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1. Hemostase en trombose

Author

Lisman, T., Coppens, M., Heineman, E., editor, Heineman, D.J., editor, Lange jr., J.F.M., editor, Blankensteijn, J.D., editor, Boermeester, M.A., editor, Borel Rinkes, I.H.M., editor, Klaase, J.M., editor, Schipper, I.B., editor, Schreurs, W.H., editor, and Wijnen, R.M.H., editor

Published
2021
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7. Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy

Author

Touw, C.E., Nemeth, B., Adrichem, R.A. van, Vlieg, A.V., Nelissen, R.G.H.H., Lisman, T., and Cannegieter, S.C.

Subjects
Arthroscopy, Thrombin generation, Coagulation, Leg injury, Hematology, Knee injury
Abstract

Background There is room for improvement of prevention of venous thromboembolism (VTE) after lower-leg cast application or knee arthroscopy. Information about the mechanism of clot formation in these patients may be useful to identify new prophylaxis targets. We aimed to study the effect of 1) lower-leg injury and 2) knee arthroscopy on thrombin generation. Methods A cross-sectional study was conducted using plasma samples of POT-(K)CAST trials to measure ex vivo thrombin generation (Calibrated Automated Thrombography [CAT]) and plasma levels of prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin (TAT), fibrinopeptide A (FPA). Plasma was obtained shortly after lower-leg trauma or before and after ( Results In patients with lower-leg injury (aim 1), endogenous thrombin potential, thrombin peak, velocity index, FPA and TAT were increased as compared with controls. In arthroscopy patients (aim 2), pre- and postoperative levels were similar for all parameters. Conclusion Lower-leg trauma increases thrombin generation both ex vivo and in vivo, in contrast to knee arthroscopy. This may imply that the pathogenesis of VTE is different in both situations.

Published
2023

13. Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units

Author

Noordermeer, Tessa, Schutgens, Roger E. G., Visser, Chantal, Rademaker, Emma, de Maat, Moniek P. M., Jansen, A. J. Gerard, Limper, Maarten, Cremer, Olaf L., Kruip, Marieke J. H. A., Endeman, Henrik, Maas, Coen, de Laat, Bas, Urbanus, Rolf T., van de Beek, D., Brouwer, M. C., de Bruin, S., Coppens, M., van Es, N., van Haaps, T. F., Juffermans, N. P., Muller, M. C. A., Vlaar, A. P. J., Hertogh, C. M. P. M., Heunks, L. M. A., Hugtenburg, J. G., van Kooten, J., Nossent, E. J., Smulders, Y., Tuinman, P. R., Noordegraaf, A. Vonk, Grootenboers, M. J. J. H., van Guldener, C., Kant, M., Lansbergen, A., Faber, J., Hajer, G., Stemerdink, A., van den Akker, J., Bierings, R., Endeman, H., Goeijenbier, M., Hunfeld, N. G. M., van Gorp, E. C. M., Gommers, D. A. M. P. J., Koopmans, M. P. G., Kruip, M. J. H. A., Kuiken, T., Langerak, T., Leebeek, Lauw, M. N., de Maat, M. P. M., Noack, D., Paats, M. S., Raadsen, M. P., Rockx, B., Rokx, C., Schurink, C. A. M., Tong-Minh, K., van den Toorn, L., den Uil, C. A., Visser, C., Boutkourt, F., Roest, T., Douma, R. A., de Haan, L. R., ten Wolde, M., Bemelmans, R. H. H., Festen, B., Stads, S., de Jager, C. P. C., Simons, K. S., Antoni, M. L., Bos, M. H., Burggraaf, J. L. I., Cannegieter, S. C., Eikenboom, H. C. J., den Exter, P. L., Geelhoed, J. J. M., Huisman, M. V., de Jonge, E., Kaptein, F. H. J., Klok, F. A., Kroft, L. J. M., Lijfering, W. M., Nab, L., Ninaber, M. K., Putter, H., Ramai, S. R. S., da Rocha Rondon, A. M., Roukens, A. H. E., Stals, M. A. M., Versteeg, H. H., Vliegen, H. W., van Vlijmen, B. J. M., van de Berg, T., Bruggemann, R., van Bussel, B. C. T., ten Cate, H., ten Cate-Hoek, A., Hackeng, T. M., Henskens, ir. Y., Hulshof, A., Mulder, M., Olie, R. H., Schurgers, L., Spaetgens, B., Spronk, H., Spruit, M. A., Winckers, K., Nieuwenhuizen, L., Franken, B., Schrover, I. M., de Waal, E. G. M., Beishuizen, A., Cornet, A., Krabbe, J., Kramers, K., Leentjens, J., de Mast, Q., Middeldorp, S., Brouwer, R. E., Ellerbroek, J. L. J., Tijmensen, J., Hovens, M. M. C., Oostdijk, E. A. N., Westerhof, B. D., Faber, L. M., van den Biggelaar, M., Meijers, J. C. M., Voorberg, J., Kevenaar, M. E., Soei, Y. L., Wils, E. J., Croles, F. N., de Laat, B., Kamphuisen, P. W., Vink, R., Lisman, T., Meijer, K., van Tichelaar, Y. I. G., Cremer, O. L., Geersing, G., Kaasjager, H. A. H., Kusadasi, N., Huisman, A., Maas, C., Nijkeuter, M., Schutgens, R. E. G., Creveldkliniek, Van, Urbanus, R. T., Westerink, J., Faber, H. J., Koster, S. C. E., van Montfort, P., van Twist, D. J. L., RS: Carim - B01 Blood proteins & engineering, Biochemie, Hematology, Intensive Care, Neurology, ANS - Neuroinfection & -inflammation, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, Graduate School, ACS - Microcirculation, Medical Microbiology and Infection Prevention, ARD - Amsterdam Reproduction and Development, Experimental Vascular Medicine, Landsteiner Laboratory, ACS - Atherosclerosis & ischemic syndromes, Elderly care medicine, APH - Aging & Later Life, Clinical pharmacology and pharmacy, APH - Health Behaviors & Chronic Diseases, Pulmonary medicine, Internal medicine, ACS - Diabetes & metabolism, Intensive care medicine, General practice, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], lupus anticoagulant, risk factor, critically ill, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], COVID-19, Hematology, thrombosis, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Contains fulltext : 286889.pdf (Publisher’s version ) (Open Access) BACKGROUND: Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) is a strong acquired risk factor for thrombosis in various diseases and is frequently observed in patients with COVID-19. Whether LA is associated with thrombosis in patients with severe COVID-19 is currently unclear. OBJECTIVE: To investigate if LA is associated with thrombosis in critically ill patients with COVID-19. PATIENTS/METHODS: The presence of LA and other antiphospholipid antibodies was assessed in patients with COVID-19 admitted to the ICU. LA was determined with dilute Russell's viper venom time (dRVVT) and LA-sensitive activated partial thromboplastin time (aPTT) reagents. RESULTS: Of 169 patients with COVID-19, 116 (69%) tested positive for at least one antiphospholipid antibody upon admission to the ICU. Forty (24%) patients tested positive for LA; of whom 29 (17%) tested positive with a dRVVT, 19 (11%) tested positive with an LA-sensitive aPTT, and 8 (5%) tested positive on both tests. Fifty-eight (34%) patients developed thrombosis after ICU admission. The odds ratio (OR) for thrombosis in patients with LA based on a dRVVT was 2.5 (95% confidence interval [CI], 1.1-5.7), which increased to 4.5 (95% CI, 1.4-14.3) in patients at or below the median age in this study (64 years). LA positivity based on a dRVVT or LA-sensitive aPTT was only associated with thrombosis in patients aged less than 65 years (OR, 3.8; 95% CI, 1.3-11.4) and disappeared after adjustment for C-reactive protein. CONCLUSION: Lupus anticoagulant on admission is strongly associated with thrombosis in critically ill patients with COVID-19, especially in patients aged less than 65 years.

Published
2022

14. PFA-100 als Marker der primären Hämostase steht in keinem Zusammenhang mit Dekompensation/Mortalität oder Blutungen/Thrombosen bei Patienten mit fortgeschrittener chronischer Lebererkrankung

Author

Balcar, L, additional, Scheiner, B, additional, Paternostro, R, additional, Simbrunner, B, additional, Jachs, M, additional, Hartl, L, additional, Semmler, G, additional, Stättermayer, AF, additional, Pinter, M, additional, Trauner, M, additional, Quehenberger, P, additional, Lisman, T, additional, Reiberger, T, additional, and Mandorfer, M, additional

Published
2022
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15. Detection and localization of early- and late-stage cancers using platelet RNA

Author

Veld, S., Arkani, M., Post, E., Antunes-Ferreira, M., D'Ambrosi, S., Vessies, D.C.L., Vermunt, L., Vancura, A., Muller, Mirte, Niemeijer, A.N., Tannous, J., Meijer, L.L., Large, T.Y. Le, Mantini, G., Wondergem, N.E., Heinhuis, K.M., Wilpe, S. van, Smits, Josien, Drees, E.E.E., Roos, E., Leurs, C.E., Fat, L.A. Tjon Kon, Lelij, E.J. van der, Dwarshuis, G., Kamphuis, M.J., Visser, Leonie N.C., Harting, R., Gregory, A., Schweiger, M.W., Wedekind, L.E., Ramaker, J., Zwaan, K., Verschueren, H., Bahce, I, Langen, A.J. de, Smit, E.F., Heuvel, M.M. van den, Hartemink, K.J., Kuijpers, M.J., Egbrink, M.G.A. Oude, Griffioen, A.W., Rossel, R., Hiltermann, T.J.N., Lee-Lewandrowski, E., Lewandrowski, K.B., Hamer, P.C., Kouwenhoven, M., Reijneveld, J.C., Leenders, W.P.J., Hoeben, A., Verdonck-de Leeuw, I.M., Leemans, C.Rene, Baatenburg de Jong, R.J., Terhaard, Chris H. J., Takes, R.P., Langendijk, J.A., Jager, S.C. de, Kraaijeveld, A.O., Pasterkamp, G., Smits, M., Schalken, J.A., Łapińska-Szumczyk, S., Łojkowska, A., Żaczek, A.J., Lokhorst, H., Donk, N. van de, Nijhof, I., Prins, H.J., Zijlstra, J.M., Idema, S., Baayen, J.C., Teunissen, C.E., Killestein, J., Besselink, M.G.H., Brammen, L., Bachleitner-Hofmann, T., Mateen, F., Plukker, J.T., Heger, M., Mast, Q. de, Lisman, T., Pegtel, D.M., Bogaard, H.J., Jassem, J., Supernat, A., Mehra, N., Gerritsen, W.R., Kroon, C.D. de, Lok, C. A. R., Piek, J.M.J., Steeghs, N., Houdt, W.J. van, Brakenhoff, R.H., Sonke, G.S., Verheul, H.M.W., Giovannetti, E., Kazemier, G., Sabrkhany, S., Schuuring, E., Sistermans, E.A., Veld, S., Arkani, M., Post, E., Antunes-Ferreira, M., D'Ambrosi, S., Vessies, D.C.L., Vermunt, L., Vancura, A., Muller, Mirte, Niemeijer, A.N., Tannous, J., Meijer, L.L., Large, T.Y. Le, Mantini, G., Wondergem, N.E., Heinhuis, K.M., Wilpe, S. van, Smits, Josien, Drees, E.E.E., Roos, E., Leurs, C.E., Fat, L.A. Tjon Kon, Lelij, E.J. van der, Dwarshuis, G., Kamphuis, M.J., Visser, Leonie N.C., Harting, R., Gregory, A., Schweiger, M.W., Wedekind, L.E., Ramaker, J., Zwaan, K., Verschueren, H., Bahce, I, Langen, A.J. de, Smit, E.F., Heuvel, M.M. van den, Hartemink, K.J., Kuijpers, M.J., Egbrink, M.G.A. Oude, Griffioen, A.W., Rossel, R., Hiltermann, T.J.N., Lee-Lewandrowski, E., Lewandrowski, K.B., Hamer, P.C., Kouwenhoven, M., Reijneveld, J.C., Leenders, W.P.J., Hoeben, A., Verdonck-de Leeuw, I.M., Leemans, C.Rene, Baatenburg de Jong, R.J., Terhaard, Chris H. J., Takes, R.P., Langendijk, J.A., Jager, S.C. de, Kraaijeveld, A.O., Pasterkamp, G., Smits, M., Schalken, J.A., Łapińska-Szumczyk, S., Łojkowska, A., Żaczek, A.J., Lokhorst, H., Donk, N. van de, Nijhof, I., Prins, H.J., Zijlstra, J.M., Idema, S., Baayen, J.C., Teunissen, C.E., Killestein, J., Besselink, M.G.H., Brammen, L., Bachleitner-Hofmann, T., Mateen, F., Plukker, J.T., Heger, M., Mast, Q. de, Lisman, T., Pegtel, D.M., Bogaard, H.J., Jassem, J., Supernat, A., Mehra, N., Gerritsen, W.R., Kroon, C.D. de, Lok, C. A. R., Piek, J.M.J., Steeghs, N., Houdt, W.J. van, Brakenhoff, R.H., Sonke, G.S., Verheul, H.M.W., Giovannetti, E., Kazemier, G., Sabrkhany, S., Schuuring, E., and Sistermans, E.A.

Abstract

Contains fulltext : 281792.pdf (Publisher’s version ) (Open Access), Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.

Published
2022

18. Proceedings of ESPGHAN Monothematic Conference 2020: 'acute Liver Failure in Children': Diagnosis and Initial Management

Author

Zellos, A. Debray, D. Indolfi, G. Czubkowski, P. Samyn, M. Hadzic, N. Gupte, G. Fischler, B. Smets, F. De Cléty, S.C. Grenda, R. Mozer, Y. Mancell, S. Jahnel, J. Auzinger, G. Worth, A. Lisman, T. Staufner, C. Baumann, U. Dhawan, A. Alonso, E. Squires, R.H. Verkade, H.J.

Abstract

Objectives:The Hepatology Committee of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) aims to educate pediatric gastroenterologists, members of ESPGHAN and professionals from other specialties promoting an exchange of clinical expertise in the field of pediatric hepatology. Herewith we have concentrated on detailing the recent advances in acute liver failure in infants and children.Methods:The 2020 ESPGHAN monothematic three-day conference on pediatric hepatology disease, entitled "acute liver failure" (ALF), was organized in Athens, Greece. ALF is a devastating disease with high mortality and most cases remain undiagnosed. As knowledge in diagnosis and treatment of ALF in infants and children has increased in the past decades, the objective was to update physicians in the field with the latest research and developments in early recognition, curative therapies and intensive care management, imaging techniques and treatment paradigms in these age groups.Results:In the first session, the definition, epidemiology, various causes of ALF, in neonates and older children and recurrent ALF (RALF) were discussed. The second session was dedicated to new aspects of ALF management including hepatic encephalopathy (HE), coagulopathy, intensive care interventions, acute on chronic liver failure, and the role of imaging in treatment and prognosis. Oral presentations by experts in various fields are summarized highlighting key learning points.Conclusions:The current report summarizes the major learning points from this meeting. It also identifies areas where there is gap of knowledge, thereby identifying the research agenda for the near future. © 2022 Lippincott Williams and Wilkins. All rights reserved.

Published
2022

31. Safety of direct oral anticoagulants (DOACs) in patients with advanced liver disease

Author

Semmler, G, additional, Pomej, K, additional, Bauer, DJ, additional, Balcar, L, additional, Simbrunner, B, additional, Binter, T, additional, Hartl, L, additional, Becker, J, additional, Pinter, M, additional, Quehenberger, P, additional, Trauner, M, additional, Mandorfer, M, additional, Lisman, T, additional, Reiberger, T, additional, and Scheiner, B, additional

Published
2021
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32. Factor VIII/protein C ratio independently predicts liver-related events but does not reflect the hypercoagulable state in patients with advanced-chronic liver disease

Author

Balcar, L, additional, Scheiner, B, additional, Nussbaumer, RJ, additional, Weinzierl, J, additional, Paternostro, R, additional, Simbrunner, B, additional, Hartl, L, additional, Jachs, M, additional, Bauer, D, additional, Stättermayer, AF, additional, Semmler, G, additional, Pinter, M, additional, Quehenberger, P, additional, Trauner, M, additional, Reiberger, T, additional, Lisman, T, additional, and Mandorfer, M, additional

Published
2021
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36. Histological Analysis of Donor Lung Derived Thrombi

Author

Bergtop, J., primary, Zhang, K.L., additional, Timens, W., additional, Venema, L.H., additional, van de Wauwer, C., additional, Erasmus, M.E., additional, Gan, C.T., additional, Lisman, T., additional, and Verschuuren, E.A., additional

Published
2021
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38. A Clinical Comparison of Two Different Oxygen Carriers for Combined Hypothermic and Normothermic Machine Perfusion of High-risk Donor Livers

Author

van Leeuwen, O.B., primary, Bodewes, S., additional, Haring, M.P., additional, Brüggenwirth, I.M., additional, Lantinga, V.A., additional, Thorne, A.M., additional, van den Berg, A.P., additional, de Boer, M.T., additional, de Kleine, R.H., additional, Lisman, T., additional, de Vries, Y., additional, de Meijer, V.E., additional, and Porte, R.J., additional

Published
2021
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