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4. CH4/CO2 Ratios and Carbon Isotope Enrichment Between Diet and Breath in Herbivorous Mammals

Author

Thure E. Cerling, Stefano M. Bernasconi, Lino S. Hofstetter, Madalina Jaggi, Fabia Wyss, Claudia Rudolf von Rohr, and Marcus Clauss

Subjects
stable isotopes, diet, methane, carbon dioxide, physiology, Evolution, QH359-425, Ecology, QH540-549.5
Abstract

Breath and diet samples were collected from 29 taxa of animals at the Zurich and Basel Zoos to characterize the carbon isotope enrichment between breath and diet. Diet samples were measured for δ13C and breath samples for CH4/CO2 ratios and for the respired component of δ13C using the Keeling plot approach. Different digestive physiologies included coprophagous and non-coprophagous hindgut fermenters, and non-ruminant and ruminant foregut fermenters. Isotope enrichments from diet to breath were 0.8 ± 0.9‰, 3.5 ± 0.8‰, 2.3 ± 0.4‰, and 4.1 ± 1.0‰, respectively. CH4/CO2 ratios were strongly correlated with isotope enrichments for both hindgut and foregut digestive strategies, although CH4 production was not the sole reason for isotope enrichment. Average CH4/CO2 ratios per taxon ranged over several orders of magnitude from 10–5 to 10–1. The isotope enrichment values for diet-breath can be used to further estimate the isotope enrichment from diet-enamel because Passey et al. (2005b) found a nearly constant isotope enrichment for breath-enamel for diverse mammalian taxa. The understanding of isotope enrichment factors from diet to breath and diet to enamel will have important applications in the field of animal physiology, and possibly also for wildlife ecology and paleontology.

Published
2021
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9. A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Lang, Nora, Pereira, Maria J., Lee, Yuhan, Friehs, Ingeborg, Vasilyev, Nikoay V., Feins, Eric N., Ablasser, Klemens, O'Cearbhail, Eoin D., Xu, Chenjie, Fabozzo, Assunta, Padera, Robert, Wasserman, Steven, Freudenthal, Franz, Ferreira, Lino S., Langer, Robert S, Karp, Jeffrey M., del Nido, Pedro J., Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Lang, Nora, Pereira, Maria J., Lee, Yuhan, Friehs, Ingeborg, Vasilyev, Nikoay V., Feins, Eric N., Ablasser, Klemens, O'Cearbhail, Eoin D., Xu, Chenjie, Fabozzo, Assunta, Padera, Robert, Wasserman, Steven, Freudenthal, Franz, Ferreira, Lino S., Langer, Robert S, Karp, Jeffrey M., and del Nido, Pedro J.

Abstract

Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.

Published
2022

12. HIV testing history and access to treatment among migrants living with HIV in Europe

Author

Fakoya, Ibidun, Arco, Débora Álvarez?Del, Monge, Susana, Copas, Andrew J., Gennotte, Anne?Francoise, Volny?Anne, Alain, Wengenroth, Claudia, Touloumi, Giota, Prins, Maria, Barros, Henrique, Darling, Katharine Ea, Prestileo, Tullio, Del Amo, Julia, Burns, Fiona M., Aerssens, A, Aguado, M, Alimi, B, Anagnostou, O, Anderson, J, Antoniadou, A, Arando, M, Barberà, Mj, Barthélemy, A, Belda?Ibáñez, J, Bertisch, B, Bil, J, Blanco, Jr, Block, K, Boesecke, C, Boura, M, Burgos, J, Cabo, J, Calabuig, E, Campbell, L, Cardoso, O, Claudia, W, Clumeck, N, Colucci, A, Corrao, S, Cuellar, S, Cunha, J, Daikos, G, Darling, K, Romero, J, Dellot, P, Domingo, P, Dronda, F, Ebeling, F, Engelhardt, A, Engler, B, Farrell, J, Fehr, J, Feijó, M, Fernández, E, García, E Fernández, Fernandez, T, Fortes, Al, Fox, J, De Olalla, P Garcia, García, F, Gargalianos?Kakolyris, P, Germano, I, Gilleran, G, Gilson, R, Goepel, S, Gogos, Ha, Sirvent, Jl Gómez, Gountas, I, Gregg, A, Gutiérrez, F, Gutierrez, Mm, Hermans, I, Iribarren, Ja, Knobel, H, Koulai, L, Kourkounti, S, La Morté, C, Lecompte, T, Ledergerber, B, Leonidou, L, Ligero, Mc, Lindergard, G, Lino, S, Lopes, Mj, Lirola, A Lopez, Louhenapessy, M, Lourida, G, Luzi, Am, Maltez, F, Manirankunda, L, Martín?Pérez, A, Martins, L, Masía, M, Mateu, Mg, Meireles, P, Mendes, A, Metallidis, S, Mguni, S, Milinkovic, A, Miró, Jm, Mohrmann, K, Montero, M, Mouhebati, T, Moutschen, M, Müller, M, Murphy, C, Nöstlinger, C, Ocaña, I, Okumu?Fransche, S, Onwuchekwa, G, Ospina, Je, Otiko, D, Pacheco, P, Palacios, R, Paparizos, V, Papastamopoulos, V, Paredes, V, Patel, N, Pellicer, T, Peña, A, Petrosillo, N, Pinheiro, A, Poças, J, Portillo, A, Post, F, Prestileo, F, Prins, P, Protopapas, K, Psichogiou, M, Pulido, F, Rebollo, J, Ribeirinho, A, Río, I, Robau, M, Rockstroh, Jk, Rodrigues, E, Rodríguez, M, Sajani, C, Salavert, M, Salman, R, Sanz, N, Schuettfort, G, Schüttfort, G, Zander, C Schwarze?, Serrão, R, Silva, D, Silva, V, Silverio, P, Skoutelis, A, Staehelin, C, Stephan, C, Stretton, C, Styles, F, Sutre, Af, Taylor, S, Teixeira, B, Thierfelder, C, Tsachouridou, O, Tudor, K, Valadas, E, Frankenhuijsen, M, Vázquez, M, Arribas, M Velasco, Vera, M, Vinciana, P, Voudouri, N, Wasmuth, Jc, Wilkins, E, Young, L, Yurdakul, S, Espinosa, T Zafra, Zuilhof, W, and Zuure, F

Subjects
Diagnosis, Care and treatment, Surveys, HIV infections -- Surveys -- Diagnosis -- Care and treatment, HIV tests -- Surveys, Immigrants -- Surveys -- Care and treatment, Health care services accessibility -- Surveys, HIV testing -- Surveys, HIV infection -- Surveys -- Diagnosis -- Care and treatment
Abstract

Introduction The HIV epidemic in Europe is characterized by a disproportionate number of infections among migrants. Although foreign citizens only made up 7% of the population of the European Union [...], : Introduction: Migrants are overrepresented in the European HIV epidemic. We aimed to understand the barriers and facilitators to HIV testing and current treatment and healthcare needs of migrants living with HIV in Europe. Methods: A cross?sectional study was conducted in 57 HIV clinics in nine countries (Belgium, Germany, Greece, Italy, The Netherlands, Portugal, Spain, Switzerland and United Kingdom), July 2013 to July 2015. HIV?positive patients were eligible for inclusion if they were as follows: 18 years or older; foreign?born residents and diagnosed within five years of recruitment. Questionnaires were completed electronically in one of 15 languages and linked to clinical records. Primary outcomes were access to primary care and previous negative HIV test. Data were analysed using random effects logistic regression. Outcomes of interest are presented for women, heterosexual men and gay/bisexual men. Results: A total of 2093 respondents (658 women, 446 heterosexual men and 989 gay/bisexual men) were included. The prevalence of a previous negative HIV test was 46.7%, 43.4% and 82.0% for women, heterosexual and gay/bisexual men respectively. In multivariable analysis previous testing was positively associated with: receipt of post?migration antenatal care among women, permanent residency among heterosexual men and identifying as gay rather than bisexual among gay/bisexual men. Access to primary care was found to be high (>83%) in all groups and was strongly associated with country of residence. Late diagnosis was common for women and heterosexual men (60.8% and 67.1%, respectively) despite utilization of health services prior to diagnosis. Across all groups almost three?quarters of people on antiretrovirals had an HIV viral load Conclusions: Migrants access healthcare in Europe and while many migrants had previously tested for HIV, that they went on to test positive at a later date suggests that opportunities for HIV prevention are being missed. Expansion of testing beyond sexual health and antenatal settings is still required and testing opportunities should be linked with combination prevention measures such as access to PrEP and treatment as prevention.

Published
2018
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17. CH4/CO2 Ratios and Carbon Isotope Enrichment Between Diet and Breath in Herbivorous Mammals

Author

Marcus Clauss, Stefano M. Bernasconi, Claudia Rudolf von Rohr, Madalina Jaggi, Thure E. Cerling, Fabia Wyss, Lino S. Hofstetter, University of Zurich, and Cerling, Thure E

Subjects
0106 biological sciences, 0301 basic medicine, 10253 Department of Small Animals, Evolution, Physiology, Stable isotopes, Diet, Methane, Carbon dioxide, 010603 evolutionary biology, 01 natural sciences, Foregut fermentation, 03 medical and health sciences, chemistry.chemical_compound, Animal science, Ruminant, QH359-425, QH540-549.5, Ecology, Evolution, Behavior and Systematics, 630 Agriculture, Ecology, biology, Isotope, δ13C, Chemistry, Stable isotope ratio, biology.organism_classification, 1105 Ecology, Evolution, Behavior and Systematics, 030104 developmental biology, Isotopes of carbon, FOS: Biological sciences, 570 Life sciences, Hindgut fermentation, 2303 Ecology
Abstract

Breath and diet samples were collected from 29 taxa of animals at the Zurich and Basel Zoos to characterize the carbon isotope enrichment between breath and diet. Diet samples were measured for δ13C and breath samples for CH4/CO2 ratios and for the respired component of δ13C using the Keeling plot approach. Different digestive physiologies included coprophagous and non-coprophagous hindgut fermenters, and non-ruminant and ruminant foregut fermenters. Isotope enrichments from diet to breath were 0.8 ± 0.9‰, 3.5 ± 0.8‰, 2.3 ± 0.4‰, and 4.1 ± 1.0‰, respectively. CH4/CO2 ratios were strongly correlated with isotope enrichments for both hindgut and foregut digestive strategies, although CH4 production was not the sole reason for isotope enrichment. Average CH4/CO2 ratios per taxon ranged over several orders of magnitude from 10–5 to 10–1. The isotope enrichment values for diet-breath can be used to further estimate the isotope enrichment from diet-enamel because Passey et al. (2005b) found a nearly constant isotope enrichment for breath-enamel for diverse mammalian taxa. The understanding of isotope enrichment factors from diet to breath and diet to enamel will have important applications in the field of animal physiology, and possibly also for wildlife ecology and paleontology., Frontiers in Ecology and Evolution, 9, ISSN:2296-701X

Published
2021
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18. CH4/CO2 ratios and carbon isotope enrichment between diet and breath in herbivorous mammals

Author

Cerling, Thure E, Bernasconi, Stefano M; https://orcid.org/0000-0001-7672-8856, Hofstetter, Lino S, Jaggi, Madalina, Wyss, Fabia, Rudolf von Rohr, Claudia, Clauss, Marcus; https://orcid.org/0000-0003-3841-6207, Cerling, Thure E, Bernasconi, Stefano M; https://orcid.org/0000-0001-7672-8856, Hofstetter, Lino S, Jaggi, Madalina, Wyss, Fabia, Rudolf von Rohr, Claudia, and Clauss, Marcus; https://orcid.org/0000-0003-3841-6207

Published
2021

19. Combined Surface Micropatterning and Reactive Chemistry Maximizes Tissue Adhesion with Minimal Inflammation

Author

Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Pereira, Maria JN, Sundback, Cathryn A, Lang, Nora, Cho, Woo Kyung, Pomerantseva, Irina, Ouyang, Ben, Tao, Sarah L, McHugh, Kevin, Mwizerwa, Olive, Vemula, Praveen K, Mochel, Mark C, Carter, David J, Borenstein, Jeffrey T, Langer, Robert, Ferreira, Lino S, Karp, Jeffrey M, Masiakos, Peter T, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Pereira, Maria JN, Sundback, Cathryn A, Lang, Nora, Cho, Woo Kyung, Pomerantseva, Irina, Ouyang, Ben, Tao, Sarah L, McHugh, Kevin, Mwizerwa, Olive, Vemula, Praveen K, Mochel, Mark C, Carter, David J, Borenstein, Jeffrey T, Langer, Robert, Ferreira, Lino S, Karp, Jeffrey M, and Masiakos, Peter T

Abstract

The use of tissue adhesives for internal clinical applications is limited due to a lack of materials that balance strong adhesion with biocompatibility. The use of substrate topography is explored to reduce the volume of a highly reactive and toxic glue without compromising adhesive strength. Micro-textured patches coated with a thin layer of cyanoacrylate glue achieve similar adhesion levels to patches employing large amounts of adhesive, and is superior to the level of adhesion achieved when a thin coating is applied to a non-textured patch. In vivo studies demonstrate reduced tissue inflammation and necrosis for patterned patches with a thinly coated layer of reactive glue, thus overcoming a significant challenge with existing tissue adhesives such as cyanoacrylate. Closure of surgical stomach and colon defects in a rat model is achieved without abdominal adhesions. Harnessing the synergy between surface topography and reactive chemistry enables controlled tissue adhesion with an improved biocompatibility profile without requiring changes in the chemical composition of reactive tissue glues. The use of substrate topography is explored to reduce the amount of a highly reactive and toxic tissue glue without compromising adhesive strength. Micro-textured patches coated with a thin layer of cyanoacrylate glue achieve similar adhesion levels as flat patches employing a thick layer of glue. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Published
2021

20. A Highly Tunable Biocompatible and Multifunctional Biodegradable Elastomer

Author

Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Pereira, Maria José Nunes, Ouyang, Ben, Sundback, Cathryn A, Lang, Nora, Friehs, Ingeborg, Mureli, Shwetha, Pomerantseva, Irina, McFadden, Jacob, Mochel, Mark C, Mwizerwa, Olive, del Nido, Pedro, Sarkar, Debanjan, Masiakos, Peter T, Langer, Robert, Ferreira, Lino S, Karp, Jeffrey M, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Pereira, Maria José Nunes, Ouyang, Ben, Sundback, Cathryn A, Lang, Nora, Friehs, Ingeborg, Mureli, Shwetha, Pomerantseva, Irina, McFadden, Jacob, Mochel, Mark C, Mwizerwa, Olive, del Nido, Pedro, Sarkar, Debanjan, Masiakos, Peter T, Langer, Robert, Ferreira, Lino S, and Karp, Jeffrey M

Abstract

Biodegradable elastomers synthesized under mild conditions with highly tunable mechanical properties are described. These elastomeric biomaterials are biocompatible, exhibit minimal deformation following cyclical tensile loading, and permit tight control over the release kinetics of encapsulated bioactive molecules. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Published
2021

27. P1133Impact of mid-septal versus apical pacing on the right ventricle performance of patients with right bundle branch block undergoing pacemaker implantation

Author

Minati, M, primary, Bencivenga, S, additional, De Ruvo, E, additional, Bressi, E, additional, Cicogna, F, additional, Martino, A M, additional, De Luca, L, additional, Fagagnini, A, additional, Bruni, G, additional, Grieco, D, additional, Borrelli, A, additional, Scara, A, additional, Milo, M, additional, Lino, S, additional, and Calo", L, additional

Published
2020
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28. Isolation, differentiation and characterization of vascular cells derived from human embryonic stem cells

Author

Massachusetts Institute of Technology. Department of Chemical Engineering, Levenberg, Shulamit, Ferreira, Lino S., Chen-Konak, Limor, Kraehenbuehl, Thomas P, Langer, Robert S, Massachusetts Institute of Technology. Department of Chemical Engineering, Levenberg, Shulamit, Ferreira, Lino S., Chen-Konak, Limor, Kraehenbuehl, Thomas P, and Langer, Robert S

Abstract

Herein, we describe a protocol for the isolation of human embryonic stem cells (hESCs)-derived vascular cells at various stages of development. The cells are isolated from 10 to 15-d-old human embryoid bodies (EBs) cultured in suspension. After dissociation, cells are labeled with anti-CD34 or anti-CD31 (PECAM1) antibody and separated from the cell mixture by magnetic-activated cell separation (MACS) or fluorescent-activated cell sorting (FACS). Isolated vascular cells are then cultured in media conditions that support specific differentiation and expansion pathways. The resulting vascular cell populations contain >80% endothelial-like or smooth muscle-like cells. Assuming typical initial cell adhesion and proliferation rates, the entire procedure can be completed within 1.5 months. Vascular cells isolated and differentiated under the described conditions may constitute a potential cell source for therapeutic application toward repair of ischemic tissues, preparation of tissue-engineered vascular grafts and design of cellular kits for drug screening applications. ©2010, NIH grant (HL060435), NIH grant (DE013023 ), FCT (PTDC/SAU-BEB/098468/2008), Swiss National Science Foundation (grant no. PBELP3-127902)

Published
2020

29. The Federal Rules of Civil Procedure: electronic discovery amendments.

Author

de Orlov, Lino S. Lipinsky and Roberts, Jennette C.

Subjects
Discovery (Law) -- Laws, regulations and rules, Electronic evidence -- Laws, regulations and rules, Government regulation, Federal Rules of Civil Procedure (Fed. R. Civ. P. 16), Federal Rules of Civil Procedure (Fed. R. Civ. P. 26), Federal Rules of Civil Procedure (Fed. R. Civ. P. 33-37)
Published
2006

30. Hemorragia retroperitoneal espontânea em doentes hipocoagulados com infeção por SARS-CoV-2.

Author

Costa, C. Carreira, Gonçalves, R. J., Cabo, J., Betkova, S., Pinto, M., Mendes, B., Torres, M., Leal, E., Dias, A., Duarte, I., Lino, S., Manata, M. J., and Maltez, F.

Abstract

Copyright of RPDI - Revista Portuguesa de Doenças Infecciosas is the property of Sociedade Portuguesa de Doencas Infecciosas e Microbiologia Clinica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

31. Infeção VIH na população migrante em Lisboa: demografia, determinantes de infeção, padrões de resistência e seguimento.

Author

Leal-dos-Santos, M., Cruz, C., Ferreira Dias, A., Pinheiro, H., Caeiro, A., Torres, M., Leal, E., Pinto, A. R., Simões, P., Betkova, S., Garrote, A. R., Ramirez, F., Póvoas, D., Seixas, D., Sousa Ribeiro, J., Lino, S., Cardoso, O., Martins, T., Manata, M. J., and Maltez, F.

Abstract

Copyright of RPDI - Revista Portuguesa de Doenças Infecciosas is the property of Sociedade Portuguesa de Doencas Infecciosas e Microbiologia Clinica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

32. Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years and older: The AGING POSITIVE study

Author

Serrão, R, Piñero, C, Velez, J, Coutinho, D, Maltez, F, Lino, S, Sarmento, E, Castro, R, Tavares, AP, Pacheco, P, Lopes, MJ, Mansinho, K, Miranda, AC, Neves, I, Abreu, R, Almeida, J, and Pássaro, L

Subjects
0301 basic medicine, Male, Aging, Cross-sectional study, HCC INF, HIV Infections, Comorbidity, 0302 clinical medicine, Prevalence, Medicine, 030212 general & internal medicine, Depression (differential diagnoses), Hypolipidemic Agents, education.field_of_study, Depression, Incidence (epidemiology), General Medicine, Middle Aged, Anxiety Disorders, Infectious Diseases, Anti-Retroviral Agents, Hypertension, Female, Microbiology (medical), medicine.medical_specialty, 030106 microbiology, Population, HIV-1 infection, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Acquired immunodeficiency syndrome (AIDS), Internal medicine, Diabetes Mellitus, Humans, lcsh:RC109-216, education, Antihypertensive Agents, Aged, Acquired Immunodeficiency Syndrome, Portugal, business.industry, medicine.disease, Confidence interval, Regimen, Non-AIDS comorbiditiess, Cross-Sectional Studies, Socioeconomic Factors, HIV-1, business
Abstract

Objective: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC. Results: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B=0.032, 95% confidence interval 0.015-0.049; p=0.0003) and between the duration of HIV-1 infection and NARC (B=0.039, 95% confidence interval 0.017-0.059; p=0.0005). Conclusions: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population. Merck Sharp & Dohme, Lda, Portugal provided financial support for the non-interventional study (Protocol Nr. MK0518-826 ). info:eu-repo/semantics/publishedVersion

Published
2019

35. HIV testing history and access to treatment among migrants living with HIV in Europe

Author

Fakoya, I. Álvarez-Del Arco, D. Monge, S. Copas, A.J. Gennotte, A.-F. Volny-Anne, A. Wengenroth, C. Touloumi, G. Prins, M. Barros, H. Darling, K.E.A. Prestileo, T. Del Amo, J. Burns, F.M. Aerssens, A. Aguado, M. Alimi, B. Anagnostou, O. Anderson, J. Antoniadou, A. Arando, M. Barberà, M.J. Barthélemy, A. Belda-Ibáñez, J. Bertisch, B. Bil, J. Blanco, J.R. Block, K. Boesecke, C. Boura, M. Burgos, J. Cabo, J. Calabuig, E. Campbell, L. Cardoso, O. Claudia, W. Clumeck, N. Colucci, A. Corrao, S. Cuellar, S. Cunha, J. Daikos, G. Darling, K. del Romero, J. Dellot, P. Domingo, P. Dronda, F. Ebeling, F. Engelhardt, A. Engler, B. Farrell, J. Fehr, J. Feijó, M. Fernández, E. Fernández García, E. Fernandez, T. Fortes, A.L. Fox, J. Garcia de Olalla, P. García, F. Gargalianos-Kakolyris, P. Germano, I. Gilleran, G. Gilson, R. Goepel, S. Gogos, H.A. Gómez Sirvent, J.L. Gountas, I. Gregg, A. Gutiérrez, F. Gutierrez, M.M. Hermans, I. Iribarren, J.A. Knobel, H. Koulai, L. Kourkounti, S. La Morté, C. LeCompte, T. Ledergerber, B. Leonidou, L. Ligero, M.C. Lindergard, G. Lino, S. Lopes, M.J. Lopez Lirola, A. Louhenapessy, M. Lourida, G. Luzi, A.M. Maltez, F. Manirankunda, L. Martín-Pérez, A. Martins, L. Masía, M. Mateu, M.G. Meireles, P. Mendes, A. Metallidis, S. Mguni, S. Milinkovic, A. Miró, J.M. Mohrmann, K. Montero, M. Mouhebati, T. Moutschen, M. Müller, M. Murphy, C. Nöstlinger, C. Ocaña, I. Okumu-Fransche, S. Onwuchekwa, G. Ospina, J.E. Otiko, D. Pacheco, P. Palacios, R. Paparizos, V. Papastamopoulos, V. Paredes, V. Patel, N. Pellicer, T. Peña, A. Petrosillo, N. Pinheiro, A. Poças, J. Portillo, A. Post, F. Prestileo, F. Prins, P. Protopapas, K. Psichogiou, M. Pulido, F. Rebollo, J. Ribeirinho, A. Río, I. Robau, M. Rockstroh, J.K. Rodrigues, E. Rodríguez, M. Sajani, C. Salavert, M. Salman, R. Sanz, N. Schuettfort, G. Schüttfort, G. Schwarze- Zander, C. Serrão, R. Silva, D. Silva, V. Silverio, P. Skoutelis, A. Staehelin, C. Stephan, C. Stretton, C. Styles, F. Sutre, A.F. Taylor, S. Teixeira, B. Thierfelder, C. Tsachouridou, O. Tudor, K. Valadas, E. van Frankenhuijsen, M. Vázquez, M. Velasco Arribas, M. Vera, M. Vinciana, P. Voudouri, N. Wasmuth, J.C. Wilkins, E. Young, L. Yurdakul, S. Zafra Espinosa, T. Zuilhof, W. Zuure, F. the aMASE Study Team

Subjects
virus diseases
Abstract

Introduction: Migrants are overrepresented in the European HIV epidemic. We aimed to understand the barriers and facilitators to HIV testing and current treatment and healthcare needs of migrants living with HIV in Europe. Methods: A cross-sectional study was conducted in 57 HIV clinics in nine countries (Belgium, Germany, Greece, Italy, The Netherlands, Portugal, Spain, Switzerland and United Kingdom), July 2013 to July 2015. HIV-positive patients were eligible for inclusion if they were as follows: 18 years or older; foreign-born residents and diagnosed within five years of recruitment. Questionnaires were completed electronically in one of 15 languages and linked to clinical records. Primary outcomes were access to primary care and previous negative HIV test. Data were analysed using random effects logistic regression. Outcomes of interest are presented for women, heterosexual men and gay/bisexual men. Results: A total of 2093 respondents (658 women, 446 heterosexual men and 989 gay/bisexual men) were included. The prevalence of a previous negative HIV test was 46.7%, 43.4% and 82.0% for women, heterosexual and gay/bisexual men respectively. In multivariable analysis previous testing was positively associated with: receipt of post-migration antenatal care among women, permanent residency among heterosexual men and identifying as gay rather than bisexual among gay/bisexual men. Access to primary care was found to be high (>83%) in all groups and was strongly associated with country of residence. Late diagnosis was common for women and heterosexual men (60.8% and 67.1%, respectively) despite utilization of health services prior to diagnosis. Across all groups almost three-quarters of people on antiretrovirals had an HIV viral load

Published
2018

36. INVENTÁRIO E DIAGNÓSTICO DA ARBORIZAÇÃO URBANA VIÁRIA DE RIO BRANCO, AC

Author

Lino S. Junior, Marcos A. Isaac Junior, Zairon Castelo, Anderson Bryan Miranda Lima, Clarice O. Farias, Solaine Costa, Arnaldo M. Junior, Cledson Reis, Anelena Carvalho, Nara V. Pantoja, Sara P. Nicheli, Marcio L. Dumont, Raimundo M. Davila, Tersio F. Pereira, Zeina S. Ferrari, Erivania Macedo, Cassia S. Melo, Renato M. Cunha, Elias A. S. Junior, Ary Vieira de Paiva, Renato A. Silva, Tatianne C. Souza, Mayara Correa, Erivelton S. Lima, Francelino M. Silva, Ranieldo Gabriel, Fabricia Sobrinho, Clivia Bezerra, Renato S. Oliveira, Robelson Dias, Aruan Gomes, and Jose Caldio Bonfim

Subjects
Arborização urbana, inventário, diagnóstico, Rio Branco, General Medicine
Abstract

O presente trabalho foi desenvolvido dentro do perímetro urbano da cidade de Rio BrancoAC, localizada entre as coordenadas geográficas de 9°58’29’’ de latitude sul e 67°48’36’’ de longitude oeste. Teve como objetivo geral o levantamento e diagnóstico da arborização viária. A metodologia estatística utilizada foi definida tomando-se como unidade amostral o quarteirão. Encontrou-se pouquíssimos espécimes nas calçadas dos quarteirões amostrados, totalizando 292 indivíduos distribuídos por 39 espécies, sendo 11 nativas e 28 exóticas. A média por quarteirão foi de 1,83 árvores, e por quilômetro de calçada foi de 4,57 árvores. Concluiu-se que o número de árvores existentes nas calçadas foi muito pequeno, tendo-se como referência 100 árvores por quilômetro de calçada como ideal. A maioria das espécies encontrada era exótica (78,57%), a despeito da cidade encontrar-se numa região com uma das maiores diversidades de espécies arbóreas do planeta. Quanto ao estado físico, a copa normal foi predominante, exceto na região central. As recomendações indicadas foram primeiramente de se elaborar um plano de arborização urbana para o município, contendo referências técnicas para escolha das espécies, técnicas de manejo e programa de educação ambiental.

Published
2019
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38. Katharine Gibbs School (Inc.) v. FTC: Restricting the Federal Trade Commission's Trade Regulation Rulemaking Authority under the Magnuson-Moss Act.

Author

Lipinsky de Orlov, Lino S.

Abstract

The application of agency authority to advertising practices and consumer protection policy of the Katharine Gibbs School, a proprietary school, under the new Federal Trade Commission Improvement Act, is reviewed and criticized. (Available from: Fred B. Rothman & Co., 10368 W. Centennial Rd., Littleton, CO 80123, $5.00). (MSE)

Published
1981

40. HIV testing history and access to treatment among migrants living with HIV in Europe

Author

Fakoya, I. Álvarez-Del Arco, D. Monge, S. Copas, A.J. Gennotte, A.-F. Volny-Anne, A. Wengenroth, C. Touloumi, G. Prins, M. Barros, H. Darling, K.E.A. Prestileo, T. Del Amo, J. Burns, F.M. Aerssens, A. Aguado, M. Alimi, B. Anagnostou, O. Anderson, J. Antoniadou, A. Arando, M. Barberà, M.J. Barthélemy, A. Belda-Ibáñez, J. Bertisch, B. Bil, J. Blanco, J.R. Block, K. Boesecke, C. Boura, M. Burgos, J. Cabo, J. Calabuig, E. Campbell, L. Cardoso, O. Claudia, W. Clumeck, N. Colucci, A. Corrao, S. Cuellar, S. Cunha, J. Daikos, G. Darling, K. del Romero, J. Dellot, P. Domingo, P. Dronda, F. Ebeling, F. Engelhardt, A. Engler, B. Farrell, J. Fehr, J. Feijó, M. Fernández, E. Fernández García, E. Fernandez, T. Fortes, A.L. Fox, J. Garcia de Olalla, P. García, F. Gargalianos-Kakolyris, P. Germano, I. Gilleran, G. Gilson, R. Goepel, S. Gogos, H.A. Gómez Sirvent, J.L. Gountas, I. Gregg, A. Gutiérrez, F. Gutierrez, M.M. Hermans, I. Iribarren, J.A. Knobel, H. Koulai, L. Kourkounti, S. La Morté, C. LeCompte, T. Ledergerber, B. Leonidou, L. Ligero, M.C. Lindergard, G. Lino, S. Lopes, M.J. Lopez Lirola, A. Louhenapessy, M. Lourida, G. Luzi, A.M. Maltez, F. Manirankunda, L. Martín-Pérez, A. Martins, L. Masía, M. Mateu, M.G. Meireles, P. Mendes, A. Metallidis, S. Mguni, S. Milinkovic, A. Miró, J.M. Mohrmann, K. Montero, M. Mouhebati, T. Moutschen, M. Müller, M. Murphy, C. Nöstlinger, C. Ocaña, I. Okumu-Fransche, S. Onwuchekwa, G. Ospina, J.E. Otiko, D. Pacheco, P. Palacios, R. Paparizos, V. Papastamopoulos, V. Paredes, V. Patel, N. Pellicer, T. Peña, A. Petrosillo, N. Pinheiro, A. Poças, J. Portillo, A. Post, F. Prestileo, F. Prins, P. Protopapas, K. Psichogiou, M. Pulido, F. Rebollo, J. Ribeirinho, A. Río, I. Robau, M. Rockstroh, J.K. Rodrigues, E. Rodríguez, M. Sajani, C. Salavert, M. Salman, R. Sanz, N. Schuettfort, G. Schüttfort, G. Schwarze- Zander, C. Serrão, R. Silva, D. Silva, V. Silverio, P. Skoutelis, A. Staehelin, C. Stephan, C. Stretton, C. Styles, F. Sutre, A.F. Taylor, S. Tei and Fakoya, I. Álvarez-Del Arco, D. Monge, S. Copas, A.J. Gennotte, A.-F. Volny-Anne, A. Wengenroth, C. Touloumi, G. Prins, M. Barros, H. Darling, K.E.A. Prestileo, T. Del Amo, J. Burns, F.M. Aerssens, A. Aguado, M. Alimi, B. Anagnostou, O. Anderson, J. Antoniadou, A. Arando, M. Barberà, M.J. Barthélemy, A. Belda-Ibáñez, J. Bertisch, B. Bil, J. Blanco, J.R. Block, K. Boesecke, C. Boura, M. Burgos, J. Cabo, J. Calabuig, E. Campbell, L. Cardoso, O. Claudia, W. Clumeck, N. Colucci, A. Corrao, S. Cuellar, S. Cunha, J. Daikos, G. Darling, K. del Romero, J. Dellot, P. Domingo, P. Dronda, F. Ebeling, F. Engelhardt, A. Engler, B. Farrell, J. Fehr, J. Feijó, M. Fernández, E. Fernández García, E. Fernandez, T. Fortes, A.L. Fox, J. Garcia de Olalla, P. García, F. Gargalianos-Kakolyris, P. Germano, I. Gilleran, G. Gilson, R. Goepel, S. Gogos, H.A. Gómez Sirvent, J.L. Gountas, I. Gregg, A. Gutiérrez, F. Gutierrez, M.M. Hermans, I. Iribarren, J.A. Knobel, H. Koulai, L. Kourkounti, S. La Morté, C. LeCompte, T. Ledergerber, B. Leonidou, L. Ligero, M.C. Lindergard, G. Lino, S. Lopes, M.J. Lopez Lirola, A. Louhenapessy, M. Lourida, G. Luzi, A.M. Maltez, F. Manirankunda, L. Martín-Pérez, A. Martins, L. Masía, M. Mateu, M.G. Meireles, P. Mendes, A. Metallidis, S. Mguni, S. Milinkovic, A. Miró, J.M. Mohrmann, K. Montero, M. Mouhebati, T. Moutschen, M. Müller, M. Murphy, C. Nöstlinger, C. Ocaña, I. Okumu-Fransche, S. Onwuchekwa, G. Ospina, J.E. Otiko, D. Pacheco, P. Palacios, R. Paparizos, V. Papastamopoulos, V. Paredes, V. Patel, N. Pellicer, T. Peña, A. Petrosillo, N. Pinheiro, A. Poças, J. Portillo, A. Post, F. Prestileo, F. Prins, P. Protopapas, K. Psichogiou, M. Pulido, F. Rebollo, J. Ribeirinho, A. Río, I. Robau, M. Rockstroh, J.K. Rodrigues, E. Rodríguez, M. Sajani, C. Salavert, M. Salman, R. Sanz, N. Schuettfort, G. Schüttfort, G. Schwarze- Zander, C. Serrão, R. Silva, D. Silva, V. Silverio, P. Skoutelis, A. Staehelin, C. Stephan, C. Stretton, C. Styles, F. Sutre, A.F. Taylor, S. Tei

Abstract

Introduction: Migrants are overrepresented in the European HIV epidemic. We aimed to understand the barriers and facilitators to HIV testing and current treatment and healthcare needs of migrants living with HIV in Europe. Methods: A cross-sectional study was conducted in 57 HIV clinics in nine countries (Belgium, Germany, Greece, Italy, The Netherlands, Portugal, Spain, Switzerland and United Kingdom), July 2013 to July 2015. HIV-positive patients were eligible for inclusion if they were as follows: 18 years or older; foreign-born residents and diagnosed within five years of recruitment. Questionnaires were completed electronically in one of 15 languages and linked to clinical records. Primary outcomes were access to primary care and previous negative HIV test. Data were analysed using random effects logistic regression. Outcomes of interest are presented for women, heterosexual men and gay/bisexual men. Results: A total of 2093 respondents (658 women, 446 heterosexual men and 989 gay/bisexual men) were included. The prevalence of a previous negative HIV test was 46.7%, 43.4% and 82.0% for women, heterosexual and gay/bisexual men respectively. In multivariable analysis previous testing was positively associated with: receipt of post-migration antenatal care among women, permanent residency among heterosexual men and identifying as gay rather than bisexual among gay/bisexual men. Access to primary care was found to be high (>83%) in all groups and was strongly associated with country of residence. Late diagnosis was common for women and heterosexual men (60.8% and 67.1%, respectively) despite utilization of health services prior to diagnosis. Across all groups almost three-quarters of people on antiretrovirals had an HIV viral load <50 copies/mL. Conclusions: Migrants access healthcare in Europe and while many migrants had previously tested for HIV, that they went on to test positive at a later date suggests that opportunities for HIV prevention are being miss

Published
2018

41. High levels of postmigration HIV acquisition within nine European countries

Author

Alvarez-Del Arco, D. Fakoya, I. Thomadakis, C. Pantazis, N. Touloumi, G. Gennotte, A.-F. Zuure, F. Barros, H. Staehelin, C. Göpel, S. Boesecke, C. Prestileo, T. Volny-Anne, A. Burns, F. Del Amo, J. Aerssens, A. Aguado, M. Alimi, B. Álvarez-Del Arco, D. Anagnostou, O. Anderson, J. Antoniadou, A. Arando, M. Barberà, M.J. Barthélemy, A. Belda-Ibáñez, J. Bertisch, B. Bil, J. Blanco, J.R. Block, K. Boesecke, C. Boura, M. Burgos, J. Burns, F.M. Cabo, J. Calabuig, E. Campbell, L. Cardoso, O. Claudia, W. Clumeck, N. Colucci, A. Corrao, S. Cuellar, S. Cunha, J. Daikos, G. Darling, K. Del Amo, J. Del Romero, J. Dellot, P. Dixneuf, M. Domingo, P. Dronda, F. Ebeling, F. Engelhardt, A. Engler, B. Fakoya, I. Farrell, J. Fehr, J. Feijó, M. Fernández, E. Fernández García, E. Fernandez, T. Fortes, A.L. Fox, J. Garcia De Olalla, P. García, F. Gargalianos-Kakolyris, P. Gennotte, A.F. Germano, I. Gilleran, G. Gilson, R. Goepel, S. Gogos, H.A. Gómez Sirvent, J.L. Gountas, I. Gregg, A. Gutiérrez, F. Gutierrez, M.M. Hermans, I. Iribarren, J.A. Knobel, H. Koulai, L. Kourkounti, S. La Morté, C. LeCompte, T. Ledergerber, B. Leonidou, L. Ligero, M.C. Lindergard, G. Lino, S. Lopes, M.J. Lopez Lirola, A. Louhenapessy, M. Lourida, G. Luzi, A.M. Maltez, F. Manirankunda, L. Martín-Pérez, A. Martins, L. Masía, M. Mateu, M.G. Meireles, P. Mendes, A. Metallidis, S. Mguni, S. Milinkovic, A. Miró, J.M. Mohrmann, K. Monge, S. Montero, M. Mouhebati, T. Moutschen, M. Müller, M. Murphy, C. Nöstlinger, C. Ocaña, I. Okumu-Fransche, S. Onwuchekwa, G. Ospina, J.E. Otiko, D. Pacheco, P. Palacios, R. Paparizos, V. Papastamopoulos, V. Paredes, V. Patel, N. Pellicer, T. Peña, A. Petrosillo, N. Pinheiro, A. Poças, J. Portillo, A. Post, F. Prestileo, F. Prestileo, T. Prins, M. Prins, P. Protopapas, K. Psichogiou, M. Pulido, F. Rebollo, J. Ribeirinho, A. Río, I. Robau, M. Rockstroh, J.K. Rodrigues, E. Rodríguez, M. Sajani, C. Salavert, M. Salman, R. Sanz, N. Schuettfort, G. Schüttfort, G. Schwarze-Zander, C. Serrão, R. Silva, D. Silva, V. Silverio, P. Skoutelis, A. Staehelin, C. Stephan, C. Stretton, C. Styles, F. Sutre, A.F. Taylor, S. Teixeira, B. Thierfelder, C. Touloumi, G. Tsachouridou, O. Tudor, K. Valadas, E. Van Frankenhuijsen, M. Vázquez, M. Velasco Arribas, M. Vera, M. Vinciana, P. Volny-Anne, A. Voudouri, N. Wasmuth, J.C. Wengenroth, C. Wilkins, E. Young, L. Yurdakul, S. Zafra Espinosa, T. Zuilhof, W. Zuure, F. Advancing Migrant Access to Health Services in Europe (aMASE) study team

Subjects
virus diseases
Abstract

Objective: We aimed to estimate the proportion of postmigration HIV acquisition among HIV-positive migrants in Europe. Design: To reach HIV-positive migrants, we designed a cross-sectional study performed in HIV clinics. Methods: The study was conducted from July 2013 to July 2015 in 57 clinics (nine European countries), targeting individuals over 18 years diagnosed in the preceding 5 years and born abroad. Electronic questionnaires supplemented with clinical data were completed in any of 15 languages. Postmigration HIV acquisition was estimated through Bayesian approaches combining extensive information on migration and patients' characteristics. CD4+ cell counts and HIV-RNA trajectories from seroconversion were estimated by bivariate linear mixed models fitted to natural history data. Postmigration acquisition risk factors were investigated with weighted logistic regression. Results: Of 2009 participants, 46% were MSM and a third originated from sub-Saharan Africa and Latin America & Caribbean, respectively. Median time in host countries was 8 years. Postmigration HIV acquisition was 63% (95% confidence interval: 57-67%); 72% among MSM, 58 and 51% in heterosexual men and women, respectively. Postmigration HIV acquisition was 71% for Latin America and Caribbean migrants and 45% for people from sub-Saharan Africa. Factors associated with postmigration HIV acquisition among heterosexual women and MSM were age at migration, length of stay in host country and HIV diagnosis year and among heterosexual men, length of stay in host country and HIV diagnosis year. Conclusion: A substantial proportion of HIV-positive migrants living in Europe acquired HIV postmigration. This has important implications for European public health policies. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Published
2017

42. BEST HOPE - Cohort of HIV newly diagnosed patients in Portugal

Author

Pingarilho, M., Pineda-Peña, A.C., Dias, S., Pimentel, V.F., Libin, P., Aleixo, M.J., Amaral-Alves, D., Ascenção, B., Azevedo, F., Baptista, T., Bredes, C., Brito, P., Cabanas, J., Cabo, J., Caixeiro, M., Caldas, C., Campos, Maria José, Cardoso, S., Carvalho, A.P., Casella, I., Correia, L., Correia-Abreu, R., Côrte-Real, R., Costa, I., Costa, O., Cunha, S., Diogo, I., Faria, D., Faria, T., Feijó, M., Ferreira, J., Germano, I., Gomes, A., Gomes, P., Gonçalves, F., Gonçalves, M.J., Granado, A., Ivo, M.S., Jesus, J., Koch, C., Lino, S., Luís, N., Maio, A., Maltez, F., Mansinho, K., Marques, N., Marques, S., Martins, S., Mateus, E., Mendão, Luís, Messias, C., Monteiro, F., Morais, C., Mota, V., Neves, I., Nunes, S., Oliveira, J., Pacheco, P., Pereira, H., Pereira-Vaz, J., Pessanha, M., Pimenta, A., Piñeiro, C., Pinheiro, S., Pinho, R., Poças, J., Proença, P., Ramos, H., Rocha, Miguel, Rodrigues, C., Rodrigues, P., Rodrigues, R., Roxo, F., Sá, J., Salvado, C., Sarmento-Castro, R., Seixas, D., Serrão, R., Silva, A.R., Silva, E.G., Silva, V., Simão, M., Simões, D., Simões, J., Simões, P., Soares, J., Tavares, R., Teófilo, E., Trigo, D., Theys, K., Martins M.R.O., Vandamme, A.M., Camacho, R.J., and Abecasis AB

Published
2016
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43. High levels of postmigration HIV acquisition within nine European countries

Author

Alvarez-Del Arco, D. Fakoya, I. Thomadakis, C. Pantazis, N. Touloumi, G. Gennotte, A.-F. Zuure, F. Barros, H. Staehelin, C. Göpel, S. Boesecke, C. Prestileo, T. Volny-Anne, A. Burns, F. Del Amo, J. Aerssens, A. Aguado, M. Alimi, B. Álvarez-Del Arco, D. Anagnostou, O. Anderson, J. Antoniadou, A. Arando, M. Barberà, M.J. Barthélemy, A. Belda-Ibáñez, J. Bertisch, B. Bil, J. Blanco, J.R. Block, K. Boesecke, C. Boura, M. Burgos, J. Burns, F.M. Cabo, J. Calabuig, E. Campbell, L. Cardoso, O. Claudia, W. Clumeck, N. Colucci, A. Corrao, S. Cuellar, S. Cunha, J. Daikos, G. Darling, K. Del Amo, J. Del Romero, J. Dellot, P. Dixneuf, M. Domingo, P. Dronda, F. Ebeling, F. Engelhardt, A. Engler, B. Fakoya, I. Farrell, J. Fehr, J. Feijó, M. Fernández, E. Fernández García, E. Fernandez, T. Fortes, A.L. Fox, J. Garcia De Olalla, P. García, F. Gargalianos-Kakolyris, P. Gennotte, A.F. Germano, I. Gilleran, G. Gilson, R. Goepel, S. Gogos, H.A. Gómez Sirvent, J.L. Gountas, I. Gregg, A. Gutiérrez, F. Gutierrez, M.M. Hermans, I. Iribarren, J.A. Knobel, H. Koulai, L. Kourkounti, S. La Morté, C. LeCompte, T. Ledergerber, B. Leonidou, L. Ligero, M.C. Lindergard, G. Lino, S. Lopes, M.J. Lopez Lirola, A. Louhenapessy, M. Lourida, G. Luzi, A.M. Maltez, F. Manirankunda, L. Martín-Pérez, A. Martins, L. Masía, M. Mateu, M.G. Meireles, P. Mendes, A. Metallidis, S. Mguni, S. Milinkovic, A. Miró, J.M. Mohrmann, K. Monge, S. Montero, M. Mouhebati, T. Moutschen, M. Müller, M. Murphy, C. Nöstlinger, C. Ocaña, I. Okumu-Fransche, S. Onwuchekwa, G. Ospina, J.E. Otiko, D. Pacheco, P. Palacios, R. Paparizos, V. Papastamopoulos, V. Paredes, V. Patel, N. Pellicer, T. Peña, A. Petrosillo, N. Pinheiro, A. Poças, J. Portillo, A. Post, F. Prestileo, F. Prestileo, T. Prins, M. Prins, P. Protopapas, K. Psichogiou, M. Pulido, F. Rebollo, J. Ribeirinho, A. Río, I. Robau, M. Rockstroh, J.K. Rodrigues, E. Rodríguez, M. Sajani, C. Salavert, M. Salman, R. Sanz, N. Schuettfort, G. Schüttfort, G. Schwarze-Zander, C. Serrão and Alvarez-Del Arco, D. Fakoya, I. Thomadakis, C. Pantazis, N. Touloumi, G. Gennotte, A.-F. Zuure, F. Barros, H. Staehelin, C. Göpel, S. Boesecke, C. Prestileo, T. Volny-Anne, A. Burns, F. Del Amo, J. Aerssens, A. Aguado, M. Alimi, B. Álvarez-Del Arco, D. Anagnostou, O. Anderson, J. Antoniadou, A. Arando, M. Barberà, M.J. Barthélemy, A. Belda-Ibáñez, J. Bertisch, B. Bil, J. Blanco, J.R. Block, K. Boesecke, C. Boura, M. Burgos, J. Burns, F.M. Cabo, J. Calabuig, E. Campbell, L. Cardoso, O. Claudia, W. Clumeck, N. Colucci, A. Corrao, S. Cuellar, S. Cunha, J. Daikos, G. Darling, K. Del Amo, J. Del Romero, J. Dellot, P. Dixneuf, M. Domingo, P. Dronda, F. Ebeling, F. Engelhardt, A. Engler, B. Fakoya, I. Farrell, J. Fehr, J. Feijó, M. Fernández, E. Fernández García, E. Fernandez, T. Fortes, A.L. Fox, J. Garcia De Olalla, P. García, F. Gargalianos-Kakolyris, P. Gennotte, A.F. Germano, I. Gilleran, G. Gilson, R. Goepel, S. Gogos, H.A. Gómez Sirvent, J.L. Gountas, I. Gregg, A. Gutiérrez, F. Gutierrez, M.M. Hermans, I. Iribarren, J.A. Knobel, H. Koulai, L. Kourkounti, S. La Morté, C. LeCompte, T. Ledergerber, B. Leonidou, L. Ligero, M.C. Lindergard, G. Lino, S. Lopes, M.J. Lopez Lirola, A. Louhenapessy, M. Lourida, G. Luzi, A.M. Maltez, F. Manirankunda, L. Martín-Pérez, A. Martins, L. Masía, M. Mateu, M.G. Meireles, P. Mendes, A. Metallidis, S. Mguni, S. Milinkovic, A. Miró, J.M. Mohrmann, K. Monge, S. Montero, M. Mouhebati, T. Moutschen, M. Müller, M. Murphy, C. Nöstlinger, C. Ocaña, I. Okumu-Fransche, S. Onwuchekwa, G. Ospina, J.E. Otiko, D. Pacheco, P. Palacios, R. Paparizos, V. Papastamopoulos, V. Paredes, V. Patel, N. Pellicer, T. Peña, A. Petrosillo, N. Pinheiro, A. Poças, J. Portillo, A. Post, F. Prestileo, F. Prestileo, T. Prins, M. Prins, P. Protopapas, K. Psichogiou, M. Pulido, F. Rebollo, J. Ribeirinho, A. Río, I. Robau, M. Rockstroh, J.K. Rodrigues, E. Rodríguez, M. Sajani, C. Salavert, M. Salman, R. Sanz, N. Schuettfort, G. Schüttfort, G. Schwarze-Zander, C. Serrão

Abstract

Objective: We aimed to estimate the proportion of postmigration HIV acquisition among HIV-positive migrants in Europe. Design: To reach HIV-positive migrants, we designed a cross-sectional study performed in HIV clinics. Methods: The study was conducted from July 2013 to July 2015 in 57 clinics (nine European countries), targeting individuals over 18 years diagnosed in the preceding 5 years and born abroad. Electronic questionnaires supplemented with clinical data were completed in any of 15 languages. Postmigration HIV acquisition was estimated through Bayesian approaches combining extensive information on migration and patients' characteristics. CD4+ cell counts and HIV-RNA trajectories from seroconversion were estimated by bivariate linear mixed models fitted to natural history data. Postmigration acquisition risk factors were investigated with weighted logistic regression. Results: Of 2009 participants, 46% were MSM and a third originated from sub-Saharan Africa and Latin America & Caribbean, respectively. Median time in host countries was 8 years. Postmigration HIV acquisition was 63% (95% confidence interval: 57-67%); 72% among MSM, 58 and 51% in heterosexual men and women, respectively. Postmigration HIV acquisition was 71% for Latin America and Caribbean migrants and 45% for people from sub-Saharan Africa. Factors associated with postmigration HIV acquisition among heterosexual women and MSM were age at migration, length of stay in host country and HIV diagnosis year and among heterosexual men, length of stay in host country and HIV diagnosis year. Conclusion: A substantial proportion of HIV-positive migrants living in Europe acquired HIV postmigration. This has important implications for European public health policies. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Published
2017

45. Bull's Eye Maculopathy in a Patient Treated with Efavirenz

Author

Vaz Pereira, C, Franco, M, Guerra Pinto, R, Lino, S, Maltez, F, Barrão, S, and Filipe, H

Subjects
genetic structures, Toxicity, HCC INF, virus diseases, HIV, sense organs, Retinal Pigment Epithelium, eye diseases
Abstract

Objective: To report a case of retinal toxicity associated with efavirenz in an adult. Methods: We describe a case of gradual-onset blurry vision in both eyes in a 37-year-old HIV Caucasian woman, on antiretroviral therapy (ART), including efavirenz. Results: The patient presented with a best corrected visual acuity of 20/100 for the right eye (RE) and 20/125 for the left eye (LE). Fundoscopy revealed mottled atrophic changes of the macular retinal pigment epithelium (RPE) in both eyes. Fluorescein angiography revealed an annular pattern of RPE atrophy in both eyes. Full-field electretinography (ERG) was normal. Conclusions: Based on our patient’s history and on previous reports, efavirenz seems to be the culprit in this case. Our report provides evidence in support of routine ophthalmological evaluation of patients on efavirenz.

Published
2014

47. Behavioral and Psychological Profiles of Cocaine Users upon Treatment Entry

Author

Bu Wang, Felipe González Castro, Lino S Dial, Erica V. Sharp, Elizabeth H. Barrington, and Richard A. Rawson

Subjects
medicine.medical_specialty, Health (social science), Addiction, media_common.quotation_subject, Treatment entry, Addicted cocaine, Public Health, Environmental and Occupational Health, Ethnic group, Medicine (miscellaneous), Drug treatment, Cocaine users, medicine, Chronic cocaine, Health profile, Psychiatry, Psychology, Clinical psychology, media_common
Abstract

This descriptive study examines the health-related profile of 112 regular users of cocaine who were recently admitted to an impatient or to an outpatient drug treatment program. Subjects reported on their health status during the days immediately preceding their entry into treatment. The health profile of these addicted cocaine users was examined in terms of behavioral, psychological and psychiatric measures of health. A lifestyle shift hypothesis was examined in these addicted cocaine users using norms from non-addicted "episodic" cocaine users for the behavioral and psychological measures, while using psychiatric norms for the psychiatric measures. This liefestyle shift hypothesis postulates illness progression with greater levels of addiction, a progression manifested by greater severity of dysfunction across serveral areas of life function. In support of this hypothesis, addicted chronic cocaine users, when compared with episodic, nonaddicted users, exhibited a remarkable unhealthy shift in lifestyle ...

Published
1992
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48. Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds

Author

Sharon, Gerecht, Lino S, Ferreira, and Robert, Langer

Subjects
Tissue Engineering, Tissue Scaffolds, Cell Survival, Myocytes, Smooth Muscle, Cell Culture Techniques, Endothelial Cells, Cell Differentiation, Dextrans, Hydrogels, Cell Separation, Flow Cytometry, Coculture Techniques, Mice, Microscopy, Electron, Scanning, Animals, Humans, Hyaluronic Acid, Biomarkers, Embryonic Stem Cells, Cell Proliferation
Abstract

The vascularization of tissue constructs remains a major challenge in regenerative medicine, as the diffusional supply of oxygen can support only 100-200 mum thick layers of viable tissue. The formation of a mature and functional vascular network requires communication between endothelial cells (ECs) and smooth muscle cells (SMCs). Potential sources of these cells that involve noninvasive methodologies are required for numerous applications including tissue-engineered vascular grafts, myocardial ischemia, wound healing, plastic surgery, and general tissue-engineering applications. Human embryonic stem cells (hESCs) can be an unlimited source of these cells. They can be expanded in vitro in an undifferentiated state without apparent limit, and hES-derived cells can be created in virtually unlimited amounts for potential clinical uses. Recently, vascular progenitor cells as well as endothelial and smooth muscle cells have been isolated from hESCs.

Published
2009

50. Vascular Progenitor Cells Isolated from Human Embryonic Stem Cells

Author

Vunjak-Novakovic, Gordana, Ferreira, Lino S., Gerecht, Sharon, Shieh, Hester F., Watson, Nicki, Rupnick, Maria A., Dallabrida, Susan M., and Langer, Robert

Subjects
inorganic chemicals, organic chemicals, health occupations, polycyclic compounds, heterocyclic compounds, Biomedical engineering
Abstract

Invariant left-right (LR) patterning or chirality is critical for embryonic development. The loss or reversal of LR asymmetry is often associated with malformations and disease. Although several theories have been proposed, the exact mechanism of the initiation of the LR symmetry has not yet been fully elucidated. Recently, chirality has been detected within single cells as well as multicellular structures using several in vitro approaches. These studies demonstrated the universality of cell chirality, its dependence on cell phenotype, and the role of physical boundaries. In this review, we discuss the theories for developmental LR asymmetry, compare various in vitro cell chirality model systems, and highlight possible roles of cell chirality in stem cell differentiation. We emphasize that the in vitro cell chirality systems have great promise for helping unveil the nature of chiral morphogenesis in development.

Published
2007
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