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4 results on '"Ling Danping"'

1. Heterodimers made of metal–organic frameworks and upconversion nanoparticles for bioimaging and pH-responsive dual-drug delivery

Author

Ling Danping, Zhuo Wang, Liyi Shi, Solomon Tiruneh Dibaba, Wensong Xi, Artur Bednarkiewicz, Lining Sun, and Li Haihong

Subjects
Drug, Antimetabolites, Antineoplastic, Fluorescence-lifetime imaging microscopy, Cell Survival, Surface Properties, media_common.quotation_subject, Biomedical Engineering, HeLa, Drug Delivery Systems, medicine, Humans, General Materials Science, Doxorubicin, Particle Size, Cytotoxicity, Metal-Organic Frameworks, Cell Proliferation, media_common, Drug Carriers, Antibiotics, Antineoplastic, Nanocomposite, biology, Chemistry, General Chemistry, General Medicine, Hydrogen-Ion Concentration, biology.organism_classification, Drug delivery, Biophysics, Nanoparticles, Metal-organic framework, Fluorouracil, Drug Screening Assays, Antitumor, HeLa Cells, medicine.drug
Abstract

Developing multifunctional nanocomposites for a pH-responsive controlled dual-drug delivery is still a huge challenge. Herein, we report a gentle and simple method for growing metal-organic frameworks (MOFs) that can load two anticancer drugs, namely DOX and 5-FU (doxorubicin and 5-fluorouracil), on the surface of upconversion nanoparticles (UCNPs) by the reactions of Schiff bases and electrostatic adsorption. The resulting pH-responsive UCMOFs@D@5 nanosystem showed effective dual-drug release by the cleavage of chemical bonds and the disruption of the MOF structure under acidic conditions. Moreover, the final nanosystem UCMOFs@D@5 showed much higher cytotoxicity in comparison with UCMOFs@D and UCMOFs@5, which loaded only one kind of drug, respectively, after being incubated with human cervical cancer (HeLa) cells, indicating that Dox and 5-FU released from the final nanosystem had synergistic effects on cytotoxicity. Cellular uptake studies showed that UCMOFs@D@5 was well uptaken by HeLa cells and has potential for bioimaging applications in intracellular fluorescence imaging with high-contrast, and is beneficial for the intracellular localization of anti-cancer drugs. In addition, the nanosystem can be successfully applied in T1-weighted magnetic resonance imaging. Therefore, we developed a visualized tracking agent combined with MOFs to load two anticancer drugs to form a nanosystem for diagnosis and synergistic treatment, thus achieving the bioimaging and stimulation-responsive dual-drug release.

Published
2020

3. Enhanced red emission from BaMoO4: Eu3+ by Bi3+ co‐doping.

Author

Luo, Wenqin, Ling, Danping, Bao, Susu, Xiong, Huifang, Zhang, Rui, Li, Bin, and Wu, Haiyan

Abstract

Abstract: A series of Bi3+,Eu3+‐doped BaMoO4 phosphors was synthesized using a hydrothermal method. The crystal structure, morphology and optical properties of the phosphors were studied using X‐ray diffraction (XRD), scanning electron microscope (SEM) and photoluminescence (PL) measurements. Three different particle morphologies were detected in the SEM observation. The energy dispersive spectroscopy (EDS) results indicated that the solubility of Bi3+ in spherical or rugby‐like BaMoO4 particles was very low and the excess Bi3+ element was cumulated in the irregular particles. Characteristic emissions of Eu3+ ions (5D0 → 7FJ; J = 0, 1, 2, 3, 4) were observed under excitation in ultraviolet (UV) light, with the most intense transition being the 5D0 → 7F2 transition. Energy transfer from MoO42− and Bi3+ to Eu3+ can be readily achieved. Red emission intensity of Eu3+ was enhanced by a factor of two by co‐doping with a small amount of Bi3+. Optical properties as a function of Bi3+ content were studied and the optimum Bi3+ content in BaMoO4 nanocrystals was determined to be 0.4 mol%. [ABSTRACT FROM AUTHOR]

Published
2018
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4. Enhanced red emission from BaMoO 4 : Eu 3+ by Bi 3+ co-doping.

Author

Luo W, Ling D, Bao S, Xiong H, Zhang R, Li B, and Wu H

Subjects
Energy Transfer, Luminescent Agents chemical synthesis, Luminescent Measurements, X-Ray Diffraction, Barium chemistry, Bismuth chemistry, Europium chemistry, Luminescent Agents chemistry
Abstract

A series of Bi 3+ ,Eu 3+ -doped BaMoO 4 phosphors was synthesized using a hydrothermal method. The crystal structure, morphology and optical properties of the phosphors were studied using X-ray diffraction (XRD), scanning electron microscope (SEM) and photoluminescence (PL) measurements. Three different particle morphologies were detected in the SEM observation. The energy dispersive spectroscopy (EDS) results indicated that the solubility of Bi 3+ in spherical or rugby-like BaMoO 4 particles was very low and the excess Bi 3+ element was cumulated in the irregular particles. Characteristic emissions of Eu 3+ ions ( 5 D 0  →  7 F J ; J = 0, 1, 2, 3, 4) were observed under excitation in ultraviolet (UV) light, with the most intense transition being the 5 D 0  →  7 F 2 transition. Energy transfer from MoO 4 2- and Bi 3+ to Eu 3+ can be readily achieved. Red emission intensity of Eu 3+ was enhanced by a factor of two by co-doping with a small amount of Bi 3+ . Optical properties as a function of Bi 3+ content were studied and the optimum Bi 3+ content in BaMoO 4 nanocrystals was determined to be 0.4 mol%., (Copyright © 2017 John Wiley & Sons, Ltd.)

Published
2018
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