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The prevalence of extensively drug-resistant Acinetobacter baumanniineuroinfection has markedly increased, and this infection is now a first-line medical emergency worldwide with a mortality rate of up to 50%. Its expanding resistance to most intravenous antibiotic treatments, as well as the severity of the initiated condition, obligates practitioners to concentrate on today's most effective therapy—the combination of intravenous and intraventricular/intrathecal colistin. The specific characteristics of the intraventricular/intrathecal route are promising for patients with supportive mechanical devices, such as extracorporeal membrane oxygenation or hemodiafiltration, which have significant impacts on drug pharmacokinetics in the blood. This influence is minimized when antibiotics are administered directly into cerebrospinal fluid. The case report represents a history of a 39-year-old man with nosocomial carbapenem-resistant A. baumanniiventriculitis and acute respiratory distress syndrome. His treatment with intravenous and intraventricular colistin, as well as extracorporeal membrane oxygenation therapy, managed to succeed in helping the patient's recovery.