2,291 results on '"Ling, Ren"'
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2. Effect of Cu content on the properties of laser powder bed fused biomedical titanium alloys
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Hui Liu, Xiaofeng Zhang, Lizhen Shi, Yang Hong, Hui Yao, Ling Ren, and Ke Yang
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Laser powder bed fusion ,Titanium alloy ,Cu content ,Comprehensive performance ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Laser powder bed fusion (LPBF) technology enables personalized customization of medical implants. However, the clinical titanium alloy is biologically inert and can't address bacterial infections. It has been proved that Copper (Cu) -bearing titanium alloys exhibit excellent antibacterial ability and potentials for clinical application. However, it still unclear that the effect of Cu content on the comprehensive properties of LPBF-produced titanium alloy which usually has high strength but poor ductility and corrosion resistance caused by its α′ martensite. This study systematically investigates the effects of Cu content (x = 2, 5, 8 wt%) on the microstructure, mechanical properties, corrosion resistance, antibacterial properties, and cytrocompatibility of the LPBF-produced Ti-xCu alloys. These results prove that the LPBF produced Ti–5Cu alloy possesses the optimal comprehensive performance and has promising clinical application prospects as implant materials.
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- 2024
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3. Prediction of the short-term efficacy and recurrence of photodynamic therapy in the treatment of oral leukoplakia based on deep learning
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Fei Wang, Yansong Song, Hao Xu, Jiaxin Liu, Fan Tang, Dan Yang, Wenhui Liang, Ling Ren, Jiongke Wang, Xiaobo Luo, Yu Zhou, Xin Zeng, Hongxia Dan, and Qianming Chen
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Photodynamic therapy ,Oral leukoplakia ,Short-term efficacy ,Recurrence ,Prediction model ,Deep learning ,Medicine (General) ,R5-920 - Abstract
Background: The treatment of oral leukoplakia (OLK) with aminolaevulinic acid photodynamic therapy (ALA-PDT) is widespread. Nonetheless, there is variation in efficacy. Therefore, this study constructed a model for predicting the short-term efficacy and recurrence of OLK after ALA-PDT. Methods: The short-term efficacy and recurrence of ALA-PDT were calculated by statistical analysis, and the relevant influencing factors were analyzed by Logistic regression and COX regression model. Finally, prediction models for total response (TR) rate, complete response (CR) rate and recurrence in OLK patients after ALA-PDT treatment were established. Features from pathology sections were extracted using deep learning autoencoder and combined with clinical variables to improve prediction performance of the model. Results: The logistic regression analysis showed that the non-homogeneous (OR: 4.911, P: 0.023) OLK and lesions with moderate to severe epithelial dysplasia (OR: 4.288, P: 0.042) had better short-term efficacy. The area under receiver operating characteristic curve (AUC) of CR, TR and recurrence predict models after the ALA-PDT treatment of OLK patients is 0.872, 0.718, and 0.564, respectively. Feature extraction revealed an association between inflammatory cell infiltration in the lamina propria and recurrence after PDT. Combining clinical variables and deep learning improved the performance of recurrence model by more than 30 %. Conclusions: ALA-PDT has excellent short-term efficacy in the management of OLK but the recurrence rate was high. Prediction model based on clinicopathological characteristics has excellent predictive effect for short-term efficacy but limited effect for recurrence. The use of deep learning and pathology images greatly improves predictive value of the models.
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- 2024
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4. Steep Slope Field Effect Transistors Based on 2D Materials
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Laixiang Qin, He Tian, Chunlai Li, Ziang Xie, Yiqun Wei, Yi Li, Jin He, Yutao Yue, and Tian‐Ling Ren
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2D materials ,low power consumption ,steep slope transistor ,short channel effect ,Electric apparatus and materials. Electric circuits. Electric networks ,TK452-454.4 ,Physics ,QC1-999 - Abstract
Abstract With field effect transistor (FET) sustained to downscale to sub‐10 nm nodes, performance degradation originates from short channel effects (SCEs) degradation and power consumption increment attributed to inhibition of supply voltage (VDD) scaling down proportionally caused by thermionic limit subthreshold swing (SS) (60 mV dec−1) pose substantial challenges for today's semiconductor industry. To further sustain the Moore's law life, incorporation of new device concepts or new materials are imperative. 2D materials are predicted to be able to combat SCEs by virtue of high carrier mobility maintainability regardless of thickness thinning down, dangling bonds free surface and atomic thickness, which contributes to super gate electrostatic controllability. To overcome increasing power dissipation problem, new device structures including negative capacitance FET (NCFET), tunnel FET (TFET), dirac source FET (DSFET) and the like, which show superiority in decreasing VDD by lowering SS below thermionic limit of 60 mV dec−1 have been brought out. The combination of 2D materials and ultralow steep slope device structures holds great promise for low power‐dissipation electronics, which encompass both suppressed SCEs and reduced VDD simultaneously, leading to improved device performance and lowered power dissipation.
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- 2024
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5. Adaptively Secure BLS Threshold Signatures from DDH and co-CDH.
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Sourav Das and Ling Ren 0001
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- 2024
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6. Exploring the Dissipation Parameter of Quartz Crystal Resonator under 3-Overtone Mode.
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Jian-Guo Hu and Tian-Ling Ren
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- 2024
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7. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro
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Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, and Yong-Ping Chen
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Amyotrophic lateral sclerosis ,Mendelian randomization ,Drug repurposing ,Druggable gene ,TBK1 ,Medicine - Abstract
Abstract Background There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment. Methods To identify therapeutic targets associated with ALS, we conducted Mendelian randomization (MR) analysis and colocalization analysis using cis-eQTL of druggable gene and ALS GWAS data collections to determine annotated druggable gene targets that exhibited significant associations with ALS. By subsequent repurposing drug discovery coupled with inclusion criteria selection, we identified several drug candidates corresponding to their druggable gene targets that have been genetically validated. The pharmacological assays were then conducted to further assess the efficacy of genetics-supported repurposed drugs for potential ALS therapy in various cellular models. Results Through MR analysis, we identified potential ALS druggable genes in the blood, including TBK1 [OR 1.30, 95%CI (1.19, 1.42)], TNFSF12 [OR 1.36, 95%CI (1.19, 1.56)], GPX3 [OR 1.28, 95%CI (1.15, 1.43)], TNFSF13 [OR 0.45, 95%CI (0.32, 0.64)], and CD68 [OR 0.38, 95%CI (0.24, 0.58)]. Additionally, we identified potential ALS druggable genes in the brain, including RESP18 [OR 1.11, 95%CI (1.07, 1.16)], GPX3 [OR 0.57, 95%CI (0.48, 0.68)], GDF9 [OR 0.77, 95%CI (0.67, 0.88)], and PTPRN [OR 0.17, 95%CI (0.08, 0.34)]. Among them, TBK1, TNFSF12, RESP18, and GPX3 were confirmed in further colocalization analysis. We identified five drugs with repurposing opportunities targeting TBK1, TNFSF12, and GPX3, namely fostamatinib (R788), amlexanox (AMX), BIIB-023, RG-7212, and glutathione as potential repurposing drugs. R788 and AMX were prioritized due to their genetic supports, safety profiles, and cost-effectiveness evaluation. Further pharmacological analysis revealed that R788 and AMX mitigated neuroinflammation in ALS cell models characterized by overly active cGAS/STING signaling that was induced by MSA-2 or ALS-related toxic proteins (TDP-43 and SOD1), through the inhibition of TBK1 phosphorylation. Conclusions Our MR analyses provided genetic evidence supporting TBK1, TNFSF12, RESP18, and GPX3 as druggable genes for ALS treatment. Among the drug candidates targeting the above genes with repurposing opportunities, FDA-approved drug-R788 and AMX served as effective TBK1 inhibitors. The subsequent pharmacological studies validated the potential of R788 and AMX for treating specific ALS subtypes through the inhibition of TBK1 phosphorylation.
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- 2024
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8. SAA1 regulated by S1P/S1PR1 promotes the progression of ESCC via β-catenin activation
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Qianqian Li, Maolin Tang, Shisheng Zhao, Junjie Yang, Yuanlin Meng, Chunmei Meng, Ling Ren, and Weimin Hu
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Serum amyloid A1 (SAA1) ,Esophageal squamous cell carcinoma (ESCC) ,pSer675-β-catenin ,S1P/S1PR1 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Serum amyloid A1 (SAA1), an inflammation-related molecule, is associated with the malignant progression of many tumors. This study aimed to investigate the role of SAA1 in the progression of esophageal squamous cell carcinoma (ESCC) and its molecular mechanisms. The expression of SAA1 in ESCC tissues and cell lines was analyzed using bioinformatics analysis, western blotting, and reverse transcription-quantitative PCR (RT‒qPCR). SAA1-overexpressing or SAA1-knockdown ESCC cells were used to assess the effects of SAA1 on the proliferation, migration, apoptosis of cancer cells and the growth of xenograft tumors in nude mice. Western blotting, immunofluorescence and RT‒qPCR were used to investigate the relationship between SAA1 and β-catenin and SAA1 and sphingosine 1-phosphate (S1P)/sphingosine 1-phosphate receptor 1 (S1PR1). SAA1 was highly expressed in ESCC tissues and cell lines. Overexpression of SAA1 significantly promoted the proliferation, migration and the growth of tumors in nude mice. Knockdown of SAA1 had the opposite effects and promoted the apoptosis of ESCC cells. Moreover, SAA1 overexpression promoted the phosphorylation of β-catenin at Ser675 and increased the expression levels of the β-catenin target genes MYC and MMP9. Knockdown of SAA1 had the opposite effects. S1P/S1PR1 upregulated SAA1 expression and β-catenin phosphorylation at Ser675 in ESCC cells. In conclusion, SAA1 promotes the progression of ESCC by increasing β-catenin phosphorylation at Ser675, and the S1P/S1PR1 pathway plays an important role in its upstream regulation.
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- 2024
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9. The Roadmap of 2D Materials and Devices Toward Chips
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Anhan Liu, Xiaowei Zhang, Ziyu Liu, Yuning Li, Xueyang Peng, Xin Li, Yue Qin, Chen Hu, Yanqing Qiu, Han Jiang, Yang Wang, Yifan Li, Jun Tang, Jun Liu, Hao Guo, Tao Deng, Songang Peng, He Tian, and Tian-Ling Ren
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Two-dimensional materials ,Roadmap ,Integrated circuits ,Post-Moore era ,Technology - Abstract
Highlights This review introduces the potential of 2D electronics for post-Moore era and discusses their current progress in digital circuits, analog circuits, heterogeneous integration, sensing circuits, artificial intelligence chips, and quantum chips in sequence. A comprehensive analysis of the current trends and challenges encountered in the development of 2D materials is summarized. An in-depth roadmap outlining the future development of 2D electronics is presented, and the most accessible and promising avenues for 2D electronics are suggested.
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- 2024
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10. Study on the Quality Difference of Yun Kang 10 Anaerobic Processed White Tea in Different Seasons
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Chenyang MA, Chang GAO, Di TIAN, Xiaohui ZHOU, Ling REN, Yuanda LI, Yali LI, and Hongjie ZHOU
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γ-aminobutyric acid (gaba) ,yun kang 10 ,quality difference ,white tea ,season ,Food processing and manufacture ,TP368-456 - Abstract
In this study, the fresh leaves of Yun kang 10 with one bud and two or three leaves in spring, summer and autumn were used as raw materials. After anaerobic treatment, white tea was processed by the same process. The quality differences of white tea made from raw materials in three seasons after anaerobic treatment were explored by sensory evaluation, physical and chemical composition determination and UHPLC-MS/MS high-throughput detection technology to detect the content of amino acid components. The results showed that there were significant differences in the quality of white tea in the three seasons. The dry tea of white tea in spring was bright green in color. The aroma was strong, lasting, high and intensive, and had a variety of aroma types such as flowery, honey, tip aroma, medicinal and the fragrance of unique process. The taste was strong, fresh, sweet and brisk. The color of tea soup was bright yellow. Infused leaf was soft and bright. The quality of sensory was the best. The contents of amino acids, soluble sugar, caffeine, water extract and flavonoids of white tea were the highest in spring, and the content of tea polyphenols white tea was the highest in summer. A total of twenty amino acids were detected, of which 18 amino acids were significantly different (P
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- 2024
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11. Single-cell transcriptomic analysis reveals the antiangiogenic role of Mgarp in diabetic retinopathy
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Jin Yao, Dan li, Yun Bai, Chang Huang, Ling Ren, Jiao Xia, and Biao Yan
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Introduction Diabetic retinopathy (DR) is a common vascular complication of diabetes mellitus and a leading cause of vision loss worldwide. Endothelial cell (EC) heterogeneity has been observed in the pathogenesis of DR. Elucidating the underlying mechanisms governing EC heterogeneity may provide novel insights into EC-specific therapies for DR.Research design and methods We used the single-cell data from the Gene Expression Omnibus database to explore EC heterogeneity between diabetic retinas and non-diabetic retinas and identify the potential genes involved in DR. CCK-8 assays, EdU assays, transwell assays, and tube formation assays were conducted to determine the role of the identified gene in angiogenic effects.Results Our analysis identified three distinct EC subpopulations in retinas and revealed that Mitochondria-localized glutamic acid-rich protein (Mgarp) gene is potentially involved in the pathogenesis of DR. Silencing of Mgarp significantly suppressed the proliferation, migration, and tube formation capacities in retinal endothelial cells.Conclusions This study not only offers new insights into transcriptomic heterogeneity and pathological alteration of retinal ECs but also holds the promise to pave the way for antiangiogenic therapy by targeting EC-specific gene.
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- 2024
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12. Ultrasound molecular imaging for early detection of acute renal ischemia–reperfusion injury
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Ling Ren, Yuzhuo Zhao, Tiantian Wang, Yan Tong, Ping Zhao, Fang Nie, Yukun Luo, and Lianhua Zhu
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acute kidney injury ,inflammation ,ischemia–reperfusion injury ,microcirculation ,ultrasound molecular imaging ,vascular cell adhesion molecule‐1 ,Chemical engineering ,TP155-156 ,Biotechnology ,TP248.13-248.65 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Background Microcirculatory perfusion disorder and inflammatory response are critical links in acute kidney injury (AKI). We aim to construct anti‐vascular cell adhesion molecule‐1(VCAM‐1) targeted microbubbles (TM) to monitor renal microcirculatory perfusion and inflammatory response. Methods TM carrying VCAM‐1 polypeptide was constructed by biological coupling. The binding ability of TM to human umbilical vein endothelial cells (HUVECs) was detected. Bilateral renal ischemia–reperfusion injury (IRI) models of mice were established to evaluate microcirculatory perfusion and inflammatory response using TM. Thirty‐six mice were randomly divided into six groups according to the different reperfusion time (0.5, 2, 6, 12, and 24 h) and sham‐operated group (Sham group). The correlation of TM imaging with serum and histopathological biomarkers was investigated. Results TM has advantages such as uniform distribution, regular shape, high stability, and good biosafety. TM could bind specifically to VCAM‐1 molecule expressed by tumor necrosis factor‐alpha (TNF‐α)‐treated HUVECs. In the renal IRI‐AKI model, the area under the curve (AUC) of TM significantly decreased both in the renal cortical and medullary after 2 h of reperfusion compared with the Sham group (p
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- 2024
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13. Quercetin attenuated ropivacaine-induced neurotoxicity in SH-SY5Y cells through upregulating Pim1 and enhancing autophagy
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Yinghai Liu, Ling Ren, Yangyang Sun, Jing Yan, and Gu Gong
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Quercetin ,Ropivacaine ,AMPK ,Pim1 ,Autophagy ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: Ropivacaine (Rop) is a local anesthetic that is widely used but is also potentially harmful. Quercetin (Quer) is a flavonoid component found in many plants and traditional Chinese medicines. It possesses anti-oxidant, anti-inflammatory, antitumor, and neuroprotective properties as a pharmaceutical. In Rop-induced neurotoxicity, the functions and molecular basis of Quer remain unclear. Methods: Cell viability and proliferation were assessed using CCK-8 and 5-ethynyl-2′-deoxyuridine (EdU) incorporation assays, respectively. Apoptosis and autophagy were defined by both morphological criteria and markers such as caspase3 cleavage and monodansylcadaverine (MDC) staining. Western blot and immunofluorescence staining were evaluated. The target proteins were then predicted using molecular docking and validated at the cellular and protein levels. Results: Quer was shown to significantly reduce Rop-induced viability inhibition and apoptosis in SH-SY5Y cells in a dose-dependent manner. Moreover, Quer reduced Rop-induced cytotoxicity by stimulating autophagy in SH-SY5Y cells by targeting the Pim1 protein, which was accomplished via the AMPK/mTOR pathway. Conclusion: Quer relieved Rop-induced neurotoxicity in SH-SY5Y cells through upregulating Pim1 and enhancing autophagy, indicating that Quer may have potential therapeutic applications in the treatment of Rop-induced neurotoxicities.
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- 2024
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14. Both States and Unknown Inputs Simultaneous Estimation for Fractional-Order Linear Systems.
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Chenchen Peng, Ling Ren 0008, and Zihao Zhao
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- 2024
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15. Deep reinforcement learning framework for end-to-end semiconductor process control.
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Thomas Hirtz, He Tian, Shazrah Shahzad, Fan Wu, Yi Yang, and Tian-Ling Ren
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- 2024
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16. Study on the Dynamics of Differential Metabolites of Pu-erh Tea Fermented by Exogenous Added Bacteria
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Juan YU, Xiaoli JIANG, Yuan HUANG, Ling REN, Siting GAO, Rui DONG, Hongjie ZHOU, and Yali LI
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pu-erh tea ,exogenous added bacteria ,liquid chromatography-mass spectrometry (lc-ms) ,differential metabolites ,tea quality ,Food processing and manufacture ,TP368-456 - Abstract
In order to explore the role of exogenous bacteria in the fermentation process of Pu-erh tea and its impact on tea quality, the present study aimed to explore the differences in metabolite changes during fermentation of Pu-erh tea treated with different bacterial strains. To achieve this, non-targeted metabolomics technology was employed, which was combined with multivariate statistical analysis and differential heat maps. The study analyzed the flavonoids, alkaloids, and terpenoids present in the tea samples. The H group was found to have a fruity and sweet aroma, a bright red soup color, and a strong and sweet taste. The A group had a strong floral and honey aroma, a bright red soup color, and a strong and sweet aftertaste. The R group had a fruity and milky aroma, a bright yellow soup color, and a strong but astringent and bitter taste. These differences in quality were found to be related to the levels of metabolites such as malvidin, genkwanin, catechins, caffeine, and lactucin. The study provided preliminary insights into the differences in metabolite content during the fermentation of Pu-erh tea with different bacterial strains, which can have varying effects on the taste, aroma, and soup color of the tea. The findings of this study could provide theoretical assistance for future Pu-erh tea fermentation.
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- 2023
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17. Recent Progress in Biosensors for Depression Monitoring—Advancing Personalized Treatment
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Jiaju Yin, Xinyuan Jia, Haorong Li, Bingchen Zhao, Yi Yang, and Tian-Ling Ren
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biosensors ,depression ,personalized treatment ,Biotechnology ,TP248.13-248.65 - Abstract
Depression is currently a major contributor to unnatural deaths and the healthcare burden globally, and a patient’s battle with depression is often a long one. Because the causes, symptoms, and effects of medications are complex and highly individualized, early identification and personalized treatment of depression are key to improving treatment outcomes. The development of wearable electronics, machine learning, and other technologies in recent years has provided more possibilities for the realization of this goal. Conducting regular monitoring through biosensing technology allows for a more comprehensive and objective analysis than previous self-evaluations. This includes identifying depressive episodes, distinguishing somatization symptoms, analyzing etiology, and evaluating the effectiveness of treatment programs. This review summarizes recent research on biosensing technologies for depression. Special attention is given to technologies that can be portable or wearable, with the potential to enable patient use outside of the hospital, for long periods.
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- 2024
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18. Effects of Different Fermentation Methods on Flavor Quality of Liupao Tea Using GC-Q-TOF-MS and Electronic Nose Analyses
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Xiaohui Zhou, Di Tian, Hongjie Zhou, Rui Dong, Chenyang Ma, Ling Ren, Xueyi Yang, Qingyi Wang, Ning Chen, Liubo Yang, Xuan Tang, Yixin Bi, Yapeng Liu, Xiujuan Deng, Baijuan Wang, and Yali Li
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Liupao tea fermentation ,Monascus purpureus inoculation ,GC-Q-TOF-MS ,electronic nose ,sensory evaluations ,odor activity value ,Chemical technology ,TP1-1185 - Abstract
To further develop Liupao tea products and enhance their flavor, this study investigated the effects of different fermentation methods on the aroma quality of Liupao tea. The aroma quality of Liupao tea was comprehensively analyzed using HS-SPME in combination with GC-Q-TOF-MS, electronic nose, and sensory evaluations. Electronic nose detection showed that the aroma fingerprints of Liupao tea samples with different fermentation methods were different. Sulfides, alcohols, ketones, and methyls were the main aroma categories affecting the aroma of the four groups of Liupao tea samples. GC-Q-TOF-MS analysis revealed significant differences in the composition of aroma components among the four fermentation methods of Liupao tea (p < 0.05). Furthermore, the total amount of aroma compounds was found to be highest in the group subjected to hot fermentation combined with the inoculation of Monascus purpureus (DMl group). Based on the OPLS-DA model, candidate differential aroma components with VIP > 1 were identified, and characteristic aroma compounds were selected based on OAV > 10. The key characteristic aroma compounds shared by the four groups of samples were 1,2,3-Trimethoxybenzene with a stale aroma and nonanal with floral and fruity aromas. The best sensory evaluation results were obtained for the DMl group, and its key characteristic aroma compounds mainly included 1,2,3-Trimethoxybenzene, nonanal, and cedrol. The results of this study can guide the development of Liupao tea products and process optimization.
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- 2024
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19. Powers of Tau in Asynchrony.
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Sourav Das, Zhuolun Xiang, and Ling Ren 0001
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- 2024
20. Micromesh reinforced strain sensor with high stretchability and stability for full‐range and periodic human motions monitoring
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Haidong Liu, Chang Liu, Jinan Luo, Hao Tang, Yuanfang Li, Houfang Liu, Jingzhi Wu, Fei Han, Zhiyuan Liu, Jianhe Guo, Rongwei Tan, Tian‐Ling Ren, Yancong Qiao, and Jianhua Zhou
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flexible strain sensor ,excellent stretchability and stability ,layered laser‐scribed graphene ,micromesh reinforced structure ,multilayer finite element model ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Information technology ,T58.5-58.64 - Abstract
Abstract The development of strain sensors with high stretchability and stability is an inevitable requirement for achieving full‐range and long‐term use of wearable electronic devices. Herein, a resistive micromesh reinforced strain sensor (MRSS) with high stretchability and stability is prepared, consisting of a laser‐scribed graphene (LSG) layer and two styrene‐block‐poly(ethylene‐ran‐butylene)‐block‐poly‐styrene micromesh layers embedded in Ecoflex. The micromesh reinforced structure endows the MRSS with combined characteristics of a high stretchability (120%), excellent stability (with a repetition error of 0.8% after 11 000 cycles), and outstanding sensitivity (gauge factor up to 2692 beyond 100%). Impressively, the MRSS can still be used continauously within the working range without damage, even if stretched to 300%. Furthermore, compared with different structure sensors, the mechanism of the MRSS with high stretchability and stability is elucidated. What's more, a multilayer finite element model, based on the layered structure of the LSG and the morphology of the cracks, is proposed to investigate the strain sensing behavior and failure mechanism of the MRSS. Finally, due to the outstanding performance, the MRSS not only performes well in monitoring full‐range human motions, but also achieves intelligent recognitions of various respiratory activities and gestures assisted by neural network algorithms (the accuracy up to 94.29% and 100%, respectively). This work provides a new approach for designing high‐performance resistive strain sensors and shows great potential in full‐range and long‐term intelligent health management and human–machine interactions applications.
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- 2024
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21. Single‐cell RNA sequencing unveils an Odc1‐marked endothelial subpopulation critical for pathological angiogenesis
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Ming Tong, Yun Bai, Jiao Lyu, Ling Ren, Linyu Zhang, Mudi Yao, Xiaoyan Han, Xiumiao Li, Dan Li, Pei‐Quan Zhao, Qin Jiang, and Biao Yan
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Medicine (General) ,R5-920 - Published
- 2024
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22. Inter-observer variation in two-dimensional and three-dimensional ultrasound measurement of papillary thyroid microcarcinoma
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Lin Yan, Ling Ren, Yingying Li, and Yukun Luo
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Thyroid cancer ,Papillary ,Ultrasound ,Reproducibility of results ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Backgrounds The reliable ultrasound (US) measurements of papillary thyroid microcarcinoma (PTMC) are very important during active surveillance. This prospective study was design to investigate the inter-observer reliability and agreement of two- dimensional ultrasound(2DUS) and three-dimensional ultrasound(3DUS) in the measurement of maximum diameter and volume for PTMC. Methods This prospective study included 51 consecutive patients with solitary PTMC confirmed by biopsy. Two independent observers performed measurements of each tumor using a standardized measurement protocol. The maximum diameter was the largest one of the three diameters measured on the largest transverse and longitudinal 2DUS images. 2DUS volume was calculated using ellipsoid formula method. The virtual organ computer aided analysis(VOCAL) was used to determine 3DUS volume. The inter-observer reliability was assessed using intraclass correlation coefficient(ICC) with 95% confidence intervals(CIs). Bland-Altman analysis was used to evaluate agreement, and expressed as a bias with 95% limits of agreement(LOA). Results The maximum diameter was 0.78 ± 0.14 cm. Volume measured by 3DUS was significantly smaller than that by 2DUS(0.163 ± 0.074 cm3 vs. 0.175 ± 0.078 cm3, P = 0.005). The ICCs of inter-observer reliability of maximum diameter, 2DUS volume and 3DUS volume was 0.922(0.864–0.955), 0.928(0.874–0.959), and 0.974(0.955–0.985), respectively. The ICCs of 2DUS and 3DUS volume was 0.955(0.909–0.976). The inter-observer agreement of maximum diameter, 2DUS volume and 3DUS volume was 1.096(0.7322 to 1.459), 1.008(0.5802–1.435), and 1.011(0.7576–1.265), respectively. The inter-observer agreement of 2DUS and 3DUS volume was 1.096(0.7322 to 1.459). Conclusion Maximum diameter had the lowest degree of observer variation among all the measurements. Volume measured by 3DUS had lower variability and higher repeatability than that by 2DUS, which might be helpful to provide more reliable estimates of tumor size for PTMC.
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- 2023
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23. Granular Synchrony.
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Neil Giridharan, Ittai Abraham, Natacha Crooks, Kartik Nayak, and Ling Ren 0001
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- 2024
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24. Two-dimensional materials for future information technology: status and prospects.
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Hao Qiu, Zhihao Yu, Tiange Zhao, Qi Zhang, Mingsheng Xu, Peifeng Li, Taotao Li, Wenzhong Bao, Yang Chai, Shula Chen, Yiqi Chen, Hui-Ming Cheng, Daoxin Dai, Zengfeng Di, Zhuo Dong, Xidong Duan, Yuhan Feng, Yu Fu, Jingshu Guo, Pengwen Guo, Yue Hao, Jun He, Xiao He, Jingyi Hu, Weida Hu, Zehua Hu, Xinyue Huang, Ziyang Huang, Ali Imran 0004, Ziqiang Kong, Jia Li, Qian Li, Weisheng Li, Lei Liao, Bilu Liu, Can Liu, Chunsen Liu, Guanyu Liu, Kaihui Liu, Liwei Liu, Sheng Liu, Yuan Liu, Donglin Lu, Likuan Ma, Feng Miao, Zhenhua Ni, Jing Ning, Anlian Pan, Tian-Ling Ren, Haowen Shu, Litao Sun, Yue Sun, Quanyang Tao, Ziao Tian, Dong Wang, Hao Wang, Haomin Wang, Jialong Wang, Junyong Wang, Wenhui Wang, Xingjun Wang, Yeliang Wang, Yuwei Wang, Zhenyu Wang, Yao Wen, Haidi Wu, Hongzhao Wu, Jiangbin Wu, Yanqing Wu, Longfei Xia, Baixu Xiang, Luwen Xing, Qihua Xiong, Xiong Xiong, Jeffrey Xu, Tao Xu, Yang Xu, Liu Yang, Yi Yang, Yuekun Yang, Lei Ye, Yu Ye, Bin Yu, Ting Yu, Hui Zeng, Guangyu Zhang, Hongyun Zhang, Jincheng Zhang, Kai Zhang, Tao Zhang, Xinbo Zhang, Yanfeng Zhang, Chunsong Zhao, Yuda Zhao, Ting Zheng, Peng Zhou, Shaohua Kevin Zhou, Yuxuan Zhu, Deren Yang, Yi Shi, Han Wang, and Xinran Wang
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- 2024
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25. On the Amortized Communication Complexity of Byzantine Broadcast.
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Jun Wan 0008, Atsuki Momose, Ling Ren 0001, Elaine Shi, and Zhuolun Xiang
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- 2023
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26. Practical Asynchronous High-threshold Distributed Key Generation and Distributed Polynomial Sampling.
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Sourav Das, Zhuolun Xiang, Lefteris Kokoris-Kogias, and Ling Ren 0001
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- 2023
27. Vectorized Batch Private Information Retrieval.
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Muhammad Haris Mughees and Ling Ren 0001
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- 2023
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28. Towards Practical Sleepy BFT.
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Dahlia Malkhi, Atsuki Momose, and Ling Ren 0001
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- 2023
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29. On the Security of KZG Commitment for VSS.
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Atsuki Momose, Sourav Das, and Ling Ren 0001
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- 2023
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30. Threshold Signatures from Inner Product Argument: Succinct, Weighted, and Multi-threshold.
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Sourav Das, Philippe Camacho, Zhuolun Xiang, Javier Nieto, Benedikt Bünz, and Ling Ren 0001
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- 2023
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31. ParBFT: Faster Asynchronous BFT Consensus with a Parallel Optimistic Path.
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Xiaohai Dai, Bolin Zhang, Hai Jin 0001, and Ling Ren 0001
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- 2023
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32. Glare sign recognition based on improved Yolox algorithm.
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Teng Xu, Ling Ren 0007, Tian-Wei Shi, Yuan Gao, Jian-Bang Ding, and Rong-Chen Jin
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- 2023
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33. Practical Settlement Bounds for Longest-Chain Consensus.
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Peter Gazi, Ling Ren 0001, and Alexander Russell
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- 2023
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34. Rail Surface Defect Detection Method Based on Deep Learning Method with 3D Range Image
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Ming, Geng, Zhou, Bo, Luo, Xiaohua, Ling, Ren, Zhou, Mingxiang, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, and Yang, Yang, editor
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- 2023
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35. Two cases of placental trisomy 21 mosaicism causing false-negative NIPT results
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Qinfei Zhao, Jing Chen, Ling Ren, Huijuan Zhang, Dedong Liu, Xuxiang Xi, Xiangsheng Wu, Chunyun Fang, Ping Ye, Shaoying Zeng, and Tianyu Zhong
- Subjects
Non-invasive prenatal testing (NIPT) ,Down syndrome ,False negative ,Placental mosaicism ,21q ,Genetics ,QH426-470 - Abstract
Abstract Background Non-invasive prenatal testing (NIPT) using cell-free DNA has been widely used for prenatal screening to detect the common fetal aneuploidies (such as trisomy 21, 18, and 13). NIPT has been shown to be highly sensitive and specific in previous studies, but false positives (FPs) and false negatives (FNs) occur. Although the prevalence of FN NIPT results for Down syndrome is rare, the impact on families and society is significant. Case presentation This article described two cases of foetuses that tested “negative” for trisomy 21 by NIPT technology using the semiconductor sequencing platform. However, the fetal karyotypes of amniotic fluid were 46,XY, + 21 der(21;21)(q10;q10) and 47,XY, + 21 karyotypes, respectively. Placental biopsies confirmed that, in the first case, the chromosome 21 placenta chimerism ratio ranged from 13 to 88% with the 46,XX, + 21,der(21;21)(q10;q10)[86]/46,XX[14] karyotype of placental chorionic cells (middle of fetal-side placental tissue). However, in the second case, of all the placental biopsies, percentage of total chimerism was less than 30%; and placental biopsies taken at the middle of maternal side and middle of fetal side, also had variable trisomy 2 mosaicism levels of 10% and 8%, respectively. Ultimately, the pregnancies were interrupted at 30 gestational age (GA) and 27GA, respectively. Conclusions In this study, we present two cases of FN NIPT results that might have been caused by biological mechanisms, as opposed to poor quality, technical errors, or negligence. Clinical geneticists and their patients must understand that NIPT is a screening procedure.
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- 2023
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36. A novel retinoic acid drug, EYE-502, inhibits choroidal neovascularization by targeting endothelial cells and pericytes
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Yaming Shen, Miao Xu, Ling Ren, Xiumiao Li, Xiaoyan Han, Xin Cao, Jin Yao, and Biao Yan
- Subjects
Medicine ,Science - Abstract
Abstract Choroidal neovascularization (CNV) occurs in neovascular age-related macular degeneration (AMD) and often leads to permanent visual impairment. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is the gold standard for the treatment of CNV. However, anti-VEGF treatment did not always cause vision improvement and sometimes had detrimental effects on normal retinal tissues. Herein, we identified a novel retinoic acid drug, EYE-502, which had great therapeutic effects on CNV. Administration of EYE-502 could inhibit VEGF-induced dysfunction of endothelial cells (ECs) and reduce platelet-derived growth factor (PDGF)-induced recruitment of pericytes to ECs in vitro. Administration of EYE-502 could reduce the area of choroidal sprouting and laser-induced CNV, exhibiting similar anti-angiogenic effects as aflibercept. Moreover, administration of EYE-502 could reduce pericyte coverage in the sprouting vessels and choroidal neovascularization. Mechanistically, EYE-502 primarily bound to retinoic acid receptors (RARs) and exerted the anti-angiogenic effects by targeting ECs and pericytes via affecting the activation of Wnt/β-catenin and PDGF/PDGFR/PI3K/Akt signaling. Taken together, this study reports a novel retinoic acid drug, EYE-502, which can exert the anti-angiogenic effects by simultaneous targeting of ECs and pericytes.
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- 2023
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37. SPME-GC-MS Technique Combined with rOAV for the Analysis of Key Aroma Substances of Zijuan White Tea with Different Processing Processes
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Yuanda LI, Ting WU, Ganghua HUANG, Ling REN, Chenyang MA, Xiaohui ZHOU, Yali LI, and Hongjie ZHOU
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zijuan ,white tea ,key aroma substances ,headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry(hs-spme-gc-ms) ,Food processing and manufacture ,TP368-456 - Abstract
In order to study the key aroma compounds of Zijuan white tea with different processing technologies, headspace solid-phase micro extraction and gas chromatography mass spectrometry (HS-SPME-GC-MS), combined with sensory evaluation, PCA validation, OPLS-DA analysis and relative odor activity value (rOAV), was used to analyze and screen the key aroma compounds of Zijuan white tea. The results showed that 82 major aroma components were detected, mainly alcohols, esters, heterocyclic and aromatic compounds, with relatively high contents of linalool, methyl salicylate, benzyl alcohol and β-Ionone. The results of rOAV analysis showed that 9 volatile organic compounds including 1-octen-3-ol, α-Ionone, phenylacetaldehyde and methyl salicylate contributed to the aroma formation of natural withering Zijuan white tea (TZW) with floral and fruity aroma and spicy medicinal aroma, and 9 volatile organic compounds including 1-octen-3-ol, α-Ionone, β-Ionone and benzaldehyde contributed to the aroma formation of compound withering Zijuan white tea (CZW) with floral and fruity aroma and spicy aroma. OPLS-DA analysis combined with rOAV showed that 1-octene-3-ol and methyl salicylate were the key compounds for aroma difference between TZW and CZW. In summary, the flower and fruit aroma of Zijuan white tea processed by natural wilting was more abundant, which could effectively improve the aroma quality of Zijuan white tea.
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- 2023
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38. Cellular automata imbedded memristor-based recirculated logic in-memory computing
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Yanming Liu, He Tian, Fan Wu, Anhan Liu, Yihao Li, Hao Sun, Mario Lanza, and Tian-Ling Ren
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Science - Abstract
Abstract Memristor-based circuits offer low hardware costs and in-memory computing, but full-memristive circuit integration for different algorithm remains limited. Cellular automata (CA) has been noticed for its well-known parallel, bio-inspired, computational characteristics. Running CA on conventional chips suffers from low parallelism and high hardware costs. Establishing dedicated hardware for CA remains elusive. We propose a recirculated logic operation scheme (RLOS) using memristive hardware and 2D transistors for CA evolution, significantly reducing hardware complexity. RLOS’s versatility supports multiple CA algorithms on a single circuit, including elementary CA rules and more complex majority classification and edge detection algorithms. Results demonstrate up to a 79-fold reduction in hardware costs compared to FPGA-based approaches. RLOS-based reservoir computing is proposed for edge computing development, boasting the lowest hardware cost (6 components/per cell) among existing implementations. This work advances efficient, low-cost CA hardware and encourages edge computing hardware exploration.
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- 2023
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39. Designs and Applications for the Multimodal Flexible Hybrid Epidermal Electronic Systems
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Ding Li, Tianrui Cui, Zigan Xu, Shuoyan Xu, Zirui Dong, Luqi Tao, Houfang Liu, Yi Yang, and Tian-Ling Ren
- Subjects
Science - Abstract
Research on the flexible hybrid epidermal electronic system (FHEES) has attracted considerable attention due to its potential applications in human–machine interaction and healthcare. Through material and structural innovations, FHEES combines the advantages of traditional stiff electronic devices and flexible electronic technology, enabling it to be worn conformally on the skin while retaining complex system functionality. FHEESs use multimodal sensing to enhance the identification accuracy of the wearer’s motion modes, intentions, or health status, thus realizing more comprehensive physiological signal acquisition. However, the heterogeneous integration of soft and stiff components makes balancing comfort and performance in designing and implementing multimodal FHEESs challenging. Herein, multimodal FHEESs are first introduced in 2 types based on their different system structure: all-in-one and assembled, reflecting totally different heterogeneous integration strategies. Characteristics and the key design issues (such as interconnect design, interface strategy, substrate selection, etc.) of the 2 multimodal FHEESs are emphasized. Besides, the applications and advantages of the 2 multimodal FHEESs in recent research have been presented, with a focus on the control and medical fields. Finally, the prospects and challenges of the multimodal FHEES are discussed.
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- 2024
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40. Anomalous Elastic Evolution Induced by Copper Hopping in van der Waals Ferroelectric CuInP2S6
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Minghao Shao, Yuzhe Yang, Ri He, Ruiting Zhao, X. Renshaw Wang, Zhicheng Zhong, Houfang Liu, Yi Yang, and Tian‐Ling Ren
- Subjects
CuInP2S6 ,ferroelectric phase transitions ,van der Waals ferroelectric materials ,Young's modulus ,Electric apparatus and materials. Electric circuits. Electric networks ,TK452-454.4 ,Physics ,QC1-999 - Abstract
Abstract Van der Waals (vdW) ferroelectric CuInP2S6 (CIPS) has great potential in post‐Moore's law electronics owing to their advantages of weak interlayer interaction, stable surface with free dangling bonds, and robust switchable spontaneous polarization. The flexoelectric effect is demonstrated as an alternative switching method for the design of ferroelectric domains in layered vdW CIPS. However, the investigation of the correlation between the polarization and elastic properties remains indistinct. Here, an elastic evolution is explored experimentally and theoretically in layered vdW CIPS with temperature, of which Young's modulus (EYoung) is determined by analyzing the force‐indentation responses of vdW ferroelectric CIPS. Interestingly, an anomalous leap in EYoung of CIPS from 35 to 65 GPa occurs when the temperature rises across the Curie temperature TC of ≈315 K. Deep potential molecular dynamic (DPMD) simulations identify that this abnormal behavior can be attributed to temperature‐dependent change of copper distribution and the local copper dynamic hopping, intertwined with the order‐disorder ferroelectric phase transition, which is quite different from the typical decrease of EYoung in the lattice constant due to temperature increasing. The exploration provides an important reference for the analysis of coupled mechanical properties and ferroelectricity in CIPS and its applications in flexible electronics.
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- 2023
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41. Landauer‐QFLPS Model for Mixed Schottky‐Ohmic Contact Two‐Dimensional Transistors
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Zhao‐Yi Yan, Zhan Hou, Kan‐Hao Xue, He Tian, Tian Lu, Junying Xue, Fan Wu, Ruiting Zhao, Minghao Shao, Jianlan Yan, Anzhi Yan, Zhenze Wang, Penghui Shen, Mingyue Zhao, Xiangshui Miao, Zhaoyang Lin, Houfang Liu, Yi Yang, and Tian‐Ling Ren
- Subjects
ambipolar transport ,contact transports ,electronic design automation ,field‐effect transistors ,quasi‐Fermi levels ,Schottky barriers ,Science - Abstract
Abstract Two‐dimensional material‐based field‐effect transistors (2DM‐FETs) are playing a revolutionary role in electronic devices. However, before electronic design automation (EDA) for 2DM‐FETs can be achieved, it remains necessary to determine how to incorporate contact transports into model. Reported methods compromise between physical intelligibility and model compactness due to the heterojunction nature. To address this, quasi‐Fermi‐level phase space theory (QFLPS) is generalized to incorporate contact transports using the Landauer formula. It turns out that the Landauer‐QFLPS model effectively overcomes the issue of concern. The proposed new formula can describe 2DM‐FETs with Schottky or Ohmic contacts with superior accuracy and efficiency over previous methods, especially when describing non‐monotonic drain conductance characteristics. A three‐bit threshold inverter quantizer (TIQ) circuit is fabricated using ambipolar black phosphorus and it is demonstrated that the model accurately predicts circuit performance. The model could be very effective and valuable in the development of 2DM‐FET‐based integrated circuits.
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- 2023
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42. Pulse electrochemical synaptic transistor for supersensitive and ultrafast biosensors
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Jianlong Ji, Zhenxing Wang, Fan Zhang, Bin Wang, Yan Niu, Xiaoning Jiang, Zeng‐ying Qiao, Tian‐ling Ren, Wendong Zhang, Shengbo Sang, Zhengdong Cheng, and Qijun Sun
- Subjects
fast response ,pH sensor ,pulse electrochemical transistor ,supersensitive ,synaptic transistor ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Information technology ,T58.5-58.64 - Abstract
Abstract High sensitivity and fast response are the figures of merit for benchmarking commercial sensors. Due to the advantages of intrinsic signal amplification, bionic ability, and mechanical flexibility, electrochemical transistors (ECTs) have recently gained increasing popularity in constructing various sensors. In the current work, we have proposed a pulse‐driven synaptic ECT for supersensitive and ultrafast biosensors. By pulsing the presynaptic input (drain bias, VD) and setting the modulation potential (gate bias) near transconductance intersection (VG,i), the synaptic ECT‐based pH sensor can achieve a record high sensitivity up to 124 mV pH−1 (almost twice the Nernstian limit, 59.2 mV pH−1) and an ultrafast response time as low as 8.75 ms (7169 times faster than the potentiostatic sensors, 62.73 s). The proposed synaptic sensing strategy can effectively eliminate the transconductance fluctuation issue during the calibration process of the pH sensor and significantly reduce power consumption. Besides, the most sensitive working point at VG,i has been elaborately figured out through a series of detailed mathematical derivations, which is of great significance to provide higher sensitivity with quasi‐nonfluctuating amplification capability. The proposed electrochemical synaptic transistor paired with an optimized operating gate offers a new paradigm for standardizing and commercializing high‐performance biosensors.
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- 2023
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43. Efficacy and safety of sedation with dexmedetomidine in adults undergoing gastrointestinal endoscopic procedures: systematic review and meta-analysis of randomized controlled trials
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Rou Tang, Yaqun Huang, Yujia Zhang, Xiaolei Ma, Haoyang Yu, Kaichao Song, Ling Ren, Bin Zhao, Lulu Wang, and Wensheng Zheng
- Subjects
dexmedetomidine ,gastrointestinal endoscopic procedures ,sedative ,metaanalysis ,randomized controlled trial ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: The sedative role of dexmedetomidine (DEX) in gastrointestinal endoscopic procedures is unclear. We performed this systematic review and meta-analysis to assess the efficacy and safety of sedation with DEX during gastrointestinal endoscopic procedures with a view to providing evidence-based references for clinical decision-making.Methods: The PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases were searched for randomized controlled trials (RCTs) that compared DEX with different sedatives comparators (such as propofol, midazolam, and ketamine) for sedation in a variety of adult gastrointestinal endoscopic procedures from inception to 1 July 2022. Standardized mean difference (SMD) and weighted mean difference (WMD) with 95% confidence interval (CI) or pooled risk ratios (RR) with 95% CI were used for continuous outcomes or dichotomous outcomes, respectively, and a random-effect model was selected regardless of the significance of the heterogeneity.Results: Forty studies with 2,955 patients were assessed, of which 1,333 patients were in the DEX group and 1,622 patients were in the control (without DEX) group. The results suggested that the primary outcomes of sedation level of DEX are comparable to other sedatives, with similar RSS score and patient satisfaction level, and better in some clinical outcomes, with a reduced risk of body movements or gagging (RR: 0.60; 95% CI: 0.37 to 0.97; p = 0.04; I2 = 68%), and a reduced additional requirement for other sedatives, and increased endoscopist satisfaction level (SMD: 0.41; 95% CI: 0.05 to 0.77; p = 0.03; I2 = 86%). In terms of secondary outcomes of adverse events, DEX may benefit patients in some clinical outcomes, with a reduced risk of hypoxia (RR:0.34; 95% CI: 0.20 to 0.55; p < 0.0001; I2 = 52%) and cough (RR: 0.25; 95% CI: 0.12 to 0.54; p = 0.0004; I2 = 0%), no significant difference in the risk of hypotension, while an increased risk of bradycardia (RR: 3.08; 95% CI: 2.12 to 4.48; p < 0.00001; I2 = 6%).Conclusion: This meta-analysis indicates that DEX is a safe and effective sedative agent for gastrointestinal endoscopy because of its benefits for patients in some clinical outcomes. Remarkably, DEX is comparable to midazolam and propofol in terms of sedation level. In conclusion, DEX provides an additional option in sedation for gastrointestinal endoscopic procedures.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/#searchadvanced
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- 2023
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44. Transoral endoscopic thyroidectomy vestibular approach in clinical practice
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Jun-Ling Ren, Bin Chen, San-Bao Liu, and Zhi-Yong Zhao
- Subjects
Surgery ,RD1-811 - Published
- 2023
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45. Imaging Features and Misdiagnosis Analysis of Hyaline Vascular Castleman Disease in the Parotid Region: A Case Report
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Pengyan Zhang, MS, Ling Ren, MD, Yuguang You, BS, Wenjun Xiao, MS
- Subjects
castleman disease ,hyaline vascular ,parotid gland ,case report ,Medical technology ,R855-855.5 ,Medicine - Abstract
Castleman disease (CD), first described in 1954, is a rare lymphoproliferative disorder. A 20-year-old female patient was treated for a "painless mass below the right ear for 1 year". The imagological examination of the patient showed a soft tissue mass about 2.8 cm in diameter in the right parotid gland. Moreover, the patient underwent a right superficial parotidectomy and facial nerve dissection. The mass in the parotid gland was removed, and CD was confirmed by further pathological examination. Imagological examination contributes to the diagnosis and preoperative evaluation of CD.
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- 2023
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46. Effects of Different Doses of Esketamine on Pain Sensitivity of Patients Undergoing Thyroidectomy: A Randomized Controlled Trial
- Author
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Yan-ling Ren, Jing-jing Yuan, Fei Xing, Li-ning Zhu, and Wei Zhang
- Subjects
Anesthesia ,Esketamine ,Remifentanil-induced hyperalgesia ,Thyroidectomy ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Introduction Several factors may lead to increased postoperative pain sensitivity, of which remifentanil-induced hyperalgesia (RIH) is one of the main factors. High-dose remifentanil exposure during anesthesia may induce RIH. Esketamine may prevent RIH by antagonizing N-methyl-d-aspartate (NMDA) receptors, thereby reducing the postoperative pain sensitivity. This study examined the effects of different esketamine doses on pain sensitivity in patients undergoing thyroidectomy and determined the optimal dose. Methods This study included 117 patients who received elective thyroidectomy. They were randomized into four groups: saline group (group C), esketamine 0.2 mg·kg−1 group (group RK1), esketamine 0.4 mg·kg−1 group (group RK2), and esketamine 0.6 mg·kg−1 group (group RK3). Five minutes before anesthesia induction, the same volume of study drugs were injected respectively in groups C, RK1, RK2, and RK3. Remifentanil was pumped at the same rate of 0.3 µg·kg−1·min−1 during surgery to ensure uniformity. This study’s primary outcomes were the mechanical pain thresholds measured before surgery, as well as at 30 min, 6 h, 24 h, and 48 h after surgery. Hyperalgesia, rescue analgesia, numerical rating scale (NRS) score, and adverse reactions were recorded. Results Compared with baseline, the mechanical pain threshold was significantly decreased in group C [(94.67 ± 22.85) versus (112.00 ± 36.62) versus (161.33 ± 53.28) g, P
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- 2023
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47. Soft Electronics for Health Monitoring Assisted by Machine Learning
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Yancong Qiao, Jinan Luo, Tianrui Cui, Haidong Liu, Hao Tang, Yingfen Zeng, Chang Liu, Yuanfang Li, Jinming Jian, Jingzhi Wu, He Tian, Yi Yang, Tian-Ling Ren, and Jianhua Zhou
- Subjects
Soft electronics ,Machine learning algorithm ,Physiological signal monitoring ,Soft materials ,Technology - Abstract
Highlights This review introduces soft electronics for health monitoring assisted by machine learning, and discusses soft materials, physiological signals, and machine learning algorithms in sequence and their relationships. The principles of classic machine learning algorithms and neural network algorithms are summarized and explained by representative examples combining with soft electronics. The potential challenges of soft electronics assisted by machine learning especially in health monitoring field are outlined, and future research directions are outlooked.
- Published
- 2023
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48. Whole-body adipose tissue multi-omic analyses in sheep reveal molecular mechanisms underlying local adaptation to extreme environments
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Ya-Xi Xu, Bo Wang, Jia-Nan Jing, Rui Ma, Yan-Hui Luo, Xin Li, Ze Yan, Ya-Jing Liu, Lei Gao, Yan-Ling Ren, Meng-Hua Li, and Feng-Hua Lv
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Survival in extreme environments and adaptations during seasonal shifts require specialized metabolic programing. A multi-omic analysis of how regulatory networks impact adipose homeostasis in sheep tails provides insight for how these animals survive extreme environments.
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- 2023
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49. Brain Computer Interface Based on Motor Imagery for Mechanical Arm Grasp Control.
- Author
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Tianwei Shi, Ke-Jin Chen, Ling Ren 0002, and Wen-Hua Cui
- Published
- 2023
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50. Traffic Sign Detection Algorithm Based on Improved Yolox.
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Teng Xu, Ling Ren 0007, Tian-Wei Shi, Yuan Gao, Jian-Bang Ding, and Rong-Chen Jin
- Published
- 2023
- Full Text
- View/download PDF
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