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1. Deceleration capacity of heart rate predicts 1-year mortality of patients undergoing transcatheter aortic valve implantation

Author

Christine S. Zuern, Lars Mizera, Nin Götz, Meinrad Gawaz, Martin Duckheim, Katharina Klee, Patrick Groga-Bada, Christian Eick, Charlotte Bensch, and Linn Kittlitz

Subjects
medicine.medical_specialty, Transcatheter aortic, Proportional hazards model, business.industry, Hazard ratio, EuroSCORE, General Medicine, 030204 cardiovascular system & hematology, medicine.disease, Confidence interval, 03 medical and health sciences, Stenosis, 0302 clinical medicine, Internal medicine, Heart rate, Clinical endpoint, medicine, Cardiology, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Background Risk prediction in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is challenging. Development of novel markers for patient risk assessment is of great clinical value. Deceleration capacity (DC) of heart rate is a strong risk predictor in post-infarction patients. Hypothesis DC provides prognostic information in patients undergoing TAVI. Methods We enrolled 374 consecutive patients with severe AS undergoing TAVI. All patients received 24-hour Holter recording or continuous heart-rate monitoring to assess DC before intervention. Primary endpoint was all-cause mortality after 1 year. Results Forty-nine patients (13.1%) died within 1 year. DC was significantly lower in nonsurvivors than in survivors (1.2 ± 4.8 ms vs 3.3 ± 2.9 ms; P < 0.001), whereas the logistic EuroSCORE and EuroSCORE II were comparable between groups (logistic EuroSCORE: 27.3% ± 17.0% vs 22.9% ± 14.2%; P = 0.122; EuroSCORE II: 8.0% ± 6.9% vs 6.7% ± 4.8%, P = 0.673). One-year mortality in the 116 patients with impaired DC (

Published
2017
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2. Deceleration capacity of heart rate predicts 1-year mortality of patients undergoing transcatheter aortic valve implantation

Author

Martin, Duckheim, Charlotte, Bensch, Linn, Kittlitz, Nin, Götz, Katharina, Klee, Patrick, Groga-Bada, Lars, Mizera, Meinrad, Gawaz, Christine, Zuern, and Christian, Eick

Subjects
Aged, 80 and over, Male, Chi-Square Distribution, Time Factors, Deceleration, Clinical Investigations, Aortic Valve Stenosis, Kaplan-Meier Estimate, Risk Assessment, Severity of Illness Index, Transcatheter Aortic Valve Replacement, Logistic Models, Treatment Outcome, Heart Rate, Risk Factors, Aortic Valve, Multivariate Analysis, Electrocardiography, Ambulatory, Humans, Female, Aged, Proportional Hazards Models
Abstract

BACKGROUND: Risk prediction in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is challenging. Development of novel markers for patient risk assessment is of great clinical value. Deceleration capacity (DC) of heart rate is a strong risk predictor in post‐infarction patients. HYPOTHESIS: DC provides prognostic information in patients undergoing TAVI. METHODS: We enrolled 374 consecutive patients with severe AS undergoing TAVI. All patients received 24‐hour Holter recording or continuous heart‐rate monitoring to assess DC before intervention. Primary endpoint was all‐cause mortality after 1 year. RESULTS: Forty‐nine patients (13.1%) died within 1 year. DC was significantly lower in nonsurvivors than in survivors (1.2 ± 4.8 ms vs 3.3 ± 2.9 ms; P < 0.001), whereas the logistic EuroSCORE and EuroSCORE II were comparable between groups (logistic EuroSCORE: 27.3% ± 17.0% vs 22.9% ± 14.2%; P = 0.122; EuroSCORE II: 8.0% ± 6.9% vs 6.7% ± 4.8%, P = 0.673). One‐year mortality in the 116 patients with impaired DC (

Published
2017

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