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1. Efficacy of Different Methods of General Anaesthesia in Pigs and their Influence on Haematological Parameters

Author

Link R., Choi E. S., Novotný J., Krepelková Z., Bardová K., and Reichel P.

Subjects
anaesthesia, haematological parameters, pigs, Veterinary medicine, SF600-1100
Abstract

This study focused on how haematology parameters differ with different types of anaesthesia that is given to piglets. In this study 18 piglets were used divided into three groups. In each of these experimental groups a different combination of anaesthetics was used. The first group received the combination of azaperone, diazepam, and ketamine. In the second group, we used the combination of azaperone, xylazine, and ketamine. In the third group, the anaesthesia was induced by azaperone, diazepam, butorphanol and ketamine. Blood samples were taken from the piglets three times throughout the procedure and the relevant haematological parameters were determined. With respect to haematological values, the combination used in group 1 appeared as the best for the anaesthesia of pig-lets. The haematological values, such as MCV (mean corpuscular volume), were similar in all groups with the exception of the third group where the MCV and the MCH (mean corpuscular haemoglobin) were significantly lower 24-hour post anaesthesia compared to the other two groups. Lymphocytes in the first two groups showed a steady decrease, while in the third group their levels increased. The opposite trend was observed for the segmented neutrophils that showed a steady increase over the 24-hour period in the 1st and 2nd group while in group 3 their levels decreased. Abolishment of pedal and nasal reflexes to external stimuli applied every 15 min post ketamine administration was observed. The piglets in the 1st group showed no reflexes to external stimuli, while the worst responses were observed in the 2nd group where many of the piglets started to show reflexes very early within the experimental time.

Published
2023
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2. Analysis of Faecal pH in Piglets from Birth to Weaning

Author

Novotný J., Haraszti K., Krepelková Z., Bardová K., Kyzeková P., Link R., and Reichel P.

Subjects
faeces, faecal ph, stool, suckling piglet, Veterinary medicine, SF600-1100
Abstract

The health of the gastrointestinal system of pigs is still a topical issue. When focusing on the youngest categories of pigs, we routinely evaluate it on the basis of appetite assessment and physical examination of faeces. A piglet’s gut health is also related to the development and changes of pH in the digestive system. Because there is little scientific work in this area, the aim of this study was to evaluate the physiological range of faecal pH in healthy suckling piglets from birth to weaning. Faecal pH measurements were performed in thirty-five suckling piglets at the time of the piglets’ birth, on the 7th, 14th, 21st, and 28th day of their life. We found the mean pH values to be 6.38 ± 0.46 within 24 hours after birth; 7.14 ± 0.23 on the 7th day after birth; 7.23 ± 0.23 on the 14th day after birth; 7.42 ± 0.60 on the 21st day after birth; and 7.72 ± 0.61 on the 28th day after birth. Statistical analysis showed significant differences between the pH of the faeces of new-born piglets and the samples taken in the following weeks of the experiment (P < 0.05; P < 0.01; P < 0.001). Measuring faecal pH can be a simple, quick and inexpensive method used to determine the health status of piglets’ intestines.

Published
2022
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3. Metalloproteinases in Inflammatory Bowel Diseases

Author

Marônek M, Marafini I, Gardlík R, Link R, Troncone E, and Monteleone G

Subjects
tissue inhibitor of metalloproteinases, crohn’s disease, ulcerative colitis, intestinal inflammation, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Martin Marônek,1,* Irene Marafini,2,* Roman Gardlík,1 René Link,3 Edoardo Troncone,2 Giovanni Monteleone2 1Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, 81108, Slovakia; 2Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, 00133, Italy; 3Institute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, Košice, 040 11, Slovakia*These authors contributed equally to this workCorrespondence: Giovanni MonteleoneDipartimento di Medicina dei Sistemi, Università di Roma “Tor Vergata”, Via Montpellier 1, Rome, 00133, ItalyTel +39 06 20903702Fax +39 06 72596391Email Gi.Monteleone@Med.uniroma2.itAbstract: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract, encompassing two main disorders: Crohn’s disease (CD) and ulcerative colitis (UC). In both these pathologies, excessive and local immune response against luminal antigens promotes a pathological process leading to various degrees of gut damage. Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. In physiological conditions, MMPs are produced at very low level and generally in the latent form and are involved in the normal tissue turnover. Their function is inhibited by tissue inhibitors of metalloproteinases (TIMPs). However, in inflamed tissue of IBD patients, MMPs are produced in excess and/or the activity of TIMPs is not sufficient to block MMPs, thereby making a major contribution to the IBD-related mucosal degradation. In this review, we summarize the available evidence on the expression and role of MMPs in IBD.Keywords: tissue inhibitor of metalloproteinases, Crohn’s disease, ulcerative colitis, intestinal inflammation

Published
2021

4. Ovarian Activity and the Size of Oocytes in Ovarian Follicles in Sexually Mature Gilts in Individual Seasons

Author

Kyzeková P., Belková L., Macák V., Reichel P., Link R., Novotný J., and Bárdová K.

Subjects
follicles, oocytes, season, sexually mature gilts, Veterinary medicine, SF600-1100
Abstract

The aim of this study was to evaluate ovarian activity and the size of oocytes in ovarian follicles in sexually mature Landrace-Yorkshire gilts in relation to the individual seasons of the year. The study was carried out on 240 gilts slaughtered at an abattoir during the four yearly seasons. The size and weight of the ovaries, the number of follicles and corpora lutea (CL) according to individual size categories were evaluated. The oocytes were aspirated from follicles and their sizes were measured. Our evaluation of the size of the ovaries showed that they were the largest in autumn, when their mean length reached 25.8 ± 3.4 mm, while in winter their mean length was 24.2 ± 2.9 mm. The smallest weight of the ovaries was determined in autumn (mean 5.7 ± 1.4 g) and the highest in spring (mean 6.2 ± 2.2 g). The largest number of follicles in the ovaries of the gilts was recorded during the autumn months, with a predominance of follicles up to 3 mm (mean number 17.9 ± 7.5). The largest number of corpora lutea was observed in spring (mean number 12.1 ± 2.6) and the smallest in winter (mean number 6.1 ± 1.1). The oocytes from follicles of up to 3 mm size, were the smallest in spring (mean size 16.99 × 103 ± 3.42 × 103 µm2) and the largest in winter (mean size 18.90 × 103 ± 2.99 × 103 µm2). In total, the largest oocytes were aspirated from 4—6 mm follicles in autumn (mean size 19.60 × 103 ± 5.37 × 103 ± µm2). The values recorded indicated that the seasons affected the ovarian activity and the growth of oocytes in gilts.

Published
2019
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5. The Influence of Probiotics on Reproductive Parameters of Sows and Health of Their Sucklings

Author

Link R., Reichel P., and Kyzeková P.

Subjects
piglets, probiotics, sows, Veterinary medicine, SF600-1100
Abstract

Thirtytwo sows were included in the trial. They were divided into the experimental group (n = 16) and a control group (n = 16). The experimental group received 1.28 × 106Bacillus subtilis and Bacillus licheniformis per gram of feed (400 ppm BioPlus 2B, Chr. Hansen, Denmark). The trial started 2 weeks before farrowing and lasted until weaning. No significant differences were revealed in the number of piglets born alive, stillborn or the number of weaned pigs between the two groups of sows. The wean-to-first service interval was not significantly different between the groups, but sows in the experimental group had earlier first services. The conception rate did not differ. Sows in the experimental group suffered from postpartum dysgalactia syndrome (PDS) less than sows in the control group. The suckling piglets in the experimental group of sows reached better weight on day 14 of the trial and this state persisted up to the end of the experiment. The differences in the weights of the experimental group and the control group were significant at the end of the trial (P < 0.01). The experimental piglets had significantly lower incidence of diarrhoea than those in the control group (P < 0.05).

Published
2016
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6. Unifying Theories of Psychedelic Drug Effects

Author

Link R. Swanson

Subjects
psychedelic drugs, LSD, psilocybin, ego dissolution, cognitive flexibility, entropic brain theory, Therapeutics. Pharmacology, RM1-950
Abstract

How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data. Next, I review late 19th-century and early 20th-century theories—model psychoses theory, filtration theory, and psychoanalytic theory—and highlight their shared features. I then briefly review recent findings on the neuropharmacology and neurophysiology of psychedelic drugs in humans. Finally, I describe recent theories of psychedelic drug effects which leverage 21st-century cognitive neuroscience frameworks—entropic brain theory, integrated information theory, and predictive processing—and point out key shared features that link back to earlier theories. I identify an abstract principle which cuts across many theories past and present: psychedelic drugs perturb universal brain processes that normally serve to constrain neural systems central to perception, emotion, cognition, and sense of self. I conclude that making an explicit effort to investigate the principles and mechanisms of psychedelic drug effects is a uniquely powerful way to iteratively develop and test unifying theories of brain function.

Published
2018
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7. Rare HCV subtypes and retreatment outcomes in a cohort of European DAA-experienced patients

Author

Antoni, C., Teufel, A., Vogelmann, R., Ebert, M., Balavoine, J., Giostra, E., Berning, M., Hampe, J., Boettler, T., Neumann-Haefelin, C., Thimme, R., De Gottardi, A., Rauch, A., Semmo, N., Ellenrieder, V., Gress, M., Herrmann, A., Stallmach, A., Hoffmann, D., Protzer, U., Kodal, A., Löbermann, M., Götze, T., Keitel-Anselmino, V., Lange, C.M., Zachoval, R., Mayerle, J., Maieron, A., Michl, P., Merle, U., Moradpour, D., Chave, J.-P., Muche, M., Epple, H.-J., Müller-Schilling, M., Kocheise, F., Müller, T., Tacke, F., Roeb, E., Rissland, J., Krawczyk, M., Schulze, P., Semela, D., Spengler, U., Rockstroh, J., Strassburg, C.P., Siebler, J., Schulze zur Wiesch, J., Piecha, F., von Felden, J., Jordan, S., Lohse, A., Sprinzl, M., Galle, P., Stauber, R., Strey, B., Steckstor, W., Schmiegel, W., Brockmeyer, N.H., Canbay, A., Trautwein, C., Uschner, F., Trebicka, J., Weber, T., Wedemeyer, H., Cornberg, M., Manns, M., Wietzke-Braun, P., Günther, R., Willuweit, K., Hilgard, G., Schmidt, H., Zizer, E., Backhus, J., Seufferlein, T., Al-Taie, O., Angeli, W., Beckebaum, S., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Haag, S., Heinzow, H., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reinhardt, L., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Wege, H., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Buggisch, P., Matschenz, K., Petersen, J., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Tal, A.O., Schneider, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, J., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Hartmann, C., Klag, C., Härter, G., Herder, M., Heuchel, T., Heuer, S., Hinrichsen, H., Seegers, B., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Wolfratshausen, Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Gute, P., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mauss, S., Mayer, C., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., K, Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, W., Schmidt-Heinevetter, G., Fabris, J. Schmidtler-von, Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Graf, Christiana, Berg, Christoph P., Port, Kerstin, Deterding, Katja, Buggisch, Peter, Peiffer, Kai-Henrik, Vermehren, Johannes, Dultz, Georg, Geier, Andreas, Reiter, Florian P., Bruns, Tony, Schattenberg, Jörn M., Durmashkina, Elena, Gustot, Thierry, Moreno, Christophe, Trauth, Janina, Discher, Thomas, Fischer, Janett, Berg, Thomas, Kremer, Andreas E., Müllhaupt, Beat, Zeuzem, Stefan, and Sarrazin, Christoph

Published
2024
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10. Long-term persistence of HCV resistance-associated substitutions after DAA treatment failure

Author

Balavoine, J., Giostra, E., Berning, M., Hampe, J., Canbay, A., Steckstor, W., Schmiegel, W., Brockmeyer, N.H., De Gottardi, A., Rauch, A., Semmo, N., Fischer, J., Gress, M., Heinzow, H., Hilgard, G., Schmidt, H., Herrmann, A., Stallmach, A., Hoffmann, D., Protzer, U., Klinker, H., Schulze, P., Kodal, A., Kremer, A., Siebler, J., Löbermann, M., Götze, T., Weigt, J., Lohse, A., Von Felden, J., Jordan, S., Lange, C.M., Zachoval, R., Mayerle, J., Maieron, A., Moradpour, D., Chave, J.-P., Moreno, C., Muche, M., Epple, H.-J., Müller-Schilling, M., Kocheise, F., Müllhaupt, B., Port, K., Deterding, K., Wedemeyer, H., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rissland, J., Semela, D., Spengler, U., Rockstroh, J., Roeb, E., Sprinzl, M., Galle, P., Stauber, R., Stremmel, W., Strey, B., Thimme, R., Boettler, T., Tacke, F., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Koenen, T., Weber, T., Wietzke-Braun, P., Günther, R., Zizer, E., Backhus, J., Seufferlein, T., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Terziroli Beretta-Piccoli, B., Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Härter, G., Herder, M., Heuchel, T., Heuer, S., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Wolfratshausen, Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, K.R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seegers, B., Seidel, T., Seitel, G., Sick, C., Simon, K., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., Von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Müllhaupt, Beat, Buggisch, Peter, Graf, Christiana, Peiffer, Kai-Henrik, Matschenz, Katrin, Schattenberg, Jörn M., Antoni, Christoph, Mauss, Stefan, Niederau, Claus, Discher, Thomas, Trauth, Janina, Dultz, Georg, Schulze zur Wiesch, Julian, Piecha, Felix, Klinker, Hartwig, Müller, Tobias, Berg, Thomas, Neumann-Haefelin, Christoph, Berg, Christoph P., Zeuzem, Stefan, and Sarrazin, Christoph

Published
2023
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11. GCAM v5.1: Representing the linkages between energy, water, land, climate, and economic systems

Author

Calvin, K, Patel, P, Clarke, L, Asrar, G, Bond-Lamberty, B, Yiyun Cui, R, Di Vittorio, A, Dorheim, K, Edmonds, J, Hartin, C, Hejazi, M, Horowitz, R, Iyer, G, Kyle, P, Kim, S, Link, R, Mcjeon, H, Smith, SJ, Snyder, A, Waldhoff, S, and Wise, M

Subjects
Earth Sciences
Abstract

This paper describes GCAM v5.1, an open source model that represents the linkages between energy, water, land, climate, and economic systems. GCAM is a market equilibrium model, is global in scope, and operates from 1990 to 2100 in 5-year time steps. It can be used to examine, for example, how changes in population, income, or technology cost might alter crop production, energy demand, or water withdrawals, or how changes in one region's demand for energy affect energy, water, and land in other regions. This paper describes the model, including its assumptions, inputs, and outputs. We then use 11 scenarios, varying the socioeconomic and climate policy assumptions, to illustrate the results from the model. The resulting scenarios demonstrate a wide range of potential future energy, water, and land uses. We compare the results from GCAM v5.1 to historical data and to future scenario simulations from earlier versions of GCAM and from other models. Finally, we provide information on how to obtain the model.

Published
2019

12. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections

Author

Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Günther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C.M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Müller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Löbermann, M., Götze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J.-P., Moreno, C., Müller, T., Muche, M., Epple, H.-J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N.H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Härter, G., Herder, M., Heuchel, T., Heuer, S., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, K.&R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K.J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K.G., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Spengler, Ulrich, Müllhaupt, Beat, Schulze zur Wiesch, Julian, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, and Sarrazin, Christoph

Published
2021
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13. Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Abreu, P., Aglietta, M., Ahn, E. J., Albuquerque, I. F. M., Allard, D., Allekotte, I., Allen, J., Allison, P., Castillo, J. Alvarez, Alvarez-Muñiz, J., Ambrosio, M., Aminaei, A., Anchordoqui, L., Andringa, S., Antičić, T., Anzalone, A., Aramo, C., Arganda, E., Arqueros, F., Asorey, H., Assis, P., Aublin, J., Ave, M., Avenier, M., Avila, G., Bäcker, T., Balzer, M., Barber, K. B., Barbosa, A. F., Bardenet, R., Barroso, S. L. C., Baughman, B., Bäuml, J., Beatty, J. J., Becker, B. R., Becker, K. H., Bellétoile, A., Bellido, J. A., BenZvi, S., Berat, C., Bertou, X., Biermann, P. L., Billoir, P., Blanco, F., Blanco, M., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Caballero-Mora, K. S., Caramete, L., Caruso, R., Castellina, A., Catalano, O., Cataldi, G., Cazon, L., Cester, R., Chauvin, J., Cheng, S. H., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Clay, R. W., Coluccia, M. R., Conceição, R., Contreras, F., Cook, H., Cooper, M. J., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Dasso, S., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., Junior, W. J. M. de Mello, Neto, J. R. T. de Mello, De Mitri, I., de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Dembinski, H., Dhital, N., Di Giulio, C., Diaz, J. C., Castro, M. L. Díaz, Diep, P. N., Dobrigkeit, C., Docters, W., D'Olivo, J. C., Dong, P. N., Dorofeev, A., Anjos, J. C. dos, Dova, M. T., D'Urso, D., Dutan, I., Ebr, J., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Luis, P. Facal San, Tapia, I. Fajardo, Falcke, H., Farrar, G., Fauth, A. C., Fazzini, N., Ferguson, A. P., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fröhlich, U., Fuchs, B., Gaior, R., Gamarra, R. F., Gambetta, S., García, B., Gámez, D. García, Garcia-Pinto, D., Gascon, A., Gemmeke, H., Gesterling, K., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Gold, M. S., Golup, G., Albarracin, F. Gomez, Berisso, M. Gómez, Gonçalves, P., Gonzalez, D., Gonzalez, J. G., Gookin, B., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Griffith, N., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Guzman, A., Hague, J. D., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Hebbeker, T., Heck, D., Herve, A. E., Hojvat, C., Hollon, N., Holmes, V. C., Homola, P., Hörandel, J. R., Horneffer, A., Hrabovský, M., Huege, T., Insolia, A., Ionita, F., Italiano, A., Jarne, C., Jiraskova, S., Kadija, K., Kampert, K. H., Karhan, P., Kasper, P., Kégl, B., Keilhauer, B., Keivani, A., Kelley, J. L., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapp, J., Koang, D. -H., Kotera, K., Krohm, N., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, J. K., Kunka, N., La Rosa, G., Lachaud, C., Lautridou, P., Leão, M. S. A. B., Lebrun, D., Lebrun, P., de Oliveira, M. A. Leigui, Lemiere, A., Letessier-Selvon, A., Lhenry-Yvon, I., López, K. Link R., Agüera, A. Lopez, Louedec, K., Bahilo, J. Lozano, Lucero, A., Ludwig, M., Lyberis, H., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Marin, J., Marin, V., Maris, I. C., Falcon, H. R. Marquez, Marsella, G., Martello, D., Martin, L., Martinez, H., Bravo, O. Martínez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Mertsch, P., Meurer, C., Mićanović, S., Micheletti, M. I., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Ragaigne, D. Monnier, Montanet, F., Morales, B., Morello, C., Moreno, E., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Müller, G., Münchmeyer, M., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Nelles, A., Nhung, P. T., Niemietz, L., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Selmi-Dei, D. Pakk, Palatka, M., Pallotta, J., Palmieri, N., Parente, G., Parizot, E., Parra, A., Parsons, R. D., Pastor, S., Paul, T., Pech, M., Pȩkala, J., Pelayo, R., Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Phan, N., Piegaia, R., Pierog, T., Pieroni, P., Pimenta, M., Pirronello, V., Platino, M., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Quel, E. J., Querchfeld, S., Rautenberg, J., Ravel, O., Ravignani, D., Revenu, B., Ridky, J., Riggi, S., Risse, M., Ristori, P., Rivera, H., Rizi, V., Roberts, J., Robledo, C., de Carvalho, W. Rodrigues, Rodriguez, G., Martino, J. Rodriguez, Rojo, J. Rodriguez, Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Rühle, C., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C. E., Santos, E., Santos, E. M., Sarazin, F., Sarkar, B., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schröder, F., Schulte, S., Schuster, D., Sciutto, S. J., Scuderi, M., Segreto, A., Settimo, M., Shadkam, A., Shellard, R. C., Sidelnik, I., Sigl, G., Lopez, H. H. Silva, Śmiałkowski, A., Šmída, R., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Stapleton, J., Stasielak, J., Stephan, M., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Šuša, T., Sutherland, M. S., Swain, J., Szadkowski, Z., Szuba, M., Tamashiro, A., Tapia, A., Tartare, M., Taşcău, O., Ruiz, C. G. Tavera, Tcaciuc, R., Tegolo, D., Thao, N. T., Thomas, D., Tiffenberg, J., Timmermans, C., Tiwari, D. K., Tkaczyk, W., Peixoto, C. J. Todero, Tomé, B., Tonachini, A., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Galicia, J. F. Valdés, Valiño, I., Valore, L., Berg, A. M. van den, Varela, E., Cárdenas, B. Vargas, Vázquez, J. R., Vázquez, R. A., Veberič, D., Verzi, V., Vicha, J., Videla, M., Villaseñor, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Weber, M., Weidenhaupt, K., Weindl, A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Will, M., Williams, C., Winchen, T., Winders, L., Winnick, M. G., Wommer, M., Wundheiler, B., Yamamoto, T., Yapici, T., Younk, P., Yuan, G., Yushkov, A., Zamorano, B., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., and Ziolkowski, M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Pierre Auger Collaboration has reported evidence for anisotropy in the distribution of arrival directions of the cosmic rays with energies $E>E_{th}=5.5\times 10^{19}$ eV. These show a correlation with the distribution of nearby extragalactic objects, including an apparent excess around the direction of Centaurus A. If the particles responsible for these excesses at $E>E_{th}$ are heavy nuclei with charge $Z$, the proton component of the sources should lead to excesses in the same regions at energies $E/Z$. We here report the lack of anisotropies in these directions at energies above $E_{th}/Z$ (for illustrative values of $Z=6,\ 13,\ 26$). If the anisotropies above $E_{th}$ are due to nuclei with charge $Z$, and under reasonable assumptions about the acceleration process, these observations imply stringent constraints on the allowed proton fraction at the lower energies.

Published
2011
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15. Exploring Halo Substructure with Giant Stars. VI. Extended Distributions of Giant Stars Around the Carina Dwarf Spheroidal Galaxy -- How Reliable Are They?

Author

Majewski, S. R., Frinchaboy, P. M., Kunkel, W. E., Link, R., Munoz, R. R., Ostheimer, J. C., Palma, C., Patterson, R. J., and Geisler, D.

Subjects
Astrophysics
Abstract

The question of the existence of active tidal disruption around various dSph galaxies remains controversial. That debate often centers on the nature (bound vs. unbound) of extended populations of stars. However, the more fundamental issue of the very existence of the extended populations is still contentious. We present an evaluation of the debate centering on one particular dSph, Carina, for which claims both for and against the existence of stars beyond the King radius have been made. Our review includes an examination of all previous studies bearing on the Carina radial profile and shows that the survey method which achieves the highest detected dSph signal-to-background in the outer parts of the galaxy is the Washington M, T2 + DDO51 (MTD) filter approach from Paper II in this series. We then address statistical methods used to evaluate the reliability of MTD surveys in the presence of photometric errors and for which a new, a posteriori statistical analysis methodology is provided. Finally, these statistical methods are tested by new spectroscopy of stars in the MTD-selected Carina candidate sample. Of 74 candidate giants with follow-up spectroscopy, the MTD technique identified 61 new Carina members, including 8 stars outside the King radius. From a sample of 29 stars not initially identified as candidate Carina giants but that lie just outside of our selection criteria, 12 have radial velocities consistent with membership, including 5 extratidal stars. Carina is shown to have an extended population of giant stars extending to a major axis radius of 40' (1.44x the nominal King radius)., Comment: 56 pages, 10 figures. Submitted to the Astronomical Journal, 2004 Sep 27

Published
2005
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17. Exploring Halo Substructure with Giant Stars IV: The Extended Structure of the Ursa Minor Dwarf Spheroidal

Author

Palma, C., Majewski, S., Siegel, M., Patterson, R., Ostheimer, J., and Link, R.

Subjects
Astrophysics
Abstract

We present a large area photometric survey of the Ursa Minor dSph. We identify UMi giant star candidates extending to ~3 deg from the center of the dSph. Comparison to previous catalogues of stars within the tidal radius of UMi suggests that our photometric luminosity classification is 100% accurate. Over a large fraction of the survey area, blue horizontal branch stars associated with UMi can also be identified. The spatial distribution of both the UMi giant stars and the BHB stars are remarkably similar, and a large fraction of both samples of stars are found outside the tidal radius of UMi. An isodensity contour map of the stars within the tidal radius of UMi reveals two morphological peculiarities: (1) The highest density of dSph stars is offset from the center of symmetry of the outer isodensity contours. (2) The overall shape of the outer contours appear S-shaped. We find that previously determined King profiles with ~50' tidal radii do not fit well the distribution of our UMi stars. A King profile with a larger tidal radius produces a reasonable fit, however a power law with index -3 provides a better fit for radii > 20'. The existence of UMi stars at large distances from the core of the galaxy, the peculiar morphology of the dSph within its tidal radius, and the shape of its surface density profile all suggest that UMi is evolving significantly due to the tidal influence of the Milky Way. However, the photometric data on UMi stars alone does not allow us to determine if the candidate extratidal stars are now unbound or if they remain bound to the dSph within an extended dark matter halo. (Abridged), Comment: accepted by AJ, 32 pages, 15 figures, emulateapj5 style

Published
2002
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18. The Extended Shapes of Galactic Satellites

Author

Majewski, S. R., Forestell, A. D., Ostheimer, J. C., Palma, C., Siegel, M. H., Sohn, S., Westfall, K. B., Patterson, R. J., Frinchaboy, P. M., and Link, R.

Subjects
Astrophysics
Abstract

We are exploring the extended stellar distributions of Galactic satellite galaxies and globular clusters. For seven objects studied thus far, the observed profile departs from a King function at large r, revealing a ``break population'' of stars. In our sample, the relative density of the ``break'' correlates to the inferred M/L of these objects. We discuss opposing hypotheses for this trend: (1) Higher M/L objects harbor more extended dark matter halos that support secondary, bound, stellar ``halos''. (2) The extended populations around dwarf spheroidals (and some clusters) consist of unbound, extratidal debris from their parent objects, which are undergoing various degrees of tidal disruption. In this scenario, higher M/L ratios reflect higher degrees of virial non-equilibrium in the parent objects, thus invalidating a precept underlying the use of core radial velocities to obtain masses., Comment: 8 pages, including 2 figures Yale Cosmology Workshop: The Shapes of Galaxies and Their Halos

Published
2001
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26. Gastric Ulcers in Pigs – A Review

Author

Krepelková Zuzana, Novotný Jaroslav, Bárdová Katarína, Link Róbert, and Csörgö Arpád

Subjects
helicobacter suis, pars esophagea, pig, stomach ulcers, Veterinary medicine, SF600-1100
Abstract

Stomach ulcers are relatively common in pigs raised in modern large-scale farms. They can result in reduced daily weight gain, reduced feed intake, and sudden death, resulting in significant economic losses. They also belong to the most common findings in the stomach of pigs at slaughterhouses and are among the most important causes of peracute mortality, associated with bleeding into the digestive system of pigs. The aim of this article was to provide an overview of the most important etiological factors, and pathogenesis of gastric ulcers in pigs.

Published
2024
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30. Leaf trait modification in European beech trees in response to climatic and edaphic drought.

Author

Weithmann, G., Schuldt, B., Link, R. M., Heil, D., Hoeber, S., John, H., Müller‐Haubold, H., Schüller, L.‐M., Schumann, K., and Leuschner, C.

Subjects
EUROPEAN beech, DROUGHTS, LEAF area, CARBON isotopes, TREES
Abstract

Leaf morphological and physiological traits control the carbon and water relations of mature trees and are determinants of drought tolerance, but it is not well understood how they are modified in response to water deficits.We analysed five sun‐canopy leaf traits (mean leaf size (LS), specific leaf area (SLA), Huber value (HV), water potential at turgor loss point (Ψtlp) and foliar carbon isotope signature (δ13C)) in European beech (Fagus sylvatica L.) across three precipitation gradients sampled in moist (2010), dry (2019) and very dry (2018) summers, and tested their response to short‐term water deficits (climatic water balance (CWB) preceding sample collection) and long‐term water availability (mean annual precipitation (MAP), plant‐available soil water capacity (AWC) and neighbourhood competition).Across the 34 sites, LS varied seven‐fold (3.9−27.0 cm2), SLA four‐fold (77.1−306.9 cm²·g−1) and HV six‐fold (1.0−6.65 cm2·m−2). In the 2018 dataset, LS showed a negative and HV a positive relationship to MAP, which contradicts relations found in multi‐species samples. Average Ψtlp ranged from −1.90 to −2.62 MPa and decreased across the sites with decreasing CWB in the month prior to measurement, as well as with decreasing MAP and AWC in 2019. Studied leaf traits varied considerably between years, suggesting that mast fruiting and the severe 2018 drought caused the formation of smaller leaves.We conclude that sun‐canopy leaf traits of European beech exhibit considerable plasticity in response to climatic and edaphic aridity, and that osmotic adjustment may be an important element in the drought response strategy of this anisohydric tree species. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Health related quality of life of patients in opioid substitution therapy at the beginning of hepatitis C treatment - Data from the German Hepatitis C-Registry

Author

Christensen, S, additional, Specka, M, additional, Buggisch, P, additional, Stoehr, A, additional, Heyne, R, additional, Naumann, U, additional, Klinker, H, additional, Link, R, additional, Serfert, Y, additional, Wedemeyer, H, additional, Scherbaum, N, additional, and Hepatitis C-Register, D, additional

Published
2021
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35. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections

Author

Dietz, Julia, Spengler, Ulrich, Mullhaupt, Beat, zur Wiesch, Julian Schulze, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, Sarrazin, Christoph, Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Guenther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C. M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Mueller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Loebermann, M., Goetze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J. -P., Moreno, C., Mueller, T., Muche, M., Epple, H. -J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N. H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Luneburg, A., Gattringer, H., Genne, D., Gschwantler, M., Gundling, F., Hametner, S., Schofl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschlager, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Baermann, C., Bastlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtlander, A., Bohm, G., Borner, N., Bohr, U., Bokemeyer, B., Bruch, H. R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Huppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H. R., Glas, M., Glaunsinger, T., Goebel, F., Gobel, U., Gorlitz, B., Graf, R., Gruber, H., Harter, G., Herder, M., Heuchel, T., Heuer, S., Hoffl, K. -H., Horster, H., Sonne, J. -U., Hofmann, W. P., Holst, F., Hunstiger, M., Hurst, A., Jagel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Kluppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Korfer, A., Koster, A., Kuhn, M., Langekamp, A., Kunzig, B., Link, R., Littman, M., Lohr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Moller, H., Heyne, R., Moritzen, D., Mross, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rossle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K. J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K. G., Stahler, D., Stenschke, F., Steffens, H., Stein, K., Steinmuller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Spengler, Ulrich, Mullhaupt, Beat, zur Wiesch, Julian Schulze, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, Sarrazin, Christoph, Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Guenther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C. M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Mueller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Loebermann, M., Goetze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J. -P., Moreno, C., Mueller, T., Muche, M., Epple, H. -J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N. H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Luneburg, A., Gattringer, H., Genne, D., Gschwantler, M., Gundling, F., Hametner, S., Schofl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschlager, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Baermann, C., Bastlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtlander, A., Bohm, G., Borner, N., Bohr, U., Bokemeyer, B., Bruch, H. R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Huppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H. R., Glas, M., Glaunsinger, T., Goebel, F., Gobel, U., Gorlitz, B., Graf, R., Gruber, H., Harter, G., Herder, M., Heuchel, T., Heuer, S., Hoffl, K. -H., Horster, H., Sonne, J. -U., Hofmann, W. P., Holst, F., Hunstiger, M., Hurst, A., Jagel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Kluppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Korfer, A., Koster, A., Kuhn, M., Langekamp, A., Kunzig, B., Link, R., Littman, M., Lohr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Moller, H., Heyne, R., Moritzen, D., Mross, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rossle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K. J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K. G., Stahler, D., Stenschke, F., Steffens, H., Stein, K., Steinmuller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., and Zipf, A.

Published
2021

40. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections

Author

Dietz, Julia, primary, Spengler, Ulrich, additional, Müllhaupt, Beat, additional, Schulze zur Wiesch, Julian, additional, Piecha, Felix, additional, Mauss, Stefan, additional, Seegers, Barbara, additional, Hinrichsen, Holger, additional, Antoni, Christoph, additional, Wietzke-Braun, Perdita, additional, Peiffer, Kai-Henrik, additional, Berger, Annemarie, additional, Matschenz, Katrin, additional, Buggisch, Peter, additional, Backhus, Johanna, additional, Zizer, Eugen, additional, Boettler, Tobias, additional, Neumann-Haefelin, Christoph, additional, Semela, David, additional, Stauber, Rudolf, additional, Berg, Thomas, additional, Berg, Christoph, additional, Zeuzem, Stefan, additional, Vermehren, Johannes, additional, Sarrazin, Christoph, additional, Balavoine, J., additional, Giostra, E., additional, Berning, M., additional, Hampe, J., additional, De Gottardi, A., additional, Rauch, A., additional, Semmo, N., additional, Discher, T., additional, Trauth, J., additional, Fischer, J., additional, Gress, M., additional, Günther, R., additional, Heinzow, H., additional, Schmidt, J., additional, Herrmann, A., additional, Stallmach, A., additional, Hilgard, G., additional, Deterding, K., additional, Lange, C.M., additional, Ciesek, S., additional, Wedemeyer, H., additional, Hoffmann, D., additional, Klinker, H., additional, Schulze, P., additional, Kocheise, F., additional, Müller-Schilling, M., additional, Kodal, A., additional, Kremer, A., additional, Ganslmayer, M., additional, Siebler, J., additional, Lammert, F., additional, Rissland, J., additional, Löbermann, M., additional, Götze, T., additional, Canbay, A., additional, Lohse, A., additional, von Felden, J., additional, Jordan, S., additional, Maieron, A., additional, Moradpour, D., additional, Chave, J.-P., additional, Moreno, C., additional, Müller, T., additional, Muche, M., additional, Epple, H.-J., additional, Port, K., additional, von Hahn, T., additional, Cornberg, M., additional, Manns, M., additional, Reinhardt, L., additional, Ellenrieder, V., additional, Rockstroh, J., additional, Schattenberg, J., additional, Sprinzl, M., additional, Galle, P., additional, Roeb, E., additional, Steckstor, M., additional, Schmiegel, W., additional, Brockmeyer, N.H., additional, Seufferlein, T., additional, Stremmel, W., additional, Strey, B., additional, Thimme, R., additional, Teufel, A., additional, Vogelmann, R., additional, Ebert, M., additional, Tomasiewicz, K., additional, Trautwein, C., additional, Tacke, F., additional, Koenen, T., additional, Weber, T., additional, Zachoval, R., additional, Mayerle, J., additional, Raziorrouh, B., additional, Angeli, W., additional, Beckebaum, S., additional, Doberauer, C., additional, Durmashkina, E., additional, Hackelsberger, A., additional, Erhardt, A., additional, Garrido-Lüneburg, A., additional, Gattringer, H., additional, Genné, D., additional, Gschwantler, M., additional, Gundling, F., additional, Hametner, S., additional, Schöfl, R., additional, Hartmann, C., additional, Heyer, T., additional, Hirschi, C., additional, Jussios, A., additional, Kanzler, S., additional, Kordecki, N., additional, Kraus, M., additional, Kullig, U., additional, Wollschläger, S., additional, Magenta, L., additional, Beretta-Piccoli, B. Terziroli, additional, Menges, M., additional, Mohr, L., additional, Muehlenberg, K., additional, Niederau, C., additional, Paulweber, B., additional, Petrides, A., additional, Pinkernell, M., additional, Piso, R., additional, Rambach, W., additional, Reiser, M., additional, Riecken, B., additional, Rieke, A., additional, Roth, J., additional, Schelling, M., additional, Schlee, P., additional, Schneider, A., additional, Scholz, D., additional, Schott, E., additional, Schuchmann, M., additional, Schulten-Baumer, U., additional, Seelhoff, A., additional, Stich, A., additional, Stickel, F., additional, Ungemach, J., additional, Walter, E., additional, Weber, A., additional, Winzer, T., additional, Abels, W., additional, Adler, M., additional, Audebert, F., additional, Baermann, C., additional, Bästlein, E., additional, Barth, R., additional, Barthel, K., additional, Becker, W., additional, Behrends, J., additional, Benninger, J., additional, Berger, F., additional, Berzow, D., additional, Beyer, T., additional, Bierbaum, M., additional, Blaukat, O., additional, Bodtländer, A., additional, Böhm, G., additional, Börner, N., additional, Bohr, U., additional, Bokemeyer, B., additional, Bruch, H.R., additional, Bucholz, D., additional, Burkhard, O., additional, Busch, N., additional, Chirca, C., additional, Delker, R., additional, Diedrich, J., additional, Frank, M., additional, Diehl, M., additional, Dienethal, A., additional, Dietel, P., additional, Dikopoulos, N., additional, Dreck, M., additional, Dreher, F., additional, Drude, L., additional, Ende, K., additional, Ehrle, U., additional, Baumgartl, K., additional, Emke, F., additional, Glosemeyer, R., additional, Felten, G., additional, Hüppe, D., additional, Fischer, U., additional, Frederking, D., additional, Frick, B., additional, Friese, G., additional, Gantke, B., additional, Geyer, P., additional, Schwind, H.R., additional, Glas, M., additional, Glaunsinger, T., additional, Goebel, F., additional, Göbel, U., additional, Görlitz, B., additional, Graf, R., additional, Gruber, H., additional, Härter, G., additional, Herder, M., additional, Heuchel, T., additional, Heuer, S., additional, Höffl, K.-H., additional, Hörster, H., additional, Sonne, J.-U., additional, Hofmann, W.P., additional, Holst, F., additional, Hunstiger, M., additional, Hurst, A., additional, Jägel-Guedes, E., additional, John, C., additional, Jung, M., additional, Kallinowski, B., additional, Kapzan, B., additional, Kerzel, W., additional, Khaykin, P., additional, Klarhof, M., additional, Klüppelberg, U., additional, Klugewitz, K., additional, Knapp, B., additional, Knevels, U., additional, Kochsiek, T., additional, Körfer, A., additional, Köster, A., additional, Kuhn, M., additional, Langekamp, A., additional, Künzig, B., additional, Link, R., additional, Littman, M., additional, Löhr, H., additional, Lutz, T., additional, Knecht, G., additional, Lutz, U., additional, Mainz, D., additional, Mahle, I., additional, Maurer, P., additional, Mayer, C., additional, Meister, V., additional, Möller, H., additional, Heyne, R., additional, Moritzen, D., additional, Mroß, M., additional, Mundlos, M., additional, Naumann, U., additional, Nehls, O., additional, Ningel, K.&R., additional, Oelmann, A., additional, Olejnik, H., additional, Gadow, K., additional, Pascher, E., additional, Petersen, J., additional, Philipp, A., additional, Pichler, M., additional, Polzien, F., additional, Raddant, R., additional, Riedel, M., additional, Rietzler, S., additional, Rössle, M., additional, Rufle, W., additional, Rump, A., additional, Schewe, C., additional, Hoffmann, C., additional, Schleehauf, D., additional, Schmidt, K.J., additional, Schmidt, W., additional, Schmidt-Heinevetter, G., additional, Schmidtler-von Fabris, J., additional, Schnaitmann, E., additional, Schneider, L., additional, Schober, A., additional, Niehaus-Hahn, S., additional, Schwenzer, J., additional, Seidel, T., additional, Seitel, G., additional, Sick, C., additional, Simon, K.G., additional, Stähler, D., additional, Stenschke, F., additional, Steffens, H., additional, Stein, K., additional, Steinmüller, M., additional, Sternfeld, T., additional, Svensson, K., additional, Tacke, W., additional, Teuber, G., additional, Teubner, K., additional, Thieringer, J., additional, Tomesch, A., additional, Trappe, U., additional, Ullrich, J., additional, Urban, G., additional, Usadel, S., additional, von Lucadou, A., additional, Weinberger, F., additional, Werheid-Dobers, M., additional, Werner, P., additional, Winter, T., additional, Zehnter, E., additional, and Zipf, A., additional

Published
2021
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