Search

Your search keyword '"Liska, David"' showing total 704 results
Start Over Author "Liska, David"
704 results on '"Liska, David"'

6. Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial

Author

Verheij, Floris S, Omer, Dana M, Williams, Hannah, Lin, Sabrina T, Qin, Li-Xuan, Buckley, James T, Thompson, Hannah M, Yuval, Jonathan B, Kim, Jin K, Dunne, Richard F, Marcet, Jorge, Cataldo, Peter, Polite, Blase, Herzig, Daniel O, Liska, David, Oommen, Samuel, Friel, Charles M, Ternent, Charles, Coveler, Andrew L, Hunt, Steven, Gregory, Anita, Varma, Madhulika G, Bello, Brian L, Carmichael, Joseph C, Krauss, John, Gleisner, Ana, Guillem, José G, Temple, Larissa, Goodman, Karyn A, Segal, Neil H, Cercek, Andrea, Yaeger, Rona, Nash, Garrett M, Widmar, Maria, Wei, Iris H, Pappou, Emmanouil P, Weiser, Martin R, Paty, Philip B, Smith, J Joshua, Wu, Abraham J, Gollub, Marc J, Saltz, Leonard B, and Garcia-Aguilar, Julio

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Rare Diseases, Radiation Oncology, Clinical Trials and Supportive Activities, Clinical Research, Orphan Drug, Patient Safety, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Humans, Adenocarcinoma, Chemoradiotherapy, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Neoplasm Staging, Organ Preservation, Rectal Neoplasms, Treatment Outcome, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.To assess long-term risk of local tumor regrowth, we report updated organ preservation rate and oncologic outcomes of the OPRA trial (ClinicalTrials.gov identifier: NCT02008656). Patients with stage II/III rectal cancer were randomly assigned to receive induction chemotherapy followed by chemoradiation (INCT-CRT) or chemoradiation followed by consolidation chemotherapy (CRT-CNCT). Patients who achieved a complete or near-complete response after finishing treatment were offered watch-and-wait (WW). Total mesorectal excision (TME) was recommended for those who achieved an incomplete response. The primary end point was disease-free survival (DFS). The secondary end point was TME-free survival. In total, 324 patients were randomly assigned (INCT-CRT, n = 158; CRT-CNCT, n = 166). Median follow-up was 5.1 years. The 5-year DFS rates were 71% (95% CI, 64 to 79) and 69% (95% CI, 62 to 77) for INCT-CRT and CRT-CNCT, respectively (P = .68). TME-free survival was 39% (95% CI, 32 to 48) in the INCT-CRT group and 54% (95% CI, 46 to 62) in the CRT-CNCT group (P = .012). Of 81 patients with regrowth, 94% occurred within 2 years and 99% occurred within 3 years. DFS was similar for patients who underwent TME after restaging (64% [95% CI, 53 to 78]) and patients in WW who underwent TME after regrowth (64% [95% CI, 53 to 78]; P = .94). Updated analysis continues to show long-term organ preservation in half of the patients with rectal cancer treated with total neoadjuvant therapy. In patients who enter WW, most cases of tumor regrowth occur in the first 2 years.

Published
2024

15. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy.

Author

Garcia-Aguilar, Julio, Patil, Sujata, Gollub, Marc, Kim, Jin, Yuval, Jonathan, Thompson, Hannah, Verheij, Floris, Omer, Dana, Lee, Meghan, Dunne, Richard, Marcet, Jorge, Cataldo, Peter, Polite, Blase, Herzig, Daniel, Liska, David, Oommen, Samuel, Friel, Charles, Ternent, Charles, Coveler, Andrew, Hunt, Steven, Gregory, Anita, Krauss, John, Gleisner, Ana, Paty, Philip, Weiser, Martin, Nash, Garrett, Pappou, Emmanouil, Guillem, José, Temple, Larissa, Wei, Iris, Widmar, Maria, Lin, Sabrina, Segal, Neil, Cercek, Andrea, Yaeger, Rona, Smith, J, Goodman, Karyn, Wu, Abraham, Saltz, Leonard, Bello, Brian, Varma, Madhulika, and Carmichael, Joseph

Subjects
Adenocarcinoma, Antineoplastic Combined Chemotherapy Protocols, Capecitabine, Chemoradiotherapy, Disease-Free Survival, Fluorouracil, Humans, Neoadjuvant Therapy, Neoplasm Staging, Organ Preservation, Oxaliplatin, Prospective Studies, Rectal Neoplasms
Abstract

PURPOSE: Prospective data on the efficacy of a watch-and-wait strategy to achieve organ preservation in patients with locally advanced rectal cancer treated with total neoadjuvant therapy are limited. METHODS: In this prospective, randomized phase II trial, we assessed the outcomes of 324 patients with stage II or III rectal adenocarcinoma treated with induction chemotherapy followed by chemoradiotherapy (INCT-CRT) or chemoradiotherapy followed by consolidation chemotherapy (CRT-CNCT) and either total mesorectal excision (TME) or watch-and-wait on the basis of tumor response. Patients in both groups received 4 months of infusional fluorouracil-leucovorin-oxaliplatin or capecitabine-oxaliplatin and 5,000 to 5,600 cGy of radiation combined with either continuous infusion fluorouracil or capecitabine during radiotherapy. The trial was designed as two stand-alone studies with disease-free survival (DFS) as the primary end point for both groups, with a comparison to a null hypothesis on the basis of historical data. The secondary end point was TME-free survival. RESULTS: Median follow-up was 3 years. Three-year DFS was 76% (95% CI, 69 to 84) for the INCT-CRT group and 76% (95% CI, 69 to 83) for the CRT-CNCT group, in line with the 3-year DFS rate (75%) observed historically. Three-year TME-free survival was 41% (95% CI, 33 to 50) in the INCT-CRT group and 53% (95% CI, 45 to 62) in the CRT-CNCT group. No differences were found between groups in local recurrence-free survival, distant metastasis-free survival, or overall survival. Patients who underwent TME after restaging and patients who underwent TME after regrowth had similar DFS rates. CONCLUSION: Organ preservation is achievable in half of the patients with rectal cancer treated with total neoadjuvant therapy, without an apparent detriment in survival, compared with historical controls treated with chemoradiotherapy, TME, and postoperative chemotherapy.

Published
2022

19. Prehabilitation as an Integral Procedure in Predictive, Preventive, and Personalized Medicine and Modern and Effective Healthcare

Author

Mrázová, Barbara, Kapalla, Marko, Liška, Dávid, Martuliak, Igor, Flašková, Martina, Mráz, Ján, Marko, Ľubomír, Golubnitschaja, Olga, Series Editor, Baban, Babak, Editorial Board Member, Bubnov, Rostylav, Editorial Board Member, Costigliola, Vincenzo, Editorial Board Member, Grech, Godfrey, Editorial Board Member, Mozaffari, Mahmood, Editorial Board Member, Parini, Paolo, Editorial Board Member, Paul, Friedermann, Editorial Board Member, Yoo, Byong Chul, Editorial Board Member, Zhan, Xianquan, Editorial Board Member, Andrews, Russell J., Editorial Board Member, Fröhlich, Holger, Editorial Board Member, Kokubo, Yoshihiro, Editorial Board Member, Krapfenbauer, Kurt, Editorial Board Member, Podbielska, Halina, Editorial Board Member, Tasker, R. Andrew, Editorial Board Member, Nardini, Christine, Editorial Board Member, Chaari, Lotfi, Editorial Board Member, Polivka Jr., Jiri, Editorial Board Member, Mandel, Silvia, Editorial Board Member, Erb, Carl, Editorial Board Member, Wang, Wei, Editorial Board Member, and Kapalla, Marko, editor

Published
2023
Full Text
View/download PDF

25. Astro2020 APC White Paper: Astronomy should be in the clouds

Author

Smith, Arfon M., Pike, Rob, O'Mullane, William, Economou, Frossie, Bolton, Adam, Momcheva, Ivelina, Bauer, Amanda E, Becker, Bruce, Bellm, Eric, Connolly, Andrew, Crawford, Steven M., Hathi, Nimish, Melchior, Peter, Peek, Joshua, Solmaz, Arif, Thomson, Ross, TollerudI, Erik, and Liska, David W.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Commodity cloud computing, as provided by commercial vendors such as Amazon, Google, and Microsoft, has revolutionized computing in many sectors. With the advent of a new class of big data, public access astronomical facility such as LSST, DKIST, and WFIRST, there exists a real opportunity to combine these missions with cloud computing platforms and fundamentally change the way astronomical data is collected, processed, archived, and curated. Making these changes in a cross-mission, coordinated way can provide unprecedented economies of scale in personnel, data collection and management, archiving, algorithm and software development and, most importantly, science.

Published
2019

28. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines

Author

Cavestro, Giulia Martina, Mannucci, Alessandro, Balaguer, Francesc, Hampel, Heather, Kupfer, Sonia S., Repici, Alessandro, Sartore-Bianchi, Andrea, Seppälä, Toni T., Valentini, Vincenzo, Boland, Clement Richard, Brand, Randall E., Buffart, Tineke E., Burke, Carol A., Caccialanza, Riccardo, Cannizzaro, Renato, Cascinu, Stefano, Cercek, Andrea, Crosbie, Emma J., Danese, Silvio, Dekker, Evelien, Daca-Alvarez, Maria, Deni, Francesco, Dominguez-Valentin, Mev, Eng, Cathy, Goel, Ajay, Guillem, Josè G., Houwen, Britt B.S.L., Kahi, Charles, Kalady, Matthew F., Kastrinos, Fay, Kühn, Florian, Laghi, Luigi, Latchford, Andrew, Liska, David, Lynch, Patrick, Malesci, Alberto, Mauri, Gianluca, Meldolesi, Elisa, Møller, Pål, Monahan, Kevin J., Möslein, Gabriela, Murphy, Caitlin C., Nass, Karlijn, Ng, Kimmie, Oliani, Cristina, Papaleo, Enrico, Patel, Swati G., Puzzono, Marta, Remo, Andrea, Ricciardiello, Luigi, Ripamonti, Carla Ida, Siena, Salvatore, Singh, Satish K., Stadler, Zsofia K., Stanich, Peter P., Syngal, Sapna, Turi, Stefano, Urso, Emanuele Damiano, Valle, Laura, Vanni, Valeria Stella, Vilar, Eduardo, Vitellaro, Marco, You, Yi-Qian Nancy, Yurgelun, Matthew B., Zuppardo, Raffaella Alessia, and Stoffel, Elena M.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results