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Der Artikel setzt sich mit der Idee der ��Vernetzung�� auseinander, die gerade auch dort eine wichtige Rolle spielt, wo es um neue Verh��ltnisse zwischen Menschen und Naturph��nomenen und eine Einbettung von Menschen in komplexe Lebenszusammenh��nge geht. Er��rtert werden die Ans��tze zweier Denkerinnen der posthumanistischen, feministischen Theorie, Rosi Braidotti und Donna Haraway, in Bezug darauf, wie sie Vernetzung und Subjektivit��t denken. Hierbei geht es auch darum, die Problematiken dieser ��berlegungen und posthumanistischer Ans��tze aufzuzeigen. Dies gelingt durch die Betrachtung des Romans Om m��rke (2013) der d��nischen Autorin Josefine Klougart. Dessen Gedanken lassen sich einerseits mit den posthumanistischen Ans��tzen verkn��pfen, zeigen aber auch Aspekte auf, die als Korrektiv dazu gelesen werden k��nnen. Es wird deutlich, dass gerade theoretische und literarische Texte in einen fruchtbaren Dialog treten k��nnen, wenn es um eine Revision des Humanen geht., The following essay examines the idea of ��interconnectedness��, which plays an important role particularly where new relationships between people and natural phenomena and an embedding of humans in complex life-nexuses are at stake. The approaches of two thinkers from posthumanist feminist theory, Rosi Braidotti and Donna Haraway, are discussed in relation to their thinking about interconnectedness and subjectivity. Some problematic issues arising from these thoughts and posthumanistic approaches are also pointed out. This is accomplished by considering the novel Om m��rke (2013) by the Danish author Josefine Klougart. On the one hand, its ideas can be linked with posthumanistic approaches, but they also highlight aspects that can be read as a corrective to them. It is shown that theoretical and literary texts can enter into a fruitful dialogue when the matter at issue is a revision of the human.

Complement resistance is an important virulence trait of Yersinia enterocolitica (Ye). The predominant virulence factor expressed by Ye is Yersinia adhesin A (YadA), which enables bacterial attachment to host cells and extracellular matrix and additionally allows the acquisition of soluble serum factors. The serum glycoprotein vitronectin (Vn) acts as an inhibitory regulator of the terminal complement complex by inhibiting the lytic pore formation. Here, we show YadA-mediated direct interaction of Ye with Vn and investigated the role of this Vn binding during mouse infection in vivo. Using different Yersinia strains, we identified a short stretch in the YadA head domain of Ye O:9 E40, similar to the ‘uptake region' of Y. pseudotuberculosis YPIII YadA, as crucial for efficient Vn binding. Using recombinant fragments of Vn, we found the C-terminal part of Vn, including heparin-binding domain 3, to be responsible for binding to YadA. Moreover, we found that Vn bound to the bacterial surface is still functionally active and thus inhibits C5b-9 formation. In a mouse infection model, we demonstrate that Vn reduces complement-mediated killing of Ye O:9 E40 and, thus, improved bacterial survival. Taken together, these findings show that YadA-mediated Vn binding influences Ye pathogenesis. © 2017 Karger Publishers