabolism, Type 2 diabetes, Determinants of weight loss, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Diabetes mellitus, Epidemiology, medicine, Humans, 030212 general & internal medicine, Life Style, Aged, Primary Health Care, Physical activity, business.industry, lcsh:Public aspects of medicine, Prevention, Real life setting, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Middle Aged, medicine.disease, Diet, Treatment Outcome, Diabetes Mellitus, Type 2, Physical therapy, Female, Biostatistics, medicine.symptom, business, Research Article
Abstract: Background Real life implementation studies performed in different settings have proved that lifestyle interventions in the prevention of type 2 diabetes (DM2) can be effective, although the weight reduction results are typically modest compared to randomized control trials. Our objective was to identify the factors that predict successful weight loss in a less intensive, lower budget, real life setting lifestyle diabetes prevention intervention. Methods Study participants (n = 175) with increased DM2 risk (Finnish Diabetes Risk Score (FINDRISC) > 14) but no diabetes at baseline received ten group lifestyle counselling sessions, physical activity and motivation sessions during a ten-month intervention. Stepwise regression analysis was used to determine demographic, clinical, and lifestyle predictors of successful weight reduction defined as a reduction of ≥5% of the initial body weight. Results At 12 months following the initiation of the intervention, 23.4% of study participants lost ≥5% weight (mean loss of 7.9 kg, SD = 5.8). Increased physical activity (44% vs 25%, p = 0.03), decreased total fat consumption (88% vs 65%, p = 0.006) and adherence to four-five lifestyle goals (71% vs 46%, p = 0.007) were more often reported among those who managed to lose ≥5% weight versus those who did not. In a multivariate analysis, meeting the ≥5% weight loss goal was most effective in individuals with a higher baseline BMI (OR 1.1, 95%CI 1.0–1.2), baseline and medium versus higher education (OR 5.4, 95% CI 1.2–24.7) and a history of increased glucose (OR 2.6, 95%CI 1.1–1.3). A reduction of total fat in the diet was an independent lifestyle predictor, increasing the probability of successful weight loss by 3.8 times (OR 3.8, 95% CI 1.2–11.4). Conclusion Baseline higher BMI, lower education and a history of increased glucose predicted the successful weight loss among individuals with a high risk for the DM2 following lifestyle intervention in a real life primary health care setting. People who manage to lose weight more often adhere to lifestyle changes, while the reduction of total fat in diet independently predicts successful weight loss. Further studies exploring the predictors of success in implementation studies in DM2 prevention should help health care providers redesign interventions to improve their effectiveness and outcomes. Trial registration ISRCTN, ID ISRCTN96692060 , registered 03.08.2016 retrospectively.
Published: 2018

39. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Author: Turcot, Valerie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tonu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Goncalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Ines, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blueher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Boeger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D'Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renee, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dube, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Joergen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Oyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Hakan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jorgensen, Marit E., Jorgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, Rene S., Kahonen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltan, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimaki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindstrom, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian'an, Lubitz, Steven A., Lyytikainen, Leo-Pekka, Mannisto, Satu, Marenne, Gaelle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Mueller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njolstad, Pal R., Nordestgaard, Borge G., Nyholt, Dale R., O'Connel, Jeffrey R., O'Donoghue, Michelle L., Loohuis, Loes M. Olde, Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renstrom, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H. -H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Toenjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, Andre G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Edwards, Digna R. Velez, Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Voelker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhou, Wei, Zondervan, Krina T., Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., Loos, Ruth J. F., Turcot, Valerie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tonu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Goncalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Ines, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blueher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Boeger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D'Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renee, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dube, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Joergen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Oyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Hakan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jorgensen, Marit E., Jorgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, Rene S., Kahonen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltan, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimaki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindstrom, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian'an, Lubitz, Steven A., Lyytikainen, Leo-Pekka, Mannisto, Satu, Marenne, Gaelle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Mueller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njolstad, Pal R., Nordestgaard, Borge G., Nyholt, Dale R., O'Connel, Jeffrey R., O'Donoghue, Michelle L., Loohuis, Loes M. Olde, Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renstrom, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H. -H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Toenjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, Andre G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Edwards, Digna R. Velez, Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Voelker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhou, Wei, Zondervan, Krina T., Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.
Abstract: Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Published: 2018
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40. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics : The FINGER trial

Author: Rosenberg, Anna, Ngandu, Tiia, Rusanen, Minna, Antikainen, Riitta, Backman, Lars, Havulinna, Satu, Hanninen, Tuomo, Laatikainen, Tiina, Lehtisalo, Jenni, Levalahti, Esko, Lindstrom, Jaana, Paajanen, Teemu, Peltonen, Markku, Soininen, Hilkka, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Solomon, Alina, Kivipelto, Miia, Rosenberg, Anna, Ngandu, Tiia, Rusanen, Minna, Antikainen, Riitta, Backman, Lars, Havulinna, Satu, Hanninen, Tuomo, Laatikainen, Tiina, Lehtisalo, Jenni, Levalahti, Esko, Lindstrom, Jaana, Paajanen, Teemu, Peltonen, Markku, Soininen, Hilkka, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Solomon, Alina, and Kivipelto, Miia
Abstract: Introduction: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. Methods: The FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1: 1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses. Results: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05). Conclusions: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia.
Published: 2018
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41. A school- and community-based intervention to promote healthy lifestyle and prevent type 2 diabetes in vulnerable families across Europe: design and implementation of the Feel4Diabetes-study

Author: Manios, Yannis, Androutsos, Odysseas, Lambrinou, Christina-Paulina, Cardon, Greet, Lindstrom, Jaana, Annemans, Lieven, Mateo-Gallego, Rocio, de Sabata, Maria Stella, Iotova, Violeta, Kivela, Jemina, Martinez, Remberto, Moreno, Luis A, Rurik, Imre, Schwarz, Peter, Tankova, Tsvetalina T, Liatis, Stavros, Makrilakis, Konstantinos, Manios, Yannis, Androutsos, Odysseas, Lambrinou, Christina-Paulina, Cardon, Greet, Lindstrom, Jaana, Annemans, Lieven, Mateo-Gallego, Rocio, de Sabata, Maria Stella, Iotova, Violeta, Kivela, Jemina, Martinez, Remberto, Moreno, Luis A, Rurik, Imre, Schwarz, Peter, Tankova, Tsvetalina T, Liatis, Stavros, and Makrilakis, Konstantinos
Abstract: Objective: To describe the design of the Feel4Diabetes-intervention and the baseline characteristics of the study sample. Design: School- and community-based intervention with cluster-randomized design, aiming to promote healthy lifestyle and tackle obesity and obesity-related metabolic risk factors for the prevention of type 2 diabetes among families from vulnerable population groups. The intervention was implemented in 2016–2018 and included: (i) the ‘all-families’ component, provided to all children and their families via a school- and community-based intervention; and (ii) an additional component, the ‘high-risk families’ component, provided to high-risk families for diabetes as identified with a discrete manner by the FINDRISC questionnaire, which comprised seven counselling sessions (2016–2017) and a text-messaging intervention (2017–2018) delivered by trained health professionals in out-of-school settings. Although the intervention was adjusted to local needs and contextual circumstances, standardized protocols and procedures were used across all countries for the process, impact, outcome and cost-effectiveness evaluation of the intervention. Setting: Primary schools and municipalities in six European countries. Subjects: Families (primary-school children, their parents and grandparents) were recruited from the overall population in low/middle-income countries (Bulgaria, Hungary), from low socio-economic areas in high-income countries (Belgium, Finland) and from countries under austerity measures (Greece, Spain). Results: The Feel4Diabetes-intervention reached 30 309 families from 236 primary schools. In total, 20 442 families were screened and 12 193 ‘all families’ and 2230 ‘high-risk families’ were measured at baseline. Conclusions: The Feel4Diabetes-intervention is expected to provide evidencebased results and key learnings that could guide the design and scaling-up of affordable and potentially cost-effective population-based interventions for the prevent
Published: 2018

42. Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention A Subgroup Analysis of a Randomized Clinical Trial

Author: Solomon, Alina, Turunen, Heidi, Ngandu, Tiia, Peltonen, Markku, Levalahti, Esko, Helisalmi, Seppo, Antikainen, Riitta, Backman, Lars, Hanninen, Tuomo, Jula, Antti, Laatikainen, Tiina, Lehtisalo, Jenni, Lindstrom, Jaana, Paajanen, Teemu, Pajala, Satu, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, Kivipelto, Miia, Solomon, Alina, Turunen, Heidi, Ngandu, Tiia, Peltonen, Markku, Levalahti, Esko, Helisalmi, Seppo, Antikainen, Riitta, Backman, Lars, Hanninen, Tuomo, Jula, Antti, Laatikainen, Tiina, Lehtisalo, Jenni, Lindstrom, Jaana, Paajanen, Teemu, Pajala, Satu, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, and Kivipelto, Miia
Abstract: IMPORTANCE The role of the apolipoprotein E (APOE) epsilon 4 allele as an effect modifier in lifestyle interventions to prevent cognitive impairment is still unclear. OBJECTIVE To examine whether the APOE epsilon 4 allele modifies the previously reported significant cognitive benefits of a multidomain lifestyle intervention (prespecified subgroup analysis). DESIGN, SETTING, AND PARTICIPANTS The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a randomized clinical trial in 6 centers across Finland (screening and randomization performed from September 7, 2009, through November 24, 2011; intervention duration, 2 years). Data analysis was performed from August 1, 2015, to March 31, 2016. The study population was at-risk older individuals from the general population. Inclusion criteria were age of 60 to 77 years; Cardiovascular Risk Factors, Aging, and Dementia risk score of at least 6 points; and cognition at a mean level or slightly lower than expected for age. Individuals with dementia or substantial cognitive impairment and conditions that prevented cooperation or safe engagement in the intervention were excluded. APOE genotype data were available for 1175 of the 1260 participants. INTERVENTIONS Participants were randomly assigned in a 1: 1 ratio to a multidomain intervention group (diet, exercise, cognitive training, and vascular risk management) or a control group (general health advice). Group allocation was not actively disclosed to participants, and outcome assessors were masked to group allocation. MAIN OUTCOMES AND MEASURES Primary outcome was change in cognition measured through a comprehensive neuropsychological test battery. Analysis was based on modified intention to treat (participants with at least 1 postbaseline assessment). RESULTS A total of 1109 participants (mean [SD] age, 69.3 [4.7] years; 514 [46.3%] female) were included in the analysis: 362 APOE epsilon 4 allele carriers (173 intervention and 189
Published: 2018
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43. Perceiving need for lifestyle counselling: findings from Finnish individuals at high risk of type 2 diabetes

Author: Salmela, Sanna M., Vahasarja, Kati A., Villberg, Jari J., Vanhala, Mauno J., Saaristo, Timo E., Lindstrom, Jaana, Oksa, Heikki H., Korpi-Hyovalti, Eeva A.-L., Moilanen, Leena, Keinanen-Kiukaanniemi, Sirkka, and Poskiparta, Marita E.
Subjects: Type 2 diabetes -- Research -- Prevention -- Risk factors -- Reports, Health counseling -- Usage, Health
Abstract: OBJECTIVE--To investigate the proportion of individuals at high risk of type 2 diabetes who perceive the need for lifestyle counseling, factors associated with this perception, and whether the perceived need [...]
Published: 2012
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44. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial

Author: Rosenberg, Anna, Ngandu, Tiia, Rusanen, Minna, Antikainen, Riitta, Backman, Lars, Havulinna, Satu, Hanninen, Tuomo, Laatikainen, Tiina, Lehtisalo, Jenni, Levalahti, Esko, Lindstrom, Jaana, Paajanen, Teemu, Peltonen, Markku, Soininen, Hilkka, Stigsdotter Neely, Anna, Strandberg, Timo, Tuomilehto, Jaakko, Solomon, Alina, Kivipelto, Miia, Clinicum, Department of Public Health, University of Helsinki, Timo Strandberg / Principal Investigator, Department of Medicine, Hjelt Institute (-2014), and HUS Internal Medicine and Rehabilitation
Subjects: PROTOCOL, Male, Geriatrik, Clinical Neurology, Intervention, EXERCISE, 3124 Neurology and psychiatry, Cognition, Risk Factors, COMPLAINTS, Humans, CORONARY-HEART-DISEASE, Cognitive Dysfunction, Healthy Lifestyle, OLDER-ADULTS, Aged, Science & Technology, Cognitive Behavioral Therapy, Prevention, 3112 Neurosciences, 1103 Clinical Sciences, Alzheimer's disease, RANDOMIZED CONTROLLED-TRIAL, IMPAIRMENT, Middle Aged, Lifestyle, Multidomain, Exercise Therapy, ALZHEIMERS-DISEASE, FINNISH GERIATRIC INTERVENTION, Cognitive impairment, Treatment Outcome, Socioeconomic Factors, Randomized controlled trial, Cardiovascular Diseases, Geriatrics, 3121 General medicine, internal medicine and other clinical medicine, Dementia, Female, Neurosciences & Neurology, PRIMARY PREVENTION, 1109 Neurosciences, Life Sciences & Biomedicine, DIABETES PREVENTION, CLINICAL-TRIALS, tervention
Abstract: Introduction: The 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition. Methods: The FINGER recruited 1260 people from the general Finnish population (60-77 years, at risk for dementia). Participants were randomized 1: 1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses. Results: Sociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini-Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05). Conclusions: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Published: 2017

45. Rare and low-frequency coding variants alter human adult height

Author: Marouli, Eirini, Graff, Mariaelisa, Medina-Gomez, Carolina, Lo, Ken Sin, Wood, Andrew R, Kjaer, Troels R, Fine, Rebecca S, Lu, Yingchang, Schurmann, Claudia, Highland, Heather M, Rueger, Sina, Thorleifsson, Gudmar, Justice, Anne E, Lamparter, David, Stirrups, Kathleen E, Turcot, Valerie, Young, Kristin L, Winkler, Thomas W, Esko, Tonu, Karaderi, Tugce, Locke, Adam E, Masca, Nicholas GD, Ng, Maggie CY, Mudgal, Poorva, Rivas, Manuel A, Vedantam, Sailaja, Mahajan, Anubha, Guo, Xiuqing, Abecasis, Goncalo, Aben, Katja K, Adair, Linda S, Alam, Dewan S, Albrecht, Eva, Allin, Kristine H, Allison, Matthew, Amouyel, Philippe, Appel, Emil V, Arveiler, Dominique, Asselbergs, Folkert W, Auer, Paul L, Balkau, Beverley, Banas, Bernhard, Bang, Lia E, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F, Blueher, Matthias, Boeing, Heiner, Boerwinkle, Eric, Boeger, Carsten A, Bonnycastle, Lori L, Bork-Jensen, Jette, Bots, Michiel L, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Carey, David J, Caulfield, Mark J, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Cocca, Massimiliano, Collins, Francis S, Cook, James P, Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J, Cuellar-Partida, Gabriel, Danesh, John, Davies, Gail, de Bakker, Paul IW, de Borst, Gert J, de Denus, Simon, de Groot, Mark CH, de Mutsert, Renee, Deary, Ian J, Dedoussis, George, Demerath, Ellen W, den Hollander, Anneke I, Dennis, Joe G, Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dunning, Alison M, Easton, Douglas F, Ebeling, Tapani, Edwards, Todd L, Ellinor, Patrick T, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Faul, Jessica D, Feitosa, Mary F, Feng, Shuang, Ferrannini, Ele, Ferrario, Marco M, Ferrieres, Jean, Florez, Jose C, Ford, Ian, Fornage, Myriam, Franks, Paul W, Frikke-Schmidt, Ruth, Galesloot, Tessel E, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Giri, Ayush, Girotto, Giorgia, Gordon, Scott D, Gordon-Larsen, Penny, Gorski, Mathias, Grarup, Niels, Grove, Megan L, Gudnason, Vilmundur, Gustafsson, Stefan, Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B, Hattersley, Andrew T, Hayward, Caroline, He, Liang, Heid, Iris M, Heikkila, Kauko, Helgeland, Oyvind, Hernesniemi, Jussi, Hewitt, Alex W, Hocking, Lynne J, Hollensted, Mette, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hoyng, Carel B, Huang, Paul L, Hveem, Kristian, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jansson, Jan-Hakan, Jarvik, Gail P, Jensen, Gorm B, Jhun, Min A, Jia, Yucheng, Jiang, Xuejuan, Johansson, Stefan, Jorgensen, Marit E, Jorgensen, Torben, Jousilahti, Pekka, Jukema, J Wouter, Kahali, Bratati, Kahn, Rene S, Kahonen, Mika, Kamstrup, Pia R, Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kee, Frank, Keeman, Renske, Kiemeney, Lambertus A, Kitajima, Hidetoshi, Kluivers, Kirsten B, Kocher, Thomas, Komulainen, Pirjo, Kontto, Jukka, Kooner, Jaspal S, Kooperberg, Charles, Kovacs, Peter, Kriebel, Jennifer, Kuivaniemi, Helena, Kury, Sebastien, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lakka, Timo A, Lange, Ethan M, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Larson, Eric B, Lee, I-Te, Lehtimaki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindstrom, Jaana, Linneberg, Allan, Liu, Yeheng, Liu, Yongmei, Lophatananon, Artitaya, Luan, Jian'an, Lubitz, Steven A, Lyytikainen, Leo-Pekka, Mackey, David A, Madden, Pamela AF, Manning, Alisa K, Mannisto, Satu, Marenne, Gaelle, Marten, Jonathan, Martin, Nicholas G, Mazul, Angela L, Meidtner, Karina, Metspalu, Andres, Mitchell, Paul, Mohlke, Karen L, Mook-Kanamori, Dennis O, Morgan, Anna, Morris, Andrew D, Morris, Andrew P, Mueller-Nurasyid, Martina, Munroe, Patricia B, Nalls, Mike A, Nauck, Matthias, Nelson, Christopher P, Neville, Matt, Nielsen, Sune F, Nikus, Kjell, Njolstad, Pal R, Nordestgaard, Borge G, Ntalla, Ioanna, O'Connel, Jeffrey R, Oksa, Heikki, Loohuis, Loes M Olde, Ophoff, Roel A, Owen, Katharine R, Packard, Chris J, Padmanabhan, Sandosh, Palmer, Colin NA, Pasterkamp, Gerard, Patel, Aniruddh P, Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Person, Thomas N, Pirie, Ailith, Polasek, Ozren, Posthuma, Danielle, Raitakari, Olli T, Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F, Reiner, Alex P, Renstrom, Frida, Ridker, Paul M, Rioux, John D, Robertson, Neil, Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Sandow, Kevin, Sapkota, Yadav, Sattar, Naveed, Schmidt, Marjanka K, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo P, Shah, Svati, Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S, Smith, Albert Vernon, Smith, Jennifer A, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Starr, John M, Steinthorsdottir, Valgerdur, Stringham, Heather M, Stumvoll, Michael, Surendran, Praveen, 't Hart, Leen M, Tansey, Katherine E, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorsteinsdottir, Unnur, Thuesen, Betina H, Toenjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P, Uher, Rudolf, Uitterlinden, Andre G, Ulivi, Sheila, van der Laan, Sander W, Van Der Leij, Andries R, van Duijn, Cornelia M, van Schoor, Natasja M, van Setten, Jessica, Varbo, Anette, Varga, Tibor V, Varma, Rohit, Edwards, Digna R Velez, Vermeulen, Sita H, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Vozzi, Diego, Walker, Mark, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wang, Yiqin, Wareham, Nicholas J, Warren, Helen R, Wessel, Jennifer, Willems, Sara M, Wilson, James G, Witte, Daniel R, Woods, Michael O, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Rotter, Jerome I, Boehnke, Michael, Kathiresan, Sekar, McCarthy, Mark I, Willer, Cristen J, Stefansson, Kari, Borecki, Ingrid B, Liu, Dajiang J, North, Kari E, Heard-Costa, Nancy L, Pers, Tune H, Lindgren, Cecilia M, Oxvig, Claus, Kutalik, Zoltan, Rivadeneira, Fernando, Loos, Ruth JF, Frayling, Timothy M, Hirschhorn, Joel N, Deloukas, Panos, Lettre, Guillaume, Consortium, EPIC-InterAct, Consortium, EPIC-CVD, Consortium, CHD Exome, Consortium, ExomeBP, Consortium, T2D-Genes, Consortium, GoT2D Genes, Consortium, Global Lipids Genetics, Consortium, ReproGen, Investigators, MAGIC, Marouli, Eirini, Graff, Mariaelisa, Medina Gomez, Carolina, Lo, Ken Sin, Wood, Andrew R., Kjaer, Troels R., Fine, Rebecca S., Lu, Yingchang, Schurmann, Claudia, Highland, Heather M., Rüeger, Sina, Thorleifsson, Gudmar, Justice, Anne E., Lamparter, David, Stirrups, Kathleen E., Turcot, Valérie, Young, Kristin L., Winkler, Thomas W., Esko, Tõnu, Karaderi, Tugce, Locke, Adam E., Masca, Nicholas G. D., Ng, Maggie C. Y., Mudgal, Poorva, Rivas, Manuel A., Vedantam, Sailaja, Mahajan, Anubha, Guo, Xiuqing, Abecasis, Goncalo, Aben, Katja K., Adair, Linda S., Alam, Dewan S., Albrecht, Eva, Allin, Kristine H., Allison, Matthew, Amouyel, Philippe, Appel, Emil V., Arveiler, Dominique, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Banas, Bernhard, Bang, Lia E., Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthia, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bonnycastle, Lori L., Bork Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Burt, Amber A., Butterworth, Adam S., Carey, David J., Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Coromina, Cox, Amanda J., Cuellar Partida, Gabriel, Danesh, John, Davies, Gail, De Bakker, Paul I. W., De Borst, Gert J., De Denus, Simon, De Groot, Mark C. H., De Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Den Hollander, Anneke I., Dennis, Joe G., Di Angelantonio, Emanuele, Drenos, Fotio, Du, Mengmeng, Dunning, Alison M., Easton, Douglas F., Ebeling, Tapani, Edwards, Todd L., Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelo, Farmaki, Aliki Eleni, Faul, Jessica D., Feitosa, Mary F., Feng, Shuang, Ferrannini, Ele, Ferrario, Marco M., Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franks, Paul W., Frikke Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmanta, Giri, Ayush, Girotto, Giorgia, Gordon, Scott D., Gordon Larsen, Penny, Gorski, Mathia, Grarup, Niel, Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Hayward, Caroline, He, Liang, Heid, Iris M., Heikkilä, Kauko, Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Hocking, Lynne J., Hollensted, Mette, Holmen, Oddgeir L., Hovingh, G. Kee, Howson, Joanna M. M., Hoyng, Carel B., Huang, Paul L., Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan Håkan, Jarvik, Gail P., Jensen, Gorm B., Jhun, Min A., Jia, Yucheng, Jiang, Xuejuan, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jousilahti, Pekka, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Keeman, Renske, Kiemeney, Lambertus A., Kitajima, Hidetoshi, Kluivers, Kirsten B., Kocher, Thoma, Komulainen, Pirjo, Kontto, Jukka, Kooner, Jaspal S., Kooperberg, Charle, Kovacs, Peter, Kriebel, Jennifer, Kuivaniemi, Helena, Küry, Sébastien, Kuusisto, Johanna, LA BIANCA, Martina, Laakso, Markku, Lakka, Timo A., Lange, Ethan M., Lange, Leslie A., Langefeld, Carl D., Langenberg, Claudia, Larson, Eric B., Lee, I. Te, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li Gao, Ruifang, Lin, Honghuang, Lin, Li An, Lin, Xu, Lind, Lar, Lindström, Jaana, Linneberg, Allan, Liu, Yeheng, Liu, Yongmei, Lophatananon, Artitaya, Luan, Jian'An, Lubitz, Steven A., Lyytikäinen, Leo Pekka, Mackey, David A., Madden, Pamela A. F., Manning, Alisa K., Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Martin, Nicholas G., Mazul, Angela L., Meidtner, Karina, Metspalu, Andre, Mitchell, Paul, Mohlke, Karen L., Mook Kanamori, Dennis O., Morgan, Anna, Morris, Andrew D., Morris, Andrew P., Müller Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Nauck, Matthia, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Ntalla, Ioanna, O'Connel, Jeffrey R., Oksa, Heikki, Loohuis, Loes M. Olde, Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Marku, Perry, James A., Perry, John R. B., Person, Thomas N., Pirie, Ailith, Polasek, Ozren, Posthuma, Danielle, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Renström, Frida, Ridker, Paul M., Rioux, John D., Robertson, Neil, Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sandow, Kevin, Sapkota, Yadav, Sattar, Naveed, Schmidt, Marjanka K., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura Lepe, Marcelo P., Shah, Svati, Sim, Xueling, Sivapalaratnam, Suthesh, Small, Kerrin S., Smith, Albert Vernon, Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Steinthorsdottir, Valgerdur, Stringham, Heather M., Stumvoll, Michael, Surendran, Praveen, Hart'T, Leen M., Tansey, Katherine E., Tardif, Jean Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Ulivi, Sheila, Van Der Laan, Sander W., Van Der Leij, Andries R., Van Duijn, Cornelia M., Van Schoor, Natasja M., Van Setten, Jessica, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vozzi, Diego, Walker, Mark, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Wareham, Nicholas J., Warren, Helen R., Wessel, Jennifer, Willems, Sara M., Wilson, James G., Witte, Daniel R., Woods, Michael O., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Rotter, Jerome I., Boehnke, Michael, Kathiresan, Sekar, Mccarthy, Mark I., Willer, Cristen J., Stefansson, Kari, Borecki, Ingrid B., Liu, Dajiang J., North, Kari E., Heard Costa, Nancy L., Pers, Tune H., Lindgren, Cecilia M., Oxvig, Clau, Kutalik, Zoltán, Rivadeneira, Fernando, Loos, Ruth J. F., Frayling, Timothy M., Hirschhorn, Joel N., Deloukas, Pano, Lettre, Guillaume, Pharmacoepidemiology and Clinical Pharmacology, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Internal Medicine, Epidemiology, Obstetrics & Gynecology, Radiology & Nuclear Medicine, Neurology, Complex Trait Genetics, Amsterdam Neuroscience - Complex Trait Genetics, British Heart Foundation, Medical Research Council (MRC), Wellcome Trust, National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, Action on Hearing Loss, Home Office, National Institutes of Health, Public Health England, EPIC-InterAct Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, ReproGen Consortium, MAGIC Investigators, Physiology, Human genetics, APH - Personalized Medicine, APH - Aging & Later Life, Epidemiology and Data Science, and Amsterdam Reproduction & Development (AR&D)
Subjects: 0301 basic medicine, Male, ReproGen Consortium, Multifactorial Inheritance, Genome-wide association study, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Androgen, ADAMTS Proteins, Gene Frequency, Missing heritability problem, MISSING HERITABILITY, Receptors, 2.1 Biological and endogenous factors, Pregnancy-Associated Plasma Protein-A, Aetiology, Non-U.S. Gov't, Glycosaminoglycans, Genetics, Multidisciplinary, Genome, CHD Exome+ Consortium, Medicine (all), Research Support, Non-U.S. Gov't, T2D-Genes Consortium, Global Lipids Genetics Consortium, Multidisciplinary Sciences, Phenotype, NADPH Oxidase 4, Receptors, Androgen, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Interferon Regulatory Factors, Science & Technology - Other Topics, Intercellular Signaling Peptides and Proteins, Female, Proteoglycans, EPIC-InterAct Consortium, ExomeBP Consortium, Common disease-common variant, Human, Adult, General Science & Technology, Biology, Development, Research Support, Article, GENETIC ARCHITECTURE, N.I.H, 03 medical and health sciences, MAGIC Investigators, Research Support, N.I.H., Extramural, Somatomedins, Genetic variation, MD Multidisciplinary, Journal Article, gene, height, rare, Humans, Hedgehog Proteins, Interleukin-11 Receptor alpha Subunit, Allele, GENOME-WIDE ASSOCIATION, Gene, Allele frequency, Alleles, Genetic association, Genetic association study, Glycoproteins, Science & Technology, MUTATIONS, Genome, Human, ta1184, Human Genome, Extramural, Genetic Variation, NADPH Oxidases, ta3121, Body Height, INTERLEUKIN-11, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], MICE, 030104 developmental biology, GoT2D Genes Consortium, Proteolysis, Procollagen N-Endopeptidase, Cell Adhesion Molecules
Abstract: Contains fulltext : 169801.pdf (Publisher’s version ) (Closed access) Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
Published: 2017

46. Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study

Author: Ilanne-Parikka, Pirjo, Eriksson, Johan G., Lindstrom, Jaana, Peltonen, Markku, Aunola, Sirkka, Hamalainen, Helena, Keinanen-Kiukaanniemi, Sirkka, Laakso, Mauri, Valle, Timo T., Lahtela, Jorma, Uusitupa, Matti, and Tuomilehto, Jaakko
Subjects: Metabolic syndrome X -- Research -- Risk factors -- Prevention, Diabetes -- Prevention -- Research -- Risk factors, Life style -- Influence -- Research, Cardiovascular diseases -- Risk factors -- Research -- Prevention, Health, Influence, Prevention, Research, Risk factors
Abstract: OBJECTIVE--The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components. RESEARCH DESIGN AND METHODS--A [...]
Published: 2008

47. Costs of a self-selected, health-promoting diet among the participants of the Finnish Diabetes Prevention Study

Author: Ottelin, Anne-Mari, Lindstrom, Jaana, Peltonen, Markku, Martikainen, Janne, Uusitupa, Matti, Gylling, Helena, Poutanen, Kaisa, Louheranta, Anne, Mannelin, Marjo, Paturi, Merja, Salminen, Virpi, and Tuomilehto, Jaakko
Subjects: Type 2 diabetes -- Prevention -- Research, Weight loss -- Health aspects -- Research -- Prevention, Diet -- Health aspects -- Research -- Finance, Health, Company financing, Finance, Prevention, Research, Health aspects
Abstract: Several studies have shown that lifestyle changes including weight reduction, increased physical activity, and dietary modification are effective in preventing the development of type 2 diabetes (1-4). However, various barriers [...]
Published: 2007

48. A school- and community-based intervention to promote healthy lifestyle and prevent type 2 diabetes in vulnerable families across Europe: design and implementation of the Feel4Diabetes-study

Author: Manios, Yannis, primary, Androutsos, Odysseas, additional, Lambrinou, Christina-Paulina, additional, Cardon, Greet, additional, Lindstrom, Jaana, additional, Annemans, Lieven, additional, Mateo-Gallego, Rocio, additional, de Sabata, Maria Stella, additional, Iotova, Violeta, additional, Kivela, Jemina, additional, Martinez, Remberto, additional, Moreno, Luis A, additional, Rurik, Imre, additional, Schwarz, Peter, additional, Tankova, Tsvetalina, additional, Liatis, Stavros, additional, and Makrilakis, Konstantinos, additional
Published: 2018
Full Text: View/download PDF

49. Long term results and determinants of outcomes in primary health care diabetes prevention. The DE-PLAN project

Author: Gilis-Januszewska, Aleksandra, primary, Lindstrom, Jaana, additional, Barengo, Noel C, additional, and Tuomilehto, Jaakko, additional
Published: 2018
Full Text: View/download PDF

50. Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance: the Finnish Diabetes Prevention Study

Author: Niskanen, Leo, Laaksonen, David E., Lindstrom, Jaana, Eriksson, Johan G., Keinanen-Kiukaanniemi, Sirkka, Ilanne-Parikka, Pirjo, Aunola, Sirkka, Hamalainen, Helena, Tuomilehto, Jaakko, and Uusitupa, Matti
Subjects: Uric acid -- Research -- Health aspects, Glucose intolerance -- Research, Diabetics -- Health aspects -- Research, Health, Research, Health aspects
Abstract: Serum uric acid is the major product of purine metabolism (1). In cross-sectional studies, uric acid correlates with components of the metabolic syndrome: hypertension, obesity, low HDL cholesterol, hypertriglyceridemia, hyperinsulinemia, [...]
Published: 2006

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