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8. Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity

Author

Maifeld, András, Wild, Johannes, Karlsen, Tine V., Rakova, Natalia, Wistorf, Elisa, Linz, Peter, Jung, Rebecca, Birukov, Anna, Gimenez-Rivera, Vladimir-Andrey, Wilck, Nicola, Bartolomaeus, Theda, Dechend, Ralf, Kleinewietfeld, Markus, Forslund, Sofia K., Krause, Andreas, Kokolakis, Georgios, Philipp, Sandra, Clausen, Björn E., Brand, Anna, Waisman, Ari, Kurschus, Florian C., Wegner, Joanna, Schultheis, Michael, Luft, Friedrich C., Boschmann, Michael, Kelm, Marcus, Wiig, Helge, Kuehne, Titus, Müller, Dominik N., Karbach, Susanne, and Markó, Lajos

Published
2022
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18. Sodium quantification in skeletal muscle: comparison between Cartesian gradient-echo and radial ultra-short echo time 23Na MRI techniques.

Author

Gerhalter, Teresa, Schilling, Felix, Zeitouni, Nour, Linz, Peter, Baudin, Pierre-Yves, Kannenkeril, Dennis, Kopp, Christoph, Dahlmann, Anke, Schmieder, Roland, Uder, Michael, Nagel, Armin M., and Gast, Lena V.

Subjects
MAGNETIC resonance imaging, SKELETAL muscle, SODIUM, WILCOXON signed-rank test
Abstract

Background: Clinical magnetic resonance imaging (MRI) studies often use Cartesian gradient-echo (GRE) sequences with ~2-ms echo times (TEs) to monitor apparent total sodium concentration (aTSC). We compared Cartesian GRE and ultra-short echo time three-dimensional (3D) radial-readout sequences for measuring skeletal muscle aTSC. Methods: We retrospectively evaluated 211 datasets from 112 volunteers aged 62.3 ± 12.1 years (mean ± standard deviation), acquired at 3 T from the lower leg. For 23Na MRI acquisitions, we used a two-dimensional Cartesian GRE sequence and a density-adapted 3D radial readout sequence with cuboid field-of-view (DA-3D-RAD-C). We calibrated the 23Na MR signal using reference tubes either with or without agarose and subsequently performed a relaxation correction. Additionally, we employed a six-echo 1H GRE sequence and a multi-echo spin-echo sequence to calculate proton density fat fraction (PDFF) and water T2. Paired Wilcoxon signed-rank test, Cohen dz for paired samples, and Spearman correlation were used. Results: Relaxation correction effectively reduced the differences in muscle aTSC between the two acquisition and calibration methods (DA-3D-RAD-C using NaCl/agarose references: 20.05 versus 19.14 mM; dz = 0.395; Cartesian GRE using NaCl/agarose references: 19.50 versus 18.82 mM; dz = 0.427). Both aTSC of the DA-3D-RAD-C and Cartesian GRE acquisitions showed a small but significant correlation with PDFF as well as with water T2. Conclusions: Different 23Na MRI acquisition and calibration approaches affect aTSC values. Applying relaxation correction is advised to minimize the impact of sequence parameters on quantification, and considering additional fat correction is advisable for patients with increased fat fractions. Relevance statement: This study highlights relaxation correction's role in improving sodium MRI accuracy, paving the way for better disease assessment and comparability of measured sodium signal in patients. Key points: • Differences in MRI acquisition methods hamper the comparability of sodium MRI measurements. • Measured sodium values depend on used MRI sequences and calibration method. • Relaxation correction during postprocessing mitigates these discrepancies. • Thus, relaxation correction enhances accuracy of sodium MRI, aiding its clinical use. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Abstract 057: The Positive Effect Of Renal Denervation Persists Even Through Regrowth Of Afferent Axons Improving Renal Afferent Nerve Activity During High Sodium Intake In Rats

Author

Rodionova, Kristina, primary, Ditting, Tilmann, additional, Lindner, Sophia, additional, Linz, Peter R, additional, Cordasic, Nada, additional, Hilgers, Karl F, additional, Schiffer, Mario, additional, Schmieder, Roland E, additional, Amann, Kerstin, additional, and Veelken, Roland, additional

Published
2023
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30. Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance)

Author

Haider, Adil, Scott, John W., Gause, Colin D., Meheš, Mira, Hsiung, Grace, Prelvukaj, Albulena, Yanocha, Dana, Baumann, Lauren M., Ahmed, Faheem, Ahmed, Na’eem, Anderson, Sara, Angate, Herve, Arfaa, Lisa, Asbun, Horacio, Ashengo, Tigistu, Asuman, Kisembo, Ayala, Ruben, Bickler, Stephen, Billingsley, Saul, Bird, Peter, Botman, Matthijs, Butler, Marilyn, Buyske, Jo, Capozzi, Angelo, Casey, Kathleen, Clayton, Charles, Cobey, James, Cotton, Michael, Deckelbaum, Dan, Derbew, Miliard, deVries, Catherine, Dillner, Jeanne, Downham, Max, Draisin, Natalie, Echinard, David, Elneil, Sohier, ElSayed, Ahmed, Estelle, Abigail, Finley, Allen, Frenkel, Erica, Frykman, Philip K., Gheorghe, Florin, Gore-Booth, Julian, Henker, Richard, Henry, Jaymie, Henry, Orion, Hoemeke, Laura, Hoffman, David, Ibanga, Iko, Jackson, Jr., Eric V., Jani, Pankaj, Johnson, Walter, Jones, Andrew, Kassem, Zeina, Kisembo, Asuman, Kocan, Abbey, Krishnaswami, Sanjay, Lane, Robert, Latif, Asad, Levy, Barbara, Linos, Dimitrios, Linz, Peter, Listwa, Louis A., Magee, Declan, Makasa, Emmanuel, Marin, Michael L., Martin, Claude, McQueen, Kelly, Morgan, Jamie, Moser, Richard, Neighbor, Robert, Novick, William M., Ogendo, Stephen, Omigbodun, Akinyinka, Onajin-Obembe, Bisola, Parsan, Neil, Philip, Beverly K., Price, Raymond, Rasheed, Shahnawaz, Ratel, Marjorie, Reynolds, Cheri, Roser, Steven M., Rowles, Jackie, Samad, Lubna, Sampson, John, Sanghvi, Harshadkumar, Sellers, Marchelle L., Sigalet, David, Steffes, Bruce C., Stieber, Erin, Swaroop, Mamta, Tarpley, John, Varghese, Asha, Varughese, Julie, Wagner, Richard, Warf, Benjamin, Wetzig, Neil, Williamson, Susan, Wood, Joshua, Zeidan, Anne, Zirkle, Lewis, Allen, Brendan, and Abdullah, Fizan

Published
2017
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33. Erratum to: Development of a Unifying Target and Consensus Indicators for Global Surgical Systems Strengthening: Proposed by the Global Alliance for Surgery, Obstetric, Trauma, and Anaesthesia Care (The G4 Alliance)

Author

Haider, Adil, Scott, John W., Gause, Colin D., Meheš, Mira, Hsiung, Grace, Prelvukaj, Albulena, Yanocha, Dana, Baumann, Lauren M., Ahmed, Faheem, Ahmed, Na’eem, Anderson, Sara, Angate, Herve, Arfaa, Lisa, Asbun, Horacio, Ashengo, Tigistu, Asuman, Kisembo, Ayala, Ruben, Bickler, Stephen, Billingsley, Saul, Bird, Peter, Botman, Matthijs, Butler, Marilyn, Buyske, Jo, Capozzi, Angelo, Casey, Kathleen, Clayton, Charles, Cobey, James, Cotton, Michael, Deckelbaum, Dan, Derbew, Miliard, deVries, Catherine, Dillner, Jeanne, Downham, Max, Draisin, Natalie, Echinard, David, Elneil, Sohier, ElSayed, Ahmed, Estelle, Abigail, Finley, Allen, Frenkel, Erica, Frykman, Philip K., Gheorghe, Florin, Gore-Booth, Julian, Henker, Richard, Henry, Jaymie, Henry, Orion, Hoemeke, Laura, Hoffman, David, Ibanga, Iko, Jackson, Jr., Eric V., Jani, Pankaj, Johnson, Walter, Jones, Andrew, Kassem, Zeina, Kisembo, Asuman, Kocan, Abbey, Krishnaswami, Sanjay, Lane, Robert, Latif, Asad, Levy, Barbara, Linos, Dimitrios, Linz, Peter, Listwa, Louis A., Magee, Declan, Makasa, Emmanuel, Marin, Michael L., Martin, Claude, McQueen, Kelly, Morgan, Jamie, Moser, Richard, Neighbor, Robert, Novick, William M., Ogendo, Stephen, Omigbodun, Akinyinka, Onajin-Obembe, Bisola, Parsan, Neil, Philip, Beverly K., Price, Raymond, Rasheed, Shahnawaz, Ratel, Marjorie, Reynolds, Cheri, Roser, Steven M., Rowles, Jackie, Samad, Lubna, Sampson, John, Sanghvi, Harshadkumar, Sellers, Marchelle L., Sigalet, David, Steffes, Bruce C., Stieber, Erin, Swaroop, Mamta, Tarpley, John, Varghese, Asha, Varughese, Julie, Wagner, Richard, Warf, Benjamin, Wetzig, Neil, Williamson, Susan, Wood, Joshua, Zeidan, Anne, Zirkle, Lewis, Allen, Brendan, and Abdullah, Fizan

Published
2017
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34. Abstract 074: Empagliflozin Improves Impaired Sensitivity Of Afferent Neurons With Renal Axons

Author

Kristina Rodionova, Tilmann Ditting, Karl F Hilgers, Linz Peter, Roland E Schmieder, Christian Ott, Mario Schiffer, Kerstin Amann, and Roland Veelken

Subjects
Internal Medicine
Abstract

Afferent renal nerve pathways likely play a role in salt sensitive hypertension. We recently reported that high salt diet (HS) impairs these afferent renal pathways in rats. Now we tested the hypothesis that during HS a decrease in sensitivity of renal afferent neurons is prevented by the SGLT2 inhibitor empagiflozin.Respective groups of rats were put on HS containing 8% NaCl or a normal diet. Two groups (HS, controls) received empagiflozin 20 mg/kg BW/day orally. Renal neurons were retrogradely labeled with DiI. In culture, labeled dorsal root ganglion neurons (DRG Th11-L2) with renal afferents were investigated electrophysiologically using current clamp mode to assess action potential generation during current injection. Neurons were characterized as tonic highly active (> 5 action potentials, AP) and phasic less active neurons (≤ 5 AP upon stimulation. )In neurons from rats on HS, the relation of tonic highly active neurons to less active phasic neurons shifted consistently towards phasic units (63,8% tonic neurons in controls vs. 42%* on HS, *p

Published
2022
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35. The SGLT2 inhibitor empagliflozin reduces tissue sodium content in patients with chronic heart failure: results from a placebo-controlled randomised trial

Author

Kolwelter, Julie, primary, Kannenkeril, Dennis, additional, Linz, Peter, additional, Jung, Susanne, additional, Nagel, Armin M., additional, Bosch, Agnes, additional, Ott, Christian, additional, Bramlage, Peter, additional, Nöh, Lisa, additional, Schiffer, Mario, additional, Uder, Michael, additional, Achenbach, Stephan, additional, and Schmieder, Roland E., additional

Published
2022
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47. Tolvaptan treatment in an adult Fontan patient with protein-losing enteropathy: a serial 23Na-MRI investigation

Author

Moosmann, Julia, Toka, Okan, Linz, Peter, Dahlmann, Anke, Nagel, Armin M., Schiffer, Mario, Uder, Michael, Cesnjevar, Robert, Dittrich, Sven, and Kopp, Christoph

Subjects
RAAS, 23Na-MRI, Tolvaptan, Case Report, ddc:610, Fontan, Congenital heart disease
Abstract

Background: Protein-losing enteropathy (PLE) is a severe complication of the univentricular Fontan circulation and associated with disturbances in salt and water homeostasis. Fontan patients with PLE have a poor prognosis, with increased morbidity and mortality. Due to limited therapeutic strategies, patients are often treated only symptomatically. Methods: We report our first experience of Tolvaptan (TLV) treatment in a Fontan patient with PLE, severe volume retention and hyponatraemia, refractory to conventional diuretic therapy. In addition to clinical parameters, we monitored drug effects including tissue sodium and volume status via serial 23Na-magnetic resonance imaging (23Na-MRI) and bioimpedance spectroscopy compared with age-matched controls. Results: 23Na-MRI identified elevated tissue sodium, which decreased under TLV treatment, as well as volume status, while serum sodium increased and the patient’s symptoms improved. During long-term treatment, we were able to differentiate between sodium and volume status in our patient, suggesting that TLV uncoupled body sodium from water. Conclusion: TLV in addition to loop diuretics improved clinical symptoms of PLE and lowered tissue sodium overload. Long-term effects should be further evaluated in Fontan patients.

Published
2021

48. Paradoxical reduction in HDL-C with fenofibrate and thiazolidinedione therapy in type 2 diabetes: The ACCORD Lipid Trial

Author

Linz, Peter E., Lovato, Laura C., Byington, Robert P., O'Connor, Patrick J., Leiter, Lawrence A., Weiss, Daniel, Force, Rex W., Crouse, John R., Ismail-Beigi, Faramarz, Simmons, Debra L., Papademetriou, Vasilios, Ginsberg, Henry N., and Elam, Marshall B.

Subjects
Fenofibrate -- Research -- Usage, Cholesterol, HDL -- Research -- Analysis -- Measurement, Type 2 diabetes -- Research -- Drug therapy -- Patient outcomes, Health
Abstract

OBJECTIVE To determine the occurrence of extremely low HDL cholesterol (HDL-C) among participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Lipid Trial and to examine the relationship [...]

Published
2014
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49. Cognitive Function and Brain Structure in Persons With Type 2 Diabetes Mellitus After Intensive Lowering of Blood Pressure and Lipid Levels: A Randomized Clinical Trial

Author

Williamson, Jeff D., Launer, Lenore J., Bryan, Nick R., Coker, Laura H., Lazar, Ronald M., Gerstein, Hertzel C., Murray, Anne M., Sullivan, Mark D., Horowitz, Karen R., Ding, Jingzhong, Marcovina, Santica, Lovato, Laura, Lovato, James, Margolis, Karen L., Davatzikos, Christos, Barzilay, Joshua, Ginsberg, Henry N., Linz, Peter E., and Miller, Michael E.

Published
2014
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50. Hemodialysis Patients with Cardiovascular Disease Reveal Increased Tissue Na+ Deposition

Author

Friedrich, Anna-Carolina, Linz, Peter, Nagel, Armin M., Rosenhauer, Daniela, Horn, Stephan, Schiffer, Mario, Uder, Michael, Kopp, Christoph, and Dahlmann, Anke

Subjects
Sodium, Dermatology, Tissue Na+, Cardiovascular disease, 23Na-magnetic resonance imaging, Hemodialysis, Magnetic Resonance Imaging, Diseases of the genitourinary system. Urology, Cardiovascular Diseases, Renal Dialysis, RL1-803, RC666-701, Humans, Kidney Failure, Chronic, Diseases of the circulatory (Cardiovascular) system, ddc:610, RC870-923, Skin
Abstract

The relationship between Na+ balance and cardiovascular disease (CVD) in hemodialysis (HD) patients is not yet fully understood. We hypothesized that HD patients co-diagnosed with CVD show increased tissue Na+ accumulation compared to HD patients without CVD. Methods: In our observational study, 52 HD patients were divided into a group with (23 subjects) or without (29 subjects) a positive history of cardiovascular events. We used 23Na-magnetic resonance imaging (23Na-MRI) at 3.0 Tesla to quantify Na+ content in skin and muscle of both groups directly before and after HD. Additionally, total body fluid distribution was determined by bioimpedance spectroscopy (BIS) and laboratory parameters were assessed. Results: Compared to HD patients without CVD, 23Na-MRI detected an increased Na+ content in skin (21.7 ± 7.3 vs. 30.2 ± 9.8 arbitrary units (a.u.), p < 0.01) and muscle tissue (21.5 ± 3.6 vs. 24.7 ± 6.0 a.u., p < 0.05) in patients with previous CVD events. Simultaneously measured fluid amount by BIS, includingexcess extracellular water (1.8 ± 1.7 vs. 2.2 ± 1.7 L, p = 0.44), was not significantly different between both groups. Tissue Na+ accumulation in HD-CVD patients was paralleled by a higher plasma concentration of the inflammation marker interleukin-6 (5.1, IQR 5.8 vs. 8.5, IQR 7.9 pg/mL, p < 0.05). Conclusion: In our cohort, HD patients with CVD showed higher tissue Na+ content than HD patients without CVD, while no difference in body water distribution could be detected between both groups. Our findings provide evidence that the history of a cardiovascular event is associated with disturbances in tissue Na+ content in HD patients.

Published
2021

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