10 results on '"Lisa Atkinson"'
Search Results
2. Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect
- Author
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Niccolò Morè, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro Montón Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, and Alessandra Polissi
- Subjects
Escherichia coli ,cell envelope ,lipopolysaccharide ,peptidoglycan ,stress response ,Microbiology ,QR1-502 - Abstract
ABSTRACT Gram-negative bacteria have a tripartite cell envelope with the cytoplasmic membrane (CM), a stress-bearing peptidoglycan (PG) layer, and the asymmetric outer membrane (OM) containing lipopolysaccharide (LPS) in the outer leaflet. Cells must tightly coordinate the growth of their complex envelope to maintain cellular integrity and OM permeability barrier function. The biogenesis of PG and LPS relies on specialized macromolecular complexes that span the entire envelope. In this work, we show that Escherichia coli cells are capable of avoiding lysis when the transport of LPS to the OM is compromised, by utilizing LD-transpeptidases (LDTs) to generate 3-3 cross-links in the PG. This PG remodeling program relies mainly on the activities of the stress response LDT, LdtD, together with the major PG synthase PBP1B, its cognate activator LpoB, and the carboxypeptidase PBP6a. Our data support a model according to which these proteins cooperate to strengthen the PG in response to defective OM synthesis. IMPORTANCE In Gram-negative bacteria, the outer membrane protects the cell against many toxic molecules, and the peptidoglycan layer provides protection against osmotic challenges, allowing bacterial cells to survive in changing environments. Maintaining cell envelope integrity is therefore a question of life or death for a bacterial cell. Here we show that Escherichia coli cells activate the LD-transpeptidase LdtD to introduce 3-3 cross-links in the peptidoglycan layer when the integrity of the outer membrane is compromised, and this response is required to avoid cell lysis. This peptidoglycan remodeling program is a strategy to increase the overall robustness of the bacterial cell envelope in response to defects in the outer membrane.
- Published
- 2019
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3. Survey of nurses and nurse-interns on the importance of chemistry topics in professional practice
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Wendy Lou Elcesser, Lisa Atkinson, and Emma Bouchard
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- 2021
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4. Current Breast Imaging Modalities, Advances, and Impact on Breast Care
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Lisa Atkinson, Lisa S. Mitchell, Eileen Kenny, Erik S. Storm, and Evelyn M. Garcia
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Diagnostic Imaging ,medicine.medical_specialty ,Breast imaging ,Breast Neoplasms ,Breast cancer screening ,Breast cancer ,medicine ,Humans ,Breast MRI ,Mammography ,Medical physics ,Early Detection of Cancer ,Ultrasonography ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Tomosynthesis ,Elasticity Imaging Techniques ,Female ,Elastography ,business ,Delivery of Health Care - Abstract
Mammography will continue as the breast cancer screening imaging study of choice for the foreseeable future. Ultrasound and magnetic resonance imaging (MRI) are widely available adjunctive studies for women with suspicious mammographic or clinical findings, and MRI is a screening tool for women with specific increased risks for breast cancer. Options for diagnosis will continue to evolve and progress. This article discusses a wide variety of imaging options currently used and in development, their strengths, limitations, and potential future roles in the continuing pursuit of early breast cancer diagnosis, treatment, and follow-up.
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- 2013
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5. Medicolegal Considerations in Breast Health
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Beverly H. Binner, Lisa Atkinson, Patrice M. Weiss, Emily Gannon, Eileen Kenny, Lisa S. Mitchell, and Catherine Hagan-Aylor
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Gynecology ,medicine.medical_specialty ,business.industry ,Specialty ,Obstetrics and Gynecology ,Medical malpractice ,medicine.disease ,Delayed diagnosis ,Clinical expertise ,Breast cancer ,Obstetrics and gynaecology ,Malpractice ,Family medicine ,medicine ,Breast disease ,skin and connective tissue diseases ,business - Abstract
A common endeavor shared by physicians practicing in specialty fields of Radiology and Obstetrics and Gynecology is the comprehensive care and diagnosis of women with breast problems and breast disease. Because each specialty provides its respective clinical expertise in breast health, each also shares a concern, which is the high risk of litigation associated with a missed or delayed diagnosis of breast cancer. This shared concern is well documented for both specialties. Instead, it is argued that physicians are better prepared by engaging in the practice of evidence-based breast care in their respective specialties.
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- 2013
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6. Evolution of Imaging in Breast Cancer
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Evelyn M. Garcia, Catherine Hagan, Lisa Atkinson, and James Crowley
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medicine.medical_specialty ,Breast imaging ,Advanced breast ,Breast Neoplasms ,Xeromammography ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,medicine ,Humans ,Medical physics ,skin and connective tissue diseases ,Randomized Controlled Trials as Topic ,medicine.diagnostic_test ,business.industry ,Mammography Quality Standards Act ,Obstetrics and Gynecology ,Magnetic resonance imaging ,Digital Breast Tomosynthesis ,medicine.disease ,Magnetic Resonance Imaging ,Molecular Imaging ,Clinical trial ,Thermography ,030220 oncology & carcinogenesis ,Female ,business ,Mammography - Abstract
The following topics are discussed in this article. A historical review of the evolution of breast cancer imaging from thermography through digital breast tomosynthesis, molecular breast imaging, and advanced breast magnetic resonance imaging. Discussion of multiple clinical trials, their strengths, and weaknesses. Historical perspective on the Mammography Quality Standards Act and its relationship with development and implementation of the Breast Imaging-Reporting and Data System (BI-RADS).
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- 2016
7. Rewiring Neural States in Couples Therapy: Advances from Affective Neuroscience
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Jeff Lata, Kari Wittmann Lata, Julie Szekely, Lisa Atkinson, Paul Weiss, Brent Atkinson, and Paula Kutz
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Cognitive science ,Psychotherapist ,Brain state ,Action (philosophy) ,Conscious awareness ,Consciousness states ,Daily living ,Flexibility (personality) ,Narrative ,Affective neuroscience ,Psychology - Abstract
Many clinical approaches assume that the development of new stories or narratives is at the heart of therapeutic change. But why is it often so difficult for clients to modify the stories that organize their lives? Why do new insights gained in therapy fade so quickly when clients return to their daily living? Provocative new neurological research suggests that self-defeating narratives may persist because they are woven into the fabric of internal states which are automatically activated in daily living, often without conscious awareness. New brain studies suggest that, for changes acquired in therapy to last, they must be integrated into brain states that become active when upsetting situations occur. This paper introduces methods for helping clients identify internal states which perpetuate outmoded thoughts, attitudes, and interactions, “re-wire” these states for more flexibility, and activate alternate states which support new avenues for thought and action.
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- 2005
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8. Medicolegal considerations in breast health: the benefits of collaboration between OB/GYNs and radiologists
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Lisa S, Mitchell, Lisa, Atkinson, Catherine, Hagan-Aylor, Beverly H, Binner, Emily, Gannon, Patrice M, Weiss, and Eileen, Kenny
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Obstetrics ,Patient Care Team ,Gynecology ,Malpractice ,Humans ,Breast Neoplasms ,Female ,Radiology ,Early Detection of Cancer - Abstract
A common endeavor shared by physicians practicing in specialty fields of Radiology and Obstetrics and Gynecology is the comprehensive care and diagnosis of women with breast problems and breast disease. Because each specialty provides its respective clinical expertise in breast health, each also shares a concern, which is the high risk of litigation associated with a missed or delayed diagnosis of breast cancer. This shared concern is well documented for both specialties. Instead, it is argued that physicians are better prepared by engaging in the practice of evidence-based breast care in their respective specialties.
- Published
- 2013
9. The relationship between counterfactual thinking and emotional reactions to event outcomes: Does one account fit all?
- Author
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Lisa Atkinson
- Subjects
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THOUGHT & thinking , *EMOTIONS , *CONDITIONED response , *EXPERIMENTAL psychology , *COMPARATIVE studies , *DECISION making - Abstract
By enabling a comparison between what is and what might have been, counterfactual thoughts amplify our emotional responses to bad outcomes. Well-known demonstrations such as the action effect (the tendency to attribute most regret to a character whose actions brought about a bad outcome) and the temporal order effect (the tendency to undo the last in a series of events leading up to a bad outcome) are often explained in this way. An important difference between these effects is that outcomes are due to decisions in the action effect, whereas in the temporal order effect outcomes are achieved by chance. In Experiment 1, we showed that imposing time pressure leads to a significant reduction in the action but not in the temporal order effect. In Experiment 2, we found that asking participants to evaluate the protagonists ("who ought to feel worse?") led to a significant reduction in the temporal order but not in the action effect. The results suggest that the action and temporal order effects require different explanations and are consistent with other work that suggests that when decisions lead to bad outcomes a comparison of decision quality is an important determinant of the emotional response attributed to the protagonists. The stimulus materials used in our experiments may be downloaded from pbr.psychonomic-journals.org/content/supplemental. [ABSTRACT FROM AUTHOR]
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- 2009
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10. Stock Ownership and Company Contributions to Charity
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Lisa Atkinson and Joseph Galaskiewicz
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Finance ,Public Administration ,Sociology and Political Science ,business.industry ,Social proximity ,Principal–agent problem ,Accounting ,CobB ,Family group ,Arts and Humanities (miscellaneous) ,Elite ,Joint-stock company ,Twin cities ,business ,Stock (geology) - Abstract
Funding for this research was provided by the National Science Foundation (SES 800 8570) and the Program on Nonprofit Organizations, Yale University. We would like to thank Denise Cobb for her assistance in typing the manuscript and an anonymous ASQ reviewer for his or her insightful comments. This paper examines the effect of ownership patterns on corporate contributions to charity and corporate beliefs rationalizing contributions. The study uses data and findings from an earlier study of the Twin Cities corporate grants economy and new data on 69 publicly held firms headquartered in Minneapolis-St. Paul to test hypotheses derived from agency theory about corporate giving. Controlling for pretax income, proximity of the company's executives to the local philanthropic elite, and the rationale used to justify contributions, we found that companies gave less money to charity in 1979-1981 if the CEO or some other individual owned a significant percentage of stock in the company. In contrast, the percentage of stock owned by a single corporate interest or family group had no effect on company contributions. Social proximity of executives to the local philanthropic activists had a positive effect on contributions, except when a family group owned more than 5 percent of the company's stock. We explore the implications of our findings from the perspective of agency theory and business policy.'
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- 1988
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